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UrduA newly published study by University of Calgary researchers reveals a potential new way to treat chronic pain using anti-cancer drugs rather than opioid-based pain medication.
Tag: Chronic Pain
How does the brain process heat as pain?
A team of researchers at the Case Western Reserve University School of Medicine believe they’ve found an answer to how thermal pain is sensed.
Discovery in the brains of army veterans with chronic pain could pave way for personalized treatments
A new study is the first to investigate brain connectivity patterns at rest in veterans with both chronic pain and trauma, finding three unique brain subtypes potentially indicating high, medium, and low susceptibility to pain and trauma symptoms.
High-Frequency Spinal Cord Stimulation Shows Improved Longer Lasting Pain Relief
Researchers at UC San Diego School of Medicine report that high-frequency spinal cord stimulation proved more effective at improving perceived pain reduction than low-frequency SCS in patients studied, and that there was some variation in PPR between male and female patients.
AI Could Predict Ideal Chronic Pain Patients for Spinal Cord Stimulation
Spinal cord stimulation is a minimally invasive FDA-approved treatment to manage chronic pain such as back and neck pain. The ability to accurately predict which patients will benefit from this treatment in the long term is unclear and currently relies on the subjective experience of the implanting physician. A study is the first to use machine-learning algorithms in the neuromodulation field to predict long-term patient response to spinal cord stimulation.
Protocol Based on Questionnaires and a Mental Health Checklist Can Replace In-Person Psychological Assessment Before Neuromodulation Therapies
Researchers at Toronto Western Hospital in Canada have proposed a protocol for patients undergoing neuromodulation implantation that incorporates a short mental health checklist and pre-defined cut-offs on validated questionnaires to assess the need for an in-person assessment by a psychologist.
Steroid Use Significantly Reduces Pain After Radiofrequency Neurotomy
Radiofrequency neurotomy is used to provide long-term relief for chronic neck and lower-back pain. The most common side effect is a sensation of burning, numbness, and shooting in the area where the needles were placed. This study found that steroids significantly reduce this side effect.
Novel Drug Delivery Matrix Significantly Extends Pain Relief After Surgery
A novel drug delivery matrix currently in pre-clinical development may offer a narcotic-free alternative for patients experiencing pain after surgery.
Wrist Innervation Anatomy Provides a Roadmap for Chronic Pain Management
More than 11 million Americans experience chronic wrist pain. Percutaneous denervation, a procedure that interrupts the signal from the nerve to the brain, is emerging as a non-invasive alternative for chronic wrist pain. A recent study explored specific sites in the wrist enable effective use of this technique.
Disparities Exist in Kyphoplasty Treatment for Black and Lower-Income Medicare Recipients
A new study found that kyphoplasty was less likely to be performed in Black patients, as well as in patients with dual Medicare and Medicaid eligibility, who tend to be lower-income older adults.
Veterans with Traumatic Brain Injury: M.O.M. to the Rescue
The M.O.M. project, which will have four units in Ohio, Florida, South Carolina and Texas, will engage veterans with traumatic brain injury, their caregivers and other stakeholders to bolster patient-centered outcomes research and comparative effectiveness research in order to identify treatment options for traumatic brain injury that are effective, acceptable, and meaningful to the veteran population.
Not So Great Expectations: Pain in HIV Related to Brain’s Expectations of Relief
Neuroimaging study reveals potential brain mechanism underlying chronic neuropathic pain in individuals with HIV. Findings may guide new clinical treatments targeting patients’ expectations for pain relief.
Exploring the Science of Acupuncture
Researchers have discovered neurons needed for acupuncture‘s anti-inflammatory response
NIH Awards Grant to Study Combination Treatment for Pain to Wake Forest School of Medicine
Chronic musculoskeletal pain (CMP) – daily pain in the muscles, bones, ligaments, tendons and nerves that lasts for six months or longer – contributes to approximately 21% of worker disability issues in this country and costs $500 billion annually from lost wages, treatment and medications, according to a study conducted by Johns Hopkins University.
In an effort to develop a more effective strategy against this debilitating condition, a team of doctors and researchers at Wake Forest School of Medicine has received a four-year grant of approximately $4 million from the National Institutes of Health.
Dr. Oscar de Leon-Casasola Named 2021 John J. Bonica Awardee, Will Present Lecture at ASRA’s 20th Annual Pain Medicine Meeting
Oscar de Leon-Casasola, MD, has been selected to receive the 2021 John J. Bonica Award. The honor recognizes an individual who has demonstrated outstanding contributions to the development, teaching and practice of pain medicine in the tradition of John J. Bonica, MD, the pioneering anesthesiologist regarded as the “founding father of pain relief medicine.”
Dr. Kevin Vorenkamp From Duke University Named 2021 ASRA Presidential Scholar
The American Society of Regional Anesthesia and Pain Medicine Presidential Scholar Award recognizes outstanding scientific and sustained contributions to regional anesthesia and acute or chronic pain medicine over the preceding 10 years.
Weather can affect pain tolerance, reports study in PAIN®
Can the weather affect pain from conditions like arthritis or migraine? It may sound like an old superstition – but on some standard quantitative sensory tests, weather-related factors do indeed affect pain tolerance, suggests a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published in the Lippincott portfolio by Wolters Kluwer.
The Promise of Regenerative Medicine to Treat Chronic Pain
Regenerative medicine has enormous implications for treatment and prevention of chronic pain including conditions like osteoarthritis, diabetic and peripheral neuropathy, and even spinal cord injuries and degenerative disk disease. According to one expert, there is potential to “[turn] back the time clock.”
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Implantable Brain Device Relieves Pain in Early Study
A computerized brain implant effectively relieves short-term and chronic pain in rodents, a new study finds.
Americans are increasingly experiencing chronic pain
This study comprehensively documents rising levels of chronic pain among Americans aged 25-84 to show that pain prevalence — already high at baseline — increased substantially from 2002-18, with increases evident in all leading pain sites (joint, back, neck, jaw, and migraine).
Practice Advisory: Contrast Agent Used in Pain Procedures Linked to Brain Damage and Death
The American Society of Regional Anesthesia and Pain Medicine has joined 10 other pain societies in issuing a practice advisory on the use of gadolinium-based contrast agents. This off-label use is an alternative option for patients with hypersensitivity to the traditional contrast medium.
With gene therapy, scientists develop opioid-free solution for chronic pain
A gene therapy for chronic pain could offer a safer, non-addictive alternative to opioids. Researchers at the University of California San Diego developed the new therapy, which works by temporarily repressing a gene involved in sensing pain. It increased pain tolerance in mice, lowered their sensitivity to pain and provided months of pain relief without causing numbness.
Digital solutions including remote monitoring can help chronic pain sufferers manage their pain and reduce the probability of misuse of prescription opioids.
For the first time, an app has been shown to reduce key symptoms of chronic pain. A UNH-led study evaluated the impact of Manage My Pain(MMP), a digital health solution on chronic pain patients.
Could a New Cell Type Discovery Lead to Better Chronic Pain Treatments?
Inflammation is a hallmark of chronic pain, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1+ macrophages are dysfunctional in an animal model of neuropathic pain.
New hope for treating chronic pain without opioids
According to some estimates, chronic pain affects up to 40% of Americans, and treating it frustrates both clinicians and patients––a frustration that’s often compounded by a hesitation to prescribe opioids for pain.
Immersive virtual reality boosts the effectiveness of spinal cord stimulation for chronic pain
For patients receiving spinal cord stimulation (SCS) for chronic pain, integration with an immersive virtual reality (VR) system – allowing patients to see as well as feel the effects of electrical stimulation on a virtual image of their own body – can enhance the pain-relieving effectiveness of SCS, reports a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Neuromonitoring Enables Patients to Sleep through Spinal Cord Stimulator Placement
Neuromonitoring has been used in the fields of neurological and orthopedic surgery for years but has just recently made its debut in SCS implantation. There are limited studies observing neuromonitoring in this application, so doctors have shared the case study of a patient who successfully underwent the procedure and reported 90% pain reduction one week later.
Researchers Uncover and Target Specific Proteins Linked to Pain in an Animal Model
Researchers are looking at the potential of a technique called differential target multiplexed programming (DTMP) to reduce chronic pain by targeting certain proteins linked to inflammation.
Reducing Drinking Among US Veterans with Unhealthy Alcohol Use Might Improve Chronic Pain Symptoms and Reduce Other Substance Use
US veterans with unhealthy alcohol use who reduce their drinking may gain some improvement in chronic pain symptoms and use of other substances, according to a study in Alcoholism: Clinical and Experimental Research. Hazardous drinking is common in the US, and frequently co-occurs with chronic pain, depression and anxiety, and with tobacco, cannabis or cocaine use. Many people use alcohol and other substances to mask or self-manage pain and psychiatric symptoms, although there is little evidence to support such use. If, conversely, a reduction in drinking (or use of treatment for alcohol misuse) were to benefit co-occurring conditions or substance use, this could support an integrated approach to screening or treatment. The new analysis assessed the impact of drinking reduction on improvement of chronic pain, psychiatric symptoms, and other substance use among US veterans with unhealthy alcohol use – a population with high rates of these co-occurring conditions.
NYU College of Dentistry Awarded NIH Grant to Investigate Endosomal Receptors as Targets for Chronic Pain Treatment
The NIH has awarded NYU College of Dentistry researchers Nigel Bunnett, PhD, and Brian Schmidt, DDS, MD, PhD, a $3.9 million grant to study targeting endosomal receptors for the treatment of chronic pain. The five-year grant will support Bunnett and Schmidt’s collaborative research, which aims to ultimately yield improved pain management without the need for opioids.
New Recommendations Steer Doctors Away from Opioids to Treat Pain in Adolescent Athletes
Athletes commonly experience pain in practice and competition. Inadequate or inappropriate pain management in adolescent athletes can lead to a lifetime of consequences including increased risk of opioid misuse. A team physician consensus statement just released by ACSM and 5 other sports medicine organizations shares guidelines to identify and manage pain in athletes ages 10 to 18.
Weizmann Institute Scientists Find that Targeting a Chronic Pain Gateway Could Bring Relief
A study led by Prof. Mike Fainzilber identifies a potential new approach to treating chronic pain: targeting an importin molecule that moves pain messages into nerve cell nuclei. The team can now “conduct screens for new and better drug molecules that can precisely target this chain of events in the sensory neurons.”
Medical Cannabis put to the test in first ever real-world evidence clinical trial led by UHN
Medical cannabis is finally being put under the microscope, in a first-of-its-kind real world evidence study led by Dr. Hance Clarke, Toronto General Hospital. In the Medical Cannabis Real-World Evidence trial patients using the online portal created by Medical Cannabis by Shoppers, will know exactly what is in their product and its effectiveness.
A sound treatment
University of Utah biomedical engineering assistant professor Jan Kubanek has discovered that sound waves of high frequency (ultrasound) can be emitted into a patient’s brain to alter his or her state. It’s a non-invasive treatment that doesn’t involve medications or surgery and has a unique potential to treat mental disorders including depression and anxiety and neurological disorders such as chronic pain and epilepsy.
Gender identity plays a role in the amount of pain experienced by individuals with chronic pain
Gender identity and genetic sex are distinctly variable when it comes to pain tolerance, according to a study published in the Journal of Pain Research.
ASRA Recognizes Eight Trailblazers as Part of the Year of Women in ASRA
Eight trailblazing women in regional anesthesia and pain medicine are being honored for their achievements and contributions to the field as part of the ASRA Trailblazer Awards. Created to acknowledge potential for bias in the past, the program is part of the “Year of Women in ASRA,” so named by ASRA President Dr. Eugene Viscusi. Other components of the campaign include year-round highlights of prominent women in the field on the ASRA website and social media channels, greater recognition of gender disparities at meetings, improved data collection to continue to assess our progress representing the field, and, most importantly, development of an organizational plan to identify and correct disparities across all minority groups.
Chronic pain physician provides guidance for patients during COVID-19
Samer Narouze, MD, PhD, is one of a group of experts who have developed guidance for healthcare providers treating chronic pain patients during the COVID-19 pandemic. The guidelines are a joint project of the American Society of Regional Anesthesia and…
‘Brain Surfing’: Ultrasound waves focused on prefrontal cortex elevate mood and change brain connectivity in human volunteers
A team of researchers at the University of Arizona has found that low-intensity ultrasound waves directed at a particular region of the brain’s prefrontal cortex in healthy subjects can elevate mood, and decrease connectivity in a brain network that has been shown to be hyperactive in psychiatric disorders. The method uses transcranial focused ultrasound (‘tFUS’), a painless, non-invasive technique to modulate brain function comparable to transcranial magnetic stimulation (‘TMS’), and transcranial direct current stimulation (‘tDCS’). This study shows, for the first time, a correlation between tFUS-induced mood enhancement, and reorganization of brain circuits.
‘Start low, go slow’ still applies for pain management, especially for older patients
Chronic pain affects a large proportion of older adults and most long-term care residents. Managing chronic pain effectively is essential but challenging, and it has been complicated by concerns about opioid abuse.
The Medical Minute: When chronic pain leads to depression in children
When chronic pain keeps children from being active and social, it’s no surprise that anxiety and depression can become unwelcome playmates. The good news: there is help, and it starts with recognizing that a problem exists.
Recognize an overdose, save a life
Every day nearly 200 people die from an overdose of drugs or from alcohol poisoning, with opioids responsible for the majority. Recognizing the signs and knowing how to respond to medical emergencies, including carrying and administering naloxone in cases of opioid overdose, can save lives says the ASA.
Epidemic levels of chronic pain, opioid use disorder add to challenges of managing patients in pain
A series of seven articles in AACN Advanced Critical Care focuses on the challenges of safe, effective pain management in the ICU, including more Americans reporting daily chronic pain and the rapidly increasing prevalence of opioid misuse and opioid use disorder.
Re-purposing existing drug could expedite development of novel chronic pain treatment caused by burn injury, helping sufferers including veterans
New research shows how second-degree burns cause hard-to-treat chronic pain, and this understanding may be key to treating these complications, common in war veterans.
Free Online Toolkit Helps People with Multiple Sclerosis Manage Symptoms
A new online program can help patients receive behavioral health care for chronic pain, fatigue and depressed mood from the comfort of their home.
American Chiropractic Association Launches Website to Enhance Public Understanding of Chiropractic
Hands Down Better, a website launched by the American Chiropractic Association (ACA), is a new resource for those who seek alternatives to pain medications and surgery for common musculoskeletal conditions such as back pain, neck pain, joint pain and headaches.
Tulane team researching ways to end opioid addiction
A Tulane University researcher is part of a nationwide initiative to improve treatment of chronic pain and ultimately achieve long-term recovery from opioid addiction.
Michael J. Moore, professor of biomedical engineering in the Tulane School of Science and Engineering, is part of a $945 million National Institutes of Health project called the HEAL Initiative, or Helping to End Addiction Long-term Initiative.
Experts available to talk about new guidelines of long-term opioid use
On Monday, the U.S. Department of Health and Human Services announced new guidelines for appropriate tapering or discontinuation of long-term opioid use. The new guidelines are a shift from previous recommendations created to combat the overprescribing of opioids in the…
UK Student, Military Researcher Explores Ways to Prevent Chronic Pain
Inspired by his time working for the Air Force and caring for wounded veterans, University of Kentucky College of Health Sciences doctoral candidate Josh Van Wyngaarden now studies ways to prevent chronic pain in those who have suffered traumatic leg injuries.
Implanted Nerve Stimulation Devices May Need Just 60 Days for Sustained Pain Control
Patients who have chosen to treat chronic pain with implanted peripheral nerve stimulation no longer need to be tethered permanently to the device. According to findings from a study in amputees, placing the device for just 60 days resulted in sustained pain relief and functional improvements.