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UrduIn a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).
Tag: Chemotherapy
Ochsner Health Advances Precision Medicine, Becomes National Leader in Universal Genomic Testing for Chemotherapy
Ochsner Health is leading the way for precision medicine nationwide by becoming one of the first hospital systems to standardize genomic testing, significantly advancing ways in which care teams can treat cancer patients. This change helps providers determine individualized treatment by understanding how patients will react to certain drugs, thereby lowering risk of adverse side effects, improving patient experience, and bettering patient outcomes.
MD Anderson Research Highlights for March 8, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Stress-Tolerant Cells Drive Tumor Initiation in Pancreatic Cancer
UC San Diego scientists discover a molecular pathway critical to the initiation of pancreatic tumors. The findings may inspire new chemotherapeutic drugs targeting early stages of tumor formation and spread.
Mouse study suggests new therapeutic strategy to reduce cardiovascular disease in cancer survivors
Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway. The study, published December 19 in the Journal of Experimental Medicine (JEM), suggests that inhibiting this pathway could reduce the chances of cancer survivors suffering heart disease later in life.
Immune system reboot in MS patients
Every day, one person in Switzerland is diagnosed with multiple sclerosis. MS is an autoimmune disease in which the body’s own immune system attacks the myelin sheath of the nerve cells in the brain and spinal cord.
New treatment can significantly increase the efficacy of chemotherapy and prevent metastasis
The researchers identified a mechanism that generated a cancer-promoting inflammatory environment in response to chemotherapy. Based on this discovery, they developed a treatment combination that reduced the incidence of lung metastasis following chemotherapy from 52% to only 6%.
Anti-sedative could alleviate cancer therapy side effects, study suggests
Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.
A Survivor’s Guide to Brain Cancer
Sheri Saenz is enjoying everyday pleasures as a Laguna Niguel grandmother, crafting and camping with her granddaughter and grandson and vacationing with her husband of 34 years.
Neurofeedback shows promise for addressing ‘chemo brain’ in UCLA pilot study
The pilot study is one of the first to indicate that neurofeedback could help address cognitive deficits of cancer patients experiencing “chemo brain.”
A New Kind of Chemo
Researchers identify a new class of drugs that offer a safer, more targeted treatment for leukemia patients.
Groundbreaking research hopes to personalise treatment for cancer patients
Cancer Council SA-funded researcher Associate Professor Stephanie Reuter Lange from UniSA hopes that a simple computer program can help personalise treatment for cancer patients.
New Way to Protect White Blood Cells in Chemotherapy
A biochemist from RUDN and IBMC has found a way to protect healthy leukocytes during leukemia chemotherapy. Small nitrogen-containing polyamine molecules give the necessary protection. They are synthesized by almost all living cells, but only in normal lymphocytes, they exhibit protective properties.
Chemo-Radio-Immunotherapy Treats Local Cancers, Minimizes Side Effects
In a study published July 5, 2022, researchers at University of California San Diego School of Medicine present a three-prong approach to targeting local cancers while minimizing adverse effects in other parts of the body. The precision cancer therapy combines…
NUS AI platform enables doctors to optimise personalised chemotherapy dose
A team of researchers from National University of Singapore, in collaboration with clinicians from the National University Cancer Institute, Singapore which is part of the National University Health System, has reported promising results in using CURATE.AI, an artificial intelligence tool that identifies and better allows clinicians to make optimal and personalised doses of chemotherapy for patients.
Black, Hispanic Patients Less Likely to Get Lifesaving Liver Cancer Treatment
Racial and ethnic minorities diagnosed with advanced liver cancer have a lower chance of receiving immunotherapy, the most effective treatment for patients with the disease, according to a new study led by Cedars-Sinai Cancer investigators.
Chula Excellence Cancer Center collabs with medical specialists from various fields to enhance treatment capabilities.
Chula now has an Excellence Chulalongkorn Comprehensive Cancer Center bringing together medical specialists from various areas of expertise to attend to cancer patients using the latest academic and technological know-how to enhance the quality of life and the possibilities of being cured for patients of all types of cancer.
Could exercise counteract cardiotoxic chemotherapy for women with breast cancer
When you’re a breast cancer survivor, the last thing you need is another health scare. So, it’s concerning to know that up to 48 per cent of breast cancer patients will go on to fight heart disease as a direct result of chemotherapy.
Chemo helps breast cancer cells get their ‘foot in the door’ to the lungs
A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.
Stress-relief Music Therapy Can Also Effectively Relieve Pain
Medical results show that music therapy can lower blood pressure, relieve pain during chemotherapy and dialysis, as well as stimulate the elderly brain. The Faculty of Fine and Applied Arts, Chulalongkorn University is offering a Music Therapy Program aiming to heal the ever-increasing patients with various chronic diseases in society.
Heated chemotherapy can help some children with cancer
Known as HIPEC, the therapy has been available for adults for years at Michigan Medicine. Now it’s an option for kids here, too.
Study Shows Immunotherapy Drug Combination Improves Response in HER2-Negative Breast Cancer Including a Subset of Estrogen Receptor Positive Cancers
In a new study by researchers at Yale Cancer Center, combining the immunotherapy drug durvalumab and PARP-inhibitor olaparib with chemotherapy improved response to treatment for women with high-risk, HER2-negative breast cancer, including a subset of estrogen receptor positive cancers.
Patients Taking Anti-Inflammatory Drugs Respond Less Well to COVID-19 Vaccine
One-quarter of people who take the drug methotrexate for common immune system disorders — from rheumatoid arthritis to multiple sclerosis — mount a weaker immune response to a COVID-19 vaccine, a new study shows.
Nanotechnology offers new hope for bowel cancer patients
Bowel cancer is the second deadliest cancer in the world, killing almost 900,000 people in 2020. New research from Indian and Australian scientists suggests that nanotechnology could provide a more effective treatment option than conventional therapy.
Atlantic Health System Physicians Co-Author 5 Studies, Presented at American Association for Cancer Research (AACR) Annual Meeting
Atlantic Health System Cancer Care physicians are co-authors of five original studies presented at this year’s AACR Annual Meeting, held virtually April 10-15 and May 17-21. The AACR meeting is one of the world’s premier scientific gatherings of cancer specialists and researchers.
Targeting microRNAs could unmask hidden vulnerability in breast cancer stem cells
Researchers in Italy have identified a pair of microRNA molecules that help maintain a population of cancerous stem cells that drive the growth of breast cancers and initiate tumor relapse after treatment. The study, which will be published April 2 in the Journal of Cell Biology (JCB), reveals that targeting these microRNAs makes cancer stem cells more susceptible to some chemotherapies and could potentially improve the prognosis of patients with aggressive forms of breast cancer.
Novel 3D printed stents deliver breakthrough treatment for oesophageal cancer
World-first 3D printed oesophageal stents developed by the University of South Australia could revolutionise the delivery of chemotherapy drugs to provide more accurate, effective and personalised treatment for patients with oesophageal cancer.
Finding a way to stop chemotherapy from damaging the heart
There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.
Exercise May Improve Effects of Radiation Therapy in Prostate Cancer
Cancer is the second leading cause of death around the world after heart disease. This week, researchers exploring the effects of exercise as a natural preventive tool and noninvasive treatment for cancer will present their work at the American Physiological Society (APS) Integrative Physiology of Exercise conference.
Regular Exercise May Protect Cardiovascular Cells during Chemotherapy
Marie Mclaughlin, MSc, from Edinburgh Napier University in Scotland, will present research on human endothelial cells treated with FEC-T, a chemotherapy regimen that combines four drugs (5 fluorouracil, epirubicin, cyclophosphamide and docetaxel). The researchers found that preconditioning the endothelial cells with serum (blood) from people who habitually exercise caused less cell death than samples that were treated with untrained serum (people who exercised less than 75 minutes per week). “Exercise preconditioning can provide protection against these detrimental effects in vitro,” Mclaughlin explained.
Exercise before and during Chemotherapy May Bolster Therapeutic Effects, Preserves Cardio Fitness and Muscle Mass
A research team led by Jared Dickinson, PhD, from Central Washington University, followed people with breast cancer who were treated with anthracycline-containing chemotherapy.
Accelerating Access to Breakthrough Cancer Therapies Leads Morristown Medical Center to Expand Infusion Center
Atlantic Health System has announced the opening of Morristown Medical Center’s new state-of-the-art, patient-centered Infusion Center located in the Carol G. Simon Cancer Center. The first of three phases of expansion of New Jersey’s pre-eminent cancer center, the new unit was funded in large part by donations made by community members in support of the Foundation for Morristown Medical Center’s Growing Forward Campaign.
Chemotherapy Drug More Effective When Combined With Microbubbles
Hepatocellular carcinoma is usually treated by blocking the flow of blood to the tumor to induce cancer cell death, but the common treatment, transarterial chemoembolization, is invasive and too imprecise to be a local drug delivery method. Aiming to increase the precision, researchers at Tulane University created a treatment that involves vaporizing tiny droplets of perfluorocarbon, a common organic material composed of carbon and fluorine. The method of gas embolization is published in APL Bioengineering.
Structure of a Complex Enzyme That Protects Cells From DNA Damage Is Uncovered by Mount Sinai Researchers
A research team from Mount Sinai has unraveled for the first time the three-dimensional structure and mechanism of a complex enzyme that protects cells from constant DNA damage, opening the door to discovery of new therapeutics for the treatment of chemotherapy-resistant cancers.
Combination therapy significantly improves survival outcomes for patients with acute myeloid leukemia
A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center.
Chemotherapy is used to treat less than 25% of people with localized sarcoma
UCLA researchers have found that chemotherapy is not commonly used when treating adults with localized sarcoma, a rare type of cancer of the soft tissues or bone. In a nationwide analysis of nearly 20,000 patients whose cancer had not yet spread to other organs, the scientists learned that only 22% were treated with some form of chemotherapy.
Sylvester Comprehensive Cancer Center Urologist Leads Collaborative Study on Fertility Counseling Prior to Chemotherapy
For younger cancer patients, fertility counseling at the time of cancer diagnosis is important for making family planning decisions. Ranjith Ramasamy, M.D., a clinician and researcher at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, was the lead author of a new collaborative study, “Evaluation of Reported Fertility Preservation Counseling Before Chemotherapy Using the Quality Oncology Practice Initiative Survey,” published JAMA Network Open.
Vitamin D could help mitigate chemotherapy side effects
New findings by University of South Australia researchers reveal that Vitamin D could potentially mitigate chemotherapy-induced gastrointestinal mucositis and provide relief to cancer patients.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Research news from Johns Hopkins Medicine.
Breaking Research News from Annual Meeting of American Society of Clinical Oncology
Johns Hopkins Kimmel Cancer Center thoracic cancer and cancer genomics experts reported promising new findings and studies in mesothelioma, lung cancer and melanoma at the annual meeting of the American Society of Clinical Oncology (ASCO), the world’s leading professional organization for physicians and oncology professionals caring for cancer patients.
Chemotherapy and Cancer Gang up to Cause a Neurological Side Effect, Study Says
Chemotherapy has been the lone suspect in a neurological ailment, but cancer may be also to blame. The havoc they wreak is much more than additive.
UK Study Finds Many Colon Cancer Patients Not Receiving Standard of Care Therapy
A new University of Kentucky Markey Cancer Center study finds that many Kentucky patients with colon cancer are not receiving the recommended standard of care therapy for their disease.
MSK: Cancer Isn’t Sheltering in Place
As the height of the COVID-19 outbreak in New York City and the Tri-State area begins to subside, Memorial Sloan Kettering Cancer Center oncologists are urging patients to schedule cancer screenings and treatments now – as the long-term toll of missed diagnoses and delayed treatments could be devastating for patients and their loved ones across the region and the country.
Combination of Chemo and Immunotherapy Is Shown to Work Against Metastatic Bladder Cancer
A clinical trial led by Mount Sinai researchers has showed for the first time that combining chemotherapy and immunotherapy can slow down metastatic bladder cancer. The trial also showed that immunotherapy alone may be an option for a subset of patients with metastatic bladder cancer if their tumor expresses a high level of a protein called PD-L1 according to the study, published in The Lancet in May.
Immunotherapy Treatment Immediately After Chemotherapy Significantly Slows Metastatic Bladder Cancer Progression
Using immunotherapy immediately after chemotherapy treatment in patients with metastatic bladder cancer significantly slowed the progression of the cancer, according to results of a clinical trial led by Mount Sinai researchers published in the Journal of Clinical Oncology in April.
Those Living in Rural Areas, Uninsured or on Medicaid Less Likely to Receive Recommended Lung Cancer Treatment
Keck Medicine of USC study reveals that non-small cell lung cancer patients with pathologic N1 disease were less likely to receive chemotherapy if they lived in rural areas or were on Medicaid or uninsured.
Two scientists at Wake Forest Baptist awarded $1.5 million for cancer research
Two scientists from Wake Forest School of Medicine, part of Wake Forest Baptist Health, have received a total of $1.5 million in research funding from the American Cancer Society (ACS) to study new chemotherapy and immunotherapy treatments for cancer.
Virtual realities: research reveals promising intervention in cancer treatment
Each year, more than 250,000 women in the U.S. alone receive a diagnosis of breast cancer, making it the most commonly diagnosed cancer among women. More than 40,000 women annually die from the disease, according to the American Cancer Society.
Virtual Reality and Breast Cancer, First Italian-American Study Shows Promising Results
Virtual Reality during chemotherapy shown to improve breast cancer patients’ quality of life during the most stressful treatments, according to a recent study.
Virtual Reality and Breast Cancer, First Italian-American Study Shows Promising Results
Virtual Reality during chemotherapy shown to improve breast cancer patients’ quality of life during the most stressful treatments, according to a recent study.