Battling treatment resistant opioid use disorder

Similar to treatment resistant depression, there is a subpopulation of those addicted to opioids who do not respond to standard opioid use disorder (OUD) treatments. In a new paper, an addiction expert at the Brown School at Washington University in St. Louis suggests a new category for these types of patients: treatment resistant opioid use disorder (TROUD).

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UCI researchers identify a connection between early life adversity and opioid addiction

Individuals with a history of early life adversity (ELA) are disproportionately prone to opioid addiction. A new UCI-led study reveals why.

Published in Molecular Psychiatry, the study titled, “On the early life origins of vulnerability to opioid addiction,” examines how early adversities interact with factors such as increased access to opioids to directly influence brain development and function, causing a higher potential for opioid addiction.

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Opioid Dependence Found to Permanently Change Brains of Rats

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats.

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FAU and Georgia State Partner to Assist Children and Families Affected by Addiction

FAU and GSU have partnered on a program to assist children and families affected by addiction. They have received a $2.64 million grant from the U.S. Department of Health and Human Services for a program aimed at improving outcomes of Georgia’s children and families and strengthening the partnership between the Division of Family and Children Services and family treatment courts.

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Tulane team researching ways to end opioid addiction

A Tulane University researcher is part of a nationwide initiative to improve treatment of chronic pain and ultimately achieve long-term recovery from opioid addiction.

Michael J. Moore, professor of biomedical engineering in the Tulane School of Science and Engineering, is part of a $945 million National Institutes of Health project called the HEAL Initiative, or Helping to End Addiction Long-term Initiative.

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Designing a new class of drugs to treat chronic pain

A UC Davis research team, led by Vladimir Yarov-Yarovoy and Heike Wulff, will receive a $1.5 million grant from the National Institutes of Health (NIH) to develop a novel class of peptides that are better at treating pain and don’t have the side effects of opioids. The grant is part of the NIH initiative Helping to End Addiction Long-Term (HEAL Initiative).

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Other treatments can reduce need for addictive pain medication

Hardly a day goes by without the public being warned about the dangers of opioids. But still, according to the National Institute on Drug Abuse, more than 130 people die every day of opioid overdose and the problem is getting worse. A Houston Methodist pain specialist says new advancements in pain management are giving patients options.

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WashU Expert: Opioid cases represent tipping point in addiction fight

An Oklahoma judge ordered Johnson & Johnson to pay $572 million for its role in the opioid crisis in a historic ruling Aug. 26. A federal case in Ohio involves at least 1,600  lawsuits from cities and counties throughout the country. Oxycontin maker Purdue Pharma has offered to settle more than 2,000 lawsuits from states and cities for between $10 billion and $12 billion.

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