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UrduA new $3.4 million award to the Wayne State University School of Medicine from the National Institutes of Health aims to overcome the limitations of conventional semen analyses by examining mitochondrial DNA levels in sperm as a novel biomarker of sperm fitness.
Tag: Biomarker
MD Anderson Research Highlights for March 7, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Blood test predicts psychosis risk, most effective treatments
Team of researchers led by Indiana University School of Medicine faculty have developed a breakthrough new blood test for schizophrenia, a psychiatric disorder that includes hallucinations and delusions.
Ketamine’s promise for severe depression grows, but major questions remain
Using an old anesthesia drug to pull people out of severe depression has gone from fringe idea to widespread use in just a few years.
Ultrasensitive blood test detects ‘pan-cancer’ biomarker
Diagnostic tools for timely, accurate and inexpensive early cancer detection that can assess risk or monitor response to treatment could help patients get the care they need faster and improve existing care strategies.
Blood-based biomarker may redefine the future treatment for advanced melanoma
Circulating tumor DNA (ctDNA) is emerging as a blood-based biomarker for many solid tumor types, including melanoma.
Genetic Biomarker May Predict Severity of Food Allergy
Researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago and colleagues reported for the first time that a genetic biomarker may be able to help predict the severity of food allergy reactions.
Tau-based biomarker tracks Alzheimer’s progression
Researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered an Alzheimer’s biomarker in the cerebrospinal fluid known as MTBR-tau243 can be used to track the progression of disease and could speed drug development.
Sea cucumbers: the marine delicacy that can deter diabetes
They’re a marine delicacy loved across Asia, but the humble sea cucumber is also proving to be a key ingredient in preventing diabetes, according to new research from the University of South Australia.
A Potential Biomarker for Pediatric Acute Liver Failure
A tiny population of T-cells could serve as a much-needed biomarker—and a potential therapeutic target—for pediatric acute liver failure, according to new research from Children’s Hospital Los Angeles.
Study: Misfolded alpha-synuclein protein key to early detection of Parkinson’s disease
The presence of a misfolded alpha-synuclein protein can be used to determine if people have Parkinson’s disease, according to a new study using technology developed by a researcher at UTHealth Houston. This biomarker could pave the way for the development of better diagnostic tools and new treatment options for the disease.
Researchers identify markers of PTSD in the blood
A new study found that people who are currently suffering or face a high risk of post-traumatic stress disorder show particular patterns in four biomarkers measurable with a simple blood test.
Researchers identify biomarker for diagnosing vascular dementia
Patients with higher levels of a key molecule involved in the formation of new blood vessels were more likely to have cognitive impairment or evidence of brain injury, a consortium of academic medical centers reported.
Spot the cancer: new advances in melanoma detection
New biomarkers to improve skin cancer detection and avoid delays in treatment are being developed by researchers at the University of South Australia.
When used as a biomarker, microRNA can help predict which breast cancer patients are more likely to see their cancer come back
MicroRNA (miRNA) can be used as a biomarker to predict which patients are likely to face breast cancer recurrence and mortality, according to study results published online ahead of print in the Journal of the American College of Surgeons (JACS).
Substance in Urine May Help Determine Asthma Severity
Article title: Urinary total conjugated 3-bromotyrosine, asthma severity and exacerbation risk Authors: Zeneng Wang, Weiling Xu, Suzy A. A. Comhair, Xiaoming Fu, Zhili Shao, Rebecca Bearden, Joe G. Zein, Eugene R. Bleecker, Mario Castro, Loren C. Denlinger, John V. Fahy,…
How Do You Measure Success in Autism Clinical Trials?
Shafali Spurling Jeste, MD, shares early findings—and a critical challenge—from the Autism Biomarkers Consortium for Clinical Trials. How do you know if a treatment for autism is effective? That’s a question that has no easy answer—due in large part to the heterogeneous nature of autism spectrum disorder.
Landmark Study of Biomarker Data May Enable Better Treatment for Early Onset Dementia
In a study publishing in Nature Medicine on September 22, 2022, University of California San Francisco researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD, combined and harmonized clinical, neuroimaging, and fluid biomarkers from nearly all familial FTD clinical research participants across North America and Europe. With that data, they developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
Research links red meat intake, gut microbiome, and cardiovascular disease in older adults
A new study shows older adults who ate about a serving of meat daily had a 22 percent higher risk of cardiovascular disease than those who didn’t eat meat, and identifies biologic pathways that help explain the risk. Higher risk and links to gut bacteria were found for red meat, not poultry, eggs, or fish.
MD Anderson Research Highlights for July 13, 2022
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include new targets involved in protecting DNA replication forks and preventing inflammatory responses, a new treatment option for elderly patients with late-stage acute myeloid leukemia, insights into the breast cancer tumor microenvironment, biomarkers of response to targeted and immune therapies, a novel cellular therapy option for osteosarcoma and a new target for inducing ferroptosis in cancer cells.
Moffitt Researchers Identify Splice Variant Biomarkers in Clear Cell Renal Cell Carcinoma
Scientists are trying to improve their understanding of the development of clear cell renal cell carcinoma to develop new targeted therapeutics. In a new study published in European Urology, Moffitt Cancer Center researchers identify biomarkers for this disease type and develop a tool to indicate which patients are at high risk of poor outcomes based on their biomarker expression.
Cannabinoid Vaping Products, Genomic Biomarkers, a Novel In Vitro Testing System, and More in New Toxicological Sciences
Cannabinoid vaping products, genomic biomarkers to determine tumorigenic potential, and analyses of various testing assays are just a few of the article topics in the July 2022 issue of Toxicological Sciences.
When it comes to ADHD and ASD, the eyes could reveal all
In the first study of its kind, researchers found that recordings from the retina could identify distinct signals for both Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) providing a potential biomarker for each condition.
UCI researchers reveal possible molecular blood signature for suicide in major depression
A University of California, Irvine-led team of researchers, along with members of the Pritzker Research Consortium, have developed an approach to identify blood biomarkers that could predict the suicide risk of major depressive disorder (MDD) patients.
Study of promising Alzheimer’s marker in blood prompts warning about brain-boosting supplements
Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.
Pituitary Reproductive Regulatory Factors, Mercury Levels, and More Featured in November 2021 Toxicological Sciences
In the November 2021 issue, Toxicological Science features leading toxicology research in areas such as biomarkers, carcinogenesis, and environmental toxicology.
Genetic biomarker test predicts recurrence and survival outcomes for men with high-risk prostate cancer
A new meta-analysis finds that a genetic biomarker test accurately predicts how men with high-risk prostate cancer will respond to treatment with radiation and hormone therapy. The study, which examined biopsy samples collected from three large, randomized clinical trials, indicates that physicians potentially can use genetic test scores to personalize treatment for men with the most aggressive form of prostate cancer. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Older Patients Benefit from Cancer Immunotherapies
A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.
Potential biomarker found for lung disease in scleroderma patients
Researchers have discovered a protein that may predict disease severity for scleroderma-associated interstitial lung disease, the leading cause of death for patients with the rare autoimmune condition. Higher circulating levels of the CTRP9 were associated with more severe lung disease, while low levels were associated with preserved function.
Precision medicine helps identify “at-risk rapid decliners” in early-stage kidney disease
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Hackensack Meridian CDI Scientists Develop ‘CATCHER’ for Crucial Biomarkers
The EV-CATCHER methodology identifies and captures tiny pieces of genetic material – and shows value in COVID-19 plasma
Epitranscriptomics, Xenobiotic Nuclear Receptors, Arsenic Exposure, and More Featured in May 2021 Toxicological Sciences
Research on biomarkers, carcinogenesis, regulatory science, and more is available in the latest issue of Toxicological Sciences.
Newly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh…
Roswell Park Researchers Identify New Biomarker of Response to Checkpoint Inhibitors
A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy. This discovery, published today in the journal Nature Communications, is not only an important step forward in lung cancer treatment, but also has implications for other malignancies, according to lead author Fumito Ito, MD, PhD, FACS.
Researchers ID blood protein that sheds light on common, post-operative complication
In a new study led by an interdisciplinary team of gerontologists, geriatricians, precision medicine experts, and bioinformaticians at Beth Israel Deaconess Medical Center (BIDMC), researchers identified a single protein present in the blood that is associated with increased risk of post-operative delirium.
Bile acids may play previously unknown role in Parkinson’s
GRAND RAPIDS, Mich. (Feb. 2, 2021) — What does bile acid production in the digestive tract have to do with Parkinson’s disease?
Subset of COVID-19 Patients Have Increased Bleeding Risk
A new potential biomarker raises concerns over the current standard for treating COVID-19 induced blood clots with high dose blood thinners.
Biomarkers in mother’s plasma predict a type of autism in offspring with 100% accuracy
UC Davis MIND Institute researchers used machine learning to crunch 10,000 autoantibody pattern combinations to identify maternal biomarkers associated with a sub-type of autism. The findings have implications for early diagnosis and intervention.
New Biomarker Identifies Patients with Aggressive Lymphoma Who Don’t Respond to Precision Therapy
A new biomarker discovered by a team that includes researchers from Penn Medicine identifies patients with an aggressive form of lymphoma unlikely to respond to the targeted treatment ibrutinib.
Extraction of Largely Unexplored Bodily Fluid Could Be New Source of Biomarkers
Using an array of tiny needles that are almost too small to see, researchers have developed a minimally invasive technique for sampling a largely unexplored human bodily fluid that could potentially provide a new source of information for routine clinical monitoring and diagnostic testing.
Researchers create hand-held device for patients to read levels of cancer biomarker in their own blood
Researchers at McMaster and Brock universities have created the prototype for a hand-held device to measure a biomarker for cancer, paving the way for home-based cancer monitoring and to improve access to diagnostic testing.
New Biomarkers for Glioma Treatment Response
Biomarkers using mass cytometry can assess patient response to an emerging vaccine for a specific pediatric brain tumor, according to a recent multi-center study published in the Journal of Clinical Investigation.
T Cell Therapy, Gut Microbiome, Tumorigenicity, and More Featured in September 2020 Toxicological Sciences
Toxicological Sciences features leading research in toxicology in the areas of biomarkers, environmental toxicology, and more in the September 2020 issue.
Telomere length varies across human tissue types
A new study comparing telomere length across 20 different tissue types from nearly 1,000 unique post-mortem donors identified variations and correlations across tissue types, which has implications for understanding biomarkers of disease and aging.
NUS researchers develop new system to conduct accurate telomere profiling in less than 3 hours
The novel STAR assay developed by NUS researchers can be used to rapidly determine telomere dysregulation in cancers and age-related diseases in clinical settings. This helps clinicians to make faster diagnosis and plan targeted treatments for patients.
Researchers make significant step toward blood test for Alzheimer’s disease
Researchers at Washington University School of Medicine in St. Louis have developed a technique to detect minute amounts of a protein fragment linked to Alzheimer’s disease in the blood. The study, which will be published July 28 in the Journal of Experimental Medicine (JEM), shows that levels of p-tau-217 are elevated during the early stages of Alzheimer’s disease and could lead to a simple blood test capable of diagnosing the neurodegenerative disorder years before any symptoms begin to appear.
Cancer Researchers Have a Head Start in Fight Against COVID-19
Researchers at Roswell Park Comprehensive Cancer Center have been actively engaged in the effort to develop treatments or other control strategies that can help communities worldwide to address the impacts of the COVID-19 pandemic.
Biomarkers May Help Us Understand Recovery Time After Concussion
A blood test may help researchers understand which people may take years to recover from concussion, according to a study published in the May 27, 2020 online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at a biomarker called neurofilament light chain, a nerve protein that can be detected in the blood when nerve cells are injured or die.
Combining Multiple Measures of Alcohol Use Helps Clarify Risky Drinking in People with HIV
Researchers and clinicians can better understand the health risks facing people with HIV through comprehensive measures of alcohol use, including objective biomarkers, according to a new study in Alcoholism: Clinical and Experimental Research. Frequent or heavy alcohol use in people with HIV can affect HIV disease progression and comorbidities. Alcohol use disorder is a barrier to effectively managing HIV and contributes in multiple ways to poor health outcomes. These effects are not well understood, however, owing in part to the limitations of self-report tools (questionnaires) for measuring alcohol use. Researchers at Louisiana State University and Tulane University correlated self-reported alcohol use, measured by multiple questionnaires, with a biomarker of alcohol consumption in people with HIV. This study explores the implications of this multi-faceted approach for understanding the alcohol use of people with HIV and the related risk factors.
Researchers Discover Biomarkers of ALS in Teeth
Mount Sinai scientists have identified biological markers present in childhood that relate to the degenerative and often fatal neurological disease called amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, according to a study published in the Annals of Clinical and Translational Neurology in May.