Opioid

Three Longtime Antibiotics Could Offer Alternative to Addictive Opioid Pain Relievers

DALLAS – Feb. 22, 2021 – Three decades-old antibiotics administered together can block a type of pain triggered by nerve damage in an animal model, UT Southwestern researchers report. The finding, published online today in PNAS, could offer an alternative to opioid-based painkillers, addictive prescription medications that are responsible for an epidemic of abuse in the U.S.

Sedative Drug in Combination with Opioids May Be Especially Dangerous

• In an analysis of information on US adults initiating hemodialysis, 16% of patients were dispensed a short-acting benzodiazepine, and approximately one-quarter of these patients were also dispensed opioids.
• Among patients with an opioid prescription, being dispensed a short-acting benzodiazepine had a 1.9-fold higher risk of dying over a median follow-up of 16 months compared with patients without a short-acting benzodiazepine.

Regional trends in overdose deaths reveal multiple opioid epidemics, according to new study

A recently published study shows the United States in the grip of several simultaneously occurring opioid epidemics, rather than just a single crisis. The epidemics came to light after the researchers analyzed county-level data on drug overdose deaths. The study highlights the importance of different policy responses to the epidemics rather than a single set of policies.

Designing a new class of drugs to treat chronic pain

A UC Davis research team, led by Vladimir Yarov-Yarovoy and Heike Wulff, will receive a $1.5 million grant from the National Institutes of Health (NIH) to develop a novel class of peptides that are better at treating pain and don’t have the side effects of opioids. The grant is part of the NIH initiative Helping to End Addiction Long-Term (HEAL Initiative).

New Data Indicate Rise in Opioid Use for Migraine Treatment

An increasing number of Americans are using opioids to treat their migraine headaches, despite the fact that opioids are not the recommended first-line therapy for migraine in most cases. Migraine care specialist Sait Ashina, MD, a neurologist and Director of the Comprehensive Headache Center at the Arnold-Warfield Pain Center at Beth Israel Deaconess Medical Center, presented the survey findings at the 61st annual meeting of the American Headache Society.