Combining microbiology with engineering technologies, this novel 3D model uses a single microfluidic chip to study the complicated processes that take place in malaria-infected placenta as well as other placenta-related diseases and pathologies. The technology supports formation of microengineered placental barriers and mimics blood circulations, which provides alternative approaches for testing and screening.
Scientists at the University of Nottingham have made a major breakthrough in understanding how malaria parasites divide and transmit the disease, which could be a major step forwards in helping to prevent one of the biggest killer infections in the world.
Scientists at the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) and the UMSOM Center for Vaccine Development and Global Health (CVD), and their collaborators report a new way to test vaccines that may be as rigorous and stringent as exposure to field strains of malaria.
WEHI researchers in Melbourne have made a crucial discovery about how asymptomatic malaria infections impact the body, informing potential strategies to control transmission and improve treatment outcomes.
In a newly published study, researchers at the University of Maryland School of Medicine have detected antibodies primarily made in response to infections in the mucous membranes — in such areas as the lungs, intestines, or vagina — in study participants with malaria.
This research, published in Nature Microbiology, showed that two genetic mutations to the parasite Plasmodium falciparum — the most common cause of malaria cases and deaths — allow it to escape detection from rapid tests.
The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.
The Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health will host its annual World Malaria Day Symposium this Friday, April 23, from 9 a.m. to 5:30 p.m. EDT.
Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.
Irvine, Calif., Nov. 3, 2020 — Employing a strategy known as “population modification,” which involves using a CRISPR-Cas9 gene drive system to introduce genes preventing parasite transmission into mosquito chromosomes, University of California researchers have made a major advance in the use of genetic technologies to control the transmission of malaria parasites.
Use of preventive antimalarial treatments reduces by half the number of malaria infections among schoolchildren, according to a new analysis published today in The Lancet Global Health.
Pregnant women from sub-Saharan Africa with malaria and human immunodeficiency virus (HIV) have a higher prevalence of anemia than pregnant women without infections according to Penn State College of Medicine researchers. The findings may have implications for reducing the risk of death in pregnant women and preventing low birth weights and neurocognitive impairment in their children as a result of anemia.
New Brunswick, N.J. (Aug. 3, 2020) – Rutgers University–New Brunswick Professor Robert E. Kopp is available to discuss a major study released today on the global consequences of climate change on death rates. The study by the Climate Impact Lab,…
Anopheles mosquitoes that have been genetically engineered with multiple anti-malaria molecules, acting at different stages of the malaria life cycle, are strongly resistant to the parasite that causes malaria and are unlikely to lose that resistance quickly, according to a study from scientists at Johns Hopkins Bloomberg School of Public Health.
The activity of the parasite that causes malaria is driven by the parasite’s own inherent clock, new research led by UT Southwestern scientists suggests.
UCLA is one of seven sites participating in a clinical trial investigating whether hydroxychloroquine, a commonly used anti-malarial and autoimmune drug, can prevent infection with COVID-19.
Malaria is a leading killer of children worldwide, and new drugs are needed. New research reports encouraging early clinical results with a new compound.
The National Institutes of Health has launched a $1 million Technology Accelerator Challenge (TAC) to spur the design and development of non-invasive, handheld, digital technologies to detect, diagnose and guide therapies for diseases with high global and public health impact. The Challenge is focused on sickle cell disease, malaria and anemia and is led by NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB).
Scientists have identified a key molecule involved in the development of cerebral malaria, a deadly form of the tropical disease. The study identifies a potential drug target and way forward toward alleviating this condition for which few targeted treatments are available.
– New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease, according to Texas Biomedical Research Institute Assistant Professor Ian Cheeseman, Ph.D.
A team of researchers at Notre Dame put out a call to the masses, enlisting researchers, data scientists and health professionals to analyze genomic data from emerging drug-resistant malaria parasites and gain a better understanding of the mechanisms of resistance.
An international team has discovered a cheap and efficient way to identify transmission hotspots for schistosomiasis, a parasitic disease that is second only to malaria in its global health impact. The research uses rigorous field sampling and aerial images to precisely map communities that are at greatest risk for infection.
According to researchers at the University of Notre Dame, data from a clinical trial in Indonesia designed to evaluate the impact of a spatial repellent on reducing malaria infections showed promising results.