Recent studies have led to the development of imaging and spinal fluid tests for patients with Alzheimer’s disease. However, the tests can only monitor severe disease. Reporting in ACS Chemical Neuroscience, researchers have now identified a biomarker that could help physicians diagnose AD earlier.
The closing plenary session at ANA2022 spotlighted neurologic health inequities and presented new research finding that neighborhood disadvantage strongly predicted likelihood of death from neurologic conditions independent of individual wealth and demographics.
Drug companies and university-based teams are working urgently to find and test new medications that could prevent or slow the decline of brain function in older adults. But a new study suggests they’ll need to work harder to find volunteers for their clinical trials.
The Alzheimer’s Clinical Trial Consortium (ACTC) will be presenting analyses of screening plasma and neuroimaging data from the AHEAD Study at CTAD in November.
Cecilia Lindestam Arlehamn, Ph.D., aims to shed light on how sex-based immune system differences may affect the development and progression of these neurodegenerative diseases in men versus women.
Exposure to urban air pollutants such as ozone (O3) is increasingly linked with Alzheimer’s disease; yet because ozone cannot travel from the lungs to the brain, the mechanism by which it contributes to development of Alzheimer’s has been poorly understood.…
Scientists at St. Jude Children’s Research Hospital created a model to study the role of RNA splicing defects in Alzheimer’s disease, revealing degeneration and toxicity caused by neuron hyperexcitability.
The American College of Surgeons (ACS) is the recipient of a $100,000 grant from the Council of Medical Specialty Societies (CMSS) to develop comprehensive educational resources to improve surgical care and outcomes for older adults with Alzheimer’s disease and related dementias who are undergoing surgery.
Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer’s disease—a finding that they say could help lead to new medicines to treat the disease. The researchers found that the female brain shows higher expression of a certain enzyme compared to males, resulting in greater accumulation of a protein called tau.
The Alzheimer’s Association welcomes the University of Kentucky’s Donna M. Wilcock, Ph.D., as the new editor-in-chief of Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.Since its inception in 2005, Alzheimer’s & Dementia has sought to bridge the knowledge gaps that separate traditional fields of dementia research by rapidly disseminating new findings and acting as a forum for articles covering clinical investigations and basic, social and behavioral research.
High blood pressure means faster slide into signs of dementia or Alzheimer’s, but does not explain the overall disparity between Hispanic/Latino people and non-Hispanic people in dementia risk.
The Alzheimer’s Association, through its Part the Cloud global research grant program, has awarded Wake Forest University School of Medicine $795,000 over two years to study potential treatments for Alzheimer’s disease.
In a study publishing in Nature Medicine on September 22, 2022, University of California San Francisco researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD, combined and harmonized clinical, neuroimaging, and fluid biomarkers from nearly all familial FTD clinical research participants across North America and Europe. With that data, they developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
New research from Wake Forest University School of Medicine shows that taking a daily supplement may improve cognition in older adults. In the study, researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years).
Older people who were infected with COVID-19 show a substantially higher risk—as much as 50% to 80% higher than a control group—of developing Alzheimer’s disease within a year, according to a study of more than 6 million patients 65 and older.
Researchers from Florida Atlantic University, in collaboration with Tel Aviv University, have received a two-year, $379,177 grant from the National Institute on Aging, National Institutes for Health, on a collaborative project to study mood-disorders changes in Alzheimer’s disease.
A new UCLA-led study has identified multiple new risk genes for Alzheimer’s disease and a rare, related brain disorder by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.
UC San Diego researchers received a $1.3 million grant from the Keck Foundation for a project that could help scientists better understand the role misfolded tau proteins play in causing neurodegenerative diseases like dementia, which may lead to more effective drug therapies.
The findings from the meeting were recently published in Molecular Neurodegeneration and raise opportunities for new treatments and cures for neurodegenerative diseases like glaucoma and Alzheimer’s.
Researchers at the University of New Hampshire will receive a five-year grant totaling $2.8 million from the National Institutes of Health (NIH) to develop and test social assistive robots to aid in the care of individuals with Alzheimer’s disease and related dementia in the comfort of their own homes.
Timothy Huang, Ph.D., has been awarded $2.8 million by the National Institute on Aging (NIA) to continue his work on Alzheimer’s disease. The four-year project will use human stem cells transplanted into mice to determine the role of specific Alzheimer’s-related gene mutations in the brain.
Beta-amyloid is far from the only factor in dementia, memory loss and Alzheimer’s disease, and far from the only target for drugs, says the director of a top Alzheimer’s center. Research on many molecules, and an emphasis on preventing or slowing the disease, are both crucial.
Two common viruses lie dormant in neurons – herpes simplex virus (HSV), and varicella zoster virus (VZV). Lab models of the human brain show that activation or re-infection of VZV can trigger neuroinflammation and wake up HSV, leading to accumulation of Alzheimer’s linked proteins and neural decline.
Hackensack Meridian Hackensack University Medical Center and the hospital’s Center for Memory Loss and Brain Health are conducting research for Alzheimer’s Disease through three clinical trials with the goal of addressing and improving the current gaps in knowledge of treatment…
Researchers evaluated a remotely supervised online chair yoga intervention targeted at older adults with dementia and measured clinical outcomes virtually via Zoom under the remote guidance. Results showed that remotely supervised online chair yoga is a feasible approach for managing physical and psychological symptoms in socially isolated older adults with dementia based on retention (70 percent) and adherence (87.5 percent), with no injury or other adverse events.
Neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations in the chemical composition of the biomolecules. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a simple and effective method for detecting such misfolding at an early stage of the disease. Misfolding is revealed by the structure of dried residue from protein and peptide solutions.
Researchers found significant differences in movement patterns between participants with normal cognition and those with mild cognitive impairment or Alzheimer’s disease.
Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue.
UC San Diego researchers tracked the evolution of a gene variant that supports cognitive health in older humans, but may have first emerged to protect against bacteria.
The Neurodegeneration Initiative was launched through a transformative $2.4 million gift to Glaucoma Research Foundation from the Melza M. and Frank Theodore Barr Foundation.
A novel, disease-modifying therapy for Alzheimer’s disease may involve the whole exchange of blood, which effectively decreased the formation of amyloid plaque in the brains of mice, according to a new study from UTHealth Houston.
Women make up two-thirds of Americans who have Alzheimer’s disease, yet scientists have yet to determine what makes them so susceptible to the condition. Bernard Schreurs, a researcher with the West Virginia University School of Medicine and Rockefeller Neuroscience Institute, directs the West Virginia Alzheimer’s…
A multisite research team from the University of California, Irvine, the University of Wisconsin–Madison and Wake Forest University has discovered that brain inflammation may link Alzheimer’s disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages.
New research published in the journal Frontiers in Aging Neuroscience by Tufts University scientists and colleagues suggests a link between Fusobacterium nucleatum (F. nucleatum), a common type of bacteria that proliferates in periodontal disease, and Alzheimer’s disease.
To build a resource that greatly expands Alzheimer’s disease genetic studies in the currently underrepresented African ancestry populations and Hispanic/Latinx groups, the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami Miller School of Medicine will lead a major five-year, international, multi-site initiative with Case Western Reserve University, Columbia University, Wake Forest University, the University of Pennsylvania, and the University of Ibadan, which is the lead institution for the African Dementia Consortium (AfDC).
New research led by the University of South Australia shows that fatty foods may not only be adding to your waistline but also aggravating Alzheimer’s disease, and causing depression and anxiety.
Dr. Ortega’s newest role as associate dean of clinical practice now places her at the helm of clinical care for both the Green Memory and Wellness Center and the FAU and Northwest Community Health Alliance’s Community Health Center (FAU/NCHA CHC), operated by the Christine E. Lynn College of Nursing. She will collaborate with FAU/NCHA CHC executive director Karethy Edwards, Dr.PH, APRN, professor and associate dean for academic programs; and clinical director Desiree’ T. Weems, APRN, a certified nurse practitioner.
Medicare could waste up to $605 million per year on the controversial Alzheimer’s drug aducanumab if it is eventually approved for widespread use because it is supplied in vials containing fixed doses that may not be appropriate for all patients–resulting in the trashing of large volumes of unused drug
People who received at least one influenza vaccine were 40% less likely than their non-vaccinated peers to develop Alzheimer’s disease over the course of four years, according to a new study from UTHealth Houston.
Researchers from the University of Kentucky’s Sanders-Brown Center on Aging say a paper recently published in Acta Neuropathologica is the most definitive assessment yet of the prevalence of a form of dementia classified in 2019 and now known as LATE. The results show that the prevalence of brain changes from LATE may be roughly 40% in older adults and as high as 50% in people with Alzheimer’s disease.
Dementia Day Center, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society prepares for Thailand’s anticipated aging society by offering various rehabilitation services to help slow down the decline of people with dementia, while planning to launch a professional course for caregivers, and establishing the “Bright Brain Club” to persuade people of all ages to learn and care for early brain health to avoid the possibility Alzheimer’s disease.
Mechanisms associated with a particular diabetes drug can also help to protect against Alzheimer’s disease, a study by researchers at Karolinska Institutet in Sweden and published in Neurology reports.
A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer’s disease, a new study in mice shows.
Medicare costs around the time of a dementia diagnosis are much lower for older adults screened proactively rather than those diagnosed while experiencing a health issue.
Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Revatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease. Drug repurposing offers a practical alternative to…
Breakthrough COVID-19 cases resulting in infections, hospitalizations and deaths are significantly more likely in cancer and Alzheimer’s patients, according to two new studies from researchers at the Case Western Reserve University School of Medicine.
Scientists have assessed the long-term effects of intranasal insulin on cognition and on gait in people with and without type 2 diabetes mellitus.
Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain.
The scientists say this discovery in mice of a new function by cells known as astrocytes opens a whole new direction for neuroscience research that might one day lead to treatments for many disorders ranging from epilepsy to Alzheimer’s to traumatic brain injury.
Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology.
The researchers revealed a new way that nature can inhibit or switch off important proteins known as intramembrane proteases — pronounced “pro tea aces” — which the team reported April 26th in the journal eLife.