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UrduCannabinoid vaping products, genomic biomarkers to determine tumorigenic potential, and analyses of various testing assays are just a few of the article topics in the July 2022 issue of Toxicological Sciences.
Tag: Biomarker
When it comes to ADHD and ASD, the eyes could reveal all
In the first study of its kind, researchers found that recordings from the retina could identify distinct signals for both Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) providing a potential biomarker for each condition.
UCI researchers reveal possible molecular blood signature for suicide in major depression
A University of California, Irvine-led team of researchers, along with members of the Pritzker Research Consortium, have developed an approach to identify blood biomarkers that could predict the suicide risk of major depressive disorder (MDD) patients.
Study of promising Alzheimer’s marker in blood prompts warning about brain-boosting supplements
Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.
Pituitary Reproductive Regulatory Factors, Mercury Levels, and More Featured in November 2021 Toxicological Sciences
In the November 2021 issue, Toxicological Science features leading toxicology research in areas such as biomarkers, carcinogenesis, and environmental toxicology.
Genetic biomarker test predicts recurrence and survival outcomes for men with high-risk prostate cancer
A new meta-analysis finds that a genetic biomarker test accurately predicts how men with high-risk prostate cancer will respond to treatment with radiation and hormone therapy. The study, which examined biopsy samples collected from three large, randomized clinical trials, indicates that physicians potentially can use genetic test scores to personalize treatment for men with the most aggressive form of prostate cancer. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Older Patients Benefit from Cancer Immunotherapies
A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.
Potential biomarker found for lung disease in scleroderma patients
Researchers have discovered a protein that may predict disease severity for scleroderma-associated interstitial lung disease, the leading cause of death for patients with the rare autoimmune condition. Higher circulating levels of the CTRP9 were associated with more severe lung disease, while low levels were associated with preserved function.
Precision medicine helps identify “at-risk rapid decliners” in early-stage kidney disease
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Hackensack Meridian CDI Scientists Develop ‘CATCHER’ for Crucial Biomarkers
The EV-CATCHER methodology identifies and captures tiny pieces of genetic material – and shows value in COVID-19 plasma
Epitranscriptomics, Xenobiotic Nuclear Receptors, Arsenic Exposure, and More Featured in May 2021 Toxicological Sciences
Research on biomarkers, carcinogenesis, regulatory science, and more is available in the latest issue of Toxicological Sciences.
Newly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…
Roswell Park Researchers Identify New Biomarker of Response to Checkpoint Inhibitors
A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy. This discovery, published today in the journal Nature Communications, is not only an important step forward in lung cancer treatment, but also has implications for other malignancies, according to lead author Fumito Ito, MD, PhD, FACS.
Researchers ID blood protein that sheds light on common, post-operative complication
In a new study led by an interdisciplinary team of gerontologists, geriatricians, precision medicine experts, and bioinformaticians at Beth Israel Deaconess Medical Center (BIDMC), researchers identified a single protein present in the blood that is associated with increased risk of post-operative delirium.
Bile acids may play previously unknown role in Parkinson’s
GRAND RAPIDS, Mich. (Feb. 2, 2021) — What does bile acid production in the digestive tract have to do with Parkinson’s disease?
Subset of COVID-19 Patients Have Increased Bleeding Risk
A new potential biomarker raises concerns over the current standard for treating COVID-19 induced blood clots with high dose blood thinners.
Biomarkers in mother’s plasma predict a type of autism in offspring with 100% accuracy
UC Davis MIND Institute researchers used machine learning to crunch 10,000 autoantibody pattern combinations to identify maternal biomarkers associated with a sub-type of autism. The findings have implications for early diagnosis and intervention.
New Biomarker Identifies Patients with Aggressive Lymphoma Who Don’t Respond to Precision Therapy
A new biomarker discovered by a team that includes researchers from Penn Medicine identifies patients with an aggressive form of lymphoma unlikely to respond to the targeted treatment ibrutinib.
Extraction of Largely Unexplored Bodily Fluid Could Be New Source of Biomarkers
Using an array of tiny needles that are almost too small to see, researchers have developed a minimally invasive technique for sampling a largely unexplored human bodily fluid that could potentially provide a new source of information for routine clinical monitoring and diagnostic testing.
Researchers create hand-held device for patients to read levels of cancer biomarker in their own blood
Researchers at McMaster and Brock universities have created the prototype for a hand-held device to measure a biomarker for cancer, paving the way for home-based cancer monitoring and to improve access to diagnostic testing.
New Biomarkers for Glioma Treatment Response
Biomarkers using mass cytometry can assess patient response to an emerging vaccine for a specific pediatric brain tumor, according to a recent multi-center study published in the Journal of Clinical Investigation.
T Cell Therapy, Gut Microbiome, Tumorigenicity, and More Featured in September 2020 Toxicological Sciences
Toxicological Sciences features leading research in toxicology in the areas of biomarkers, environmental toxicology, and more in the September 2020 issue.
Telomere length varies across human tissue types
A new study comparing telomere length across 20 different tissue types from nearly 1,000 unique post-mortem donors identified variations and correlations across tissue types, which has implications for understanding biomarkers of disease and aging.
NUS researchers develop new system to conduct accurate telomere profiling in less than 3 hours
The novel STAR assay developed by NUS researchers can be used to rapidly determine telomere dysregulation in cancers and age-related diseases in clinical settings. This helps clinicians to make faster diagnosis and plan targeted treatments for patients.
Researchers make significant step toward blood test for Alzheimer’s disease
Researchers at Washington University School of Medicine in St. Louis have developed a technique to detect minute amounts of a protein fragment linked to Alzheimer’s disease in the blood. The study, which will be published July 28 in the Journal of Experimental Medicine (JEM), shows that levels of p-tau-217 are elevated during the early stages of Alzheimer’s disease and could lead to a simple blood test capable of diagnosing the neurodegenerative disorder years before any symptoms begin to appear.
Cancer Researchers Have a Head Start in Fight Against COVID-19
Researchers at Roswell Park Comprehensive Cancer Center have been actively engaged in the effort to develop treatments or other control strategies that can help communities worldwide to address the impacts of the COVID-19 pandemic.
Biomarkers May Help Us Understand Recovery Time After Concussion
A blood test may help researchers understand which people may take years to recover from concussion, according to a study published in the May 27, 2020 online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at a biomarker called neurofilament light chain, a nerve protein that can be detected in the blood when nerve cells are injured or die.
Combining Multiple Measures of Alcohol Use Helps Clarify Risky Drinking in People with HIV
Researchers and clinicians can better understand the health risks facing people with HIV through comprehensive measures of alcohol use, including objective biomarkers, according to a new study in Alcoholism: Clinical and Experimental Research. Frequent or heavy alcohol use in people with HIV can affect HIV disease progression and comorbidities. Alcohol use disorder is a barrier to effectively managing HIV and contributes in multiple ways to poor health outcomes. These effects are not well understood, however, owing in part to the limitations of self-report tools (questionnaires) for measuring alcohol use. Researchers at Louisiana State University and Tulane University correlated self-reported alcohol use, measured by multiple questionnaires, with a biomarker of alcohol consumption in people with HIV. This study explores the implications of this multi-faceted approach for understanding the alcohol use of people with HIV and the related risk factors.
Researchers Discover Biomarkers of ALS in Teeth
Mount Sinai scientists have identified biological markers present in childhood that relate to the degenerative and often fatal neurological disease called amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, according to a study published in the Annals of Clinical and Translational Neurology in May.
Roswell Park’s Dr. Pawel Kalinski to Lead $14.5M NCI-Funded Immunotherapy Effort
A team led by Pawel Kalinski, MD, PhD, of Roswell Park Comprehensive Cancer Center has earned a five-year, $14.54 million award from the National Cancer Institute (NCI) to expand a promising immunotherapy platform. Funded through the NCI’s Program Project Grant program, this prestigious five-year grant will fund five clinical trials, all focused on a strategy for making some of the most common immunotherapies work for more cancer patients.
Discovery of new biomarker in blood could lead to early test for Alzheimer’s disease
UC San Diego researchers discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer’s disease. The work could lead to the development of a blood test to identify individuals who will develop the disease years before they show symptoms.
Vinyl Chloride, Nerve Growth Factor, Chemical Warfare, and More Examined in March 2020 Toxicological Sciences
The March 2020 issue of Toxicological Sciences features leading research in toxicology, covering investigations in biotransformation, toxicokinetics, and pharmacokinetics in addition to work in exposure sciences and environmental toxicology.
Blood test identifies risk of disease linked to stroke and dementia
A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S.