Personalized medicine research focuses on Hispanics with diabetes in South Texas

A team of researchers studying genetic data to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity recently received a $3.5 million grant to fund a five-year study set to begin in late 2021.

Structural Racism and Inequitable Pediatric Diabetes Care

Data show racial disparities in type 1 diabetes treatment and outcomes in non-Hispanic Black (NHB) children in the US. NHB children are less likely to be treated with diabetes technology, have poorer glycemic control and higher rates of diabetes complications and diabetes-related mortality than non-Hispanic white children. There is much to be done to ensure equitable care, but as yet, structural racism has not been a focus.

Experts mark the centennial anniversary of the discovery of insulin by highlighting the critical role adipose tissue has played in understanding insulin’s control of metabolism.

2021 marks 100 years since researchers identified insulin, a hormone produced by the pancreas that regulates the amount of glucose, or sugar, in the blood.  Soon after, insulin was shown to be effective in lowering blood glucose in humans with…

High readmission rate found for adults with type 1 diabetes hospitalized for diabetic ketoacidosis

One in five adults with type 1 diabetes who require in-hospital treatment of the life-threatening condition diabetic ketoacidosis has an unplanned repeat hospital visit within a month and is twice as likely to die during the second hospitalization, a new study finds. The results, which will be presented at ENDO 2021, the Endocrine Society’s annual meeting, also identified several factors that increased the readmission risk for these patients.

Tubeless automated insulin delivery system improves blood glucose outcomes

People with type 1 diabetes can improve their blood sugar control while reducing time with low blood sugar, or hypoglycemia, using Insulet Corporation’s Omnipod 5 Automated Insulin Delivery System compared to their standard insulin therapy. Results from an industry-sponsored study of the latest Omnipod, the first tubeless, wearable insulin pump, will be presented at ENDO 2021, the Endocrine Society’s annual meeting.

Children, teens with type 1 diabetes had better glucose control during COVID-19 lockdown

Blood glucose levels improved among children and teens with type 1 diabetes during the first 12 weeks of COVID-19 lockdown in the United Kingdom, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

Addressing the Impact of Structural Racism on Disparities in Children with Type 1 Diabetes

Advancements in diabetes technology have improved quality of life and glycemic control in children with type 1 diabetes. However, data show that a subset of children is being left behind. Those from low-income families and non-Hispanic Black (NHB) children are not experiencing benefits associated with technological advances, and are at higher risk for diabetes complications and adverse outcomes through ongoing poor glycemic control.

Routine eye scans may give clues to cognitive decline in diabetes

In older people with type 1 diabetes, damage to the retina may be linked to memory problems and other cognitive conditions.BOSTON – (December 31, 2020) – As they age, people with diabetes are more likely to develop Alzheimer’s disease and other cognitive disorders than are people without diabetes. Scientists at Joslin Diabetes Center now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes.

Targeting T cell protein could prevent type 1 diabetes, study suggests

Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes. The study, which will be published December 9 in the Journal of Experimental Medicine (JEM), reveals that inhibiting a protein called OCA-B protects mice from type 1 diabetes by limiting the activity of immune cells that would otherwise destroy the pancreas’ insulin-producing β cells.

Racial Disparities in Pediatric Diabetes Treatment

Type 1 diabetes (T1D) is the third most common pediatric chronic disease in the United States, and the risk of the disease has risen sharply in non-Hispanic Black (NHB) children in the last 20 years, data show. Ironically, the significant advances in T1D therapeutics over recent years, especially new technologies, may have exacerbated racial disparities in diabetes treatment and outcomes

Raising Awareness During Diabetes Awareness Month – Adult and Pediatric Diabetes Experts Available

More than 34 million people in the U.S, or 10.5% of the population, have diabetes, according to the Centers for Disease Control and Prevention. And as many as 7 million more Americans have the disease and don’t know it. Diabetes is the seventh-leading cause of death in the country..

Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection

Transplanting cadaver pancreatic islets is a promising therapy for Type 1 diabetes, but a reactivated autoimmunity means low graft viability after five years. Research now shows that a protective coating of two biopolymers can delay allograft and autoimmune-mediated rejection in mouse models of T1D.

15-Year Trend Persists in Disparate Insulin Pump Use in Children

Insulin pumps are widely used in the management of type 1 diabetes (T1D) and reviews have shown insulin pump therapy to be associated with improved glycemic control, fewer severe hypoglycemia events, and improved quality of life. Yet, non-Hispanic white children (NHW) are more than twice as likely as non-Hispanic Black children (NHB) to use this technology.

Complications from diabetes linked to worse memory, IQ in children

A study led by UC Davis Health researchers uncovered that even one severe episode of diabetic ketoacidosis (DKA) in children newly diagnosed with type 1 diabetes is linked to cognitive problems; and among children with a previous diagnosis, repeated DKA exposure predicted lower cognitive performance after accounting for glycemic control.

Helping Teens with Type 1 Diabetes Improve Diabetes Control with MyDiaText

Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM). The challenges of managing multiple doses of daily insulin administration, blood glucose monitoring, dietary and exercise requirements, can make self-care difficult and complicate outcomes. Adolescents with T1DM often have poorer diabetes outcomes than others, indicating that glucose control is difficult for them to maintain.

Novel diabetes drug candidate shows promising properties in human islets and mouse models

Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.

NIH Awards $9.5 Million for Einstein-Mount Sinai Diabetes Research Center

Albert Einstein College of Medicine has received a $9.5 million, five-year grant from the National Institutes of Health (NIH) to support the Einstein-Mount Sinai Diabetes Research Center (ES-DRC). The multi-institutional center is a leader in basic, translational, clinical, and community-based research and training in type 1 and type 2 diabetes, obesity, and other metabolic disorders.

For the First Time, Study Identifies Time Trends in Pregnancy-Related Outcomes Among American Women with Type 1 Diabetes

Largest US database of pregnant women with type 1 diabetes provides a first-time, big picture view of mother’s health, and neonatal and delivery outcomes.

The analysis found a threefold increase in insulin pump use at the end of the study period, compared to the start of the study, but A1c levels remained steady across the 13-year period.

Over time the study showed a trend toward pre-pregnancy obesity and unhealthy maternal weight gain.

Promising treatment to slow kidney disease doesn’t prove out in clinical trial

Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure requiring hemodialysis or a kidney transplant for survival. Progression of kidney disease in type 1 diabetes is correlated with increased amounts of uric acid. A multi-institution randomized clinical trial of a drug used to control uric acid did not show the desired clinical benefits, but did give a very clear answer to an important scientific question.

Effect of Continuous Glucose Monitoring on Hypoglycemia in Older Adults With Type 1 Diabetes

Fewer than one in five adolescents and young adults with type 1 diabetes are successful in achieving the recommended 2019 A1C goal of below 7.5%, and the overwhelming majority fail to achieve the 2020 target of less than 7%. But young people who use continuous glucose monitoring (CGM) devices can significantly improve their overall blood glucose control, without increasing severe low or high glucose levels, according to findings from a 6-month, multi-center clinical trial. And both severe hypoglycemia (low glucose) and hyperglycemia (high glucose) can lead to emergency care and hospitalization.

Health care organizations issue joint framework to increase utilization of diabetes self-management education and support

Seven leading diabetes organizations issued a consensus report today highlighting the value of diabetes self-management education and support (DSMES) services as part of comprehensive diabetes medical care. The report provides compelling evidence for the need for increased utilization of DSMES, four key times that DSMES is most beneficial, and specific recommendations for both clinicians and health systems to increase access to and participation in DSMES services.

Joslin Research Ties Autoimmunity-Associated Heart Dilation to Potential Heart-Failure Risk in Type 1 Diabetes

There’s a higher case fatality rate in type 1 than type 2 diabetes, which suggests different mechanisms for heart failure might be involved in type 1 diabetes.” Given the burden of heart failure in type 1 diabetes, the early identification of patients at particular risk is of importance.

Mount Sinai Discovers New Drug Combo to Induce High Rates of Human Beta Cell Regeneration

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells—the cells in the pancreas that produce insulin—without harming most other cells in the body. The result is an important step toward a diabetes treatment that restores the body’s ability to produce insulin.

DNA Misfolding in White Blood Cells Increases Risk for Type 1 Diabetes

Researchers found, in mice, that changes in DNA sequence can trigger the chromosomes to misfold in a way that puts one at a heightened risk for Type 1 diabetes. The study revealed that differences in DNA sequences dramatically changed how the DNA was folded inside the nucleus, ultimately affecting the regulation of genes linked to the development Type 1 diabetes.

New president officially recognized at the Association of Diabetes Care & Education Specialists

Kellie Antinori-Lent, MSN, RN, ACNS-BC, BC-ADM, CDCES, FADCES was officially recognized last week at the meeting of the board of directors as the 2020 president of the newly rebranded Association of Diabetes Care & Education Specialists (ADCES).

Former AADE rebrands as Association of Diabetes Care & Education Specialists

The former American Association of Diabetes Educators is now the Association of Diabetes Care & Education Specialists (ADCES). The rebranding reflects the association’s shift from referencing the specialty title as “diabetes educator” to the more comprehensive “diabetes care and education specialist.” The new title more accurately signifies the range of expertise diabetes care and education specialists provide to people with diabetes, prediabetes and cardiometabolic conditions, the health care system, payers and providers.

Listening to Patients Provides Insights into ‘Diabetes Burnout,’ Says Study in American Journal of Nursing

Essentially all patients living with type 1 diabetes experience “diabetes burnout” at some time or other. What is diabetes burnout, what factors contribute to the problem, and what can patients and nurses do about it? Those questions are addressed in a descriptive study in the December issue of the American Journal of Nursing. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Study finds associations between rheumatoid arthritis, other diseases before and after diagnosis

A Mayo Clinic-led study involving 3,276 patients has found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. The study, published in Mayo Clinic Proceedings, also found that people who have rheumatoid arthritis are at increased risk of developing heart disease, blood clots and sleep apnea.

AADE and AANP Partner to Increase Adoption of Professional Continuous Glucose Monitoring Programs

The American Association of Diabetes Educators (AADE) and the American Association of Nurse Practitioners (AANP) have partnered to release a new tool kit that guides healthcare professionals in the implementation of a professional continuous glucose monitoring (CGM) program within their health systems.

Artificial pancreas system better controls blood glucose levels than current technology

A multi-center randomized clinical trial evaluating a new artificial pancreas system — which automatically monitors and regulates blood glucose levels — has found that the new system was more effective than existing treatments at controlling blood glucose levels in people with type 1 diabetes.The study showed that the system improved participants’ blood glucose control throughout the day and overnight.