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UrduA novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to research from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy and Johns Hopkins Drug Discovery.
Tag: Macrophage
Variations in “ancient” immune cells linked to patients’ survival in cancer
Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS), have achieved breakthroughs in understanding relapse after chemotherapy for a type of cancer known as diffuse large B-cell lymphoma (DLBCL).
Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation
Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value o
White Blood Cell Changes Develop in Acute Kidney Injury, Regardless of Cause
Article title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…
A new pathway to shrink cancerous tumors through body’s immune cells
Cancer researchers at the Case Western Reserve University School of Medicine say they have successfully suppressed the growth of some solid tumors in research models by manipulating immune cells known as a macrophages.
Brain Cancer: Hunting What’s Left
Like a mystery detective, Sara G.M. Piccirillo, PhD, is hunting deadly bad actors by studying the crime scene and questioning bystanders one by one. But these bad actors are cells in the brain. She is using two grants to study tumor cells and cells in the surrounding area, one by one.
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Examining how coronavirus infects cells
Identifying the genetic mechanisms through which the new coronavirus enters and infects cells can help scientists combat COVID-19—and perhaps other emerging viruses.
Macrophages Play Important Role in Pediatric Obesity-associated Kidney Disease
Article title: Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats Authors: Bibek Poudel, Corbin A. Shields, Andrea K. Brown, Ubong Ekperikpe, Tyler Johnson, Denise C. Cornelius, Jan M. Williams From the…
Lipid signaling from beta cells can potentiate an inflammatory macrophage polarization
The insulin-producing beta cells in the pancreas unwittingly produce a signal that may aid their own demise in Type 1 diabetes, according to a study of the lipid signals that drive macrophage cells in the body to two different phenotypes of activated immune cells.
Researchers identify immune-suppressing target in glioblastoma
Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the almost uniformly lethal brain tumor.
University of Chicago scientists unveil the secret of cancer-associated Warburg effect
A new study, led by researchers at the University of Chicago, provides an answer to why cancer cells consume and use nutrients differently than their healthy counterparts and how that difference contributes to their survival and growth.