Specific gut bacteria increase risk of severe malaria

Researchers have identified multiple species of bacteria that, when present in the gut, are linked to an increased risk of developing severe malaria in humans and mice. Their findings could lead to the development of new approaches targeting gut bacteria to prevent severe malaria and associated deaths.

Expert Available to Discuss Rise in Rare and Obscure Diseases

There’s been an uptick in the U.S. recently in relatively obscure and rare diseases — malaria, leprosy, measles –– making a comeback, with many in the health community sounding the alarm bells. Philadelphia College of Osteopathic Medicine’s Brian DeHaven, PhD, an expert in virology and immunology,…

Second gene implicated in malaria parasite resistance evolution to chloroquine

How malaria parasites evolved to evade a major antimalarial drug has long been thought to involve only one key gene. Now, thanks to a combination of field and lab studies, an international research team has shown a second key gene is also involved in malaria’s resistance to the drug chloroquine.

Johns Hopkins Malaria Research Institute Hosting World Malaria Day Symposium on Tuesday, April 25

The Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health will host its annual World Malaria Day Symposium Tuesday, April 25, from 8:30 a.m. to 5:45 p.m. EDT. The theme is the blood stage of malaria, which is the most devastating phase of the disease. The event will take place in person in Baltimore with thirteen panelists. A remote option is available to journalists.

Climate Change Portends Wider Malaria Risk as Mosquitos Spread South and to Higher Elevations in Africa

Based on data that span the past 120 years, scientists at Georgetown University Medical Center have found that the mosquitoes responsible for transmitting malaria in Africa are spreading deeper into southern Africa and to higher elevations than previously recorded. The researchers estimate that Anopheles mosquito populations in sub-Saharan Africa have gained an average of 6.5 meters (21 feet) of elevation per year, and the southern limits of their ranges moved south of the equator by 4.7 kilometers (nearly 3 miles) per year.

Small Study Shows Promise for Antimalarial Monoclonal Antibody to Prevent Malaria

monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).

Global health researchers use human movement patterns to determine risk of malaria spreading during certain times of day

In a paper recently published in Malaria Journal, global health researchers, Daniel Parker, PhD, assistant professor, and Guiyun Yan, PhD, professor, both from the UCI Program in Public Health, analyzed the movement ecology of humans in two places of heightened importance for Ethiopia’s malaria control and elimination strategies: Gambella and Benishangul-Gumuz (on the international border with Sudan and South Sudan).

‘Placenta-on-a-chip’ Mimics Malaria-infected Nutrient Exchange between Mother-Fetus

Combining microbiology with engineering technologies, this novel 3D model uses a single microfluidic chip to study the complicated processes that take place in malaria-infected placenta as well as other placenta-related diseases and pathologies. The technology supports formation of microengineered placental barriers and mimics blood circulations, which provides alternative approaches for testing and screening.

New Genomic Research Shows Why Testing Malaria Vaccines in the Clinic is as Rigorous as Natural Exposure in the Field

Scientists at the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) and the UMSOM Center for Vaccine Development and Global Health (CVD), and their collaborators report a new way to test vaccines that may be as rigorous and stringent as exposure to field strains of malaria.

Cone Snail Venom Shows Potential for Treating Severe Malaria

Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.

UC researchers pioneer more effective method of blocking malaria transmission in mosquitoes

Irvine, Calif., Nov. 3, 2020 — Employing a strategy known as “population modification,” which involves using a CRISPR-Cas9 gene drive system to introduce genes preventing parasite transmission into mosquito chromosomes, University of California researchers have made a major advance in the use of genetic technologies to control the transmission of malaria parasites.

Penn State College of Medicine study explores the association of malaria, HIV with anemia during pregnancy

Pregnant women from sub-Saharan Africa with malaria and human immunodeficiency virus (HIV) have a higher prevalence of anemia than pregnant women without infections according to Penn State College of Medicine researchers. The findings may have implications for reducing the risk of death in pregnant women and preventing low birth weights and neurocognitive impairment in their children as a result of anemia.

Rutgers Expert Can Discuss Global Climate Change Mortality Study

New Brunswick, N.J. (Aug. 3, 2020) – Rutgers University–New Brunswick Professor Robert E. Kopp is available to discuss a major study released today on the global consequences of climate change on death rates. The study by the Climate Impact Lab,…

Scientists Engineer Mosquitoes That Resist Malaria Parasite with Combination of Anti-Parasite Molecules

Anopheles mosquitoes that have been genetically engineered with multiple anti-malaria molecules, acting at different stages of the malaria life cycle, are strongly resistant to the parasite that causes malaria and are unlikely to lose that resistance quickly, according to a study from scientists at Johns Hopkins Bloomberg School of Public Health.