Simple new tool allows primary caregivers to detect young kids at high risk of asthma

In the study, CHART was applied to data from 2,354 children participating in CHILD, a longitudinal research study launched in 2008 that has been following the physical, social and cognitive development of nearly 3,500 Canadian children from before birth.
From information about the children’s wheezing and coughing episodes, use of asthma medications, and related hospital visits at three years of age, CHART was able to predict with 91% accuracy which of these kids would have persistent wheeze—a key indicator of asthma—by age five.

NAU research collaborative receives $21M grant to continue pioneering work into health equity in the Southwest

A groundbreaking research collaborative at Northern Arizona University received another $21 million grant to continue its work to promote health equity and study health disparities among diverse populations of the American Southwest.

Key Mechanisms of Airway Relaxation in Asthma Revealed in New Study

Many therapeutics for asthma and other obstructive lung diseases target the β2-adrenergic receptor (β2AR), a G protein-coupled receptor (GPCR) that rapidly supports airway relaxation when stimulated. Yet, overuse of these agents is associated with adverse health outcomes, including death, which has limited their utility as frontline therapies. Now, a mouse model study published in today’s issue of Molecular Cell, from investigators at University Hospitals (UH) and Case Western Reserve University, identifies a novel strategy to isolate the beneficial effects of β2AR stimulation. This suggests a new therapeutic approach to airway diseases as well as numerous other conditions involving the aberrant function of GPCRs.

Renowned Pulmonary Disease Specialist to Lead UCSF Pulmonology Program

Prescott Woodruff, MD, MPH, a renowned leader in the pathogenesis and treatment of airway disease, has been appointed chief of UC San Francisco’s Division of Pulmonary, Critical Care, Allergy and Sleep Medicine. Prescott will assume the role of chief on July 1.

NAVIGATOR Data Show Half of Patients with Severe, Uncontrolled Asthma Improved with Tezepelumab Therapy

A greater proportion of patients with severe, uncontrolled asthma had more significant clinical responses to tezepelumab than placebo, according to research published at the ATS 2022 international conference. The study showed that nearly half of those enrolled achieved complete response to treatment across measures of exacerbation reduction, asthma control, lung function, and clinician assessment.

Novel Therapeutic Strategies May Finally Bring Relief to Those Suffering from Asthma and Allergies

Asthma and allergies are chronic health conditions that continue to adversely impact the quality of life for many around the world. Thanks to exciting breakthroughs by Mark Siracusa, a researcher at Rutgers, The State University of New Jersey, there may be early signs of light at the end of the tunnel.

Increased use of household fireworks creates a public health hazard, UCI study finds

Irvine, Calif., June 29, 2021 – Fireworks are synonymous in the United States with the celebration of Independence Day and other special events, but the colorful displays have caused a growing risk to public safety in recent years, according to a study by environmental health researchers at the University of California, Irvine.

In Utero Exposure to Tiny Pollution Particles in the Air Is Linked to Asthma in Preschoolers, Study Shows

Women who were highly exposed to ultra-fine particles in air pollution during their pregnancy were more likely to have children who developed asthma, according to a study published in the American Journal of Respiratory and Critical Care Medicine in May. This is the first time asthma has been linked with prenatal exposure to this type of air pollution, which is named for its tiny size and which is not regulated or routinely monitored in the United States.

Family History, Race and Sex Linked to Higher Rates of Asthma in Children

A national study on childhood asthma led by Henry Ford Health System has found that family history, race and sex are associated in different ways with higher rates of asthma in children.

In a study published in JAMA Pediatrics (hyperlink goes here), researchers found that children with at least one parent with a history of asthma had two to three times higher rates of asthma, mostly through age 4.

Mouse Study Suggests Androgens and Their Receptors Play Important and Positive Role in Asthma

Article title: Androgen receptor activation alleviates airway hyperresponsiveness, inflammation and remodeling in a murine model of asthma Authors: Rama Satyanarayana Raju Kalidhindi, Nilesh Sudhakar Ambhore, Premanand Balraj, Taylor Schmidt, M. Nadeem Khan, Venkatachalem Sathish From the authors: “Overall, our findings from…

As Wildfires Increase in Severity, Experts Call for Coordinated Federal Response;

In advance of a wildfire season projected to be among the worst, the American Thoracic Society has released a report that calls for a unified federal response to wildfires that includes investment in research on smoke exposure and forecasting, health impacts of smoke, evaluation of interventions, and a clear and coordinated communication strategy to protect public health.

UChicago Medicine’s community benefit investment totals $567.1 million in fiscal 2020

The UChicago Medicine health system provided $567.1 million in community benefits and services to the South Side, and UChicago Medicine Ingalls Memorial provided $89.5 million to Harvey and nearby areas.

Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases

The complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases, according to a team of Mount Sinai researchers.

Coal-fired power plant closures tied to fewer asthma ER visits for kids

Sarah Komisarow is an Assistant Professor of Public Policy and Economics at the Sanford School of Public Policy at Duke University.  She is an applied microeconomist with research interests in public policies that affect children’s health and education.  Her work…

During pandemic, potentially avoidable hospitalizations for non-COVID conditions fell more among whites

New research suggests that the COVID-19 crisis has exacerbated existing racial health care disparities and that during the pandemic, African Americans may have had worse access than whites to outpatient care that could have helped prevent deterioration of their non–COVID-19 health conditions

New strategy blocks chronic lung disease in mice

A new study from Washington University School of Medicine in St. Louis has uncovered a previously unknown role for exosomes in inflammatory respiratory diseases. The study has implications for finding new therapies. Exosomes are tiny compartments released from cells that carry different types of cargo, including inflammatory chemicals called cytokines that can drive lung disease.

Health Disparities and COVID-19, Toxicity of E-cigarette Generated Aerosols, and More Featured in February 2021 Toxicological Sciences

Toxicological Sciences continues to feature leading toxicology research in the areas of developmental and reproductive toxicology; endocrine toxicology; neurotoxicology; molecular, biochemical, and systems toxicology; and more.