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UrduAlexander Chase and colleagues collect samples from Earth’s oceans using SMIRC, which could be the first step in uncovering compounds that lead to next-generation antibiotics.
Tag: Antibiotics
Indagar en la mente de la inteligencia artificial para fabricar mejores antibióticos
La inteligencia artificial (IA) ha explotado en popularidad, pero al igual que un ser humano, es difícil leer la mente de la IA. La IA explicable (XAI), un subconjunto de la tecnología, podría ayudarnos a hacer justamente eso justificando las decisiones de un modelo.
Dual action antibiotic could make bacterial resistance nearly impossible
New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance
Largest-ever antibiotic discovery effort uses AI to uncover potential cures in microbial dark matter
Almost a century ago, the discovery of antibiotics like penicillin revolutionized medicine by harnessing the natural bacteria-killing abilities of microbes. Today, a new study co-led by researchers at the Perelman School of Medicine at the University of Pennsylvania suggests that natural-product antibiotic discovery is about to accelerate into a new era, powered by artificial intelligence (AI).
Rise seen in use of antibiotics for conditions they can’t treat – including COVID-19
America is going the wrong way when it comes to prescribing antibiotics, with 1 in 4 prescriptions going to patients who have conditions that the drugs won’t touch, a new study finds.
Antibiotics Aren’t Effective for Most Lower Tract Respiratory Infections
Use of antibiotics provided no measurable impact on the severity or duration of coughs even if a bacterial infection was present, finds a large, prospective study of people who sought treatment in U.S. primary or urgent care settings for lower-respiratory tract infections.
Breakthrough antibiotic shows promise against obstinate mycobacterial infections
A team of scientists led by Prof Guillermo Bazan from NUS Institute for Functional Intelligent Materials (I-FIM) has developed a novel antibiotic named COE-PNH2 that is capable of combating hard-to-treat mycobacterial lung infections.
Binghamton University biologist named Fellow of American Academy of Microbiology
Binghamton University, State University of New York researcher Karin Sauer is among 65 scientists elected as Fellows of the American Academy of Microbiology this year. Fellows are elected by their peers based on their scientific achievements and original contributions to the field of microbiology.
RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments – pharmacophores – are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.
Discovery about bacterial cell walls can lead to new antibiotics
Researchers at Umeå University in Sweden, led by Professor Felipe Cava, have identified a new family of enzymes that creates a unique type of cross-linking between the building blocks of bacterial cell walls. This discovery could help develop new antibiotics against infectious diseases.
UIC research helps create new antibiotic that evades bacterial resistance
New drug inspired by images that captured how bacteria block antibiotic activity
Do sugar-free candy and gum give you gas? Researchers think they know why
Scientists at the UC Davis School of Medicine may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.
Machine learning to battle COVID-19 bacterial co-infection
University of Queensland researchers have used machine learning to help predict the risk of secondary bacterial infections in hospitalised COVID-19 patients.
Resistant bacteria can remain in the body for years
Fighting disease-causing bacteria becomes more difficult when antibiotics stop working.
RUDN Chemists Obtained Effective and Safe Antibiotics
RUDN University chemists and colleagues from Belarus obtained derivatives of the natural polymer chitosan, which exceeded existing antibiotics in antibacterial activity. Moreover, the new substances are non-toxic, and the production method is safe.
HMS Researcher to Lead $104 Million Federal Project Tackling Antibiotic Resistance
Multi-institutional effort aims to develop technology to transform diagnosis, treatment of bacterial infections
SLU Study: Head and Neck Cancer Diagnostic Delays Linked to Antibiotics Despite Clinical Practice Guidelines
Researchers at Saint Louis University School of Medicine say diagnostic delays frequently occur in patients with undiagnosed head and neck cancer (HNC) and are calling for improved dissemination of current clinical practice guidelines in a new paper published Aug. 24 in JAMA Otolaryngology – Head & Neck Surgery.
Apply Today! Advance Media Registration for American College of Surgeons Clinical Congress
Members of the media can apply today to cover the American College of Surgeons Clinical Congress 2023.
Towards new antibiotics with the first artificial synthesis of tanzawaic acid b
The discovery of antibiotics in 1928 was a major turning point in the history of medicine. For the first time since the dawn of human civilization, doctors had gained access to an extremely powerful and effective tool to fight against a wide variety of bacterial infections.
Alarming antibiotic resistance discovered in war-torn Ukraine
Researchers led by Lund University in Sweden have assisted microbiologists in Ukraine in investigating bacterial resistance among the war-wounded patients treated in hospitals.
Phage pioneer Graham Hatfull helps when antibiotics can’t
Graham Hatfull has pioneered the use of bacteriophages, or just “phages,” to combat antibiotic resistant infections. He was honored with the Gardner Middlebrook Lifetime Achievement award for his research.
Drug-resistant fungi are thriving in even the most remote regions of Earth
New McMaster research has found that a disease-causing fungus — collected from one of the most remote regions in the world — is resistant to a common antifungal medicine used to treat infections.
A potential new weapon in the war against superbugs
For nearly 25 years, Dr. James Kirby has worked to advance the fight against infectious diseases by finding and developing new, potent antimicrobials, and by better understanding how disease-causing bacteria make us sick. In a recent paper published in PLOS Biology, Kirby and colleagues investigated a naturally occurring antimicrobial agent discovered more than 80 years ago.
Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria
An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.
Routine antibiotics don’t improve outcomes of post-mastectomy breast reconstruction
For breast cancer patients undergoing breast reconstruction after mastectomy, avoiding postoperative oral antibiotics does not reduce the risk of infections, reports a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Gut bacteria use super-polymers to dodge antibiotics
The discovery shows why it can be so difficult to tackle drug-resistant bacteria, but does provide a possible avenue for tackling the problem.
Optimizing sepsis treatment timing with a machine learning model
A new machine learning model that estimates optimal treatment timing for sepsis could pave the way for support tools that help physicians personalize treatment decisions at the patient bedside, researchers say.
Seniors’ use of urinary-tract infection antibiotics halved
As an international study involving University of Gothenburg researchers has shown, a decision tool for health professionals has proved capable of halving the use of antibiotics against urinary tract infections while maintaining patient safety.
Preeminent expert on antibiotic resistance, Dele Ogunseitan, available to speak on superbugs
Oladele “Dele” Ogunseitan, PhD serves as the University of California Presidential Chair and Professor of Population Health and Disease Prevention at the University of California, Irvine Program in Public Health. He is a renowned expert in the field of global…
Restricting antibiotics for livestock could limit spread of antibiotic-resistant infections in people
A new study shows that a 2018 California bill banning routine antibiotic use in livestock is linked with reduction in some antibiotic-resistant infections
Are you still allergic to penicillin?
A new program is finding many diagnosed in childhood with antibiotic allergies are no longer allergic after retesting
Mapping E. coli to overcome antibiotic resistance
Antibiotic resistance, when infection-causing bacteria evolve so they are no longer affected by typical antibiotics, is a global concern.
Scientists invent pioneering technique to construct rare molecules discovered in sediments from the Bahamas with potential to help treat disease and infection
Scientists have created a much faster way to make certain complex molecules, which are widely used by pharmaceuticals for antibiotics and anti-fungal medicines.
Calls for further research into family of antibiotics to reduce risk of serious side effects
Experts reviewing the use of a commonly prescribed family of drugs, known as fluoroquinolones, say safety warnings differ internationally
Restoring the gut biome after antibiotics could lead to better outcomes for ovarian cancer patients
Antibiotics routinely used in ovarian cancer care indiscriminately kill gut bacteria, leading to faster cancer progression and lower survival rates, according to recent Cleveland Clinic research.
Limiting antibiotics for cows may create a new dairy market
Consumers would be willing to buy milk from cows only treated with antibiotics when medically necessary – as long as the price isn’t much higher than conventional milk, according to researchers at Cornell University.
A Major Clinical Trial Shows How to Reduce the Risk of Stomach Bleeding Occasionally Caused by Regular Aspirin Use
A new study, led by experts at the University of Nottingham found that the risk of stomach bleeding caused by using aspirin long-term, can be reduced with a short course of antibiotics, potentially improving the safety of aspirin when used to prevent heart attacks, strokes and possibly some cancers.
A new method for studying ribosome function
Scientists report a method for stable attachment of peptides to tRNAs, which has allowed them to gain new fundamental insights into ribosome function by determining the atomic-level structures of ribosomes and the shapes that peptides take inside the ribosome.
UAlbany Researchers Awarded $1.4M to Identify RNAs Linked to Cancer and Bacterial Infections
Researchers from The RNA Institute at the University at Albany have been awarded $1.4 million to investigate stress-induced RNA modifications and associated cell response. The focus of the study — “wobble uridines” in tRNA — could hold important clues for treating bacterial infections and detecting cancer.
Certain antibiotics are associated with an increased risk of mortality in critically ill patients
Michigan Medicine research suggests that administration of antibiotics with activity against anaerobic bacteria has a profound effect on the gut microbiome and, ultimately, an adverse impact on critically ill patients.
Dietary supplementation may improve antibiotic-induced GVHD following stem cell transplants
Researchers at The University of Texas MD Anderson Cancer Center have identified a specific gut bacterium involved in the progression of graft-versus-host disease (GVHD) after antibiotic treatment of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and discovered that nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models, according to a study published today in Cell.
New drug candidate fights off more than 300 drug-resistant bacteria
Urinary tract infections are common, yet can be tough to treat as the bacteria that cause them become resistant to many antibiotics. In ACS Central Science, researchers report a new molecule that inhibits drug-resistant bacteria in lab experiments, as well as in mice with pneumonia and UTIs.
Early Exposure to Antibiotics Can Cause Permanent Asthma and Allergies
Early exposure to antibiotics kills healthy bacteria in the digestive tract and can cause asthma and allergies, a new study demonstrates.
Most patients with appendicitis can be treated with antibiotics
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many patients to avoid surgery and hospitalization, and should be considered as part of shared decision-making between doctor and patient.
Study Reveals Why Highly Infectious Cholera Variant Mysteriously Died Out
A new study reveals why a highly infectious variant of the cholera bug, which caused large disease outbreaks in the early 1990s, did not cause the eighth cholera pandemic as feared – but instead unexpectedly disappeared.
Plastic Pollution in Ocean May Harbor Novel Antibiotics, Study Shows
Plastic pollution in the ocean may serve as a source for novel antibiotics, according to a new student-led study conducted in collaboration with the Scripps Institution of Oceanography. The research will be presented at the American Society for Microbiology’s conference in Washington, D.C. on June 9-13, 2022.
Antibiotics Wreak Havoc on Athletic Performance
New research demonstrates that by killing essential gut bacteria, antibiotics ravage athletes’ motivation and endurance. The UC Riverside-led mouse study suggests the microbiome is a big factor separating athletes from couch potatoes.
Most Doctors Still Believe in Prescribing Unnecessary Antibiotics to Treat Asymptomatic Infections, UM School of Medicine Study Suggests
An estimated 70 percent of primary care physicians reported in a survey that they would still prescribe antibiotics to treat asymptomatic infections based solely on a positive urine specimen.
Mystery mechanism in small peptide shows big promise for fighting antibiotic-resistant bacteria
Using neutrons, researchers at Oak Ridge National Laboratory pieced together the molecular mechanics behind a peptide’s ability to deal significant damage to bacterial cells. Their findings could inform new therapeutic strategies for treating bacterial infections where antibiotics have fallen short.
New Model for Antibacterial Mechanism
Biologists have discovered an aberrant protein that’s deadly to bacteria. The discovery could help scientists unravel the lethal mechanism of certain antibiotics—and potentially point the way to future antibacterial drugs.