Scientists investigate solutions for building cell membrane defense against COVID-19

Researchers from Virginia Tech and Oak Ridge National Laboratory (ORNL) are using neutron scattering at ORNL’s Spallation Neutron Source to investigate how cell membranes and the COVID-19 virus impact each other and what therapeutic candidates could make cell membranes more resistant to viral entry.

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Scientists achieve higher precision weak force measurement between protons, neutrons

Through a one-of-a-kind experiment at Oak Ridge National Laboratory, nuclear physicists have precisely measured the weak interaction between protons and neutrons. The result quantifies the weak force theory as predicted by the Standard Model of Particle Physics.

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Novel cell membrane model could be key to uncovering new protein properties

Researchers have recently shed light on how cell membrane proteins could be influenced by the lipids around them. By developing a novel type of membrane model, they were able to show that the shape and behavior of a protein can be altered by exposure to different lipid compositions. The research team confirmed the artificial membrane’s structure using x-ray and neutron scattering at the Department of Energy’s (DOE’s) Brookhaven (BNL) and Oak Ridge National Laboratories (ORNL).

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West Virginia researchers use neutrons to study materials for power plant improvements

Researchers from West Virginia University are using neutron scattering at Oak Ridge National Laboratory to study novel materials called high entropy oxides, or HEOs. Their goal is to collect insights into how the atoms in the HEOs bind together and whether the materials can be used to develop useful applications to improve power plant operations.

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Analyzing Matter’s Building Blocks

Nobuo Sato is working to put the know in femto. He’s just been awarded a five-year, multimillion dollar research grant by the Department of Energy to develop a “FemtoAnalyzer” that will help nuclear physicists image the three-dimensional internal structure of protons and neutrons. Now, Sato is among 76 scientists nationwide who have been awarded a grant through the DOE Office of Science’s Early Career Research Program to pursue their research.

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X-rays size up protein structure at the ‘heart’ of COVID-19 virus

Researchers have performed the first room temperature X-ray measurements on the SARS-CoV-2 main protease—the enzyme that enables the virus to reproduce. It marks an important first step in the ultimate goal of building a comprehensive 3D model of the enzymatic protein that will be used to advance supercomputing simulations aimed at finding drug inhibitors to block the virus’s replication mechanism and help end the COVID-19 pandemic.

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History of insightful HIV research inspires neutron scattering approach to studying COVID-19

What began as novel investigations into HIV, abruptly pivoted to the novel coronavirus as it began to spread across the globe. Now, ORNL researchers are using neutrons to learn more about the SARS-CoV-2 protease—a protein enzyme that enables the virus to replicate within the human body. Insights on the protein structure and its behaviors will be used to create more accurate models for simulations in aims of finding drug inhibitors to block the virus’s ability to reproduce.

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