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UrduMolecules that are induced by light to rotate bulky groups around central bonds could be developed into photo-activated bioactive systems, molecular switches, and more.
Tag: PHARMACEUTICAL CHEMISTRY
Drug precursor biosynthesis hinges on carrier-mediated ring formation
The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.
Toward one drug to treat all coronaviruses
Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers…
Martin Thornhill named 2021 recipient of the IADR Distinguished Scientist Award in PPT
Alexandria, Va., USA – The International Association for Dental Research (IADR) announced Martin Thornhill, University of Sheffield, England, as the 2021 recipient of the IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. Thornhill was recognized during the Opening Ceremonies of the…
New approach eradicates breast cancer in mice
CHAMPAIGN, Ill. — A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks…
A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
Artificial sweeteners enable delivery of carbon monoxide to treat organ injury
ATLANTA–An oral prodrug developed by a team of scientists led by Binghe Wang, Regents’ Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science .…
Scientists identify new gut-liver drug recycling process
Implications for developing treatments for intestinal diseases
Microcrystal electron diffraction supports a new drug development pipeline
CAMBRIDGE July 13, 2021 – To date, solving structures of potential therapeutics using X-ray diffraction (XRD) has been an assumed, pivotal step in the drug development process. But a recent paper by a team of researchers led by NanoImaging Services…
Reduced vs. standard CT dose for lung nodules in children, young adults with cancer
Reduced-dose CT depicts greater than 90% of lung nodules in children and young adults with cancer, identifying the presence of nodules with moderate sensitivity and high specificity
Study sheds light on mechanism of liposome accumulation in tumors
CU Cancer Center researcher says results could impact how we diagnose, monitor, and treat tumors with liposomes.
Harnessing AI to discover new drugs
Nature has a vast store of medicinal substances. “Over 50 percent of all drugs today are inspired by nature,” says Gisbert Schneider, Professor of Computer-Assisted Drug Design at ETH Zurich. Nevertheless, he is convinced that we have tapped only a…
Mucus and mucins may become the medicine of the future
Many people instinctively associate mucus with something disgusting, but in fact, it has incredibly many valuable functions for our health. It keeps track of our important intestinal flora and feeds the bacteria. It covers all internal surfaces of our body,…
Chemo upsets gut health in cancer patients
New research in BMC Cancer has shown myelosuppressive chemotherapy destabilises gut microbiome in patients with solid organ cancers.
Mefloquine: A promising drug ‘soldier’ in the battle against COVID-19
Scientists propose the repurposing of anti-malarial drug mefloquine to fight the novel coronavirus
Reactive oxygen species (ROS): Key components in cancer therapies
The article by Dr. Biswa Mohan Sahoo et al. is published in Anti-Cancer Agents in Medicinal Chemistry, 2021
Clinical and pre-clinical antimicrobial drug development
This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. It covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry,…
Had COVID-19? One vaccine dose enough; boosters for all, study says
Two mRNA vaccines against COVID-19 have proven safe and effective in clinical trials, as well as in the millions of people who have been vaccinated so far. But how prior SARS-CoV-2 infection affects vaccine response, and how long that response…
Seeking a treatment for IBS pain in tarantula venom
For patients who have inflammatory bowel syndrome (IBS), the condition is literally a pain in the gut. Chronic — or long-term — abdominal pain is common, and there are currently no effective treatment options for this debilitating symptom. In a…
FDA advisory panelist outlines issues with aducanumab’s approval for Alzheimer’s disease
Below please find a summary for a new article that will be published today in Annals of Internal Medicine . The summary is not intended to substitute for the full article as a source of information. This information is under…
Reduced-dose gadobutrol vs standard-dose gadoterate for contrast-enhanced brain MRI
A 25% reduced gadobutrol dose demonstrated non-inferior efficacy versus 100%-standard dose of gadoterate for contrast-enhanced brain MRI, particularly in patients undergoing multiple contrast-enhanced examinations
Measuring the elimination of plastic particles from the body in mice
Postdoctoral Researcher Outi Keinänen from the University of Helsinki developed a method to radiolabel plastic particles in order to observe their biodistribution on the basis of radioactivity with the help of positron emission tomography (PET). As a radiochemist, Keinänen has…
Scientists prepare for next coronavirus pandemic, maybe in 2028?
New drug target found for future and current coronaviruses
Compounds derived from hops show promise as treatment for common liver disease
CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…
Easy, inexpensive, efficient: Researchers improve efficacy of new malaria drug
Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team from Martin Luther University Halle-Wittenberg (MLU)…
New adaptable nanoparticle platform enables enhanced delivery of gene therapies
Scientists have developed polypeptide-based materials that act as effective vectors for delivering gene therapies. The first-of-its-kind platform enables the vectors to be adapted to suit the specific gene therapy cargo. The work, led by researchers from RCSI University of Medicine…
Cell Reports publishes data supporting the importance of ion channel, Kv7.2/7.3 as a target in ALS
Data supports QurAlis’ approach to treat hyperexcitability induced neurodegeneration in ALS patients; QurAlis gears up for clinical development of therapeutic candidate, QRL-101
Study helps to deeper understanding of brain dysfunctions in patients with schizophrenia
Researchers used protein mapping to show how abnormal levels of the neurotransmitter glutamate impair the functioning of neurons and oligodendrocytes. The findings could serve as a basis for more effective treatment
New drug-formulation method may lead to smaller pills
Chemical engineers have found a way to load more drug into a tablet, which could then be made smaller and easier to swallow
Autobahn Labs, Cold Spring Harbor Laboratory partner to advance novel science to clinic
Expansion to East Coast validates Autobahn Labs’ novel incubator model
MDI Biological Laboratory scientist identifies signaling underlying regeneration
Discovery in Salamanders by James W. Godwin, Ph.D., brings science closer to the development of regenerative medicine therapies
Antibiotics no help for mysterious lung-scarring disease, large trial finds
Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients…
Safe laboratory-made molecules for global vaccination success
Chemists succeed in artificially manufacturing important building blocks for mRNA vaccines
Fight against antibiotic-resistant bacteria has a glowing new weapon
AUSTIN, Texas — In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments…
Resetting the biological clock by flipping a switch
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists…
Conquering COVID-19 with antivirals
The COVID-19 pandemic has seen scientists perform incredible feats in a short amount of time, from developing tests to new types of vaccines. Despite these victories, experts are still working to develop an effective antiviral drug to kill the SARS-CoV-2…
Racemases: The hunt for drugs to neutralise these critical enzymes
Scientists from the University of Bath in the UK explore racemases and propose strategies for finding drugs that target these important enzymes.
To make particles flow more efficiently, put an obstacle in their way
Microfluidic chips speed up biological and chemical experiments; researchers made them more efficient by using cleverly designed ‘traffic circles’ to direct the flow of fluids
Making the gray cells happy
Neutrons show a connection between lithium concentrations in the brain and depression
A peptide that allows cannabis-derived drugs to relieve pain without side effects
Scientists from the Proteomics and Protein Chemistry Research Group and the Neuropharmacology-Neurophar Laboratory have developed a peptide which is an ideal candidate for reducing the cognitive side effects of pain treatment with cannabis derivatives.
Novel immunotherapy boosts long-term stroke recovery in mice
PITTSBURGH, May 19, 2021 – Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is…
Using personalized medicine to avoid resistance to leukemia treatment
T-cell acute lymphoblastic leukemia (T-ALL) is a very aggressive type of blood cancer. It is relatively rare but still draws a lot of attention as it mostly develops in children under the age of 20. The standard treatment for T-ALL…
Research with neutrons for better mRNA medicines
If not before, then certainly since the first messenger RNA (mRNA) vaccines to combat the SARS CoV2 virus were approved in Germany, mRNA has become a recognized term even outside scientific circles. What is less well known is that mRNA…
Frontiers in Clinical Drug Research – Anti-Cancer Agents
Bentham Science has recently launched the new volume of the book, Frontiers in Clinical Drug Research – Anti-Cancer Agents. Frontiers in Clinical Drug Research – Anti-Cancer Agents is a book series essential for pharmaceutical scientists, postgraduate students and researchers seeking…
Researchers identify a psychedelic-like drug without the hallucinogenic side effects
Psychedelic drugs have shown promise for treating neuropsychiatric disorders such as depression and posttraumatic stress disorder. However, due to their hallucinatory side effects, some researchers are trying to identify drugs that could offer the benefits of psychedelics without causing hallucinations.…
Capsaicin analog could help treatment-resistant lung cancer
Small cell lung cancer cells exposed to synthetic analog of chili pepper compound responded better to chemotherapy
Physical activity reduces cardiovascular risk in rheumatic patients
People with diseases such as rheumatoid arthritis and lupus are more likely to have heart attacks, angina, and strokes. A review of the scientific literature on the subject shows that regular exercise improves vascular function in these patients
New formulation of existing medicines prove highly effective against drug-resistant fungus
CLEVELAND–A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the presence of the fungus Candida auris ( C. auris ) on skin, controlling its spread and potentially keeping it…
Mt. Sinai Health Care Foundation awards $1 million grant to CWRU School o
The Mt. Sinai Health Care Foundation–continuing Mt. Sinai Medical Center’s century-old tradition of caring for Northeast Ohio–has expanded its commitment to the region through a $1 million challenge grant to the Case Western Reserve University School of Medicine. With this…
Pumping the ‘brain brake’ in pediatric anxiety
UC researchers find ways to predict treatment outcomes for adolescent anxiety using brain imaging