UC San Diego researchers discover two distinct molecular subtypes of Crohn’s disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.
Tag: Personalized Medicine
Targeting cancer with precision: neoantigen vaccines show promise
In an elegant fusion of science and medicine, neoantigen cancer vaccines are emerging as a formidable strategy in the battle against cancer. These vaccines, a testament to the power of personalized medicine, target cancer’s unique protein signatures, rallying the immune system for a precise and potent attack.
Age impacts pharmacogenomics and treatment outcomes for most common form of leukemia
Explore how scientists at St. Jude Children’s Research Hospital have identified causes for age-related differences in treatment outcomes of B-cell acute lymphoblastic leukemia.
FAU Researcher Receives Grant to Personalize Radiation Therapy for Cancer
While chemotherapy has advanced in personalization, personalized radiation therapy for cancer remains underdeveloped. A new project will use AI, in particular, deep reinforcement learning, to analyze multimodal data, and enhance cancer characterization and treatment to ultimately improve patient outcomes. Using personal health data, genetic information about the tumor, and patient treatment and follow-up data, digital twins will simulate diagnoses and treatment options to help physicians choose the most effective treatments and monitor responses over time.
Q&A: New Frontiers in ALS Research
Clive Svendsen, PhD, executive director of the Board of Governors Regenerative Medicine Institute and professor of Medicine and Biomedical Sciences at Cedars-Sinai, is developing new treatments and models for amyotrophic lateral sclerosis (ALS) using stem cells.
Get Ready for ASCO 2024 Annual Meeting
ASCO, the largest event in cancer research, is approaching on May 31st. This year’s meeting promises to be particularly groundbreaking, with new findings and innovations that could revolutionize cancer treatment.
Sylvester Cancer Launches New Brain Tumor Institute to Personalize Brain Cancer Treatment
Sylvester Comprehensive Cancer Center today announced establishment of the Sylvester Brain Tumor Institute. It will focus on personalized medicine approaches for treating all patients with brain tumors.
Nucleus Genomics launches to bring whole-genome sequencing to the public
Nucleus Genomics, the next-generation genetic testing and analysis company, today announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone.
The Time Is Now for Artificial Intelligence, Machine Learning
From artificial intelligence (AI) and data integration to natural language processing and statistics, the Cedars-Sinai Department of Computational Biomedicine is utilizing the latest technological advances to find solutions to some of the most complex healthcare issues.
VUMC part of major step to achieving precision medicine
An analysis of genomic data from nearly 250,000 participants in the National Institutes of Health’s Research Program has identified more than 275 million previously unreported genetic variations, nearly 4 million of which have potential health consequences. The data, reported Feb. 19 in the journal , constitutes a research resource that is unprecedented in its scale and diversity, as 77% of the participants historically have been underrepresented in biomedical research, and 46% are from underrepresented racial and ethnic minorities.
How AI and Wearable Technologies Are Transforming Medicine
Imagine a world in which the digital watch on your wrist tracks not only your step count, but also your blood sugar, heart rate, blood pressure and respiration.
UCLA biobank study reveals disease risk, heath care use among LA’s diverse population
The research underscores the limitations of the health care system’s frequent reliance on broad self-reported race and ethnicity data to assess patients’ risk of developing disease, and the findings also support expanding genetic screening to more groups.
Cedars-Sinai Establishes Center for Artificial Intelligence Research and Education
The Cedars-Sinai Department of Computational Biomedicine recently sharpened its focus on advancing artificial intelligence and machine learning by establishing the Center for Artificial Intelligence Research and Education.
Study finds genetic screening of adults would be cost-effective
An exhaustive cost-benefit analysis of population genetic testing published in Annals of Internal Medicine concludes with a recommendation to U.S. health policymakers to adopt routine testing of adults ages 40 and under for three genetic conditions posing high risk of life-threatening illness.
Optimizing sepsis treatment timing with a machine learning model
A new machine learning model that estimates optimal treatment timing for sepsis could pave the way for support tools that help physicians personalize treatment decisions at the patient bedside, researchers say.
IU neuroscientists lead new study laying groundwork for Alzheimer’s disease precision medicine
A 5-year, $41 million study will help researchers better understand the biological pathways underlying Alzheimer’s disease and ultimately create more personalized patient care through the development of a blood test for multiple pathways implicated in the disease – enabling earlier and less-invasive diagnosis.
An extra X chromosome-linked gene may explain decreased viral infection severity in females
Researchers may have found why viral infections hit males more severely than females. They found that female mouse and human NK cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.
UChicago Medicine-led team selected for the 2022 Michael & Lori Milken Family Foundation-PCF Challenge Award to develop novel immunotherapy approaches in advanced prostate cancer
The Prostate Cancer Foundation (PCF) has awarded a $1 million grant to a renowned specialist at the University of Chicago Medicine Comprehensive Cancer Center.
Soldiers in Recovery from Alcohol Use Disorder Who Experience Cardiovascular Withdrawal Symptoms May Benefit from Medication Targeting Brain Stress Response
Prazosin, a medication FDA-approved for hypertension and used off-label for alcohol use disorder, may help prevent drinking relapse in people with cardiovascular or behavioral symptoms of alcohol withdrawal, according to a new study involving active-duty soldiers.
December 2022 Issue of Neurosurgical Focus: “Personalized Medicine in the Treatment of Neuro-Oncology and Neurosurgical Disease”
Announcement of contents of the December 2022 issue of Neurosurgical Focus
Integrating Genetic Testing in Electronic Health Records Saves Time, Study Finds
Ordering and managing genomic testing in electronic health records significantly cut the time Penn Medicine clinicians spent doing it
Muscle Models Mimic Diabetes, Inform Personalized Medicine
Scientists are using in vitro skeletal muscle engineering to gain a better understanding of the complex genetic and environmental factors underlying diabetes, putting lab-grown, healthy skeletal muscle tissues in a state resembling diabetes or growing skeletal muscle from diabetic patients’ muscle stem cells. In Biophysics Reviews, researchers describe how skeletal muscle engineering has advanced significantly during the past few decades and recent developments that make it easier to explore diabetes in humans and have led to more personalized medicine.
Artificial Intelligence in Personalized Medicine, Genomic Sequencing Advances, Human Brain Organogenesis, Building Trust with Patients, Guiding Patient Decisions with Mass Spectrometry, and Much More to Be Explored at 2022 AACC
At the 2022 AACC Annual Scientific Meeting & Clinical Lab Expo, laboratory medicine experts will present the cutting-edge research and technology that is revolutionizing clinical testing and patient care.
New Understanding of Congenital Heart Disease Progression Opens Door to Improved Treatment Options
A team of investigators from Texas Heart Institute, Texas Children’s Hospital and Baylor College of Medicine uncovered new insights into the mechanisms underlying the progression of congenital heart disease (CHD) ― a spectrum of heart defects that develop before birth and remain the leading cause of childhood death.
Penn Medicine and Children’s Hospital of Philadelphia Announce Partnership with Costa Rica for CAR T Cell Therapy
Penn Medicine and Children’s Hospital of Philadelphia (CHOP), who together pioneered the research and development of the world’s first personalized cellular therapy for cancer — also known as CAR T cell therapy — have announced plans with Costa Rica’s CCSS, or the Caja Costarricense de Seguro Social (Social Security Program), to facilitate CAR T research in Costa Rica.
Personalized medicine research focuses on Hispanics with diabetes in South Texas
A team of researchers studying genetic data to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity recently received a $3.5 million grant to fund a five-year study set to begin in late 2021.
Multi-Algorithm Approach Helps Deliver Personalized Medicine for Cancer Patients
John F. McDonald and his research team have created a ‘multi-algorithm’ machine learning approach to boost accuracy in predicting drug responses for ovarian cancer patients.
$2.1 Million Gift Launches Comprehensive Breast Cancer Database
Philanthropists Richard and Carol Dean Hertzberg have committed $2.1 million to develop and maintain the Dean-Hertzberg Breast Cancer Database System Initiative at UC San Diego Health Moores Cancer Center to support the work of Anne Wallace, MD and her collaborators at Moores Cancer Center.
Scientists Create a Labor-Saving Automated Method for Studying Electronic Health Records
Scientists at the Icahn School of Medicine at Mount Sinai described the creation of a new, automated, artificial intelligence-based algorithm that can learn to read patient data from electronic health records. In a side-by-side comparison, they showed that their method, called Phe2vec (FEE-to-vek), accurately identified patients with certain diseases as well as the traditional, “gold-standard” method, which requires much more manual labor to develop and perform
When provided personalized health resources, patients often share with others
A survey of participants in a clinical trial for CommunityRx, a community resource referral intervention, found that nearly half of users reported sharing their personalized health resources with at least one other person.
Personalized Immunotherapy Response Studied in Body-on-a-Chip Cancer Models
Wake Forest researchers and clinicians are using patient-specific tumor ‘organoid’ models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer.
University of Chicago Medicine Comprehensive Cancer Center Researcher Receives National Cancer Clinical Investigator Team Leadership Award
Daniel Catenacci, MD, a physician-scientist and associate professor of medicine at UChicago Medicine, has received the National Cancer Institute (NCI) 2021 Cancer Clinical Investigator Team Leadership Award (CCITLA).
UCLA Health receives $4.8M NIH grant to improve genetic estimates of disease risk in diverse populations
UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.
The simulated patient
Digital twins enable customized medical therapies. Empa researchers have now modeled several hundred such avatars based on real people and treated them experimentally. For the first time, the digital twins received feedback from real patients.
New wiki on salivary proteins may transform diagnostic testing and personalized medicine
To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.
UB pharmacy researcher aims to develop real-time algorithm to lower hospital readmission rates
To lower hospital readmission rates for patients with chronic obstructive pulmonary disease (COPD), University at Buffalo pharmacy researcher David Jacobs has received a $962,000 award from the National Heart, Lung, and Blood Institute to develop a real-time readmission risk prediction algorithm.
Immunomics: A Conversation on the Future of Diagnostics with Ramy Arnaout
In a recent perspective article, pathologists outline how the immunome — all of the genes collectively expressed by an individual’s immune cells — holds the potential to provide researchers and physicians with unprecedented insight into an individual’s health. Collecting that information from large numbers of patients could one day facilitate diagnostics via a near-universal blood test and pave the way to targeted therapies for a wide variety of conditions.
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Curcumin Selected as Cognition Supplement of the Year: 2021, says Dr. Leslie Norins of MCI911.com
As yet there is no prescription drug to cure mild cognitive impairment (MCI), often a harbinger of Alzheimer’s disease. Medical research journals reveal curcumin can sometimes bolster cognition. It merits a try.
DrugCell: New Experimental AI Platform Matches Tumor to Best Drug Combo
UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer.
Mount Sinai Doctors Elected to National Academy of Medicine for Contributions to Emergency Medicine and Translational Genetics
Brendan G. Carr, MD, MA, MS, and Judy H. Cho, MD, of the Icahn School of Medicine at Mount Sinai, have been elected to the National Academy of Medicine (NAM).
Researchers Use Lab-grown Tissue Grafts for Personalized Joint Replacement
A multidisciplinary team from Columbia Engineering, Columbia’s College of Dental Medicine and Department of Medicine, Louisiana State University, LaCell LLC, and Obatala Sciences has now bioengineered living cartilage-bone temporomandibular joint grafts, precisely matched to the recipient, both biologically and anatomically. Their new study, published today in Science Translational Medicine, builds upon a long series of their previous work on bioengineering functional cartilage and bone for regenerative medicine and tissue models of disease.
Phosphoprotein biomarkers to guide cancer therapy are identified
Post-translational modification analysis may broadly identify new biomarkers of cancer drivers for a much more precise prediction of patient responses to treatments. A recent study demonstrates this diagnostic alternative for neuroendocrine neoplasms driven by a protein kinase called Cdk5.
First-of-its-Kind Personalized ‘COVID-19 Risk Score’ Launches to Enable Safer Re-opening and Return to Work Plans
Coriell Life Sciences is rolling out a new tool in the fight against COVID-19: personalized COVID-19 Risk Scores designed to enable safer re-opening and return to work plans (especially given the recent release of the CDC guidelines for re-opening).
Precision medicine guides choice of better drug therapy in severe heart disease
Is personalized medicine cost-effective? Researchers have answered that question for one medical treatment, genotype-guided antiplatelet therapy for acute coronary syndrome patients with PCI. Their study uses pharmacogenomics and economic analysis of real-world clinical data.
Genetic complexity: A spanner in the works?
The promise of personalized medicine has not fully materialized, say two McMaster researchers, because the full sophistication of the genetic blueprint has a more complex and far-reaching influence on human health than scientists had first realized.
April’s Edition of SLAS Technology is Accessible
Just released is the April edition of SLAS Technology featuring cover article, “CURATE.AI: Optimizing Personalized Medicine with Artificial Intelligence,” by Agata Blasiak, Ph.D., Jeffrey Khong, Ph.D., and Theodore Kee, Ph.D., (University of Singapore and The N.1 Institute for Health).
Coriell Researchers Identify SNP Associated with Obesity Risk
Obesity is among the most common complex diseases in the United States and has been a stubborn public health challenge for decades. Its causes are wide ranging, but genetic heritability is increasingly understood to be an influential factor in determining a person’s risk for the disease. Coriell researchers have found a new genetic indicator of obesity risk and bolstered the understood importance of one gene’s role in obesity risk.
Superior “Bio-Ink” for 3D Printing Pioneered
Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.
Weizmann Scientists Devise New Algorithm that Predicts Gestational Diabetes
Using machine learning to analyze data on nearly 600,000 pregnancies, researchers devised an algorithm that identified nine parameters – out of more than 2,000 analyzed – that can predict which women are at risk of gestational diabetes. The parameters can identify risk early in – even before – pregnancy, enabling early intervention.