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UrduDr. Alan Rothman is a biomedical researcher at the University of Rhode Island’s College of the Environment and Life Sciences. He leads the University’s Laboratory of Viral Immunity and Pathogenesis. Dr. Rothman is an infectious disease specialist who has been involved in…
Tag: Dengue
Dengue: Experta de Mayo Clinic explica la infección transmitida por mosquitos
Aproximadamente la mitad de la población mundial vive en zonas vulnerables a dengue, una infección viral potencialmente mortal transmitida a través de las picaduras de mosquitos infectados. No hay tratamiento, y solo las personas que ya han tenido dengue son elegibles para la vacuna.
Dengue: Especialista da Mayo Clinic explica a infecção transmitida por mosquitos
Cerca de metade da população mundial vive em zonas vulneráveis a dengue, uma infecção viral potencialmente fatal transmitida através das picadas de mosquitos infectados. Não há tratamento, e apenas as pessoas que já tiveram dengue são elegíveis para a vacina.
Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2
A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.
Prior dengue infection may make Zika virus outcomes worse
Researchers in New York and Texas have identified that female marmosets are more likely to transmit the Zika virus during pregnancy if they have been previously infected by a different virus, dengue.
LJI Instructor Annie Elong Ngono, Ph.D., wins GVN support to advance infectious disease research
LJI Instructor Annie Elong Ngono, Ph.D., has spearheaded important studies into the immune response to deadly pathogens such as dengue virus. Now, this dedication to global health and virology has earned her acceptance to the Global Virus Network’s (GVN) highly selective Rising Star Mentorship Program.
Dengue immune function discovery could benefit much-needed vaccine development
The discovery of new possible biomarkers to predict clinical and immune responses to dengue virus infection could be critical to informing future vaccines for the mosquito-borne virus, which saw a record number of over 400 million cases in 2019.
With “herd immunity” unlikely, antivirals will play key role in COVID-19 management
According to The New York Times, the prospects for reaching “herd immunity” in the fight against COVID-19 are increasingly dim. Subsequently, the virus “will most likely become a manageable threat that will continue to circulate in the United States for…
Fighting Zika? Call in the T cells
In a new Science Advances study, Shresta and her colleagues at LJI report that the immune system’s T cells have the power to prevent Zika infection in mice. This finding suggests that effective Zika vaccines need to activate T cells to work alongside antibodies.
Rutgers Expert Can Discuss Global Climate Change Mortality Study
New Brunswick, N.J. (Aug. 3, 2020) – Rutgers University–New Brunswick Professor Robert E. Kopp is available to discuss a major study released today on the global consequences of climate change on death rates. The study by the Climate Impact Lab,…
Mosquitoes Engineered to Repel Dengue Virus
An international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. The development marks the first engineered approach in mosquitoes that targets the four known types of dengue, improving upon previous designs that addressed single strains.
Engineered mosquitoes cannot be infected with or transmit any dengue virus
Genetically engineered mosquitoes are resistant to multiple types of dengue virus (DENV), according to a study published January 16 in the open-access journal PLOS Pathogens by Prasad Paradkar of the Australian Animal Health Laboratory, and Omar Akbari of the University of California, San Diego, and colleagues. As noted by the authors, this is the first engineered approach that targets all types of DENV, which is crucial for effective disease suppression.
Cellular culprit suspected of pushing dengue fever from bad to worse is cleared by advanced transcriptomics
No one knows what makes a mild dengue viral infection morph into a severe and sometimes deadly dengue hemorrhagic fever/dengue shock syndrome. Experts previously believed the likely cause was ramped up activity of T cells, which can massively boost an immune response to a virus. Now, however, researchers at the La Jolla Institute for Immunology (LJI), have found definitive evidence that CD4 T cells, one of two main subtypes of T cells, are not to blame.
Researchers discover how Zika virus remodels its host cell to boost viral production
Researchers in China have discovered how a Zika virus protein reshapes its host cell to aid viral replication. The study, which will be published December 23 in the Journal of Cell Biology, reveals that the viral protein NS1 converts an interior cellular compartment called the endoplasmic reticulum (ER) into a protective region where the virus can survive and replicate. Blocking this process could be a novel therapeutic strategy to treat patients infected with Zika or similar viral pathogens, such as the yellow fever and dengue viruses.
Simulating amino acid starvation may improve dengue vaccines
In a new paper in Science Signaling, researchers at the University of Hyderabad in India and the Cornell University College of Veterinary Medicine show that a plant-based compound called halofuginone improves the immune response to a potential vaccine against dengue virus.
On the RISE: Joshua and Caleb Marceau Use NIGMS Grant to Jump-Start Their Research Careers
A college degree was far from the minds of Joshua and Caleb Marceau growing up on a small farm on the Flathead Indian Reservation in rural northwestern Montana.
Dengue new vaccine performs well in large trial, but safety remains key concern
News wise on Dengue related news. An experimental dengue vaccine has shown promising early results in a large, multicountry trial, but critical questions remain about its effectiveness and safety. Still unclear, for example, is whether the vaccine—which had an efficacy…