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UrduThe repair of bone tissue damage is a complex process that is well-orchestrated in time and space, a focus and difficulty in orthopedic treatment. In recent years, the success of mesenchymal stem cells (MSCs)-mediated bone repair in clinica
Category: Research Alert
Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19
Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection typically presents with fever and respiratory symptoms, which can progress to
Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing
Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibitin
Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages
BACKGROUNDMesenchymal stem cells (MSCs) have been extensively studied for therapeutic potential, due to their regenerative and immunomodulatory properties. Serial passage and stress factors may affect the biological characteristics of MSCs,
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
BACKGROUNDLeukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional ther
Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine
BACKGROUNDStem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple lineages. In humans, their limited numbers pose a challenge in fulfilling the necessary demands for
Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation
Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value o
Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health
BACKGROUNDOsteoporosis (OP) has become a major public health problem worldwide. Most OP treatments are based on the inhibition of bone resorption, and it is necessary to identify additional treatments aimed at enhancing osteogenesis. In the
Adipose-derived regenerative therapies for the treatment of knee osteoarthritis
Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying therapy. Definitive treatment ultimately requires joint replacement. Therapies capable of regenerating cartilage could significantly
Ultrasound, ultraprecise: Advancing super-resolution imaging with deep learning
Researchers at the Beckman Institute for Advanced Science and Technology developed a new technique to make ultrasound localization microscopy, an emerging diagnostic tool used for high-resolution microvascular imaging, more practical for clinical settings. Their method uses deep learning to advance…
Warming of Antarctic deep-sea waters contribute to sea level rise in North Atlantic, study finds
A new study published in the journal Nature Geoscience led by scientists at University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, and the National Oceanic and Atmospheric Administration’s Atlantic Oceanographic and Meteorological Laboratory, found that human-induced environmental changes around Antarctica…
New Study Leads to Potential Therapy for Acute Pancreatitis
Rockville, Md. (April 19, 2024)—Blocking a specific calcium channel called CM4620 may become a new way to treat the life-threatening inflammatory disease acute pancreatitis. While this therapy appears to be the first effective treatment for acute pancreatitis, it has yet…
Researchers look at how pollution, weather, noise, social factors impact AFib
There’s a growing recognition of how the environment we live in affects our heart health. Atrial fibrillation, a common heart rhythm disorder, affects millions worldwide and can lead to serious health problems. While we’ve studied how genetics and lifestyle play…
How Obesity Impacts Kidney Tubules in Mice
Rockville, Md. (April 17, 2024)—The lipids in kidney tubular segments (used to carry filtered nutrients to and from the blood) are unknown. In this study, researchers identified, counted and compared more than 500 types of fats. Significant compositional differences were…
Impact of Meditation Versus Exercise on Psychological Characteristics, Paranormal Experiences, and Beliefs: Randomized Trial
Abstract Background: Research indicates that meditation increases mindfulness and paranormal experiences of precognition, telepathy, clairvoyance, and synchronicities. There is limited knowledge about the prevalence or impact of these experiences on meditators and the general population. Aims: To compare self-reported well-being,…
White Blood Cell Changes Develop in Acute Kidney Injury, Regardless of Cause
Article title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…
Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women
Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…
Exercise Testing Uncovers Cardiovascular Disease Risk Factor in Black Postmenopausal Women
Article title: Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females Authors: João L. Marôco, Linda M Szymanski, Tracy Baynard, Bo Fernhall From the authors: “Our findings show that maximal exercise unmasks…
Routinely Wearing High Heels Reduces Energy Cost of Walking, Even Out of Heels
Article title: Habitually wearing high heels may improve user walking economy in any footwear Authors: Owen N. Beck, Jordyn N. Schroeder, Gregory S. Sawicki From the authors: “Habitually wearing high-heeled footwear structurally remodels leg muscle tendons and improves user walking…
Timing of Both Fasting and Meals Affects Degree of DNA Damage to Small Intestine Caused by Chemotherapy
Article title: Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine Authors: Kali Deans-Fielder, Timothy Wu, Thanh Nguyen, Sarah To, Yang-Zhe Huang, Steven J. Bark, Jason C. Mills, Noah F. Shroyer From the authors: “Our results also showed…
Baylor Scott & White Presents at ISHLT 44th Annual Meeting
The International Society of Heart and Lung Transplantation (ISHLT) 44th Annual Meeting is April 10-13 in Prague. Baylor Scott & White researchers will present the latest insights to better serve patients with end-stage heart and lung disease.Investigators at Baylor Scott &…
High Blood Pressure Linked to Increased Risk of Malaria in Mice
Rockville, Md. (April 4, 2024)—Hypertensive mice with abnormal red blood cells are at greater risk for developing malaria, according to a new study. Until now, the link between high blood pressure and malaria has not been extensively studied. Physiologists compared…
Chemotherapy in Pediatric Mice Linked to Long-term Muscle Defects
Rockville, Md. (April 3, 2024)—Recent progress in research related to cancer treatment has made it possible for children with cancer to survive into adulthood. However, the long-term physiological consequences of chemotherapy are understudied. This study investigated persistent musculoskeletal consequences of…
Pancreas Cells in People Who Have Died Show Significant Signs of Stress
Rockville, Md. (April 1, 2024)—People with Type 1 diabetes require daily insulin shots to regulate their blood sugar levels. This is because their immune system kills beta cells found in islets in the pancreas. Beta cells release and disburse insulin…
Study: Pregnancy accelerates biological aging
Researchers at Yale School of Medicine find in a new study that pregnancy accelerates aging. The good news: There appears to be a significant reversal of the effect in the first few months after childbirth. Using data from blood samples…
Inflammation-reducing drug shows no benefit for dry age-related macular degeneration in NIH trial
The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI),…
The Perceived Meaning of Traumatic Brain Injury for Older Adults: A Longitudinal-Multiple Case Study
Abstract Purpose The aim of this study was to explore the perceived meaning of traumatic brain injury (TBI) over the first-year postinjury among older adults and to explore if and how meaning changes. Design A longitudinal multiple-case study design was…
Machine learning algorithm identifies individuals who experience the largest reduction in depression risk from Medicaid coverage
Previous research has demonstrated that Medicaid coverage reduces the risk for developing depression among recipients, but the question is who benefits most from coverage. Using a tool called machine learning causal forest to analyze data from the Oregon Health Insurance…
Researchers Find That Length of Opioid Treatment for Hospitalized Infants Differs by Institution and Geography
Los Angeles (March 12, 2024) – Opioids such as fentanyl and morphine can provide effective pain relief for infants with complex medical conditions when used carefully. But who decides what careful actually means? In a study published in JAMA Network…
Working-Age Caregivers of Stroke Survivors: Needs, Concerns, and Quality of Life
Abstract Purpose The purpose of this study was to characterize the unmet needs and concerns of working-age caregivers of stroke survivors and to explore the relationships between these unmet needs and concerns and factors such as stroke survivor functional independence,…
Harvard Medical School Media Immersion: Thursday, May 30, Boston
Application Deadline: March 31 Harvard Medical School will host a daylong educational immersion for science reporters on Thursday, May 30, on the Harvard Medical School campus in Boston. The Opportunity Seating is limited. Harvard Medical School will cover the cost…
An aspirin a day? Poll of older adults suggests some who take it may be following outdated advice
One in four older adults take aspirin at least three times a week, mostly in hopes of preventing heart attacks and strokes, a new poll shows. But many people aged 50 to 80 who said they take aspirin may not need to because hey don’t have a history of cardiovascular disease.
Children’s Hospital Los Angeles Study Finds Many Kids With Sickle Cell Anemia Lack Preventative Care
Press Release EMBARGOED until Wednesday, March 6, 12:05 AM EST LOS ANGELES (March 6, 2024)—Children with sickle cell anemia are vulnerable to serious infections and stroke, but many do not receive the preventative care that could help them stay healthier…
Noteworthy studies to be presented at the 2024 Multidisciplinary Head and Neck Cancers Symposium
Research on patient-centered treatment of head and neck cancers will be presented at the 2024 Multidisciplinary Head and Neck Cancers Symposium, which takes place in Phoenix and online today through March 2. Media registration is available. Studies recommended by symposium leadership for media are noted below, and outside experts are available to provide commentary.
Biodiversity appears to strongly suppress pathogens and pests in many plant and animal systems, but this “dilution effect” can vary strikingly in magnitude
This study uses forest inventory data from over 25,000 plots to show that the prevalence of tree pests is jointly controlled by the diversity and phylogenetic composition of forests.
New quantum entangled material could pave way for ultrathin quantum technologies
Two-dimensional quantum materials provide a unique platform for new quantum technologies, because they offer the flexibility of combining different monolayers featuring radically distinct quantum states. Different two-dimensional materials can provide building blocks with features like superconductivity, magnetism, and topological matter.…
Recent progress in hair follicle stem cell markers and their regulatory roles
Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biom
Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells
In this editorial, we offer our perspective on the groundbreaking study entitled “Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells”, recently publis
Advances in the differentiation of pluripotent stem cells into vascular cells
Blood vessels constitute a closed pipe system distributed throughout the body, transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and kidneys. Changes in blood vessels are related to
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation
Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow and adipose tissue, and differentiate into various cell types, such as osteoblasts and adipocytes. Recent studies on MSCs have revealed that many transcrip
Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling
BACKGROUNDOsteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic activity. During osteoporosis, bone mesenchymal stem cells (BMSCs) exhibit an increased ability to differentiate
Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects
Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt
Cellular preconditioning and mesenchymal stem cell ferroptosis
In this editorial, we comment on the article published in the recent issue of the World Journal of Stem Cells. They focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionine γ-lyase/hydrogen sulfide (H2S) pa
Human dental pulp stem/stromal cells in clinical practice
Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical c
Human pluripotent stem cell-derived kidney organoids: Current progress and challenges
Human pluripotent stem cell (hPSC)-derived kidney organoids share similarities with the fetal kidney. However, the current hPSC-derived kidney organoids have some limitations, including the inability to perform nephrogenesis and lack of a c
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
BACKGROUNDCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
BACKGROUNDIn vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo, but its effect on hematopoietic
Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics
This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enha