NIH Awards Wake Forest University School of Medicine $10 Million to Study Long-term Opioid Use, Chronic Pain

Researchers at Wake Forest University School of Medicine have received a five-year $10 million grant from the National Institute on Drug Abuse, part of the National Institutes of Health (NIH), to create a broad research program that will work to reduce opioid-related harms and improve quality of life in patients on long-term opioid therapy.

Long COVID patients show distinct immune, hormone responses to virus

People suffering from long COVID symptoms show different immune and hormonal responses to the virus that causes COVID-19, according to a new study led by researchers at Yale School of Medicine. An estimated 7.5% of people infected with the SARS-CoV-2…

Symptoms of the body and the mind are frequent fellow travelers

Chronic pain is often accompanied by depression and anxiety. An invited commentary discusses the relationship between pain, the most common symptom for which individuals visit a physician, and depression and anxiety, the two most prevalent mental health conditions worldwide. It highlights the importance of not neglecting psychological symptoms in patients experiencing pain.

When Blood Is a New Alternative Medicine for Pain Relief at Chula Pain Clinic

Chula Medicine researchers have successfully published an article on the injection of patient’s own platelets rich plasma into the shoulder ligaments resulting in pain reduction, heal torn ligaments and restore torn muscles as an alternative to surgery while reducing the side effects of prolonged use of pain medications.

A Leader Fighting the Overdose Crisis Urges Standardizing Addiction Medicine Education and Supporting New DEA Requirements

According to the Centers for Disease Control and Prevention (CDC) and The National Vital Statistics System, drug-related overdose deaths have been rising over the past two decades in the United States. In 2021, 106,699 drug overdose deaths occurred. Adults aged 65 and over…

Debunking pain myths could help teens recover faster

Whether it’s headaches, abdominal pain, or unrelenting joint soreness, up to a third of young people in Australia experience chronic pain. Now, a world-first study from the University of South Australia is providing valuable insights about how young people understand chronic pain, potentially helping thousands of sufferers to better manage their symptoms and long-term wellbeing.

Study Unravels Interplay Between Sleep, Chronic Pain and Spinal Cord Stimulation

Spinal cord stimulation uses low levels of electricity to relieve pain. A study is the first to measure this treatment’s effects on patients by gauging improvement in insomnia after spinal cord stimulation. Results showed a 30 percent or more improvement of both nighttime and daytime components of insomnia in 39.1 percent of study participants and a 30 percent or more improvement of daytime sleepiness in 28.1 percent of participants. Findings correlated with improvement in disability and depression and revealed associations with sleep and both pain and depression. Results will help clinicians gain a better understanding of the type of patient most likely to benefit from this treatment.

Ultrasound Device for Pain Gets ‘Nod’ from Shark Tank and NIH Funding

A project using focused ultrasound is one of seven selected by the NIH, which also has received successful reviews from ABC’s “Shark Tank.” Researchers are developing a handheld probe to provide a noninvasive, non-opioid-based treatment for aggravated chronic pain for use in a physician’s office or potentially even at home. The device directs low-intensity ultrasound at the dorsal root ganglia – small bundles of nerves along the spine that control pain signals reaching the spinal cord – to provide means for precise treatment of back and leg pain.

Dr. Jose De Andres to Present the 2022 John J. Bonica Lecture at the 21st Annual Pain Medicine Meeting

ASRA Pain Medicine has selected Jose De Andres, MD, PhD, FIPP, EDRA, EDPM, to receive the 2022 John J. Bonica Award. The honor recognizes an individual who has demonstrated outstanding contributions to the development, teaching, and practice of pain medicine in the tradition of John J. Bonica, MD, the pioneering anesthesiologist regarded as the founding father of pain relief medicine.

Drinking to Manage Physical Pain Results in Perceived Relief, Increasing Vulnerability to Dangerous Alcohol Use

People who self-medicate pain with alcohol may be vulnerable to hazardous drinking, with their experience of pain relief a potentially powerful driver of alcohol consumption, a new study suggests. Both pain and dangerous alcohol use are major public health issues. Each affects millions of US adults and costs hundreds of billions of dollars annually in health care and lost productivity. Recent studies have demonstrated a strong correlation between pain and alcohol use; people with chronic pain are more likely than others to report heavy drinking, and those with alcohol use disorder (AUD) are more likely to report chronic pain. Alcohol has known analgesic effects. Evidence of shared neural mechanisms underlying chronic pain and substance misuse suggest alcohol’s pain-relieving capacity might be influenced by individuals’ experience of chronic pain. Better understanding the relationship between chronic pain and alcohol use could inform improved prevention and treatment approaches. For the

Online Chair Yoga Viable Exercise for Isolated Older Adults with Dementia

Researchers evaluated a remotely supervised online chair yoga intervention targeted at older adults with dementia and measured clinical outcomes virtually via Zoom under the remote guidance. Results showed that remotely supervised online chair yoga is a feasible approach for managing physical and psychological symptoms in socially isolated older adults with dementia based on retention (70 percent) and adherence (87.5 percent), with no injury or other adverse events.

Scientists develop blueprint for turning stem cells into sensory interneurons

Key takeaways:
• Just like the real thing. The stem cell–derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body.
• Tomorrow’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain.
• Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.

AI Could Predict Ideal Chronic Pain Patients for Spinal Cord Stimulation

Spinal cord stimulation is a minimally invasive FDA-approved treatment to manage chronic pain such as back and neck pain. The ability to accurately predict which patients will benefit from this treatment in the long term is unclear and currently relies on the subjective experience of the implanting physician. A study is the first to use machine-learning algorithms in the neuromodulation field to predict long-term patient response to spinal cord stimulation.

Protocol Based on Questionnaires and a Mental Health Checklist Can Replace In-Person Psychological Assessment Before Neuromodulation Therapies

Researchers at Toronto Western Hospital in Canada have proposed a protocol for patients undergoing neuromodulation implantation that incorporates a short mental health checklist and pre-defined cut-offs on validated questionnaires to assess the need for an in-person assessment by a psychologist.

Veterans with Traumatic Brain Injury: M.O.M. to the Rescue

The M.O.M. project, which will have four units in Ohio, Florida, South Carolina and Texas, will engage veterans with traumatic brain injury, their caregivers and other stakeholders to bolster patient-centered outcomes research and comparative effectiveness research in order to identify treatment options for traumatic brain injury that are effective, acceptable, and meaningful to the veteran population.

NIH Awards Grant to Study Combination Treatment for Pain to Wake Forest School of Medicine

Chronic musculoskeletal pain (CMP) – daily pain in the muscles, bones, ligaments, tendons and nerves that lasts for six months or longer – contributes to approximately 21% of worker disability issues in this country and costs $500 billion annually from lost wages, treatment and medications, according to a study conducted by Johns Hopkins University.
In an effort to develop a more effective strategy against this debilitating condition, a team of doctors and researchers at Wake Forest School of Medicine has received a four-year grant of approximately $4 million from the National Institutes of Health.

Dr. Oscar de Leon-Casasola Named 2021 John J. Bonica Awardee, Will Present Lecture at ASRA’s 20th Annual Pain Medicine Meeting

Oscar de Leon-Casasola, MD, has been selected to receive the 2021 John J. Bonica Award. The honor recognizes an individual who has demonstrated outstanding contributions to the development, teaching and practice of pain medicine in the tradition of John J. Bonica, MD, the pioneering anesthesiologist regarded as the “founding father of pain relief medicine.”

Weather can affect pain tolerance, reports study in PAIN®

Can the weather affect pain from conditions like arthritis or migraine? It may sound like an old superstition – but on some standard quantitative sensory tests, weather-related factors do indeed affect pain tolerance, suggests a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published in the Lippincott portfolio by Wolters Kluwer.

Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.

With gene therapy, scientists develop opioid-free solution for chronic pain

A gene therapy for chronic pain could offer a safer, non-addictive alternative to opioids. Researchers at the University of California San Diego developed the new therapy, which works by temporarily repressing a gene involved in sensing pain. It increased pain tolerance in mice, lowered their sensitivity to pain and provided months of pain relief without causing numbness.