Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt

Praedicare Leverages AI, Mathematical Models of Disease Progression and Mapping in World’s First In Silico Clinical Trial of Its Kind

The in silico trial demonstrated 2X the efficacy of the current treatment (>80% vs 39%); 3X shorter treatment time to cure (6 vs 18 months); 1 drug compared to a 3-drug combo for the standard of care; and preclinical results in shorter time than animal models.

Researchers Discover Why One Type of Chemotherapy Works Best in Bladder Cancer

Tisch Cancer Institute researchers discovered that a certain type of chemotherapy improves the immune system’s ability to fight off bladder cancer, particularly when combined with immunotherapy, according to a study published in Cell Reports Medicine in January.

High cure rate, low toxicity maintained with shortened radiation treatment for intermediate risk prostate cancer, study finds

People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests.

Urology Insights: Vision, Research and Education

Hyung L. Kim, MD, a leading urologic oncologist, skilled surgeon and accomplished researcher frequently funded by the National Institutes of Health, was recently selected to be the inaugural chair of the Department of Urology at Cedars-Sinai.

New Community Partnership Model Boosts Inclusion of Participants into HIV Cure-Directed Research

Scientists have long used community advisory boards to engage communities and provide feedback on studies, but this model has limitations. Now, Wistar Institute researchers are sharing how a more inclusive model for community engagement can lead to deeper insights and greater community participation in HIV research.

Bilingual, digital health tool helps reduce alcohol use, UC Irvine-led study finds

An automated, bilingual, computerized alcohol screening and intervention health tool is effective in reducing alcohol use among Latino emergency department patients in the U.S., according to a study led by the University of California, Irvine. “This is the first bilingual, large-scale, emergency department-based, randomized clinical trial of its kind in the country focused on English- and Spanish-speaking Latino participants,” said lead author Dr.

Alzheimer’s Drug Development Pipeline: Promising Therapies, Pharma Investment Drive Momentum in Clinical Trials

According to the newly released “Alzheimer’s Disease Drug Development Pipeline: 2023,” there are currently 187 clinical trials in the Alzheimer’s drug development pipeline – the most ever on record. This momentum is driven in part by greater investment from the pharma industry and a bump in biologic therapies – particularly monoclonal antibodies – that were central to the success of both recent FDA-approved drugs.

The annual report spots trends in clinical trial design and outcome measures, and also investigate the types of agents and biological targets that are being pursued.

A Tool to Prevent Deaths Due to Female Underrepresentation in Clinical Trials

ROCKVILLE, MD – Women are often underrepresented in cardiac clinical trials—yet they are at least at equally high risk of death due to cardiovascular disease, and at higher risk of developing drug-induced heart complications compared to men. Clinical trials of medicines generally rely on electrocardiograms (EKG) to measure a patient’s heart’s response to a medicine and determine its safety, yet males and females have a number of differences in their heart physiology that are reflected in consistent variations in their EKGs.

Jaime Merchán, M.D., Named a Translational and Clinical Oncology Research Program Co-Leader

Jaime Merchán, M.D., is the new Translational and Clinical Oncology Research Program co-leader at Sylvester Comprehensive Cancer Center, part of UHealth – University of Miami Health System.

FSU psychologist receives $3.7 million grant to combat anxiety in older adults with Alzheimer’s, cognitive impairment

For the more than 6 million Americans living with Alzheimer’s disease, related dementias, or mild cognitive impairment, anxiety is often an accompanying challenge. A Florida State University psychologist has received a five-year, $3.7 million grant from the National Institute on Aging to study intervention techniques that aim to combat anxiety in these groups and improve quality of life.

A Leading-Edge Lymphoma Program

Less than three years after joining the Cedars-Sinai Cancer faculty, hematologist-oncologists Justin Darrah, MD, and Akil Merchant, MD, are pioneering new research and bringing a new, comprehensive set of treatment options to patients in the recently established Lymphoma Program.

Controversial Alzheimer’s drug approval sparks surprising impact

Irvine, Calif., Nov. 29, 2022 — When the U.S. Food and Drug Administration gave controversial accelerated approval to the first Alzheimer’s drug in nearly 20 years, it had a surprising impact on attitudes about research into the disease. A survey by University of California, Irvine neuroscientists has found news coverage of the FDA’s decision made the public less willing to volunteer for Alzheimer’s pharmaceutical trials.

NCCN Announces Funding for Bladder Cancer Research Projects, in Collaboration with Pfizer and EMD Serono

The National Comprehensive Cancer Network’s Oncology Research Program selects projects focused on improving patient care and outcomes in locally advanced or metastatic bladder cancer.

Restored blood flow meant less pain, better quality of life for those with leg artery disease

estoring blood flow to the legs, whether through bypass surgery or a less invasive artery-opening procedure with a stent, reduced pain and improved quality of life for people with peripheral artery disease (PAD), according to preliminary, late-breaking research presented today at the American Heart Association’s Scientific Sessions 2022.

Many middle-aged adults wary of taking part in studies of dementia prevention drugs

Drug companies and university-based teams are working urgently to find and test new medications that could prevent or slow the decline of brain function in older adults. But a new study suggests they’ll need to work harder to find volunteers for their clinical trials.

Breast Cancer Research Foundation Renews Support for Mount Sinai Research on Triple-Negative Breast Cancer

The Breast Cancer Research Foundation (BCRF) has renewed its funding to Elisa Port, MD, and Hanna Irie, MD, PhD, to study new therapeutic approaches that target aggressive triple-negative breast cancer. The latest installment of $225,000 brings the total to almost $2 million over the past nine years. It will fund research into the immune microenvironment of triple-negative breast cancer in order to identify new strategies to enhance cancer-fighting immune responses for this aggressive breast cancer, which traditionally has few options for treatment.

Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in San Antonio

The American Society for Radiation Oncology (ASTRO) announced today the 10 studies that will be highlighted in the 2022 ASTRO Annual Meeting press program. Researchers will discuss their findings in two news briefings to be held October 24 and 25 in the Henry B. Gonzalez Convention Center in San Antonio and via live webcast. Reporters can register for the meeting at astro.org/annualmeetingpress.

UCI receives $580 million in research funding for fiscal 2021-22

Irvine, Calif., Aug. 25, 2022 — From monitoring sandy beaches to gauge the effects of sea-level rise to holding clinical trials for potentially lifesaving cancer treatments, scholars, scientists and physicians at the University of California, Irvine are blazing new paths to help change the world. And their impact keeps growing.

Prompt Recognition and Treatment Found Effective for Lung Disease in Patients Who Received New Drug for Advanced Cancer

Lung disease caused by a new drug for cancers—including metastatic or advanced breast cancer—can be effectively treated using approaches that focus on early detection and prompt management, according to a study published in ESMO Open on August 11, 2022.

FAU Announces Formation of FAU Health Network

Three South Florida counties that collectively are home to the largest metropolitan population in the state will soon be served by an academic health network that is a true collaboration of the region’s leading public and private academic and medical leaders.

Groundbreaking for Major Expansion of University of Maryland Greenebaum Comprehensive Cancer Center

The University of Maryland Medical Center celebrates the groundbreaking of a nine-story patient care tower – the Roslyn and Leonard Stoler Center for Advanced Medicine – that will become the new home of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center. The $219 million building will enable the cancer center to provide the most technologically advanced, integrated care to cancer patients throughout Maryland and the region well into the future