‘MUSIC map’ reveals some brain cells age faster and are more prevalent in Alzheimer’s

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease. Additionally, researchers observed sex-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of “old” oligodendrocytes to “old” neurons compared to the male cortex.

Novel Biological Mechanism Discovered That Could Lead to New Treatments for Neurological Disorders, Cancers

The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.

Cleveland Clinic Researchers Uncover How Virus Causes Cancer, Point to Potential Treatment

Cleveland Clinic researchers have discovered a key mechanism used by Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi’s sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.

RNA Scientist Receives Federal Funding to Commercialize Molecular Tool Against Alzheimer’s Disease

University at Albany scientist Scott Tenenbaum, founder of UAlbany spinoff company sxRNA Technologies, Inc. (sxRNA Tech), has received $500,000 from the National Institute on Aging, part of the National Institutes of Health, to study how aging brain cells shape the progression of Alzheimer’s disease, and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer’s and related dementias.

The Future of Medicine Rises in University City: University of Pennsylvania Opens New Multi-Disciplinary Research Labs in One uCity Square

Wexford Science & Technology, LLC and the University of Pennsylvania today announced that the University has signed a lease for new laboratory space that will usher in a wave of novel vaccine, therapeutics and engineered diagnostics research to West Philadelphia.

Rensselaer Researcher Uses Pressure To Understand RNA Dynamics

Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn.Rensselaer Polytechnic Institute’s Catherine Royer, Constellation Chair Professor of Bioinformatics and Biocomputation at the Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) and professor of biological sciences, is dedicated to understanding the conformational landscapes of biomolecules and how they modulate cell function.

UAlbany Researchers Awarded $1.4M to Identify RNAs Linked to Cancer and Bacterial Infections

Researchers from The RNA Institute at the University at Albany have been awarded $1.4 million to investigate stress-induced RNA modifications and associated cell response. The focus of the study — “wobble uridines” in tRNA — could hold important clues for treating bacterial infections and detecting cancer.

Cleveland Clinic Researchers Discover New Signal for Triggering Human Immune Response

Researchers from Cleveland Clinic’s Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a “priming signal” for the body to respond to a virus. These findings, published in Cell this week, potentially lay the groundwork for development of new anti-viral vaccines and treatments.

Modified nucleotides used in COVID-19 vaccines work as designed

The remarkable effectiveness of mRNA vaccines against SARS-CoV-2 has generated much interest in synthetic mRNA therapeutics for treating and preventing disease. But some basic science questions have remained about whether the modified nucleotides used in the vaccines faithfully produce the protein products that they are designed to make.

Yale researchers develop RNA-based therapy that clears SARS-CoV-2 from mice

Researchers at Yale School of Medicine have discovered that an RNA molecule that stimulates the body’s early antiviral defense system can protect mice from a range of emerging SARS-CoV-2 variants. The study, published today in the Journal of Experimental Medicine (JEM), could lead to new treatments for COVID-19 in immunocompromised patients, as well as providing an inexpensive therapeutic option for developing countries that currently lack access to vaccines.

‘Molecular Twin’ Initiative Will Help Advance Precision Cancer Treatment

Cedars-Sinai Cancer and Tempus, a leader in artificial intelligence and precision medicine, are harnessing the power of big data and AI to design personalized cancer treatment options by creating virtual replicas of patients’ DNA, RNA, protein and other information to help identify the most effective approach to each individual’s disease.

Not Just A Phase For RNAS

DALLAS – June 9, 2021 – A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water, appears to tightly regulate the activity of Pumilio. A new study led by UT Southwestern scientists suggests that such RNA-driven “phase separation,” in turn, protects against genome instability, premature aging, and neurodegenerative diseases, and may represent a previously unrecognized way for RNAs to regulate cellular processes.

Weizmann Institute Scientists Reveal the Triple Threat of Coronavirus

Scientists at the Weizmann Institute and the Israel Institute for Biological, Chemical and Environmental Sciences took a novel tack to investigating SARS-CoV-2’s powerful ability to infect, finding that the virus deploys an apparently unique three-pronged strategy to take over the cell’s protein-synthesis abilities. The work could help develop effective Covid-19 treatments.

2021 Warren Alpert Prize Awarded to Two Scientists for RNA Discoveries

The 2021 Warren Alpert Foundation Prize has been awarded to scientists Lynne Maquat and Joan Steitz for seminal discoveries in the biology and function of RNA, the workhorse molecule of cells. Their discoveries have reshaped the understanding of RNA’s myriad roles in healthy cell function and in disease-causing dysfunction and have informed the conceptualization and design of RNA-based therapies in various stages of development.

More than 1,000 SARS-CoV-2 Coronavirus Protein 3D Structures Available

New Brunswick, N.J. (March 3, 2021) – The 3D structures of more than 1,000 SARS-CoV-2 coronavirus proteins are freely available from the RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick. The data bank reached the milestone this week, with 1,018 proteins as…

MicroRNA Testing of Healthy Children Could Provide a Window on Heart and Kidney Health Later in Life

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics.

Health Disparities and COVID-19, Toxicity of E-cigarette Generated Aerosols, and More Featured in February 2021 Toxicological Sciences

Toxicological Sciences continues to feature leading toxicology research in the areas of developmental and reproductive toxicology; endocrine toxicology; neurotoxicology; molecular, biochemical, and systems toxicology; and more.

Rutgers Expert Can Discuss AI Advances Linked to RCSB Protein Data Bank

New Brunswick, N.J. (Dec. 3, 2020) – Stephen K. Burley, director of the RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick, is available for interviews on how the bank’s 50 years of data on the 3D biomolecular structures of life and artificial intelligence can lead…

UNLV Immunologist on the Differences Between Two Leading COVID-19 Vaccine Candidates

Millions around the world have waited for news about a COVID-19 vaccine, regarding it as the beginning of the end for the global pandemic and a herald for the eventual return to “normal life.” Recent announcements from pharmaceutical companies Pfizer and Moderna that their respective late-stage vaccine trials have shown a 90% or better effectiveness rate have received international applause, excitement furthered with estimates that doses could be ready as early as December.

Testing Wastewater for COVID-19

UNLV researcher Edwin Oh and colleagues have implemented wastewater surveillance programs to screen samples for the presence of COVID-19 and to extract the RNA from the SARS-COV-2 virus to find targets that make vaccines more effective.

Gut Microbiome Manipulation Could Result from Virus Discovery

Scientists have discovered how a common virus in the human gut infects and takes over bacterial cells – a finding that could be used to control the composition of the gut microbiome, which is important for human health. The Rutgers co-authored research, which could aid efforts to engineer beneficial bacteria that produce medicines and fuels and clean up pollutants, is published in the journal Nature.

The Hidden Reason Children Born by C-Section Are More Likely to Develop Asthma

Researchers at Rutgers University, the Copenhagen Prospective Studies on Asthma in Childhood and the University of Copenhagen have described for the first time how delivery by caesarean section interferes with a baby’s ability to obtain beneficial germs from the mother’s microbiome, and how this can lead to early childhood asthma.

Jennifer Doudna Wins 2020 Nobel Prize in Chemistry

Biochemist Jennifer Doudna, a professor at UC Berkeley and faculty scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), is co-winner of the 2020 Nobel Prize in Chemistry for “the development of a method for genome editing.”

Researchers identify RNA molecule that helps lung cancer cells evade immune system

Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the body’s immune cells. The study, which will be published August 27 in the Journal of Cell Biology (JCB), suggests that targeting this RNA molecule could boost the effectiveness of immunotherapies that are currently only successful in ~20% of lung cancer patients.

September Edition of SLAS Discovery Highlights “Applications of Functional Genomics for Drug Discovery”

September’s edition of SLAS Discovery features the cover article, “Applications of Functional Genomics for Drug Discovery” by Ami M. Kabadi, Ph.D., (Element Genomics), Eoin McDonnell, Ph.D. (Element Genomics), Christopher L. Frank, Ph.D., (Element Genomics), and Lauren Drowley, Ph.D., (UCB Biosciences). The article reviews how functional genomic tools are better able to understand the biological interplay between genes, improving disease modeling and identifying novel drug targets.