Chula Veterinary Lecturer and “National Outstanding Researcher 2022” has revealed the genetic code that causes drug resistance in animals that affects human health, animals, and the environment, and suggests comprehensive solutions under the concept “One Health”.
Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer. A team of scientists including Markus Seeliger, PhD, of the Renaissance School of Medicine at Stony Brook University, believe they have found a new process through which drug resistance happens.
A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.
A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…
Right now, U.S. veterinarians rely on three types of drugs to kill the hookworms, but the parasites appear to becoming resistant to all of them.
During ACA’s 71st annual meeting, Celia Schiffer, from the University of Massachusetts, will talk about her lab’s work with virus substrate recognition as a method to avoid drug resistance. Schiffer and her team expanded their work on HIV and the hepatitis C virus to include human T-cell lymphotropic virus type 1 and SARS-CoV-2, the virus that causes COVID-19, and discovered that designing robust inhibitors to fit within the substrate envelope tips this balance toward decreasing the probability of resistance.
One type of the salmonella bacteria is much more likely to cause disease and fend off frontline antibiotics when acquired in Europe, Asia, and parts of Africa rather than domestically in the United States.
The compound TA-C is metabolized by TB bacteria – weakening the germ from within like a ‘Trojan horse’ attack
Sabrina L. Spencer, PhD, is a CU Boulder researcher and CU Cancer Center member. Spencer recently won the Damon Runyon-Rachleff Innovation Award and the Emerging Leader Award. She will use the grants to continue her research on drug resistance in cancer cells.
St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response.
To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.
Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.
Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have developed a novel strategy to find the genes responsible.
Bacteria are becoming increasingly resistant to antibiotics. A major cause is their overuse in both humans and animals. At the same time, a lack of financial incentives is setting back efforts to discover new classes of antibiotics. The problem is both global and local, and without new initiatives, many common medical conditions could become deadly once again.
Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle. Results are being presented at the American Society of Hematology Annual Meeting.
A team of researchers at Notre Dame put out a call to the masses, enlisting researchers, data scientists and health professionals to analyze genomic data from emerging drug-resistant malaria parasites and gain a better understanding of the mechanisms of resistance.
Swapping a single amino acid in a simple bacterial protein changes its structure and function, revealing the effects of complex gene evolution, finds a new study published in the journal eLife. The study—conducted using E. coli bacteria—can help researchers to better understand the evolution of transporter proteins and their role in drug resistance.
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
STONY BROOK, NY, June 24,, 2019 — A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail. Scientists in recent years have hypothesized that cell-cell differences, also known as cell heterogeneity, aides…