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UrduUC San Diego researchers develop a method to grow hematopoietic stem cells in culture, with clinical implications for bone marrow transplants and aging research.
Tag: Hematology
Cardio-cerebrovascular disease history complicates hematopoietic cell transplant outcomes
Researchers find pre-transplant cardiovascular diseases indirectly affect mortality and survival through increased post-transplant disease occurrence
New method predicts COVID-19 severity, could help with hospital triage
During the height of the pandemic, some hospitals were overwhelmed with patients seeking treatment for COVID-19. This situation could happen again during future outbreaks, especially with SARS-CoV-2 variants of concern on the rise. Now, researchers reporting in ACS’ Analytical Chemistry…
New theory suggests blood immune and clotting components could contribute to psychosis
A scientific review has found evidence that a disruption in blood clotting and the first line immune system could be contributing factors in the development of psychosis. The article, a joint collaborative effort by researchers at RCSI University of Medicine…
Engineers find imaging technique could become treatment for deep vein thrombosis
Penn State College of Engineering researchers set out to develop technology capable of localizing and imaging blood clots in deep veins. Turns out their work may not only identify blood clots, but it may also be able to treat them.…
Red blood cell ‘traffic’ contributes to changes in brain oxygenation
Adequate blood flow supplies the brain with oxygen and nutrients, but the oxygenation tends to fluctuate in a distinct, consistent manner. The root of this varied activity, though, is poorly understood. Now, Penn State researchers have identified one cause of…
Early anticoagulant treatment shown to reduce death in moderately ill COVID-19 patients
International RAPID Trial could contribute to clinical practice
Sensing “junk” RNA after chemotherapy enhances blood regeneration
Hematopoietic stem cells take advantage of RNA from pathogenic remnants integrated in the genome to replenish the blood system
American Society for Radiation Oncology (ASTRO) to host Annual Meeting in Chicago 10/24-27
#ASTRO21 will be the first major medical conference in the city; a curated digital program also will be offered for remote attendees
Can leukemia in children with Down syndrome be prevented?
Princess Margaret Scientists reveal a new target that suggests it can
McMaster researchers identify how VITT happens
The work will have both diagnostic and therapeutic implications
Next generation cytogenetics is on its way
Does optical genome mapping turn cytogenetics upside down?
UCLA scientist honored for pioneering work in hematology research
LOS ANGELES – Dr. Elizabeta Nemeth, professor of medicine and director of the Center for Iron Disorders at the David Geffen School of Medicine at UCLA, has been awarded the 2021 William Dameshek Prize by the American Society of Hematology…
Study identifies risk factors for severe COVID-19 in individuals with sickle cell disease
Researchers urge high-risk patients to get COVID-19 vaccine
Knowledge of nurses for pain management of patients on maintenance hemodialysis
The article by Dr. Eman Khamis Al Nazly and Dr. Husam Al Khatib is published in the journal, The Open Nursing Journal
Repairing ‘broken’ hearts — new promising surgical technique for heart attacks
Medical researchers devise a new way to repair the ruptured wall of the heart from a severe heart attack
Thrombosis in cancer
Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it…
Running in the blood: Blood lipids are linked to cancer, but depending on family history
Medical researchers identify the role of family history in the link between blood lipids and esophageal cancer
Microscopic CCTV reveals secrets of malaria invasion
State-of-the-art video microscopy has enabled researchers at WEHI, Australia, to see the molecular details of how malaria parasites invade red blood cells – a key step in the disease. The researchers used a custom-built lattice light sheet microscope – the…
Researchers identify why COVID-19 patients develop life-threatening clots
New insights could lead to new therapies for COVID-19
Free event will connect heart, lung, blood and sleep point-of-care inventors with resources
M2D2 program to feature NIH, Johnson & Johnson leaders
UC San Diego Health Begins Treating Multiple Myeloma with CAR T-cell Therapy
As the first designated medical center in San Diego certified to offer this type of immunotherapy, UC San Diego Health will begin treating patients this month.
Genetic base editing treats sickle cell disease in mice
Converting a pathogenic hemoglobin gene to a benign variant enables healthy blood cell production in an animal model of sickle cell disease
UC San Diego Health begins treating multiple myeloma with CAR T-cell therapy
Following the Food and Drug Administration’s approval, UC San Diego Health is the first designated medical center in San Diego certified to offer a new immunotherapy treatment of multiple myeloma outside of a clinical trial. The new immunotherapy is a…
Using advanced imaging to study sickle cell disease
Pitt’s Tamer Ibrahim uses recently optimized 7-Tesla MRI imaging technology to study SCD’s effect on the brain
Blood clot-busting nanocapsules could reduce existing treatment’s side effects
Tested on human blood in the lab, the selective nanocapsules could reduce the side effects of a major blood clot dissolving drug, which include bleeding on the brain. If confirmed with animal tests, the nanocapsules could also make the drug…
CHOP Researchers Develop Proof-of-Concept Treatment that Elevates Both Adult and Fetal Hemoglobin
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers developed an approach that could produce more hemoglobin through a single vector. The results were published in Haematologica.
Researchers develop proof-of-concept treatment that elevates adult and fetal hemoglobin
CHOP study shows vector developed to treat blood disorders could simultaneously reactivate fetal hemoglobin, suppress mutant adult hemoglobin, and supply functional adult hemoglobin
Mini bone marrow model predicts response to blood disorder treatment
Scientists have described a miniature 3D bone marrow model that can both predict the response of patients to a new therapy for blood platelet disorders and facilitate studies to better understand these disorders
Innovative technologies to develop cancer and virus biomarkers
Politecnico di Torino’s ANFIBIO project will develop a set of technologies and advanced sensors to detect and quantify cancer and viral bio-markers in bodily fluids, making simpler, faster and more economical the diagnosis of many diseases
A review on the current updates in the field of gastroenterology and hepatology
Knowledge in medicine is a very dynamic process due to the continuing progress in this field. New developments influence research, but also the clinical practice. Hence the continuous need for improvement in the field in which we work is required.…
Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits
Schizophrenia is a heterogeneous psychiatric disorder characterized by positive symptoms such as hallucinations and delusions, negative symptoms such as apathy and lack of emotion, and cognitive impairment. We have reported that VB6 (pyridoxal) levels in peripheral blood of a subpopulation…
An illuminating possibility for stroke treatment: Nano-photosynthesis
Blocked blood vessels in the brains of stroke patients prevent oxygen-rich blood from getting to cells, causing severe damage. Plants and some microbes produce oxygen through photosynthesis. What if there was a way to make photosynthesis happen in the brains…
Novel simulation method predicts blood flow conditions behind von Willebrand disease
Lehigh University researchers’ breakthrough could advance diagnosis and treatment of bleeding disorder and lead to improved design of left ventricular assist devices used in heart failure patients
COVID-19 vaccination: Thrombosis can be prevented by prompt treatment
A rare syndrome has been observed in people following vaccination against Covid-19.
No-one knew if lymph vessel cells bear cilia; turns out, they’re indispensable for health
The primary cilium, an antenna-like subcellular structure (‘organelle’) protruding from the outside of many types of vertebrate cells, has an important but previously overlooked role in guiding the growth of lymphatic vessels, shows a new study.
Emergency physicians first to safely treat vaccine-induced blood clot with heparin alternative
WASHINGTON, DC — A new case report, detailed in Annals of Emergency Medicine , is the first known case of a patient with VITT (vaccine-induced thrombotic thrombocytopenia) treated with a heparin alternative following the Centers for Disease Control and Prevention…
Study finds potential therapeutic target for pediatric acute myeloid leukemia
Novel gene variants may point the way to precision medicine for AML in children
NCCN releases new patient guidelines on anemia and neutropenia
New resource helps patients and caregivers recognize and understand blood cell production deficiencies, to better participate in their care planning; available for free at NCCN.org/patientguidelines
Toward safer stem cell transplants
For cancer patients, the use of hematopoietic stem cell transplants can be a game changer in terms of treatment and recovery. However, most people need to undergo a combination of chemotherapy and radiation before transplants become an option. A new…
Blood pressure and hemorrhagic complication risk after renal transplant biopsy
2021 ARRS Virtual Annual Meeting Scientific Electronic Exhibit found no statistically significant threshold for increased renal transplant biopsy risk based on systolic, diastolic, or mean arterial blood pressure alone
Studies suggest people with blood cancers may not be optimally protected after COVID-19 vaccination
Two new studies published in Blood suggest that the mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia (CLL) and multiple myeloma, two types of blood cancer.
ACS Spring 2021 press conference schedule
Watch live and recorded press conferences at http://www. acs. org/ acsspring2021conferences . Press conferences will be held Monday, April 5, through Friday, April 16, 2021. Below is the schedule, which will be updated as needed. ALL TOPICS ARE STRICTLY EMBARGOED…
Studies suggest people with blood cancers may not be optimally protected after COVID-19 vaccination
Two new studies published in Blood suggest that the mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia (CLL) and multiple myeloma, two types of blood cancer. According to researchers, these studies could help inform the…
CHOP-led Research Study Identifies Key Target in Treatment-Resistant Hemophilia A
Researchers at Children’s Hospital of Philadelphia (CHOP) have identified a key target that may be responsible for treatment failure in about 30% of patients with hemophilia A. The target, known as B cell activating factor (BAFF), appears to promote antibodies against and inhibitors of the missing blood clotting factor that is given to these patients to control their bleeding episodes. The findings, published in the Journal of Clinical Investigation, raise the possibility of using anti-BAFF therapies, potentially in combination with immune tolerance therapies, to tame the immune response in some patients with severe hemophilia A.
Alliance for Cancer Gene Therapy Summit 2021 features world renowned cancer researchers advancing so
James P. Allison, PhD, Carl H. June, MD and Siddhartha Mukherjee, MD Keynote April 29 Summit
Diet and exercise may increase efficacy of chemotherapy for children with cancer
Pilot study suggests nutrition improves success of pediatric leukemia treatment; national trial to launch this year
Crnic Institute discovery may explain high risk of leukemia in children with Down syndrome
Groundbreaking identification of precocious clonal hematopoiesis unlocks new lines of research and discovery for scientists
FDA approvals strengthen Octapharma USA pediatric critical care product portfolio
Octaplas™ and fibryga® receive new product labeling following FDA’s approval of BLA supplements to update therapy research; FDA expands fibryga® indication to include treatment of children under 12 years of age
One drop of blood brings progression of multiple myeloma into better view
Sensitive test opens door to personalized therapy