NUS researchers target ‘undercover’ gene that helps cancer cells proliferate

Researchers from the Cancer Science Institute of Singapore at the National University of Singapore found that little-known genes called “onco-requisite factors” can enlist other genes to assist them in helping cancer cells proliferate. The gene produces an enzyme called aldehyde dehydrogenase that recruits other enzymes to supply cancer cells with energy for growth. As such, depriving cells of aldehyde dehydrogenase may be a possible way to treat cancer.

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Targeting SARS-CoV-2 Enzyme with Inhibitors

As the COVID-19 pandemic continues to spread, many researchers are studying epidemiological models to predict its propagation. However, a mathematician and expert in complex systems decided to focus on finding targets within SARS-CoV-2 for new drugs to attack. In the journal Chaos, he discusses the dramatic increase in the sensitivity of the main protease of SARS-CoV-2 to small disturbances, which made him suspect there is a role for inhibitors to play in killing the virus.

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