In cancer research, seeing is believing. Before they can diagnose or treat cancer, researchers and doctors need to have a clear understanding of what’s happening at a microscopic level. While existing technology allows us to see things the naked eye can’t, a team of researchers at the Department of Energy’s Oak Ridge National Laboratory (ORNL) is working to standardize a process for staining and seeing cancer in a whole new perspective – in 3D (three dimensions).
Tag: Cancer Research
Less chemoradiation is possible for some cancer patients
Scaling back treatment can mean better quality of life for oropharynx cancer patients who qualify
Targeted drug shows promising ability in treating rare head and neck cancers
Experts at Rogel Cancer Center develop and study the impact of a new drug for salivary gland cancers
LJI welcomes new faculty member Miguel Reina-Campos, Ph.D.
Cancer researcher Miguel Reina-Campos, Ph.D., has joined the faculty of La Jolla Institute for Immunology (LJI) as an Assistant Professor to lead the Laboratory of Tissue Immune Networks. His laboratory at LJI aims to investigate the basis of CD8+ T cell tissue immunity to improve life-saving cancer immunotherapies.
Researchers uncover a potential genetic marker associated with better survival outcomes in patients with head and neck cancer
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.
Uniformed Services University to Represent DoD in New Cancer Screening Research Network
To identify cancers earlier and better understand when they may be easier to treat, the National Cancer Institute (NCI), part of the National Institutes of Health, has launched a new clinical trials network to evaluate emerging technologies for cancer screening.
Promising target for CAR T-cell therapy leads to potent antitumor responses against cutaneous and rare melanomas
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.
New treatment for a rare and aggressive cancer improves survival rates in breakthrough clinical trial
An innovative treatment significantly increases the survival of people with malignant mesothelioma, a rare but rapidly fatal type of cancer with few effective treatment options, according to results from a clinical trial led by Queen Mary University of London.
UCLA-led research results in FDA approval of 4-drug combination for frontline treatment of metastatic pancreatic cancer
A four-drug chemotherapy regimen of irinotecan liposome (Onivyde) in combination with oxaliplatin, leucovorin, and fluorouracil has been approved by the FDA for the first-line treatment of metastatic pancreatic adenocarcinoma.
Clues to early onset colorectal cancer found in microbiome of Hispanic patients
Nina Sanford, M.D., Chief of Gastrointestinal Radiation Oncology Service, UT Southwestern Medical Center Most people have a screening colonoscropy around age 50, however recent research has uncovered a rise in early onset colorectal cancer in patients younger than 50. What can…
Immunotherapy before surgery leads to promising long-term survival in sarcoma patients
Patients with soft-tissue sarcoma treated with neoadjuvant, or pre-surgical, immunotherapy had very little residual tumor at the time of surgery and promising long-term survival, according to Phase II trial results published today in Nature Cancer by researchers at The University of Texas MD Anderson Cancer Center
Case Western Reserve University researcher awarded $2 million federal grant to further explore possible new effective treatments for colorectal and other cancers
With a new $2 million federal grant, a researcher with the Case Western Reserve University School of Medicine will lead a team to further explore preliminary findings of an effective treatment for colorectal and possibly other cancers.
Sara Federico, MD, named director of the Solid Tumor Division at St. Jude Children’s Research Hospital
Established clinician researcher will focus on novel treatments and clinical trials for difficult-to-treat childhood cancers.
Inaugural class of Damon Runyon–St. Jude Pediatric Cancer Research Fellows announced
The initiative aims to provide support for early-career scientists to study pediatric cancer, addressing a funding gap that drives top talent to seek more prevalent opportunities in adult cancer research or the pharmaceutical sector.
Scientists engineer potent immune cells for ‘off-the-shelf’ cancer immunotherapy
UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for “off-the-shelf” cell therapy to treat challenging cancers.
High biological age may increase the risk of dementia and stroke
People who have a higher biological age than their actual chronological age have an increased risk of stroke and dementia. The findings suggest that by slowing down the body’s aging processes, it may be possible to reduce or delay the onset of disease.
At the same PSA level, Black men are more likely to have prostate cancer than white men
Findings indicate the importance of earlier and more frequent prostate cancer screening for Black men.
Mount Sinai Researchers Receive $7 Million to Improve Outcomes for High-risk Blood Cancer Patients From the Multiple Myeloma Research Foundation
The Mount Sinai Health System has received a $7 million grant from the Multiple Myeloma Research Foundation for a three-year project that aims to fast-track novel translational concepts to improve outcomes for people with high risk myeloma, the second most common blood cancer in the United States.
Metabolite tells cells whether to repair DNA
Findings from researchers at the University of Michigan Health Rogel Cancer Center, published in Cancer Discovery, show how a specific nucleotide metabolite called GTP controls responses to radiation and chemotherapy in an unexpected way.
Cancer Prevention and Research Institute of Texas Awards $7.5 Million to Baylor Scott & White Research Institute
Baylor Scott & White Research Institute will establish the Texas site of the Connect for Cancer Prevention StudyTM (Connect), a project of the National Cancer Institute (NCI), part of the National Institutes of Health. Nine healthcare systems plan to enroll 200,000 adults across the U.S.
The sunscreen paradox: McGill University researchers warn of ‘false sense of security’
Sunscreen is important, says Dr. Ivan Litvinov, but it is also the least effective way to protect your skin when compared to sun protective clothing and sun avoidance
Antibody-drug conjugate helps patients with metastatic non-small cell lung cancer live longer, delaying disease progression
Treatment with datopotamab deruxtecan (Dato-DXd), a novel Trop-2 directed antibody-drug conjugate, was found to significantly improve progression-free survival in patients with metastatic non-small cell lung cancer, an improvement that was primarily driven by patients with non-squamous tumors.
KU Cancer Center receives $2.4 million grant to foster the next generation of translational scientists
In order to grow and train future clinical and translational scientists, The University of Kansas Cancer Center has received a $2.4 million grant from the National Cancer Institute (NCI).
Does diabetes affect the survival of individuals with colorectal cancer?
Study reveals a link between complicated diabetes and a higher risk of death
New Cancer Therapy Target Stops Tumor Cells From Sharing Resources
Researchers at University of California San Diego have discovered a process in which liver cells share molecules in order to multiply under conditions that would ordinarily suppress cell proliferation. They also found evidence that this process occurs in various types of cancer cells.
Huntsman Cancer Institute and Utah Valley University Join Forces to Shape the Future of Cancer Research and Care
Huntsman Cancer Institute and Utah Valley University unveil a new health collaborative, a groundbreaking partnership aiming to transform health education, advance cancer research, and secure a lasting impact through a $1 million donation.
Using recent diagnostic scans can substantially cut time to treatment for patients needing urgent palliation
Using previously taken diagnostic computed tomography (CT) scans in place of CT simulation scans to plan simple palliative radiation treatments can substantially reduce the time some people spend waiting for urgent treatment, improving the patient experience, a new study suggests.
Accelerated radiation treatment could reduce head and neck cancer patient burden in low- and middle-income countries
A type of head and neck cancer predominantly diagnosed in people who reside in low- and middle-income countries may be treated effectively with fewer, but higher doses of radiation, a large new international study suggests.
Precision medicine navigators increase genomic testing rates for Black patients with prostate cancer
The presence of a clinical navigator to act as a liaison between people with prostate cancer and the health care system greatly increases the likelihood that patients, especially Black patients, will receive advanced testing that can help predict the severity of their disease and guide treatment, a new study suggests.
Short-course radiation as effective as standard treatment for patients who opt for breast reconstruction after mastectomy
In a first-of-its-kind study, people with breast cancer who underwent implant-based breast reconstruction immediately following a mastectomy reported that getting fewer, higher doses of radiation was just as effective as standard radiation, did not increase side effects and saved them time and money.
High-dose radiation offers new treatment option for older patients with inoperable kidney tumors
Older adults diagnosed with kidney tumors that are not suitable for surgery may benefit from targeted, high-dose radiation, a new study from Australian and Dutch researchers suggests.
Sexual activity and vaginal dilation associated with fewer side effects after cervical cancer treatment
People who engage in sexual activity or vaginal dilation after chemoradiation treatment for cervical cancer are at lower risk for long-term side effects, according to a new study from researchers in Austria.
Liquid biopsies can rapidly detect residual disease following cervical chemoradiation, study finds
Two liquid biopsy tests that look for the presence of human papillomavirus (HPV) in the blood accurately identified patients with a high risk of cervical cancer recurrence after the completion of chemoradiation, a new study confirms.
High cure rate, low toxicity maintained with shortened radiation treatment for intermediate risk prostate cancer, study finds
People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests.
Research Highlights for September 2023
Huntsman Cancer Institute shines the spotlight on new discoveries and cutting-edge cancer research. This month, researchers found that increasing access for Black people with prostate cancer may save lives. Also, the first patient in a new small cell lung cancer clinical trial has been enrolled, researchers are using an app to help adolescents and young adults manage cancer symptoms, and investigators are trying to reduce cognitive side-effects after chemotherapy.
MD Anderson Research Highlights: ASTRO 2023 Special Edition
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.
When cancer takes a deadly turn: NUS study sheds a new light on cancer metastasis
The ability of cancer cells to metastasise, or spread from one part of the body to another, is one of the reasons why cancer can be extremely challenging to treat. However, the process that drives metastasis is complex and not fully understood.
Cancer Prevention and Research Institute of Texas awards $2 Million grant to SMU
The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded $2 million to recruit Annika Wylie to SMU and fund five years of her research, which focuses on the p53 gene, a naturally occurring tumor suppressor.
UChicago Medicine breaks ground on $815M project to build state’s first freestanding cancer care and research pavilion
The University of Chicago Medicine broke ground Tuesday on its $815 million project to build the state’s first and only standalone structure dedicated to cancer care and research. The 575,000-square-foot, seven-story pavilion builds off UChicago’s decades of work and leadership in cancer research and its prestigious National Center Institute designation as a Comprehensive Cancer Center.
Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in San Diego
The American Society for Radiation Oncology (ASTRO) announced today the 10 studies to be highlighted in the 2023 ASTRO Annual Meeting press program. Researchers will discuss their findings in news briefings held October 2 and 3 at the San Diego Convention Center and via live webcast.
Montefiore Einstein Comprehensive Cancer Center Awarded Comprehensive Designation from the National Cancer Institute
The newly renamed Montefiore Einstein Comprehensive Cancer Center (MECCC) has been awarded comprehensive designation by the National Cancer Institute (NCI) of the National Institutes of Health, the ultimate standard achieved by only 55 other NCI cancer centers in the U.S.
Mount Sinai Awarded $3.4 Million to Study Prostate Cancer in People With HIV
The National Cancer Institute has awarded the Icahn School of Medicine at Mount Sinai a $3.4 million grant to create a model that identifies the best prostate cancer treatment for people with HIV.
$1.92M NIH Award Fuels Research to Uncover How Key Protein Transport Mechanism Goes Awry in Cancer
The National Institute of General Medical Sciences has awarded Justin Taylor, M.D., a researcher at Sylvester Comprehensive Cancer Center, a five-year grant totaling $1.92 million for his work to better define the role of XPO1 (Exportin-1) in cancer.
Researchers awarded $2.5 million to develop brain cancer treatment
A multidisciplinary team of investigators from the UCLA Jonsson Comprehensive Cancer Center was awarded a $2.5 million Translational Team Science Award from the Department of Defense to develop a tailored treatment for glioblastoma, a deadly brain tumor with limited treatment options.
Gene therapy for brain tumor shows promising early results in humans
A new study from the University of Michigan Department of Neurosurgery and Rogel Cancer Center shows promising early results that a therapy combining cell-killing and immune-stimulating drugs are safe and effective in extending survival for patients with gliomas, a highly aggressive form of brain cancer.
Gene therapy study identifies potential new treatment for liver cancer
Gene therapy with microRNA-22 produced better survival outcomes than the current FDA-approved drug for liver cancer and without noticeable toxicity in new mouse study.
Study Unlocks New Insight about Breast Cancer Risk
A new study led by a researcher at New York Institute of Technology provides insight that could change how scientists and clinicians understand genetic predisposition to breast cancer, a condition that affects one in eight U.S. women in her lifetime.
New LJI research has major implications for controlling T cell activity
According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells.
Detecting risk of metastatic prostate cancer in Black men
To explore prostate cancer disparities, researchers looked to another disorder, diabetes. They conducted a clinical trial and report four biomarkers linked to a higher risk of metastatic prostate cancer in men of West African heritage. They will present their results at ACS Fall 2023.
July Research Highlights
Huntsman Cancer Institute investigators find a way to reduce infection after pancreatic surgery, discover the best treatment combination that’s cost effective for prostate cancer patients, and learn lung cancer patients receiving chemotherapy have more emergency department visits. They also found a genetic mutation that makes anemia more likely after chemotherapy, and a non-invasive way to remove brain tumors.