monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).
Tag: Monoclonal Antibody

UPMC and Pitt Share Insights on Operationalizing Outpatient COVID-19 Monoclonal Antibody Treatment
As evidence mounts supporting the use of monoclonal antibody treatment to reduce hospitalizations and deaths from COVID-19, UPMC and University of Pittsburgh School of Medicine physician-scientists are sharing the health system’s experience administering the life-saving medication.

COVID-19: Monoclonal Antibody Drugs Available for High-Risk Patients
UVA Health is offering monoclonal antibody drugs for appropriate patients with COVID-19 who are at highest risk for developing severe symptoms and requiring hospitalization.

Rapid Method Finds Potent COVID-19 Monoclonal Antibody Among a Trillion Possibilities
University of Pittsburgh School of Medicine scientists have discovered the fastest way to identify potent, neutralizing human monoclonal antibodies against SARS-CoV-2, the virus that causes COVID-19. The method – as well as a trio of successful animal studies on an antibody called “Ab1” – are described today in the Proceedings of the National Academy of Sciences. Ab1 is on track for human clinical trials by early next year.

NEJM: Clinical Trial Indicates Monoclonal Antibody Lowered Hospitalizations and Emergency Visits
COVID-19 (coronavirus) patients who were administered a novel antibody had fewer symptoms and were less likely to require hospitalization or emergency medical care than those who did not receive the antibody, according to a new study published in the The New England Journal of Medicine.
Preclinical testing of inhaled monoclonal antibody for COVID-19 shows therapeutic efficacy
An inhaled monoclonal antibody treatment against the SARS-CoV-2 virus may lead to self-administered therapy for COVID-19, according to preclinical tests. It was discovered at UAB and the Texas Biomedical Research Institute, and it has been licensed for development to Aridis Pharmaceuticals.

First Patients in NIH ACTIV-3 Clinical Trial Enroll in Dallas
On Wednesday in Dallas, just one day after the initiative was launched by the National Institutes of Health (NIH), Baylor Scott & White Research Institute enrolled the first patient in the world for the ACTIV-3 clinical trial. A second patient was enrolled the following day.