Modification of Common Diabetes Drug Improved Blood Sugar Control in Mouse Model

Article title: Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice Authors: Rathin Bauri, Shilpak Bele, Jhansi Edelli, Neelesh C. Reddy, Sreenivasulu Kurukuti, Tom Devasia, Ahamed Ibrahim, Vishal Rai, Prasenjit Mitra From the authors: “Chronic…

Researchers Find Link between Immune Cell Traits and Parkinson’s Disease

Article title: Genetic causal relationship between multiple immune cell phenotypes and Parkinson’s disease: a two-sample bidirectional Mendelian randomization study Authors: Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xie From the authors: “Our study identified a close link between immune cells and…

Oral Probiotic Delivers Colitis Treatment Directly to Gut in Multiple Animal Models

Article title: Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models Authors: Emelie Öhnstedt, Cristian Doñas, Kristel Parv, Yanhong Pang, Hava Lofton Tomenius, Macarena Carrasco López, Venkata Ram Gannavarapu, Jacqueline Choi, Maria Ovezik, Peter Frank, Margareth…

Intake Reduction and Pre-surgery Body Weight Explain Efficacy of Weight Loss Surgery

A new study finds that pre-surgery weight plays a role in how much weight loss occurs after gastric bypass. The study is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology and has been chosen as an APSselect article for June.

White Blood Cell Changes Develop in Acute Kidney Injury, Regardless of Cause

Article title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…

Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women

Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…

Exercise Testing Uncovers Cardiovascular Disease Risk Factor in Black Postmenopausal Women

Article title: Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females Authors: João L. Marôco, Linda M Szymanski, Tracy Baynard, Bo Fernhall From the authors: “Our findings show that maximal exercise unmasks…

Timing of Both Fasting and Meals Affects Degree of DNA Damage to Small Intestine Caused by Chemotherapy

Article title: Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine Authors: Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J. Bark, Jason C. Mills, Noah F. Shroyer From the authors: “Our results also showed…

Older Adults Show Greater Increase in Body Temperature in Simulated Heatwave Than Previously Reported

Under conditions designed to better mirror real-world conditions, a new study finds that adults 65 and older are affected more by heatwave-like temperatures than previously reported. The study included intermittent bouts of light activity and was published in the Journal of Applied Physiology.

Mitochondrial Changes Linked to High Blood Pressure in Pregnancy

A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.

Women with Long COVID May Develop High Blood Pressure

New research identifies parts of the cardiovascular system that are disrupted by long COVID. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology and was chosen as an APSselect article for June.

Blood Flow-restricted Resistance Exercise Could Help Counteract Age-related Muscle Loss

Low-load blood flow-restricted resistance exercise helped counter age-related muscle decay “with a modest exercise volume and in a very time-efficient manner.” The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for May.

Vitamin A May Protect Heart from Some Effects of Obesity

Research in a mouse model of diet-induced obesity found greater disruption to genes involved in heart function when coupled with vitamin A deficiency. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for January.

Gender Affirmation Treatment Delivery Route May Affect Heart Health

Transgender and gender diverse (TGD) people assigned male at birth are at increased heart health risk. The delivery route of estrogen medication is known to affect heart health risk in cisgender women. However, research is lacking on how estrogen route affects heart health in the TGD population.

Vitamin B5 May Help Weight Loss by Turning on Brown Fat

Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.

Researchers Identify Potential Target for Treating Autoimmune Diseases

New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.