Toward one drug to treat all coronaviruses

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers…

Martin Thornhill named 2021 recipient of the IADR Distinguished Scientist Award in PPT

Alexandria, Va., USA – The International Association for Dental Research (IADR) announced Martin Thornhill, University of Sheffield, England, as the 2021 recipient of the IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. Thornhill was recognized during the Opening Ceremonies of the…

New approach eradicates breast cancer in mice

CHAMPAIGN, Ill. — A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks…

Artificial sweeteners enable delivery of carbon monoxide to treat organ injury

ATLANTA–An oral prodrug developed by a team of scientists led by Binghe Wang, Regents’ Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science .…

Microcrystal electron diffraction supports a new drug development pipeline

CAMBRIDGE July 13, 2021 – To date, solving structures of potential therapeutics using X-ray diffraction (XRD) has been an assumed, pivotal step in the drug development process. But a recent paper by a team of researchers led by NanoImaging Services…

Harnessing AI to discover new drugs

Nature has a vast store of medicinal substances. “Over 50 percent of all drugs today are inspired by nature,” says Gisbert Schneider, Professor of Computer-Assisted Drug Design at ETH Zurich. Nevertheless, he is convinced that we have tapped only a…

Clinical and pre-clinical antimicrobial drug development

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. It covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry,…

Had COVID-19? One vaccine dose enough; boosters for all, study says

Two mRNA vaccines against COVID-19 have proven safe and effective in clinical trials, as well as in the millions of people who have been vaccinated so far. But how prior SARS-CoV-2 infection affects vaccine response, and how long that response…

Seeking a treatment for IBS pain in tarantula venom

For patients who have inflammatory bowel syndrome (IBS), the condition is literally a pain in the gut. Chronic — or long-term — abdominal pain is common, and there are currently no effective treatment options for this debilitating symptom. In a…

FDA advisory panelist outlines issues with aducanumab’s approval for Alzheimer’s disease

Below please find a summary for a new article that will be published today in Annals of Internal Medicine . The summary is not intended to substitute for the full article as a source of information. This information is under…

Measuring the elimination of plastic particles from the body in mice

Postdoctoral Researcher Outi Keinänen from the University of Helsinki developed a method to radiolabel plastic particles in order to observe their biodistribution on the basis of radioactivity with the help of positron emission tomography (PET). As a radiochemist, Keinänen has…

Compounds derived from hops show promise as treatment for common liver disease

CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…

Easy, inexpensive, efficient: Researchers improve efficacy of new malaria drug

Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team from Martin Luther University Halle-Wittenberg (MLU)…

New adaptable nanoparticle platform enables enhanced delivery of gene therapies

Scientists have developed polypeptide-based materials that act as effective vectors for delivering gene therapies. The first-of-its-kind platform enables the vectors to be adapted to suit the specific gene therapy cargo. The work, led by researchers from RCSI University of Medicine…

Antibiotics no help for mysterious lung-scarring disease, large trial finds

Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients…

Fight against antibiotic-resistant bacteria has a glowing new weapon

AUSTIN, Texas — In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments…

Conquering COVID-19 with antivirals

The COVID-19 pandemic has seen scientists perform incredible feats in a short amount of time, from developing tests to new types of vaccines. Despite these victories, experts are still working to develop an effective antiviral drug to kill the SARS-CoV-2…

A peptide that allows cannabis-derived drugs to relieve pain without side effects

Scientists from the Proteomics and Protein Chemistry Research Group and the Neuropharmacology-Neurophar Laboratory have developed a peptide which is an ideal candidate for reducing the cognitive side effects of pain treatment with cannabis derivatives.

Novel immunotherapy boosts long-term stroke recovery in mice

PITTSBURGH, May 19, 2021 – Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is…

Research with neutrons for better mRNA medicines

If not before, then certainly since the first messenger RNA (mRNA) vaccines to combat the SARS CoV2 virus were approved in Germany, mRNA has become a recognized term even outside scientific circles. What is less well known is that mRNA…

Frontiers in Clinical Drug Research – Anti-Cancer Agents

Bentham Science has recently launched the new volume of the book, Frontiers in Clinical Drug Research – Anti-Cancer Agents. Frontiers in Clinical Drug Research – Anti-Cancer Agents is a book series essential for pharmaceutical scientists, postgraduate students and researchers seeking…

Researchers identify a psychedelic-like drug without the hallucinogenic side effects

Psychedelic drugs have shown promise for treating neuropsychiatric disorders such as depression and posttraumatic stress disorder. However, due to their hallucinatory side effects, some researchers are trying to identify drugs that could offer the benefits of psychedelics without causing hallucinations.…

New formulation of existing medicines prove highly effective against drug-resistant fungus

CLEVELAND–A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the presence of the fungus Candida auris ( C. auris ) on skin, controlling its spread and potentially keeping it…

Mt. Sinai Health Care Foundation awards $1 million grant to CWRU School o

The Mt. Sinai Health Care Foundation–continuing Mt. Sinai Medical Center’s century-old tradition of caring for Northeast Ohio–has expanded its commitment to the region through a $1 million challenge grant to the Case Western Reserve University School of Medicine. With this…

The role of benzothiazole analogs in the treatment of tuberculosis

Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes,…