CRISPR | sciencenewsnet.in

Light-Activated ‘CRISPR’ Triggers Precision Gene Editing and Super-Fast DNA Repair

June 17, 2020 sarah Jonas Cancer, CRISPR, Dna Repair, Gene Editing

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

Research Results

Tomato’s Hidden Mutations Revealed in Study of 100 Varieties

June 17, 2020 sarah Jonas Agriculture, CRISPR, crop breeding, Crops, Tomatoes

A new analysis of difficult-to-access genetic variation is the most comprehensive ever conducted in plants. It could guide the improvement of tomatoes and other crops.

Feature

Scientists Aim Gene-Targeting Breakthrough Against COVID-19

June 4, 2020 sarah Jonas Antiviral Compounds, Antiviral Drugs, Bioengineering, Chemistry, Chemistry & Materials, Coronavirus, COVID-19, CRISPR, Department of Energy (DOE), Department of Energy Office of Science, Epithelial Cells, flu, Gene Editing, Gene Therapy, Gene Therapy Drugs, human cells, Infectious Disease, Influenza, Medicine, Medicine & Health: Infectious/Emerging Diseases., Molecular Foundry, Nanomaterials, Nanoscience, Nanoscience & Technology, Nucleotides, Pandemic, Pandemic Flu, Peptide, Peptoids, Pneumonia, Polymers, preclinical research, respiratory ailments, Respiratory Infections, Respiratory Therapy, RNA Biology, Rna Editing, RNA enzyme, RNA sequencing, self-assembling RNA, Stanford University, Stanford University School of Medicine, Transfection, Upper Respiratory Infection, Viral Infections, viral mutations, Viral Replication, Virus

Scientists at Berkeley Lab and Stanford have joined forces to aim a gene-targeting, antiviral agent called PAC-MAN against COVID-19.

Announcement

Grant will help scientists break new ground in gene editing

May 18, 2020 sarah Jonas CRISPR, Gene Editing, Genetics, Iowa State, Iowa State University, Zebrafish

A new grant from the National Institutes of Health will allow Iowa State University scientists to continue to develop gene editing technologies to model human disease in zebrafish. The research aims to build new tools to determine which genes have therapeutic potential to treat human genetic diseases that affect the cardiovascular, immune and nervous systems.

Research Tip Sheet

Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences

May 7, 2020 sarah Jonas Acute Kidney Injury, adverse outcome pathway, adverse outcomes, aop, biomarkers, Cas9, CRISPR, CRISPR cas, CRISPR/Cas9, Drug Safety, Environmental Exposure, environmental exposures, LIVER, lung, Mechanism, Mechanisms, Mouse, Pancreas Cancer, Radiotherapy, Rat, Receptor, Society Of Toxicology, SOT, Toxicity, toxicological sciences, TOXICOLOGY, toxsci, Transcriptome, Xenobiotic

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.

Research Results

Finding Leukemia’s Weakness Using Genome-Wide CRISPR Technology

April 20, 2020 sarah Jonas Cancer, Cell Biology, CRISPR, genes, Genetics, Hematology, Leukemia

Researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia.

Research Results

“CRISPR: A Screener’s Guide” Headlines the March Edition of SLAS Discovery

February 24, 2020 sarah Jonas Cancer, CRISPR, Gene Editing, high-content screening, Rnai

The March edition of SLAS Discovery features the cover article, “CRISPR: A Screener’s Guide,” by Carlos le Sage, Ph.D., Steffen Lawo, Ph.D., and Benedict C.S. Cross, Ph.D., (Horizon Discovery, United Kingdom). In their review, the authors discuss how CRISPR-Cas9 systems are being used widely throughout the drug discovery process and the development of new precision medicines.

Research Results

CRISPR Gene Cuts May Offer New Way to Chart Human Genome

February 24, 2020 sarah Jonas CRISPR, DNA, Nanopore, Sequencing

In search of new ways to sequence human genomes and read critical alterations in DNA, researchers at Johns Hopkins Medicine say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.

Research Tip Sheet

Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences

February 4, 2020 sarah Jonas Bisphenol S (BPS), CRISP/Cas9, CRISPR, estrogenic compounds, Kidney, metabolite levels, Metabolites, Screening, single cell, Society Of Toxicology, toxicological sciences, TOXICOLOGY, Zebrafish

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

Research Results

Stem Cells, CRISPR and Gene Sequencing Technology are Basis of New Brain Cancer Model

January 28, 2020 sarah Jonas 0 Comments Big Data, Bioinformatics, Brain Cancer, Cancer, Cell Biology, CRISPR, Genetics, Glioblastoma, Molecular Biology, Neurobiology, Stem Cells

University of California San Diego School of Medicine researchers created a new type of brain cancer model for glioblastoma using stem cells, CRISPR and gene sequencing.

Research Results

Tiny containers transport targeted treatments

January 27, 2020 sarah Jonas 0 Comments Brain Cancer, CRISPR, targeted therapeutics

Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.

Research Results

Opening Up DNA to Delete Disease

January 14, 2020 sarah Jonas 0 Comments APL Bioengineering, Arizona State University, Bioengineering, Biophysics, Chromatin, CRISPR, DNA, Gene, Gene Editing, Physics, Protein, University Of Utah

Protein editorial assistants are clearing the way for cut-and-paste DNA editors, like CRISPR, to access previously inaccessible genes of interest. Opening up these areas of the genetic code is critical to improving CRISPR efficiency and moving toward futuristic, genetic-based assaults on disease. The DNA-binding editorial assistants were devised by a U.S.-based team of bioengineers, who describe their design in APL Bioengineering.

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