In an analysis of data on US patients with autosomal dominant polycystic kidney disease, patient outcomes such as age of onset of kidney failure and access to kidney transplantation were strongly associated with race and ethnicity.
• Although clinical trials have linked diabetes medications called sodium glucose transport-2 inhibitors to higher bone fracture risks, a large study found no additional risks when the medications were compared with diabetes drugs not associated with fractures.
• The findings applied to older adults with normal kidney function as well as to those with mild or moderate kidney disease.
2011 changes in policies and recommendations related to the use of erythropoietin-stimulating agents were associated with lower hemoglobin levels and lower risks of major adverse cardiovascular events, mortality, and stroke among adults receiving hemodialysis, but with a higher risk of heart attack.
In hospitalized patients with COVID-19, the SGLT2 inhibitor dapagliflozin was well tolerated regardless of kidney function, but did not significantly lower patients’ risk of organ failure, kidney problems, or death compared with placebo.
A Chula research team has developed a screening strip kit to detect the early stage of chronic kidney disease (CKD) that’s easy to use, yields quick results, increasing the chance of being cured for patients, and helping to cut over 10 billion baht of the ever-increasing annual healthcare costs for CKD patients. The CKD screening strip kits are expected to be released early next year.
• Researchers have identified several metabolites in the blood whose levels are altered by coffee consumption.
• Levels of 3 of these coffee-related metabolites were significantly associated with individuals’ risk of developing chronic kidney disease.
Rockville, Md. (August 25, 2021)—The results of a new study indicate the anesthetic gas sevoflurane—which is commonly used during surgery to keep a patient sedated—causes the kidneys to save water and salts as opposed to when the patient is conscious.…
University of South Australia researchers have a bone to pick when it comes to drinking too much coffee as new research finds that excess caffeine may be linked to an increased risk of osteoporosis.
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
• Primary nephrotic syndrome is characterized by high urinary excretion of protein, low protein in the blood, high cholesterol, and swelling in the arms and legs.
• A new analysis highlights the high risk of kidney failure and different cardiovascular complications in patients with primary nephrotic syndrome.
• The virus that causes COVID-19 can infect and replicate in human kidney cells, but this does not typically lead to cell death.
• Kidney cells that already have features of injury may be more easily infected and develop additional injury.
The kidneys become resistant to the water-balance hormone vasopressin within just a few days of potassium deficiency being detected in the blood, according to a new research article published in the America Journal of Physiology-Renal Physiology.
Embargoed press materials are now available for the virtual Experimental Biology (EB) 2021 meeting, featuring cutting-edge multidisciplinary research from across the life sciences. EB 2021, to be held April 27–30, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
The Wake Forest Institute for Regenerative Medicine is investigating how cats with chronic kidney disease could someday help inform treatment for humans.
An artificial intelligence-enabled in vitro diagnostics company and the University of Utah today announced a partnership to improve kidney health and reduce the risk of kidney failure for large scale populations in the earliest stages of kidney disease.
— The American Society of Nephrology (ASN) re- affirms its supporti for the Organ Procurement Organizations (OPOs) Conditions for Coverage final rule issued on November 20, 2020. The society calls for the Biden-Harris administration to implement this final policy as expediently as possible. By bringing objective and verifiable standards to assess the performance of OPOs, this final rule will increase the number of organs available for transplant and reduce racial inequity in the U.S. transplant system.
Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury.
Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.
Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.
On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.
A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.
Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.
Scientists say the analysis should motivate researchers and cl
• Acute kidney injury (AKI) is common during hospitalization with COVID-19 in the U.S. veterans, and it’s associated with a higher risk of death. This risk is especially high for Black veterans.
• Nearly half of the veterans with AKI in this analysis did not fully recover their kidney function by the time of hospital discharge.
Researchers have created an experimental device that, instead of inhibiting inflammatory proteins in COVID-19 patients, changes the phenotype of circulating white blood cells, helping wean two patients off ECMO.
Article title: Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging Authors: Ebrahim Tahaei, Richard Coleman, Turgay Saritas, David H. Ellison, Paul A. Welling From the authors: “Female mice expressed a greater density of [sodium cotransporters] in a shorter…
What about the kidneys make them a hotspot for COVID-19’s cytokine storm? A research team says it’s the presence of a protein found on specialized renal transport cells.
Use of drug-coated balloon angioplasty to treat blocked blood vessels used for hemodialysis offers hope for millions of patients globally
UC San Diego Health is ranked first in San Diego and sixth in California, placing it among the nation’s best hospitals, according to the 2020-2021 U.S. News & World Report. Eight common procedures and conditions were also rated “high performing.”
• A recent study found that most kidney transplant recipients with COVID-19 do not need to be hospitalized.
• Another study found that patients on dialysis who develop COVID-19 may have symptoms that are different from other patients with the infectious disease.
• A new study has found that common terms used by physicians to describe kidney health may be distressing or too difficult to understand for patients with kidney disease.
. Ashita Tolwani, a nephrologist at the University of Alabama at Birmingham, explains how COVID-19 is impacting patients and putting a strain on the availability of dialysis supplies..
• The American Society of Nephrology has launched several initiatives to provide guidance on COVID-19 as it relates to the care of patients with kidney disease.
• Exposure to higher amounts of fine particulate matter air pollution was associated with a higher degree of albuminuria—a marker of kidney dysfunction—as well as a higher risk of developing chronic kidney disease over time.
The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.
High levels of protein in a patient’s urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.
• Wearable and implantable devices may allow for intensive self-care for patients with kidney failure outside of the clinic.
• Additional research must focus on technological improvements to bring such ambulatory devices to patients as envisioned by the recent Executive Order on the “Advancing American Kidney Health Initiative”.
A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for control of cell proliferation and organ identity and is implicated in cancer, thus having broad implications for health and development of new therapeutics
A common receptor may serve differentiated roles related to aging-associated cardiovascular disease in males and females. Jennifer DuPont, PhD, will present the findings of this first-of-its-kind study today at the American Physiological Society Aldosterone and ENaC Conference in Estes Park, Colo.
In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of death and kidney failure within a few months or years after surgery.
The complex interplay among the arteriovenous grafts, the vessels they connect, and the blood they transport has been difficult to simulate with computers, but one new method provides a way. Researchers report in Physics of Fluids on a series of simulations that reconstructed the fluid dynamics affected by the insertion of an AVG.
Pilot study finds that considering body composition rather than weight could improve patient management Charlottesville, Va. (June 25, 2019)—A common metric for monitoring kidney health may not accurately represent the kidney function of Indian patients. However, tweaks to an older…
Lipopolysaccharide improved outcomes for male, but not female, rats Charlottesville, Va. (June 25, 2019)—In a counterintuitive result, researchers found that giving male rats a low dose of the endotoxin lipopolysaccharide (LPS) prior to inducing a model of acute kidney injury…