New test to study language development in youth with Down syndrome

A team led by UC Davis Health researchers tested and validated elaborated language sampling (ELS) as a set of procedures for collecting, measuring and analyzing the spoken language of youth with Down syndrome in a naturalistic setting. They found that ELS is a reliable and feasible tool that can be used to detect meaningful changes in communication skills of individuals with Down syndrome.

Study finds risk of leukemia higher than expected in children with Down syndrome

The risk of childhood leukemia among kids with Down syndrome is higher than predicted, according to a new study led by UC Davis and UC San Francisco researchers. Early diagnosis remains critical.

NIH Awards Over $100 Million to Examine Biomarkers of Alzheimer’s Disease in Adults with Down Syndrome

The Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a multi-institution research team, co-led by members from the University of California, Irvine, has been awarded an unprecedented five-year, $109 million grant by the National Institutes of Health (NIH), to expand research on the biomarkers of Alzheimer’s disease in adults with Down syndrome.

New Insights Into Why People With Down Syndrome Are At Higher Risk For Leukemia

Scientists from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago were the first to examine endothelial cells – one of the main sources of blood production – for clues as to why people with Down syndrome have higher prevalence of leukemia. They identified a new set of genes that are overexpressed in endothelial cells of patients with Down syndrome. This creates an environment conducive to leukemia, which is characterized by uncontrolled development and growth of blood cells. Their findings, published in the journal Oncotarget, point to new potential targets for treatment and possibly prevention of leukemia, in people with Down syndrome and in the general population.

Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.

Genes Related to Down Syndrome Abnormalities May Protect Against Solid Tumors

Scientists from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems. Impairment in these same genes may also protect people with Down syndrome from developing solid tumors. Their findings were published in Scientific Reports.

Why Do So Many Pregnancies and In Vitro Fertilization Attempts Fail?

Scientists have created a mathematical model that can help explain why so many pregnancies and in vitro fertilization attempts fail. The Rutgers-led study, which may help to improve fertility, is published in the journal Proceedings of the National Academy of Sciences.

Validating NIH Toolbox to help evaluate cognitive processing in people with intellectual disability

Cognitive processing in people with intellectual disability can now be accurately assessed thanks to UC Davis Health researchers who updated and validated series of tests, part of the NIH Toolbox Cognitive Battery.