Transplanting Muscle Mitochondria among Species May Create Opportunity for New Treatments

Article title: Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis Authors: Debasmita Bhattacharya, Mikhaela B. Slavin, David A. Hood From the authors: “Our study illustrates the feasibility of using mouse skeletal muscle-derived mitochondria for transplantation in intraspecies- and interspecies-specific…

Urban Pollution Changes Properties of Lung Cells, Causes Fibrosis

Article title: Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis Authors: Randa Belgacemi, Bruno Ribeiro Baptista, Grégoire Justeau, Marylène Toigo, Andrew Frauenpreis, Rojda Yilmaz, Audrey Der Vartanian, Mathieu Cazaunau, Edouard Pangui, Antonin Bergé, Aline Gratien,…

The YABBY gene SHATTERING1 controls activation rather than patterning of the abscission zone in Setaria viridis

Plants have highly evolved mechanisms to shed or drop organs (abscission) in response to environmental or developmental cues. It’s why you have to rake leaves in the Fall! But in agriculture, the natural shedding of flowers or seeds is detrimental, and cereal crops with abscission-inhibiting mutations in certain genes, like SHATTERING1, have been bred to dramatically increase yield. Using Crispr gene editing and detailed analyses, Yu et al. show for the first time some mechanistic features of abscission in the grasses, including the role of the plant hormone auxin.

Long COVID patients show distinct immune, hormone responses to virus

People suffering from long COVID symptoms show different immune and hormonal responses to the virus that causes COVID-19, according to a new study led by researchers at Yale School of Medicine. An estimated 7.5% of people infected with the SARS-CoV-2…

Protein p53 regulates learning, memory, sociability in mice

Researchers at the Beckman Institute for Advanced Science and Technology have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders.

Investigators at Mount Sinai Find Strong Association of Kidney Injury with Dasatinib, a Commonly Used Oncological Therapeutic

Investigators at Mount Sinai Find Strong Association of Kidney Injury with Dasatinib, a Commonly Used Oncological Therapeutic Findings suggest an update may be warranted for current clinical care, screening guidelines, and FDA guidance on adverse events Principal Investigator: Evren U.…

Theoretical and Experimental Physics Team Up in the Search for Particle Flavor Change

Scientists recently discovered that neutrinos have mass, counter to long-held understanding. This means that neutrinos can change flavor. Now, advances in theory and experiment are helping scientists to determine whether the neutrinos’ charged counterparts—electrons, muons, and tauons—can also change flavor and how future experiments can look for those changes.

Simple ballpoint pen can write custom LEDs

Researchers working with Chuan Wang, an associate professor of electrical and systems engineering at the McKelvey School of Engineering at Washington University in St. Louis, have developed ink pens that allow individuals to handwrite flexible, stretchable optoelectronic devices on everyday materials including paper, textiles, rubber, plastics and 3D objects.

Reduced frequency & intensity of migraine attacks after single dose of psilocybin

Psilocybin – the active ingredient in psychedelic mushrooms – shows promise for the transitional treatment of episodic migraines in early clinical trials, according to a review from Yale School of Medicine’s Emmanuelle Schindler, M.D., Ph.D.  In the first and only…

Analysis suggests access to primary care could play an important role in reducing hospitalizations

A secondary analysis of a randomized encouragement study found that Medicare patients who received social needs case management had a 3% increase in primary care visits and an 11% reduction in inpatient hospitalizations. These findings suggest that increased access to primary care could play an important role in reducing acute care use. A brief research report is published in Annals of Internal Medicine.

Physicians who care for patients of reproductive potential should initiate conversations about contraception

A new Annals ‘In the Clinic’ provides a detailed summary of contraceptive methods and presents evidence-based discussion points that physicians can use to initiate a dialogue with their patients of reproductive potential. The timing of this release is crucial as pregnancy-associated mortality is on the rise, abortion access is decreasing, and the mini pill has just been approved for over-the-counter use in the United States. The ‘In the Clinic’ feature is published in Annals of Internal Medicine.

Type 2 diabetes is associated with hospital stays for a wide range of medical conditions but, in people diagnosed at a young age, mental health disorders are the biggest contributing factor

Type 2 diabetes is associated with hospital stays for a wide range of medical conditions but, in people diagnosed at a young age, mental health disorders are the biggest contributing factor ##### In your coverage, please use this URL to…

AI model isolates olive oil ingredients that may fight Alzheimer’s

A growing body of evidence suggests extra virgin olive oil can help prevent cognitive decline due to Alzheimer’s disease. In a new study, Yale School of Medicine researchers led by Natalie Neumann, MD, trained a machine learning algorithm on current…

Excess Testosterone Can Lead to Increased Cardiovascular Risks in People with Polycystic Ovary Syndrome

Article title: Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome Authors: Tori Stone, Licy L. Yanes Cardozo, Toni N. Oluwatade, Cheryl A. Leone, Melanie Burgos, Faith Okifo, Lubna Pal, Jane F. Reckelhoff, Nina. S. Stachenfeld From…

Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage

Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…

Atopic dermatitis associated with schizophrenia, schizoaffective disorder

Atopic dermatitis (AD) is a chronic, inflammatory skin disorder that has well-established associations with depression and anxiety. A new Yale School of Medicine study finds AD is also associated with increased risk for schizophrenia and shizoaffective disorder. Schizophrenia is a…