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UrduThis article by Dr. F. David Rodriguez is published in the journal, Current Pharmaceutical Design, 2021
Tag: PHARMACEUTICAL CHEMISTRY
The role of benzothiazole analogs in the treatment of tuberculosis
Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes,…
Focusing on the unhealthy brain to speed drug discovery
University of Houston collaboration with National Institutes of Health delivers toolkit to accelerate process
Antibody injections could become more affordable with new production method
Antibody injections are a highly desirable treatment for people with chronic diseases such as cancer, psoriasis, Crohn’s disease and arthritis. And recently, antibodies have been in the news as a promising treatment for severe cases of COVID-19. But the costly,…
Uniform drying time for goldenseal to enhance medicinal qualities of forest herb
Developing a standardized drying protocol for goldenseal could lead to more predictable health applications and outcomes by preserving the alkaloids found in the plant, which is native to Appalachia, according to Penn State researchers, who conducted a new study of…
Anti-tuberculosis drug can be safely dosed even higher
Publication in European Respiratory Journal
Important advance in research on future drugs
Most drugs operate via the membranes that surround the body’s cells. A study by researchers at Karolinska Institutet in Sweden has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, plays a part in…
1 in 3 older thyroid patients take medications that interfere with thyroid function tests
Study highlights complexity of managing thyroid hormone replacement in older adults
Study finds inflammatory mechanism responsible for bone erosion in rheumatoid arthritis
In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at a FAPESP-supported research center identified a novel pathway in the inflammatory process relating to bone damage
CAS Common Chemistry™ expands collection of publicly available chemical information
COLUMBUS, Ohio, March 17, 2021 — CAS, a division of the American Chemical Society (ACS) that specializes in scientific information solutions, has expanded the CAS Common Chemistry resource. To strengthen the accuracy of publicly available scientific information, CAS Common Chemistry…
Health promotion, prevention, and psychosocial health
This article by Dr. Tannys Helfer et al. is published in The Open Public Health Journal, Volume 14, 2021
Trackable and guided ‘nanomissiles’ deliver cancer-fighting drug straight to the tumor
Researchers from Skoltech and their colleagues from Hadassah Medical Center have developed hybrid nanostructured particles that can be magnetically guided to the tumor, tracked by their fluorescence and pushed to release the drug on demand by ultrasound. This technology can…
URI researchers develop new test for coronavirus, launch clinical trial
Non-invasive saliva test increases access, is accurate, simple and cost-effective
UC-led research looks at alternative to treat eye diseases
Federally funded study says drug delivery for certain common eye diseases could be improved
Injections or light irradiation?
A new concept of on-demand drug delivery system has emerged in which the drugs are automatically released from in vivo medical devices simply by shining light on the skin. A research team led by Professor Sei Kwang Hahn of the…
Electrochemistry opens ways for the sustainable production of sulfonamides
Researchers at Mainz University developed a new procedure for the quick, cost-effective, and environmentally-friendly production of essential substances required by the pharmaceutical industry
A trio that could spell trouble: Many with dementia take risky combinations of medicines
Despite guidelines, 14% are on three or more drugs that act on the brain and nervous system; families and providers should review prescriptions regularly
New inhibitor found to combat drug-resistant cancer cells
A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy. The new substance blocks…
Exploring pieces of heart muscle that fail to compact
University of Houston researcher awarded $2.5M to study “spongy heart”
Purdue Research Foundation partners with IdentifySensors Biologics for COVID-19 technology
WEST LAFAYETTE, Ind. – IdentifySensors Biologics, a Purdue University-affiliated technology firm developing a rapid diagnostic platform for detecting pathogens, including SARS-CoV-2, has entered into a new partnership with Purdue Research Foundation and will open an office in Purdue’s Discovery Park…
Innovative cancer treatment found to be promising for the control of fungal infections
The use of CAR T-cells reprogrammed to ‘recognize’ Cryptococcus spp. proved effective to combat the infection in vitro and in mice
Scientists explore the action mechanism of a new antibiotic
Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy . All bacterial cells contain topoisomerases, an important group of…
The battle against hard-to-treat fungal infections
Systemic fungal infections are much rarer than other illnesses, but they are potentially deadly, with limited options for treatment. In fact, fungi are becoming increasingly resistant to the few drugs that are available, and infections are growing more common. A…
Study reveals details of immune defense guidance system
Results could lead to better drugs used to fight inflammation
Researchers discover SARS-CoV-2 inhibitors
Pharmacists at the University of Bonn: Substances block key step in coronavirus replication
UNF professor awarded US patent to fight cancer tumors using synthetic curcumin analogs
Dr. Kenneth Laali, University of North Florida Presidential Professor of Chemistry, has recently been awarded a US patent for his research on the synthesis of novel curcumin analogs (curcuminoids) to fight cancer tumors. The compounds that Laali has developed provide…
March SLAS Discovery explores COVID-19 drug therapies six months later
Oak Brook, IL – The March edition of SLAS Discovery features the cover article, “Therapeutic and Vaccine Options for COVID-19: Status After 6 Months of the Disease Outbreak” by Christian Ogaugwu (Federal University Oye-Ekiti, Ekiti State, Nigeria ), Dawid Maciorowski,…
A new hub for developing medicines of the future at the University of Gothenburg
In recent years, techniques have been developed to treat diseases with what are known as oligonucleotide drugs, based on short DNA or RNA molecules. The Wallenberg Centre for Molecular and Translational Medicine at the University of Gothenburg has now been…
Assessing a compound’s activity, not just its structure, could accelerate drug discovery
Biological activity-based modeling could improve screening for promising drug compounds
Bentham Science launches new journal, Current Cosmetic Science
Bentham Science is pleased to announce the launch of a new subscription-based journal, Current Cosmetic Science . The first issue of the journal will be available online by the start of the year, 2021. The journal is edited by Dr.…
Cerium sidelines silver to make drug precursor
Rice University lab’s process simplifies fluoroketone synthesis
ALS neuron damage reversed with new compound
Scientists identify first compound to repair degenerating brain cells in paralyzing disease
Tricking the novel coronavirus with a fake “handshake”
Fool the novel coronavirus once and it can’t cause infection of cells, new research suggests. Scientists have developed protein fragments that bind to the Spike protein, effectively tricking the virus into “shaking hands” with a replica rather than the receptor that lets the virus into a cell.
Tricking the novel coronavirus with a fake “handshake”
Scientists develop peptides that could inactivate coronavirus
Study examines aspirin and statin use among older Americans
An analysis published in the Journal of the American Geriatrics Society indicates that while adults aged 75 years and older do not benefit from taking aspirin to prevent cardiovascular disease, many do so on a regular basis. Also, although statins…
Hide-and-seek can lead to higher drug prices
In Switzerland and other European countries, drug prices are regulated to ensure affordable access to drugs. In the last few years, many European countries have introduced rebate schemes for drugs. In most cases, however, the rebates negotiated with the manufacturer…
Discovering the therapeutic applications of medicinal plants
Both Asia and Africa are home to many plants that can be used for the treatment of many diseases and their medicinal properties are gaining interest in western societies. Medicinal plants from Asia and Africa are used for their healing…
Geisel study examines variation in intensity of fracture-associated prescription drug use
Findings from a new Geisel-led study, published in the Journal of General Internal Medicine , reveal that there is substantial variation across different regions of the country in the intensity of fracture-associated drug (FAD) use among long-term care facility residents,…
The body produces new satiety factor during prolonged exercise
A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity. One of the emerging drug candidates that interest researchers is the hormone GDF15 that, when given to…
Cheap, potent pathway to pandemic therapeutics
PITTSBURGH, Feb. 15, 2021 – By capitalizing on a convergence of chemical, biological and artificial intelligence advances, University of Pittsburgh School of Medicine scientists have developed an unusually fast and efficient method for discovering tiny antibody fragments with big potential…
Antitumoral effects of LXR activation
Macrophages that boost tumor growth
New study suggests better approach in search for COVID-19 drugs
Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of COVID-19, revealing vital clues for the discovery of antiviral drugs.
Get a load of ZIF! Better delivery of cancer immunotherapy
Loading a cancer immunotherapy drug onto a metal organic framework improves both its delivery and its sustained release for treating leukemia. Furthermore, coating the drug-loaded framework with a cancer cell membrane improves targeted delivery to solid tumors. These findings could…
Industrial compound gets eco-friendly reaction
Scientists have found catalysts that improve an important industrial reaction and make it more eco-friendly
Using Nature’s strategies in the development of new drugs
Dimerization of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules
Inhibition of the BAF complex causes rapid loss of DNA accessibility
When human cells have to adapt due to a wide variety of external influences, the BAF complex plays a central role because it controls the accessibility of the DNA and thus the information stored in it. In every fifth human…
Bentham Science joins ORCID as member organization
Bentham Science has joined the Membership Program offered by ORCID to facilitate its stakeholders including the authors, Editorial Board Members, and their affiliating institutions. Through the ORCID Membership, Bentham Science endeavors to ensure that the researchers have a trustable connection…
Porto University joins Bentham Open as Institutional Member
Bentham Open is pleased to announce an Institutional Member partnership with the Porto University, Faculty of Dental Medicine (FMDUP). The partnership provides the opportunity to the researchers, from the university, to publish their research under an Open Access license with…
Popular breast cancer drugs don’t work the way we thought they did
Study suggests changes in so-called PARP inhibitors could boost potency, efficacy
Study may help pregnant women and others ‘scratch’ spinal morphine-induced itch
PITTSBURGH, Feb. 3, 2021 – For years, many pregnant women and surgery patients have suffered from chronic itching when they get spinal or epidural morphine to reduce pain. Now, researchers at the University of Pittsburgh School of Medicine have shown…