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UrduAs an associate professor at Sanford Burnham Prebys, Dhar focuses on how lifestyle factors such as high-calorie diets, excessive alcohol consumption and minimal exercise—along with genetic predispositions—can lead to problematic changes in the liver, heart and kidneys. By studying the conversation among the liver, the immune system, heart and kidneys, Dhar hopes to discover signals that could be used to detect metabolic disorders, especially metabolic-associated steatohepatitis (MASH), and liver cancer much earlier, when they’re easier to treat.
Tag: Kidney Function
Parathyroidectomy shows no effect on kidney function in older adults with hyperparathyroidism
An emulated randomized trial performed using observational data from more than 43,000 adults with primary hyperparathyroidism found that parathyroidectomy had no estimated effect on long-term kidney function in older adults when compared to observation. However, early parathyroidectomy may preserve kidney function in patients younger than 60 years of age with primary hyperparathyroidism. The study is published in Annals of Internal Medicine.
Chemotherapy Drug Increases Kidney Injury in Mouse Model of Lung Cancer
Article title: Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity Authors: Andrew Orwick, Sophia M. Sears, Cierra N. Sharp, Mark A. Doll, Parag P. Shah, Levi J. Beverly, Leah J. Siskind From the authors: “This…
Diabetes Drug Improves Kidney Function and Inflammation
Article title: Reno-protective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system Authors: Xin Chen, Denis Delić, Yaochen Cao, Linghong Shen, Qin Shao, Zheyu Zhang, Hongwei Wu, Ahmed A. Hasan, Christoph…
How would eliminating race-based adjustments in estimates of kidney function impact clinical trials?
• In an analysis of data from a recent clinical trial, researchers found that removing a race-based adjustment in the estimation of individuals’ kidney function had a small but potentially important impact on the inclusion of participants, with differing effects on Black and non-Black participants.
• Removal of the race-based adjustment also influenced inclusion parameters such as participants’ severity of kidney function impairment at baseline as well as their risk of developing cardiovascular- and kidney-related outcomes.
Update: Reassessing Inclusion of Race in Diagnosing Kidney Diseases
The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) congratulate the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases for submitting its final report for publication.
Study Compares Strategies to Eliminate Race-Based Adjustments in Estimates of Kidney Function
• Removal of race adjustments to equations that estimate kidney function would increase the number of people categorized as having chronic kidney disease.
• There are several modifications for removing race that vary in their expected impact on predicted kidney function values and associated clinical decisions.
• Among race-free equations, the one based on blood measurements of cystatin C would likely result in the smallest changes.
Precision medicine helps identify “at-risk rapid decliners” in early-stage kidney disease
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Cardiologists at Henry Ford Are First in U.S. to Implant New Device to Treat Heart Failure, Improve Kidney Function
Cardiologists at Henry Ford Hospital are first in the U.S. and second in the world to implant a circulatory support device that is being investigated in a clinical trial for patients hospitalized with acute decompensated heart failure (ADHF) and worsening kidney function, a condition known as cardiorenal syndrome.
MicroRNA Testing of Healthy Children Could Provide a Window on Heart and Kidney Health Later in Life
Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics.
Nicotine Worsens Renal Disease in Smokers with Diabetes, Damages Kidney Filters
New research suggests the toxic effects of nicotine on the kidneys’ filtering function are partly responsible for the progression of diabetes-related kidney disease in people who smoke. The study is published ahead of print in the American Journal of Physiology-Renal Physiology.
Rethinking Race and Kidney Function
Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.
Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.
On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.
A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.
Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.
Scientists say the analysis should motivate researchers and cl
Combining Omics, Function and Phenotype Brings New Insight to Kidney Function and Physiology
Researchers use a novel integrative approach to examine function and proteins expressed by a highly specialized segment of the kidneys in a new study published ahead of print in the journal Function. Current technology makes it possible to analyze molecules…
Kidney Function May Affect Risks Associated with Prescription Opioids
• Compared with other pain medications, prescription opioids were linked with higher risks of death and hospitalization, particularly with higher doses.
• The risk of death associated with opioids was highest among people with lower kidney function.
Researchers to Discuss Hormonal and Sodium-related Factors of Cardiovascular Disease at APS Conference
International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.
Baking Soda Boosts Immunity, Impairs Insulin Response in Type 2 Diabetes
Researchers learn insulin response connected to alkaline load, not inflammation Charlottesville, Va. (June 24, 2019)—Early research suggests that the common pantry staple baking soda affects inflammation and insulin handling in type 2 diabetes. The findings will be presented today at…
Donald Kohan Details Recent Advances and New Frontiers in Kidney Research in Keynote Address
Charlottesville, Va. (June 23, 2019)—New treatments, exciting research and future trends in kidney health are the focus of discussion at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville,…