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UrduTaken together these Oncotarget findings show that the CTD and OD domains of mtp53 R273H play critical roles in mutant p53 GOF that pertain to processes associated with DNA replication.
Tag: MEDICINE/HEALTH
Elsevier partners with American College of Medical Genetics and Genomics to publish GIM
Collaboration signifies strong commitment by all stakeholders to maintain the journal’s high standards and expand its global prominence
Anticipate a resurgence of respiratory viruses in young children
Canada should anticipate a resurgence of a childhood respiratory virus as COVID-19 physical distancing measures are relaxed, authors warn in CMAJ ( Canadian Medical Association Journal) . Cases of respiratory syncytial virus (RSV) have risen sharply in Australia and, more…
Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas
This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas
New statement provides path to include ethnicity, ancestry, race in genomic research
American Heart Association Scientific Statement
Two types of blood pressure meds prevent heart events equally, but side effects differ
Hypertension Journal Report
Among effective antihypertensive drugs, less popular choice is slightly safer
NEW YORK, NY (July 26, 2021)–Two types of drugs that are recommended as a first treatment for patients with high blood pressure were found equally effective in improving cardiovascular outcomes, but the more popular type causes slightly more side effects,…
Improving air quality reduces dementia risk, multiple studies suggest
DENVER, JULY 26, 2021 — Improving air quality may improve cognitive function and reduce dementia risk, according to several studies reported today at the Alzheimer’s Association International Conference® (AAIC®) 2021 in Denver and virtually. Previous reports have linked long-term air…
International experts call for a unified public health response to NAFLD and NASH epidemic
Patients with obesity or type 2 diabetes are at a higher risk of developing NAFLD and NASH.
Misplaced trust: When trust in science fosters pseudoscience
Trust in science makes people vulnerable to pseudoscience
What’s riskier for young soccer players, practice or game time?
On average, impacts are more frequent during drills, more severe during games
New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors
Team identifies crucial interaction between platelets and tumors for the first time
Bacteria navigate on surfaces using a ‘sense of touch’
Many disease-causing bacteria such as Pseudomonas aeruginosa crawl on surfaces through a walk-like motility known as “twitching”. Nanometers-wide filaments called type IV pili are known to power twitching, but scientists ignore which sensory signals coordinate the microbes’ movements. Now, EPFL…
Using silicone wristbands to measure air quality
A Texas A&M study found that these inexpensive, convenient devices can measure exposure to a class of chemicals that can be harmful during pregnancy
Device cracks milk protein
‘Refolding’ molecules to support medical solutions
Advantages of intranasal vaccination against SARS-CoV-2
Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract
Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma
MUSC Hollings Cancer Center part of promising clinical trial for aggressive lymphoma
AZ heroes study awarded $15M to continue, expand evaluation of COVID-19 immunity
A University of Arizona Health Sciences study of COVID-19 vaccine effectiveness and immunity among frontline workers has received a $15 million award from the U.S. Centers for Disease Control and Prevention (CDC) to continue the current research for another year…
Novel imaging agent identifies biomarker for iron-targeted cancer therapies
Reston, VA–A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help…
‘Feel good’ brain messenger can be willfully controlled, new study reveals
Neuroscientists show that mice can learn to manipulate random dopamine impulses for reward
Mount Sinai researchers develop novel therapy that could be effective in many cancers
New York, NY (July 23, 2021) — Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery , a…
A new mathematical model assesses ICU patients’ mortality risk
A research team led by Dr Rosario Delgado from the UAB Department of Mathematics, in collaboration with the Hospital de Mataró, developed a new machine learning-based model that predicts the risk of mortality of intensive care unit patients according to…
Featured articles from the journal CHEST®, July 2021
Glenview, Ill. – Published monthly, the journal CHEST® features peer-reviewed, cutting-edge original research in chest medicine: Pulmonary, critical care, sleep medicine and related disciplines. Journal topics include asthma, chest infections, COPD, critical care, diffuse lung disease, education and clinical practice,…
Why do some people get severe COVID-19? The nose may know
People who develop severe COVID-19 have markedly blunted antiviral responses in the nasopharynx
Better healthcare management can reduce the risk of delirium among older adults
New research outlines how those admitted on Sunday and Tuesday are more likely to develop delirium, a hospital complication
High school student presents on oral-health impact profile 5: analyzing a private practice adult population’s distribution
Alexandria, Va., USA – Hiba Nasir, Wayzata High School, Plymouth, Minn., presented the poster “Oral-Health Impact Profile 5: Analyzing A Private Practice Adult Population’s Distribution” at the virtual 99th General Session & Exhibition of the International Association for Dental Research…
Strategies for disseminating guidance to dentists during the COVID-19 pandemic
Alexandria, Va., USA – Ruth Lipman, American Dental Association (ADA) Science and Research Institute, Chicago, Ill., U.S., presented the poster “Strategies for Disseminating Guidance to Dentists during the COVID-19 Pandemic” at the virtual 99th General Session & Exhibition of the…
Association of wealth with longevity at midlife
What The Study Did: Researchers investigated the association between net worth at midlife and subsequent longevity in individuals as well as with siblings and twins. Authors: Eric D. Finegood, Ph.D., of Northwestern University in Evanston, Illinois, is the corresponding author.…
Experiences, perpetration of identity-based bullying among adolescents
What The Study Did: Using survey responses from students in some Pittsburgh, Pennsylvania, high schools, researchers investigated how experiences of bullying based on race/ethnicity/ national origin and other marginalized identities are associated with outcomes for health, mental health and violence…
Neuroscientists posit that brain region is a key locus of learning
Small and seemingly specialized, the brain’s locus coeruleus (LC) region has been stereotyped for its outsized export of the arousal-stimulating neuromodulator norepinephrine. In a new paper and with a new grant from the National Institutes of Health, an MIT neuroscience…
Oncotarget: Fgr and Numb in retinoic differentiation and G0 arrest of non-APL AML cells
In sum the Oncotarget data support a paradigm where signaling molecules bound to a Numb scaffold in a signalsome are activated by RA-induced Fgr expression
Four themes identified as contributors to diseases of despair in Pennsylvania
Hershey, Pa. — Financial instability, lack of infrastructure, a deteriorating sense of community and family fragmentation are key contributors to diseases of despair in Pennsylvania communities, according to Penn State College of Medicine and Highmark Health researchers. The researchers conducted…
Professional rugby may be associated with changes in brain structure
Participation in elite adult rugby may be associated with changes in brain structure.
Prostate cancer treatment among black, white patients during pandemic
What The Study Did: This study included 647 patients with untreated nonmetastatic prostate cancer (269 patients during the pandemic and 378 from before the pandemic). During the initial COVID-19 lockdown, only 1% of Black men underwent prostatectomy, while 26% of…
Researchers automate brain MRI image labelling, more than 100,000 exams labelled in under 30 minutes
Researchers from the School of Biomedical Engineering & Imaging Sciences at King’s College London have automated brain MRI image labelling, needed to teach machine learning image recognition models, by deriving important labels from radiology reports and accurately assigning them to…
Perfecting collagen production in osteogenesis imperfecta
By studying the controversial idea that hematopoietic stem cells could give rise to osteoblasts, researchers at MUSC Health aim to address the root cause of brittle bone disease
3D imaging reveals neural ‘vicious cycle’ in fatty liver disease
With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is…
NIH awards more than $20 million to international HIV database centers
IeDEA program analyzes health data from over 2 million people to advance HIV care
New insights into uncontrolled inflammation in COVID-19 patients
Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients
Study on chromosomal rearrangements in yeast reveals potential avenue for cancer therapy
Researchers from Osaka University uncover a mechanism by which chromosomal rearrangements occur, with implications for novel cancer therapies
Study shows cancer misinformation common on social media sites
A new study published online today in the Journal of the National Cancer Institute reports that one third of the most popular cancer treatment articles on social media contain misinformation. Further, the vast majority of that misinformation has the potential…
Llama ‘nanobodies’ could hold key to preventing deadly post-transplant infection
Scientists have developed a ‘nanobody’ – a small fragment of a llama antibody – that is capable of chasing out human cytomegalovirus (HCMV) as it hides away from the immune system. This then enables immune cells to seek out and…
Less-sensitive COVID-19 tests may still achieve optimal results if enough people tested
Analysis suggests same epidemiological outcomes possible with rapid-antigen versus RT-PCR tests
Higher levels of omega-3 acids in the blood increases life expectancy by almost five years
A 1% increase in this substance in the blood is associated with a change in mortality risk similar to that of quitting smoking.
A case for intranasal COVID-19 vaccinations
Of the nearly 100 SARS-CoV-2 vaccines currently undergoing clinical trials, only seven are delivered intranasally – despite this vaccine type’s long success in providing protection from influenza. In a Perspective, Frances Lund and Troy Randall argue that intranasal vaccines could…
Neurotransmitter levels predict math ability
Glutamate and GABA in the brain have reverse relationships with math ability, which switch during development
Antibiotics may help to treat melanoma
Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental…
Spontaneous retinal waves simulate optical flow before neonatal mice can see
Like dreaming of walking through a world they’ve not yet experienced, the retinas of neonatal mice practice for what mature eyes must later process by generating spontaneous patterns of activity that mimic the perception of directional movement through space, according…
Global warming may limit spread of dengue fever, new research finds
UNIVERSITY PARK, Pa. — Infection with dengue virus makes mosquitoes more sensitive to warmer temperatures, according to new research led by Penn State researchers. The team also found that infection with the bacterium Wolbachia, which has recently been used to…
Bidirectional impact of cardiovascular disease, cancer in Blacks focus of new AHA center
Cardiovascular disease and cancer, the nation’s top two killers, share common ground like obesity and chronic inflammation, as well as a disproportionate impact on Black Americans. A new American Heart Association-funded center at the Medical College of Georgia is working…