A study by University of Liverpool researchers has identified new factors accompanying previous findings that frequent consumption of peanuts by cancer patients could increase risk of cancer spread.
Taken together these Oncotarget findings show that the CTD and OD domains of mtp53 R273H play critical roles in mutant p53 GOF that pertain to processes associated with DNA replication.
This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas
In sum the Oncotarget data support a paradigm where signaling molecules bound to a Numb scaffold in a signalsome are activated by RA-induced Fgr expression
These Oncotarget results may reflect the unselected patient population enrolled in these studies, including no selection for WHO histologic subtype or molecular aberrations.
List includes potential carcinogens that act by stimulating production of hormones that fuel breast tumors
These Oncotarget results show that a degree of chemotherapeutic drug effects on biomechanical and biophysical properties of cancer cells is distinguishable in normoxia and hypoxia`
Together these Oncotarget results describe the first ever CAC case with a BRCAness genetic background
The Oncotarget authors found that AIM2 inflammasome is at the crossroad between COPD and lung cancer in that its higher presence is correlated to lower survival rate of smoking COPD adenocarcinoma patients.
This Oncotarget finding might have potential therapeutic implications, as anti-EGFR could be reconsidered in primarily RAS mutant patients reverted to a wild-type status after bevacizumab exposure.
CEA is not associated with survival outcomes in SCCA, and is not a clinically relevant biomarker in this disease
These Oncotarget findings demonstrate that Tomivosertib exhibits potent anti-leukemic properties on AML cells and support the development of clinical translational efforts involving the use of this drug
EGCG, a green tea polyphenol, as a modulator of in vitro methylglyoxal-induced Tau glycation and its impact on reducing advanced glycation end products in neuroblastoma cells.
They identify LAPAS1 as a novel E2F-regulated lncRNA that has a potential role in human cancer and regulates cell-cycle progression and cell proliferation
This Oncotarget work strongly suggests exploiting urine RNAs as diagnostic markers of bladder cancer and it suggests specific novel markers.
This Oncotarget study suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash.
New grant expands Texas tobacco program, targets substance use patients in rural communities
Cells that have undergone EMT can promote tumor growth and neovascularization either indirectly, by promoting endothelial transdifferentiation of carcinoma cells, or directly, by acquiring an endothelial phenotype, with FOXC2 playing key roles in these pr
The major finding of this Oncotarget study was perioperative tryptophan depletion and increased taurine synthesis.
These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells
CPAP also plays a vital role in suppressing tumorigenesis in OSCC by facilitating EGFR homeostasis
The article by Dr. Biswa Mohan Sahoo et al. is published in Anti-Cancer Agents in Medicinal Chemistry, 2021
Medical researchers identify the role of family history in the link between blood lipids and esophageal cancer
Study provides mechanistic link between red meat consumption and colorectal cancer development
PHILADELPHIA–The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust announced today the 2021 class of the Pew-Stewart Scholars Program for Cancer Research. The five early-career scholars who comprise the 2021 class will each receive a four-year grant to…
‘Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide, with a poor median survival time after diagnosis of six months’
Studies on cancer are limited by the threshold at which cellular transformations become clinically detectable. However, the very initial phase on the way to malignancy is histologically invisible, as the process originates from one single cell. In this early phase,…
‘Head and neck squamous cell carcinomas (HNSCC) are heterogeneous tumors that arise in the upper respiratory tract and are the 6th most common cancer worldwide by incidence’
Lung cancer is the leading cause of cancer-related deaths across the globe with more than 1.7 million deaths annually’
Decades after federal bans ended widespread use of lead-based paint and gasoline, some urban soils still contain lead levels that exceed children’s safety guidelines
Impact Journals is an exhibitor/sponsor and will be presenting our scientific integrity process at the Society for Scholarly Publishing (SSP) Annual Meeting, occurring virtually from May 24-27, 2021
Study links secondhand smoke during pregnancy to epigenetic changes in babies
Findings could explain why women of color in particular are more highly exposed to harmful chemicals
Bentham Science has recently launched the new volume of the book, Frontiers in Clinical Drug Research – Anti-Cancer Agents. Frontiers in Clinical Drug Research – Anti-Cancer Agents is a book series essential for pharmaceutical scientists, postgraduate students and researchers seeking…
‘Head and Neck Cancer: Hallmarks of The Inflammation Ecosystem’ aims to highlight the significant roles of inflammation in head and neck malignancy. This entails the screening, diagnosis, treatment as well as follow-up schemes of head and neck cancer patients. Now,…
Updated USPSTF LCS guidelines based solely on age, pack-years, and quit-years perpetuate eligibility disparities among racial and ethnic minorities, although incorporating certain risk prediction models may help reduce such inequalities
The Oncotarget article provides evidence that antitumor activity and prolonged stable disease are achieved with Z-endoxifen despite prior tamoxifen therapy.
Replacing an old couch with a new one free of flame retardants reduces harmful exposures in the home
Consumption of ultra-processed foods and drink could increase the risk of developing colorectal cancer. This was the conclusion of a large study undertaken by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the “la Caixa” Foundation, based…
Hydroxyprogesterone caproate may contribute to increasing rates of early-onset cancer, researchers say
CLEVELAND–A new technique for sampling and testing cells from Barrett’s esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease is at high risk of progressing toward cancer, according…
This Oncotarget study had significantly lower mutation rates in ASXL1 and SETBP1, and a higher rate of muTET2/wtASXL1
The Oncotarget data shed new light on the biochemical mechanisms behind ibuprofen’s action on alternative spliced RAC1B and may support its use in personalized approaches to CRC therapy or chemoprevention regimens.
Dr. Glenn J. Hanna from CCR/NCI in Bethesda, MD as well as The Dana-Farber Cancer Institute in Boston Massachusetts said, “Merkel cell carcinoma (MCC) is a relatively rare cancer, with roughly 400 cases per 100,000 persons each year in the United States”
The present Oncotarget work shed light on a brief mechanistic framework of PTs aggressive nature and present potential biomarkers to differentiate overlapping FELs that would be of practical utility in augmenting existing diagnosis and disease management
In this Oncotarget study, the authors characterized the mutational and neoantigen burden between primary and first recurrence tumors in 23 patients with HNSCC
UMass Amherst research suggests propylparaben is an endocrine disruptor
A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer. “Squamous cell carcinoma…
This @Oncotarget study indicates that HIPK2 isoform 3, the main HIPK2 isoform expressed in NSCLC, promotes YAP/TEAD transcriptional activity in NSCLC cells
Showing a clear clinical benefit for patients, irrespective of RAS mutational status, primitive tumor side and metastases surgery