Scientists uncover a novel approach to treating Duchenne muscular dystrophy

Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. The study, published in EMBO Reports, reveals a promising new therapeutic approach for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting condition.

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Communication between Skeletal Muscle Stem Cells and Fibers Supports Muscle Growth in Mice

A new study suggests that communication between skeletal muscle cells and muscle fibers promotes muscle growth. Adult muscle stem cells, called satellite cells, release extracellular vesicles that are delivered to muscle fibers responsible for contraction, to promote this muscle growth. The first-of-its-kind study is published ahead of print in the journal Function.

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Research on Cellular ‘Packages’ Receives $900k in Federal Funding

Scientists from Johns Hopkins and elsewhere have been selected to receive more than $940,000 to study cellular “packages” that can be used to diagnose disease, track disease status and potentially deliver therapies. The packages, called extracellular vesicles, are ubiquitous among all types of human cells and are being studied for their use in cancer, neurocognitive disorders and other conditions.

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