Researchers uncover how tumors circumvent prostate cancer therapy, identify promising treatment strategy

A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…

Comparing SARS-CoV-2 antibody response after Moderna, Pfizer-BioNTech vaccines in immunosuppressed patients

About The Study: Researchers compared antispike antibody titers after the 2-dose Pfizer-BioNTech and Moderna COVID-19 vaccines in incrementally immunosuppressed patients. These individuals, such as people with rheumatic and musculoskeletal diseases and solid organ transplant recipients, have decreased immune responses to these…

Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational

Background: Digital health interventions could help to prevent age-related diseases, but little is known about how older adults engage with such interventions, especially in the long term, or whether engagement is associated with cha…

Reversal of Heart Enlargement Differs in the Sexes; Doesn’t Use Universal Signaling Pathways

Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…

Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease

Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…

Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity

Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…

Study Explores Function and Characteristics of Enteric Nervous System Cells in Context of Injury

Article title: Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury Authors: Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek,…

Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease

Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…

Public Beware: Study Finds Potential for Massive Cancer Nutrition Misinformation on Pinterest

A multi-center team including researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine claims that the social media site Pinterest is rife with cancer misinformation. Their study found that about a third of posts…