Viruses found hiding in lungs’ immune cells long after initial illness

A study by researchers at WashU Medicine shows that respiratory viruses can hide out in immune cells in the lungs long after the initial symptoms of an infection have resolved, creating a persistently inflammatory environment that promotes the development of chronic lung diseases such as asthma.

Addressing Health Equity in Childhood Asthma Requires Engaging Affected Communities

Systemic racism remains a significant challenge in efforts to address health disparities in childhood asthma. A new American Thoracic Society report provides practical frameworks to begin the research necessary to make real progress in treating asthma in Black and Latino children, who are more likely than their white counterparts to report to emergency rooms in the U.S.

Cedars-Sinai Experts Available to Comment on Children’s Health Topics

Experts from Cedars-Sinai Guerin Children’s are available to discuss a range of pediatric topics, including infectious diseases, adolescent weight management and the latest pediatric research coming out of the American Academy of Pediatrics (AAP) annual conference happening Sept. 27-Oct. 1 in Orlando, Florida.

Advancing Synthetic Ephedra-Type Alkaloids With a Two-Step Enzymatic Approach

The development of versatile and efficient biocatalysts for the synthesis of α-hydroxyketones and Ephedra-type alkaloids represents a significant advancement in synthetic biology and medicinal chemistry. In this study, researchers explore the potential of acetolactate synthase (AlsS) from Bacillus subtilis (BsAlsS) for the production of phenylacetylcarbinol (PAC) and its derivatives. Additionally, the study investigates the use of intermediate reductive amination enzymes (introduction of amine group using enzymes) for functionalizing α-hydroxyketones to generate synthetic Ephedra-type alkaloids.

Mount Sinai Experts to Present New Research on Long COVID, Lung Cancer, Asthma, Sleep Apnea, and More at ATS 2024 International Conference

Available for interview on breaking news, trending topics in respiratory medicine

IU School of Medicine researchers to present respiratory therapy advancements at ATS 2024

Researchers will showcase promising respiratory disease research at the American Thoracic Society (ATS) 2024 International Conference and ATS 2024 Respiratory Innovation Summit (RIS), May 17-22 in San Diego, California.

Cedars-Sinai Pulmonary and Critical Care Experts Present Latest Research at International Conference

Cedars-Sinai experts in pulmonology, critical care medicine and lung transplant attending the May 17-22 American Thoracic Society’s (ATS) 2024 International Conference in San Diego are available to comment on scientific advances being presented throughout the conference.

Study: Hillocks challenge our understanding of lung biology

A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other cells within the lung and consist of a stratified outer layer of scale-like squamous cells that protect an underlying layer of rapidly expanding basal stem cells that are capable of restoring airway tissue after injury.

Contracting RSV Before Age 2 Can Cause Long-term Lung Changes and Impairment

Infants and children who have severe cases of respiratory syncytial virus (RSV) before age 2 are likely to have changes to their lung structure and function that could affect respiratory health later in life.

Asthma rates climb for high school students as cannabis use increases

Asthma is more common among high school students who use cannabis, relative to those who do not and the prevalence of asthma increases with the frequency of its use among the students, according to a new study at Columbia University Mailman School of Public Health and the City University of New York. The findings are published in the journal Pediatric Pulmonology.

Army of specialized T cells may trigger asthma attacks in older men

LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.

CHOP Researchers Validate Pediatric “Allergic March” in Largest National Study of its Kind

In the largest study of its kind, researchers from Children’s Hospital of Philadelphia (CHOP) used electronic health record (EHR) data from more than 200,000 pediatric patients to describe patterns of pediatric allergies across the United States, validating a population-level pattern of allergy development known as the “allergic march,” in which allergies first present as eczema, followed by food allergies, asthma, and environmental allergies. The researchers also found that a rare food allergy called eosinophilic esophagitis (EoE), which has historically been considered a disease affecting primarily White males, is more common among non-White patients than previously reported.

Asthma, COPD, Health Disparities Research, and Virtual Press Event: ATS 2023

We’re mere days away from the largest gathering of respiratory health professionals! You can still register to cover ATS 2023 in Washington, DC. Before you join us, here are some of the research abstracts that will be presented to this year’s gathering of pulmonary, critical care and sleep medicine health professionals.

Simple new tool allows primary caregivers to detect young kids at high risk of asthma

In the study, CHART was applied to data from 2,354 children participating in CHILD, a longitudinal research study launched in 2008 that has been following the physical, social and cognitive development of nearly 3,500 Canadian children from before birth.
From information about the children’s wheezing and coughing episodes, use of asthma medications, and related hospital visits at three years of age, CHART was able to predict with 91% accuracy which of these kids would have persistent wheeze—a key indicator of asthma—by age five.

NAU research collaborative receives $21M grant to continue pioneering work into health equity in the Southwest

A groundbreaking research collaborative at Northern Arizona University received another $21 million grant to continue its work to promote health equity and study health disparities among diverse populations of the American Southwest.

Key Mechanisms of Airway Relaxation in Asthma Revealed in New Study

Many therapeutics for asthma and other obstructive lung diseases target the β2-adrenergic receptor (β2AR), a G protein-coupled receptor (GPCR) that rapidly supports airway relaxation when stimulated. Yet, overuse of these agents is associated with adverse health outcomes, including death, which has limited their utility as frontline therapies. Now, a mouse model study published in today’s issue of Molecular Cell, from investigators at University Hospitals (UH) and Case Western Reserve University, identifies a novel strategy to isolate the beneficial effects of β2AR stimulation. This suggests a new therapeutic approach to airway diseases as well as numerous other conditions involving the aberrant function of GPCRs.