Parathyroidectomy shows no effect on kidney function in older adults with hyperparathyroidism

An emulated randomized trial performed using observational data from more than 43,000 adults with primary hyperparathyroidism found that parathyroidectomy had no estimated effect on long-term kidney function in older adults when compared to observation. However, early parathyroidectomy may preserve kidney function in patients younger than 60 years of age with primary hyperparathyroidism. The study is published in Annals of Internal Medicine.

Chemotherapy Drug Increases Kidney Injury in Mouse Model of Lung Cancer

Article title: Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity Authors: Andrew Orwick, Sophia M. Sears, Cierra N. Sharp, Mark A. Doll, Parag P. Shah, Levi J. Beverly, Leah J. Siskind From the authors: “This…

How would eliminating race-based adjustments in estimates of kidney function impact clinical trials?

• In an analysis of data from a recent clinical trial, researchers found that removing a race-based adjustment in the estimation of individuals’ kidney function had a small but potentially important impact on the inclusion of participants, with differing effects on Black and non-Black participants.
• Removal of the race-based adjustment also influenced inclusion parameters such as participants’ severity of kidney function impairment at baseline as well as their risk of developing cardiovascular- and kidney-related outcomes.

Study Compares Strategies to Eliminate Race-Based Adjustments in Estimates of Kidney Function

• Removal of race adjustments to equations that estimate kidney function would increase the number of people categorized as having chronic kidney disease.
• There are several modifications for removing race that vary in their expected impact on predicted kidney function values and associated clinical decisions.
• Among race-free equations, the one based on blood measurements of cystatin C would likely result in the smallest changes.

Cardiologists at Henry Ford Are First in U.S. to Implant New Device to Treat Heart Failure, Improve Kidney Function

Cardiologists at Henry Ford Hospital are first in the U.S. and second in the world to implant a circulatory support device that is being investigated in a clinical trial for patients hospitalized with acute decompensated heart failure (ADHF) and worsening kidney function, a condition known as cardiorenal syndrome.

MicroRNA Testing of Healthy Children Could Provide a Window on Heart and Kidney Health Later in Life

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics.

Nicotine Worsens Renal Disease in Smokers with Diabetes, Damages Kidney Filters

New research suggests the toxic effects of nicotine on the kidneys’ filtering function are partly responsible for the progression of diabetes-related kidney disease in people who smoke. The study is published ahead of print in the American Journal of Physiology-Renal Physiology.

Rethinking Race and Kidney Function

Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.

Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.

On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.

A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.

Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.

Scientists say the analysis should motivate researchers and cl

Researchers to Discuss Hormonal and Sodium-related Factors of Cardiovascular Disease at APS Conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

Baking Soda Boosts Immunity, Impairs Insulin Response in Type 2 Diabetes

Researchers learn insulin response connected to alkaline load, not inflammation Charlottesville, Va. (June 24, 2019)—Early research suggests that the common pantry staple baking soda affects inflammation and insulin handling in type 2 diabetes. The findings will be presented today at…

American Physiological Society (APS)

Donald Kohan Details Recent Advances and New Frontiers in Kidney Research in Keynote Address

Charlottesville, Va. (June 23, 2019)—New treatments, exciting research and future trends in kidney health are the focus of discussion at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville,…