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Tag: Alzheimer’s Disease
Mayo Clinic scientists define new type of memory loss in older adults
Researchers at Mayo Clinic have established new criteria for a memory-loss syndrome in older adults that specifically impacts the brain’s limbic system. It can often be mistaken for Alzheimer’s disease.
Brain inflammation triggers muscle weakness after infections
Research from Washington University School of Medicine in St. Louis reveals how brain inflammation triggers extreme muscle weakness across several diseases, including viral infection, bacterial infection and Alzheimer’s disease. The study, in fruit flies and mice, also identified ways to block this process, which could have implications for treating or preventing the muscle wasting sometimes associated with inflammatory diseases, including bacterial infections, Alzheimer’s disease and long COVID.
Advocate Health champions health equity through new, innovative dementia care model
Advocate Health has been selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Guiding an Improved Dementia Experience (GUIDE) Model. Following years of neurocognitive disorders research pioneered by Advocate Health’s academic core, Wake Forest University School of Medicine, patients across the health system’s footprint will now benefit from the GUIDE Model’s new standardized approach to care for patients with dementia and their caregivers.
UAlbany Chemist Available to Discuss Eli Lilly Alzheimer’s Drug
ALBANY, N.Y. (July 9, 2024) — Last week, the Food and Drug Administration (FDA) approved a new Alzheimer’s medication developed by Eli Lilly that has shown in clinical trials to moderately delay the progression of memory and cognitive decline in…
Expert available: FDA approval of new Alzheimer’s drug, Kisunla
Aaron Burberry, Assistant Professor, Department of Pathology, School of Medicine https://case.edu/medicine/pathology/faculty/aaron-burberry
Expert available: FDA approval of Alzheimer’s disease drug, donanemab
The FDA approved a new Alzheimer’s disease treatment today called donanemab (brand name Kisunla), after it was reviewed and recommended by an advisory panel earlier this year. Sanjeev Vaishnavi, MD, PhD, an assistant professor of neurology at Penn Medicine, is…
New research identifies biomarkers that link alcohol use disorder and Alzheimer disease
Researchers agree that alcohol use can produce global and regional tissue volume changes in the brain, and that excessive alcohol use is associated with dementia and cognitive decline. A new study has examined the relationship between Alzheimer disease – the most common type of dementia – and alcohol use disorder (AUD), discovering biomarkers that link the two.
UC San Diego Receives $5M to Support Geriatrics Workforce Enhancement Program
The San Diego Imperial Geriatric Education Center has received renewed funding from the Health Resources and Services Administration, allowing the center to relocate to UC San Diego.
‘Fit2Drive’ Transforms Assessing Older Drivers with Cognitive Decline
With the help of an evidence-based calculator called “Fit2Drive,” researchers have made it easy to administer and evaluate an in-office test to predict an older individual’s probability of passing an on-road driving test. Based upon brief, easily administered cognitive tests, Fit2Drive provides an objective estimation of the ability to drive for those with cognitive concerns. Results show that the Fit2Drive algorithm demonstrated a strong 91.5% predictive accuracy.
Rensselaer Professor Receives $3.7 Million Grant for Alzheimer’s Disease Research
Chunyu Wang, M.D., Ph.D., professor of biological sciences and chemistry and chemical biology at Rensselaer Polytechnic Institute, has been awarded a five-year grant of more than $3.7 million by the National Institutes of Health’s National Institute on Aging to study Apolipoprotein E (ApoE) isoform interactions with heparan sulfate (HS) in Alzheimer’s disease (AD).
Icahn School of Medicine at Mount Sinai Awarded $21 Million NIH Grant to Advance Understanding of Aging-Related Hormone
Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $21 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), to further advance understanding of an aging-related hormone known as follicle-stimulating hormone (FSH), including its potential role in obesity, osteoporosis, and Alzheimer’s disease.
NUTRITION 2024 showcases groundbreaking research on what we eat and why it matters
Be among the first to hear breaking news in food and nutrition science at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition held June 29–July 2 at McCormick Place in Chicago.
Researchers Wrestle with Accuracy of AI Technology Used to Create New Drug Candidates
Researchers at the UNC School of Medicine, UCSF, Stanford, and Harvard determined that a protein prediction technology can yield accurate results in the hunt to efficiently find the best possible drug candidates for many conditions.
‘MUSIC map’ reveals some brain cells age faster and are more prevalent in Alzheimer’s
Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease. Additionally, researchers observed sex-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of “old” oligodendrocytes to “old” neurons compared to the male cortex.
Uniformed Services University Contributes to Groundbreaking Global Study on Multiple System Atrophy
In a groundbreaking study published May 2, 2024 in Neuron, researchers have identified four new genetic risk factors for multiple system atrophy (MSA), shedding light on this poorly understood disorder.
FAU Researchers Receive $1M in FDOH Grants to Fight Alzheimer’s Disease
With this funding, FAU researchers will shed light on the biological functions of Alzheimer’s disease (AD) by taking advantage of synthetic chemistry strategies; provide an innovative online screening tool for older drivers with cognitive decline; and gain a deeper understanding of the role of brain cholesterol in AD.
NeuroTherapia Receives Grant from Alzheimer’s Association for Development of First-in-Class Drug for Alzheimer’s Disease
NeuroTherapia, an early-stage clinical pharmaceutical company, announced today that it has received a grant from the Alzheimer’s Association Part the Cloud program for the development of its first-in-class drug, NTRX-07, for the treatment of Alzheimer’s disease (AD).
Belfer family’s $20 million donation invigorates neurodegeneration research at MD Anderson
Laurence Belfer, on behalf of Robert Belfer and the Belfer family, today announced a $20 million gift to The University of Texas MD Anderson Cancer Center to strengthen neurodegeneration research through the Belfer Neurodegeneration Consortium (BNDC), a transformative multi-institutional initiative to advance the study and treatment of Alzheimer’s disease.
Program announced for NUTRITION 2024 to be held June 29–July 2
Reporters are invited to join leading nutrition researchers and professionals at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition.
Early Alzheimer’s Detection with Artificial Intelligence
“AI-driven neuroimaging techniques have the potential to improve prediction models for Alzheimer’s progression and facilitate personalized treatment strategies,” says Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM).
Alzheimer’s Drug Development Pipeline: Positive Results, New Insight Position 2024 as ‘Learning Year’
Alzheimer’s treatment studies offer hope as UNLV expert predicts new potential drugs, biomarkers will yield critical insight for future development.
Innovative Microscopy Demystifies Metabolism of Alzheimer’s
Using state-of-the-art microscopy techniques developed on campus, researchers at UC San Diego School of Medicine have shed new light on the underlying mechanisms driving Alzheimer’s disease.
Alzheimer’s disease progresses faster in people with Down syndrome
Nearly everyone with Down syndrome will eventually develop Alzheimer’s disease. Researchers at Washington University School of Medicine in St. Louis have discovered that Alzheimer’s disease starts earlier and moves faster in people with Down syndrome.
Common HIV treatments may aid Alzheimer’s disease patients
Scientists at Sanford Burnham Prebys have now identified promising real-world links between common HIV drugs and a reduced incidence of Alzheimer’s disease. The study, led by Jerold Chun, M.D., Ph.D., was published in Pharmaceuticals.
Young-Onset Dementia Tied to New Risk Factors
“Are the risk factors for early onset Alzheimer’s the same as late onset?” asks Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM)
Study Suggests Racial Discrimination During Midlife Associated with Alzheimer’s Disease Pathology Later in Life
Racial discrimination experienced during midlife is associated with Alzheimer’s disease pathology, according to a new study from researchers at Wake Forest University School of Medicine and the University of Georgia. The findings appear online today in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Key to Unlocking the Secret of Degenerative Brain Disorders Found
A research team led by Dr. Kim Yun Kyung from the Brain Science Institute at the Korea Institute of Science and Technology (KIST), in collaboration with Professor Chang Young-Tae’s team from Pohang University of Science and Technology, has announced the development of a next-generation neuron labeling technology called NeuM.
Immunotherapy for Alzheimer’s disease shows promise in mouse study
Scientists at Washington University School of Medicine in St. Louis have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer’s disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean up damaging plaques (blue) in the brain.
Immune Cells Identified as Key Players in Brain Health
Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer’s and other diseases.
New research at Case Western Reserve University aims to address racial disparities in cognitive decline
According to new research at Case Western Reserve University, connecting with friends is key to limiting social isolation—something researchers believe could also reduce Alzheimer’s, dementia
EXPERT INTERVIEW: Alzheimer’s Association report reveals new Alzheimer’s disease incidence, costs figures and dementia care barriers/challenges
EMBARGOED UNTIL 20 MARCH 2024 On March 20, the Alzheimer’s Association will release its 2024 Alzheimer’s Disease Facts and Figures report, which provides an in-depth look at the latest statistics and information on Alzheimer’s disease prevalence, incidence, mortality, caregiving, dementia care workforce,…
Unlocking Alzheimer’s Mysteries: A Revolutionary Leap in Brain Network Analysis
Dementia stands as one of the most significant global health challenges of the 21st century, with over 50 million individuals worldwide currently affected, a number projected to triple by 2050, reaching 152 million, due to global population aging.
New study reveals breakthrough in understanding brain stimulation therapies
For the first time, researchers at the University of Minnesota Twin Cities showed that non-invasive brain stimulation can change a specific brain mechanism that is directly related to human behavior.
“Anti-Choke Mug” – Chula Innovation for Neuro Patients to Drink Water Confidently
Chula Medicine has designed an anti-choke mug with calculated angle, amount, and time of water flow from the mug to the patient’s lips hoping to reduce choking that may lead to lung infection, bring peace of mind to caregivers, and make it safer for patients who will have a better quality of life.
‘Curved’ Walking and a Depth Camera: New Tool Detects Early Cognitive Decline
Gait impairments often are prevalent in the early stages of cognitive decline. Researchers quantitatively compared straight walking and curved walking – a more natural yet complex activity – in healthy older adults and adults with mild cognitive impairment (MCI). A depth camera detected and tracked 25 joints of body movement and signals were processed to extract 50 gait markers. Intriguingly, curved walking illuminated notable disparities between the study groups.
Wrist Device That Monitors Activity Could Help Provide Early Warning of Alzheimer’s
Monitoring daily activity patterns using a wrist-worn device may detect early warning signs of Alzheimer’s disease, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
Doctor discusses a recent study about dementia.
Tresa Mcneal, MD, at Baylor Scott & White Health, discusses a recent study about dementia. What You Need to Know: Dementia affects thinking, memory and social ability. Stroke can cause dementia. Dementia risks increase for those who are sedentary. Reduce…
Study Detects Cognitive Changes in Older Drivers Using In-vehicle Sensors
Continuous, unobtrusive sensors and related monitoring devices are installed in older drivers’ vehicles to detect changes in highly complex activities over time. A driver facing camera, forward facing camera, and telematics unit provide video in real-time to enable researchers to analyze abnormal driving such as getting lost, reaction time and braking patterns as well as travel patterns such as miles driven, miles during the night and daytime, and driving in severe weather. Detecting changes in behavior could generate early warning signs of possible changes in cognition.
Neurons help flush waste out of brain during sleep
Researchers at Washington University School of Medicine in St. Louis have found that brain cell activity during sleep is responsible for propelling fluid into, through and out of the brain, cleaning it of debris.
AI Finds Key Signs That Predict Patient Survival Across Dementia Types
Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients. The study, published in the February 28 online issue of Communications Medicine, addresses critical challenges in dementia care by pinpointing patients at high risk of near-term death and uncovers the factors that drive this risk. Unlike previous studies that focused on diagnosing dementia, this research delves into predicting patient prognosis, shedding light on mortality risks and contributing factors in various kinds of dementia.
Yoga provides unique cognitive benefits to older women at risk of Alzheimer’s disease, study finds
A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.
Fixing rogue brain cells may hold key to preventing neurodegeneration
A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases.
Drug Repairs Systems That Drain Alzheimer’s-Causing Waste From Brain, Study Shows
Rutgers study led by undergrads and gap-year students breaks ground in the field of neuroscience and suggests experimental medication could treat dementia.
Dementia Researchers Share Recruitment Strategies for Pragmatic Clinical Trial
The Dementia Care (D-CARE) Study (2019-2023), which was conducted at four clinical trial sites in the U.S., compared three approaches in dementia care. Despite challenges during the COVID-19 pandemic, D-CARE successfully enrolled 2,176 racially/ethnically diverse persons with Alzheimer’s disease or related dementias and their caregivers.
UC Irvine-led research team creates novel rabies viral vectors for neural circuit mapping
Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.
Protein Accumulation on Fat Droplets Implicated in Late-Onset Alzheimer’s Disease
In an effort five years in the making, UNC School of Medicine cell biologist Sarah Cohen, PhD, and Rockefeller University’s Ian Windham, PhD, describe the interplay between fats and proteins in brain cells and how their dysfunction contributes to the development of late-onset Alzheimer’s disease.
Better together: Beckman imaging facilities share $3M Alzheimer’s research grant
Beckman researchers and collaborators received $3 million from the U.S. National Institute on Aging to develop diagnostic tools and imaging agents for the early detection of Alzheimer’s disease.
Dr. Claudia Padilla discusses Alzheimer’s and a new treatment.
Claudia Padilla, MD, at Baylor Scott & White Health, discusses Alzheimer’s and a new treatment. What You Need to Know: Alzheimer’s disease is a type of dementia. The most common sign is short-term memory loss. New medication targets the protein…
RNA Scientist Receives Federal Funding to Commercialize Molecular Tool Against Alzheimer’s Disease
University at Albany scientist Scott Tenenbaum, founder of UAlbany spinoff company sxRNA Technologies, Inc. (sxRNA Tech), has received $500,000 from the National Institute on Aging, part of the National Institutes of Health, to study how aging brain cells shape the progression of Alzheimer’s disease, and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer’s and related dementias.