Experimental Biology 2021 Press Materials Available Now

Embargoed press materials are now available for the virtual Experimental Biology (EB) 2021 meeting, featuring cutting-edge multidisciplinary research from across the life sciences. EB 2021, to be held April 27–30, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.

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The University of Utah and RenalytixAI Partner to drive innovation in kidney health

An artificial intelligence-enabled in vitro diagnostics company and the University of Utah today announced a partnership to improve kidney health and reduce the risk of kidney failure for large scale populations in the earliest stages of kidney disease.

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AMERICAN SOCIETY OF NEPHROLOGY CALLS ON BIDEN- HARRIS ADMINISTRATION TO INCREASE TRANSPLANT AVAILABILITY AND EQUITY

— The American Society of Nephrology (ASN) re- affirms its supporti for the Organ Procurement Organizations (OPOs) Conditions for Coverage final rule issued on November 20, 2020. The society calls for the Biden-Harris administration to implement this final policy as expediently as possible. By bringing objective and verifiable standards to assess the performance of OPOs, this final rule will increase the number of organs available for transplant and reduce racial inequity in the U.S. transplant system.

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Kidney Injury in Diabetic Ketoacidosis Linked to Brain Injury

Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury.

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Rethinking Race and Kidney Function

Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients.

Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist.

On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs.

A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people.

Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and
health disparities are not exacerbated.

Scientists say the analysis should motivate researchers and cl

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UC San Diego Health Ranked #1 by U.S. News & World Report

UC San Diego Health is ranked first in San Diego and sixth in California, placing it among the nation’s best hospitals, according to the 2020-2021 U.S. News & World Report. Eight common procedures and conditions were also rated “high performing.”

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Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

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Protein levels in urine after acute kidney injury predict future loss of kidney function

High levels of protein in a patient’s urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.

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Wearable and Implantable Devices May Transform Care for Patients with Kidney Failure

• Wearable and implantable devices may allow for intensive self-care for patients with kidney failure outside of the clinic.
• Additional research must focus on technological improvements to bring such ambulatory devices to patients as envisioned by the recent Executive Order on the “Advancing American Kidney Health Initiative”.

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Researchers Find New Role for Dopamine in Gene Transcription and Cell Proliferation

A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for control of cell proliferation and organ identity and is implicated in cancer, thus having broad implications for health and development of new therapeutics

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Same Receptor, Different Effect: Research Uncovers New Sex-specific Factor in CV Disease

A common receptor may serve differentiated roles related to aging-associated cardiovascular disease in males and females. Jennifer DuPont, PhD, will present the findings of this first-of-its-kind study today at the American Physiological Society Aldosterone and ENaC Conference in Estes Park, Colo.

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Careful Monitoring of Children Following Cardiac Surgery May Improve Long-Term Outcomes

In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of death and kidney failure within a few months or years after surgery.

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Simulations Characterize Turbulence Caused by Common Connection for Dialysis

The complex interplay among the arteriovenous grafts, the vessels they connect, and the blood they transport has been difficult to simulate with computers, but one new method provides a way. Researchers report in Physics of Fluids on a series of simulations that reconstructed the fluid dynamics affected by the insertion of an AVG.

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Common Clinical Estimates of Kidney Function May Not Accurately Assess Indian Patients

Pilot study finds that considering body composition rather than weight could improve patient management Charlottesville, Va. (June 25, 2019)—A common

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