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UrduArticle title: The bottlenose dolphin (Tursiops truncatus): A novel model for studying healthy arterial aging Authors: Yara Bernaldo de Quirós, Sophia A. Mahoney, Nicholas S. VanDongen, Nathan T. Greenberg, Ravinandan Venkatasubramanian, Pedro Saavedra, Gregory Bossart, Vienna E. Brunt, Zachary S. Clayton, Antonio…
Tag: APSselect
Cannabis Exposure during Pregnancy Had Sex-dependent Effects on Rats’ Breathing in Adult Offspring
Article title: Long-term effects on cardiorespiratory and behavioral responses in male and female rats prenatally exposed to cannabinoid Authors: Luis Gustavo A. Patrone, Alana T. Frias, Gabriel T. Fantinatti, Angelita M. Stabile, Wilfried Klein, Kênia C. Bicego, Luciane H. Gargaglioni From the…
Older Women Are at Greater Risk of Heat Stress Than Older Men
Article title: Sex differences in heat stress vulnerability among middle-aged and older adults (PSU HEAT project) Authors: Olivia K. Leach, Rachel M. Cottle, Kat G. Fisher, S. Tony Wolf, W. Larry Kenney From the authors: “Our data confirm that women…
Type 2 Diabetes Medication Improves Liver Health in Mice Fed High Fat Diet
Article title: SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis Authors: Ileana Mendez Espinoza, Elijah N. D. Choos, Carolyn M. Ecelbarger, Blythe D. Shepard From the authors: “Here, we…
77-year-old Marathon World-record Holder Showed Elevated VO2Max, Heart Remodeling after Lifetime of Endurance Exercise
Article title: Lifelong physiology of a former marathon world-record holder – the pros and cons of extreme cardiac remodeling Authors: Stephen J. Foulkes, Mark J. Haykowsky, Peter M. Kistler, Glenn McConell, Scott Trappe, Mark Hargreaves, David Costill, André La Gerche…
Disruptions to Cholesterol in Cells Is an Early Sign of Beta Cell Damage in Model of Type 2 Diabetes
Article title: Dysregulation of cholesterol homeostasis is an early signal of beta cell proteotoxicity characteristic of type 2 diabetes Authors: Tatyana Gurlo, Ruoshui Liu, Zhongying Wang, Jonathan Hoang, Sergey Ryazantsev, Marie Daval, Alexandra E. Butler, Xia Yang, Montgomery Blencowe, Peter…
Disruptions to Fatty Compounds Inside Muscle Cells Coincides with Model of Cancer-induced Muscle Wasting
Article title: Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia Authors: Thomas D. Cardaci, Brandon N. VanderVeen, Alexander R. Huss, Brooke M. Bullard, Kandy T. Velazquez, Norma Frizzell, James A. Carson, Robert L. Price, E.…
Model of Running Outcomes Could Inform Training for Different Groups
Article title: An empirical model for world record running speeds with distance, age, and sex: anaerobic and aerobic contributions to performance Authors: Tuhin K. Roy, Michael J. Joyner, Jonathon W. Senefeld, Chad C. Wiggins, Timothy W. Secomb From the authors: “This empirical…
Genome Study Identifies Predictors of Individual Responsiveness to Muscle-building Exercise
Article title: Genome-wide association study of exercise-induced skeletal muscle hypertrophy and the construction of predictive model Authors: Xiaolin Yang, Yanchun Li, Tao Mei, Jiayan Duan, Xu Yan, Lars McNaughton, Zihong He From the authors: “We identified genetic variants that underlie [resistance training]…
Eating Patterns and the Neural Respiratory Clock Coordinate Daily Rhythms of Breathing
Article title: Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice. Authors: Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble From the authors: “We find that central circadian timing synergizes with metabolism to optimize…
Novel Molecule Shows Promise Combatting Treatment-resistant Leukemia in Cell Culture Study
Article title: ASP210: a potent oligonucleotide-based inhibitor effective against TKI-resistant CML cells Authors: Veronika Nemethova, Petra Babiakova, Boglarka Teglasova, Lucia Uhelska, Andrea Babelova, Michal Selc, Kristina Jakic, Ondrej Mitrovsky, Denisa Myslivcova, Marketa Zackova, Alexandra Poturnayova, Angelika Batorova, Lubos Drgona, Filip Razga From…
Researchers Identify How Kidneys Protect Themselves from Too Much Phosphate
Article title: Endogenous activation of peroxisome proliferator-activated receptor alpha in proximal tubule cells in counteracting phosphate toxicity Authors: Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Takeshi Yamamoto, Masayuki Mizui, Shohei Uchinomiya, Hisakazu Kato, Akio Ojida,…
Lung Surfactant Changes Implicated in COVID-19 Acute Respiratory Failure in Mice
Article title: Activation of alveolar epithelial ER stress by β-coronavirus infection disrupt surfactant homeostasis in mice: implications for COVID-19 respiratory failure Authors: Aditi Murthy, Luis R. Rodriguez, Thalia Dimopoulos, Sarah Bui, Swati Iyer, Katrina Chavez, Yaniv Tomer, Valsamma Abraham, Charlotte…
Fentanyl May Increase or Decrease Oxygen Levels Depending on Dosage
Article title: Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience Authors: Shinbe Choi, Michael R. Noya, Eugene A. Kiyatkin From the authors: “We report that fentanyl’s effects are highly dose-dependent, drawing…
Modification of Common Diabetes Drug Improved Blood Sugar Control in Mouse Model
Article title: Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice Authors: Rathin Bauri, Shilpak Bele, Jhansi Edelli, Neelesh C. Reddy, Sreenivasulu Kurukuti, Tom Devasia, Ahamed Ibrahim, Vishal Rai, Prasenjit Mitra From the authors: “Chronic…
Researchers Find Link between Immune Cell Traits and Parkinson’s Disease
Article title: Genetic causal relationship between multiple immune cell phenotypes and Parkinson’s disease: a two-sample bidirectional Mendelian randomization study Authors: Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xie From the authors: “Our study identified a close link between immune cells and…
Oral Probiotic Delivers Colitis Treatment Directly to Gut in Multiple Animal Models
Article title: Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models Authors: Emelie Öhnstedt, Cristian Doñas, Kristel Parv, Yanhong Pang, Hava Lofton Tomenius, Macarena Carrasco López, Venkata Ram Gannavarapu, Jacqueline Choi, Maria Ovezik, Peter Frank, Margareth…
Intake Reduction and Pre-surgery Body Weight Explain Efficacy of Weight Loss Surgery
A new study finds that pre-surgery weight plays a role in how much weight loss occurs after gastric bypass. The study is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology and has been chosen as an APSselect article for June.
White Blood Cell Changes Develop in Acute Kidney Injury, Regardless of Cause
Article title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…
Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women
Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…
Exercise Testing Uncovers Cardiovascular Disease Risk Factor in Black Postmenopausal Women
Article title: Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females Authors: João L. Marôco, Linda M Szymanski, Tracy Baynard, Bo Fernhall From the authors: “Our findings show that maximal exercise unmasks…
Routinely Wearing High Heels Reduces Energy Cost of Walking, Even Out of Heels
Article title: Habitually wearing high heels may improve user walking economy in any footwear Authors: Owen N. Beck, Jordyn N. Schroeder, Gregory S. Sawicki From the authors: “Habitually wearing high-heeled footwear structurally remodels leg muscle tendons and improves user walking…
Timing of Both Fasting and Meals Affects Degree of DNA Damage to Small Intestine Caused by Chemotherapy
Article title: Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine Authors: Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J. Bark, Jason C. Mills, Noah F. Shroyer From the authors: “Our results also showed…
High-intensity Aerobic Exercise Helps Prevent Menopause-related Muscle Power Loss
Menopause causes a decrease in “muscle power,” an indication of muscle function and strength. However, postmenopausal loss of muscle power can be partially prevented by using high-intensity interval training (HIIT), a form of aerobic exercise.
Older Adults Show Greater Increase in Body Temperature in Simulated Heatwave Than Previously Reported
Under conditions designed to better mirror real-world conditions, a new study finds that adults 65 and older are affected more by heatwave-like temperatures than previously reported. The study included intermittent bouts of light activity and was published in the Journal of Applied Physiology.
Mitochondrial Changes Linked to High Blood Pressure in Pregnancy
A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.
Women with Long COVID May Develop High Blood Pressure
New research identifies parts of the cardiovascular system that are disrupted by long COVID. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology and was chosen as an APSselect article for June.
Blood Flow-restricted Resistance Exercise Could Help Counteract Age-related Muscle Loss
Low-load blood flow-restricted resistance exercise helped counter age-related muscle decay “with a modest exercise volume and in a very time-efficient manner.” The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for May.
Vitamin A May Protect Heart from Some Effects of Obesity
Research in a mouse model of diet-induced obesity found greater disruption to genes involved in heart function when coupled with vitamin A deficiency. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for January.
Gender Affirmation Treatment Delivery Route May Affect Heart Health
Transgender and gender diverse (TGD) people assigned male at birth are at increased heart health risk. The delivery route of estrogen medication is known to affect heart health risk in cisgender women. However, research is lacking on how estrogen route affects heart health in the TGD population.
Short ‘Activity Snacks’ Help Maintain Muscle Mass
Interrupting prolonged sitting with periodic “activity snacks” may help maintain muscle mass and quality, according to researchers at the University of Toronto in Canada.
Inhaling Silica Particles May Cause Kidney Disease
New research in rats demonstrates that inhaling amorphous silica particles—of the size released from burning sugarcane—could damage the kidneys. The study, chosen as an APSselect for August, is published ahead of print in the American Journal of Physiology-Renal Physiology.
Vitamin B5 May Help Weight Loss by Turning on Brown Fat
Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.
Researchers Identify Potential Target for Treating Autoimmune Diseases
New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.