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UrduA new tool under development by University at Buffalo researchers could one day help clinicians better predict resistance to immunoglobulin therapy among children with Kawasaki disease in the United States.
Tag: Drug Resistance
Don’t give up the fight. Read the latest news about drug and antibiotic resistance
Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
Cleveland Clinic Researchers Shed New Light on Importance of Ecological Cellular Interactions in Targeted Therapy Resistance in Lung Cancer
New Cleveland Clinic research has uncovered key information about cellular interaction between tumor cells and normal tissue, providing better understanding of how therapeutic resistance develops. Findings published in Science Advances.
National Researcher of the Year 2022 Decodes Drug Resistance in Animals – A Step towards Sustainable Solutions
Chula Veterinary Lecturer and “National Outstanding Researcher 2022” has revealed the genetic code that causes drug resistance in animals that affects human health, animals, and the environment, and suggests comprehensive solutions under the concept “One Health”.
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs
Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer. A team of scientists including Markus Seeliger, PhD, of the Renaissance School of Medicine at Stony Brook University, believe they have found a new process through which drug resistance happens.
Gut bacteria can make blood pressure medication less effective
A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.
Researchers uncover how tumors circumvent prostate cancer therapy, identify promising treatment strategy
A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…
Dog parasite is developing resistance to treatments
Right now, U.S. veterinarians rely on three types of drugs to kill the hookworms, but the parasites appear to becoming resistant to all of them.
Avoiding Drug Resistance by Understanding Evolution of Viruses
During ACA’s 71st annual meeting, Celia Schiffer, from the University of Massachusetts, will talk about her lab’s work with virus substrate recognition as a method to avoid drug resistance. Schiffer and her team expanded their work on HIV and the hepatitis C virus to include human T-cell lymphotropic virus type 1 and SARS-CoV-2, the virus that causes COVID-19, and discovered that designing robust inhibitors to fit within the substrate envelope tips this balance toward decreasing the probability of resistance.
Drug-Resistant Germ Packs Punch to US Travelers
One type of the salmonella bacteria is much more likely to cause disease and fend off frontline antibiotics when acquired in Europe, Asia, and parts of Africa rather than domestically in the United States.
Hackensack Meridian CDI Scientists Discover New Tuberculosis Treatment Pathway
The compound TA-C is metabolized by TB bacteria – weakening the germ from within like a ‘Trojan horse’ attack
CU Cancer Researcher Wins Two Awards to Study Drug-Resistant Cancer Cells
Sabrina L. Spencer, PhD, is a CU Boulder researcher and CU Cancer Center member. Spencer recently won the Damon Runyon-Rachleff Innovation Award and the Emerging Leader Award. She will use the grants to continue her research on drug resistance in cancer cells.
Building bridges: PARP enzymes bring broken DNA together
St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
Adult stem cell study shows fish oil may help with depression
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response.
Computer model IDs drug-resistant mutations
To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.
Long-Lasting, Low Toxicity Antimicrobial Peptide Fights ‘Superbug’ Lung Infections
Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.
St. Jude finds cancer drug resistance genes and possibly how to limit their effects
Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have developed a novel strategy to find the genes responsible.
Why It Matters: Prescription for Disaster
Bacteria are becoming increasingly resistant to antibiotics. A major cause is their overuse in both humans and animals. At the same time, a lack of financial incentives is setting back efforts to discover new classes of antibiotics. The problem is both global and local, and without new initiatives, many common medical conditions could become deadly once again.
Calcium Signaling Identified as Exploitable Target in Addressing Drug Resistance to Non-Hodgkin Lymphoma Treatment
Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle. Results are being presented at the American Society of Hematology Annual Meeting.
Strength in numbers: Crowdsourcing challenge seeks new methods to combat drug-resistant malaria
A team of researchers at Notre Dame put out a call to the masses, enlisting researchers, data scientists and health professionals to analyze genomic data from emerging drug-resistant malaria parasites and gain a better understanding of the mechanisms of resistance.
Single Mutation Dramatically Changes Structure and Function of Bacteria’s Transporter Proteins
Swapping a single amino acid in a simple bacterial protein changes its structure and function, revealing the effects of complex gene evolution, finds a new study published in the journal eLife. The study—conducted using E. coli bacteria—can help researchers to better understand the evolution of transporter proteins and their role in drug resistance.
UC San Diego Researchers Convert Pro-Tumor Macrophages into Cancer Killers
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
Engineered Cell Evolution May Provide Pathway to Halting Cancer Drug Resistance
STONY BROOK, NY, June 24,, 2019 — A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail. Scientists in recent years have hypothesized that cell-cell differences, also known as cell heterogeneity, aides…