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UrduResearchers studying the enzyme DHPS have determined that blocking its activity in mouse macrophages leads to a reduction in proteins that drive inflammation during obesity, leading to improved glycemic control.
Tag: Macrophages
Kidney Resident Macrophages Share Properties across Species, May Lead to Targeted Treatment for Kidney Diseases
Article title: Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes Authors: Kurt A. Zimmerman, Zhengqin Yang, Jeremie M. Lever, Zhang Li, Mandy J. Croyle, Anupam Agarwal, Bradley K. Yoder, James F. George From the…
‘Fortunate Accident’ May Yield Immunity Weapon Against Antibiotic-Resistant Bacteria
In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.
Trojan horses and tunneling nanotubes: Ebola virus research at Texas Biomed gets NIH funding boost
Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus. Olena Shtanko, Ph.D., a Staff Scientist at the Texas Biomedical Research Institute (Texas Biomed), has received more than $1 million from the National Institutes of Health (NIH) to explore different aspects of Ebola virus infection.
Study Explores Regulatory Role for White Blood Cells in Recruitment of Brown Fat
Article title: Thermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition Authors: Nathalie Boulet, Ineke H.N. Luijten, Barbara Cannon, Jan Nedergaard From the authors: “A regulatory or mediatory role—positive or negative—for macrophages…
Immune System Killer Cells Controlled by Circadian Rhythms
Macrophages, the killer cells of the immune system, are controlled by circadian rhythms, a finding which may indicate that our ability to fight disease relies more heavily on daily circadian cycles than previously assumed.
New technology tracks role of macrophages in cancer spread
A Morgridge imaging study of macrophages — immune cells that are important to human health, but paradoxically can help some cancers grow and spread — is offering better ways to understand these cells and target them with immunotherapies.
Protein that Keeps Immune System from Freaking Out Could Form Basis for New Therapeutics
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction and supports a mechanism critical for survival in mouse models of sepsis and colitis, according to a UC San Diego study.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.
Researchers Identify a Protein That Is Critical for Wound Healing after a Central Nervous System Injury
after a Central Nervous System Injury
(New York – March 2, 2020) Plexin-B2, an axon guidance protein in the central nervous system (CNS), plays an important role in wound healing and neural repair following spinal cord injury (SCI), according to research conducted at the Icahn School of Medicine at Mount Sinai and published today in Nature Neuroscience.
UC San Diego Researchers Convert Pro-Tumor Macrophages into Cancer Killers
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.