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UrduA hallmark of cancer is its ability to replicate, a process commonly driven by the reactivation of the telomerase enzyme complex, which helps prevent the aging and death of healthy cells and keeps stem cells in bone marrow and the intestines from producing normal cells in those organs. When telomerase is activated in cancer cells, it helps them survive and duplicate in the body.
Tag: Gene Mutation
Are Heavy Metals Toxic? Scientists Find Surprising New Clues in Yeast
Scientists at Berkeley Lab and UC Berkeley have compiled the most complete library yet of lanthanide heavy metals and their potential toxicity – by exposing baker’s yeast to lanthanides. Their findings could help researchers uncover hidden pathways between lanthanide metals and disease.
Mayo study finds colon cancer driven by hereditary gene mutations in 1 in 6 patients
A new Mayo Clinic study bolsters evidence that colorectal cancer is often imprinted in family genes and passed on from one generation to the next.
Stem Cell Study Illuminates the Cause of a Devastating Inherited Heart Disorder
Stem cell study findings show that LMNA gene mutations can disrupt the “identity” of heart muscle cells
Even in People with Parkinson’s Gene, Coffee May Be Protective
Even for people with a gene mutation tied to Parkinson’s disease, coffee consumption may be associated with a lower risk of actually developing the disease, according to a new study published in the September 30, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The genetics of blood: a global perspective
To better understand the properties of blood cells, an international team led by UdeM’s Guillaume Lettre has been examining variations in the DNA of 746,667 people worldwide.
Lung cancer trial of RET inhibitor selpercatinib achieves durable responses in majority of patients with RET gene fusions
For patients with non-small cell lung cancers marked by RET gene fusions, the targeted therapy selpercatinib was well tolerated and achieved durable objective responses, or tumor shrinkage, in the majority of patients in a Phase I/II trial.
A New Way to Target Cancers Using ‘Synthetic Lethality’
Researchers at Ludwig Institute for Cancer Research and University of California San Diego School of Medicine report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.
Zinc Transporter Gene Mutation May Play Role in Lactation Performance
Article title: A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics Authors: Olivia C. Rivera, Donna T. Geddes, Shiran Barber-Zucker, Raz Zarivach, Annie Gagnon, David I. Soybel,…
NUS researchers uncover hereditary mutation that drives aggressive head and neck, and lung cancers in Asian population
New research from the Cancer Science Institute of Singapore at the National University of Singapore revealed a genetic variant in a gene called MET that is responsible for more aggressive growth of head and neck, and lung cancers in Asian populations.