Light-Activated ‘CRISPR’ Triggers Precision Gene Editing and Super-Fast DNA Repair

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

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Scientists Aim Gene-Targeting Breakthrough Against COVID-19

Scientists at Berkeley Lab and Stanford have joined forces to aim a gene-targeting, antiviral agent called PAC-MAN against COVID-19.

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Grant will help scientists break new ground in gene editing

A new grant from the National Institutes of Health will allow Iowa State University scientists to continue to develop gene editing technologies to model human disease in zebrafish. The research aims to build new tools to determine which genes have therapeutic potential to treat human genetic diseases that affect the cardiovascular, immune and nervous systems.

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Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.

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“CRISPR: A Screener’s Guide” Headlines the March Edition of SLAS Discovery

The March edition of SLAS Discovery features the cover article, “CRISPR: A Screener’s Guide,” by Carlos le Sage, Ph.D., Steffen Lawo, Ph.D., and Benedict C.S. Cross, Ph.D., (Horizon Discovery, United Kingdom). In their review, the authors discuss how CRISPR-Cas9 systems are being used widely throughout the drug discovery process and the development of new precision medicines.

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Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

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Opening Up DNA to Delete Disease

Protein editorial assistants are clearing the way for cut-and-paste DNA editors, like CRISPR, to access previously inaccessible genes of interest. Opening up these areas of the genetic code is critical to improving CRISPR efficiency and moving toward futuristic, genetic-based assaults on disease. The DNA-binding editorial assistants were devised by a U.S.-based team of bioengineers, who describe their design in APL Bioengineering.

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