It’s long been thought that having “autoreactive” T cells in the pancreas was a sure sign of type 1 diabetes. Yet a new study led by scientists at La Jolla Institute for Immunology (LJI) shows that even healthy people have these cells lurking in the pancreas—in surprisingly high numbers.
Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.
Research from doctors at The Ohio State University Wexner Medical Center finds a new “virtual biopsy” allows them to definitively diagnose cysts in the pancreas with unprecedented accuracy. This means they can eliminate precancerous cysts and potentially save lives.
A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for control of cell proliferation and organ identity and is implicated in cancer, thus having broad implications for health and development of new therapeutics