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UrduScientists have discovered the origins of how animals adapt to and live in freshwater.
Category: Research Alert
Engineering Research Provides Non-Invasive Solutions for Diagnosing and Treating Neurological and Psychiatric Conditions
Could artificial intelligence help solve the mental health crisis? What if an algorithm allowed neurologists to know the area affected by a brain seizure? These are just a few of the questions that Maryam Ravan, Ph.D., assistant professor of electrical and…
Combined human and veterinary services enhance primary care access for homeless youth and their pets
In 2018, a multidisciplinary team in Seattle created a combined clinical space to care for homeless youth and their pets.
Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells
BACKGROUNDRecent studies have demonstrated that mesenchymal stem cells (MSCs) can rescue injured target cells via mitochondrial transfer. However, it has not been fully understood how bone marrow-derived MSCs repair glomeruli in diabetic kidney
Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia
BACKGROUNDThe effect of hypoxia on mesenchymal stem cells (MSCs) is an emerging topic in MSC biology. Although long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) are reported to play a critical role in regulating the biological character
Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells
BACKGROUNDHeart diseases are the primary cause of death all over the world. Following myocardial infarction, billions of cells die, resulting in a huge loss of cardiac function. Stem cell-based therapies have appeared as a new area to support h
Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease
Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis and is an idiopathic, chronic inflammatory disease of the colonic mucosa. The occurrence of IBD, causes irreversible damage to the colon and increases the risk o
Researchers should avoid use terms like ‘race,’ ‘ancestry,’ or ‘ethnicity’ interchangeably
McMaster expert advises on using terms like ‘race’ in health-care research Health-care researchers should avoid use terms like ‘race,’ ‘ancestry,’ or ‘ethnicity’ interchangeably in their studies and research reports, says McMaster University professor Sonia Anand in her latest study in…
NEJM: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement
A study published today in the New England Journal of Medicine (NEJM) found that among patients with aortic stenosis undergoing transfemoral TAVR, the use of a debris capturing device called cerebral embolic protection reduced the risk of disabling stroke from 1.3% to 0.5%.
Artificial Intelligence Shown to More Rapidly and Objectively Determine Calcium Scores Than Physicians
A study published today in the Journal of the American College of Cardiology (JACC): Cardiovascular Imaging shows that artificial intelligence tools can more rapidly, and objectively, determine calcium scores in computed tomographic (CT) and positron emission tomographic (PET) images than physicians, even when obtained from very-low-radiation CT attenuation scans.
Persistence, protective potential of SARS-CoV-2 antibody levels after COVID-19 vaccination
About The Study: Researchers assessed SARS-CoV-2 spike antibody levels and their association with subsequent infection among 2,100 West Virginia nursing home residents and staff who had previously received SARS-CoV-2 vaccination. Authors: Sally Hodder, M.D., of the West Virginia University School of Medicine…
Researchers Present New Mathematical Model for Studying Kidney Cells
Rockville, Md. (September 13, 2022)—Research published ahead of print in the journal Function presents a new mathematical model using opossum kidney cells to study the endocytic capacity of proximal tubule cells in the kidneys. The specialized cells in the proximal…
Faulty Neurotransmitter Causes Weak, Overactive Bladder in Mice
Rockville, Md. (September 8, 2022)—Urinating more frequently and in lower volumes can be a sign of overactive bladder, according to physiologists from Beth Israel Deaconess Medical Center and Harvard Medical School in Boston. Researchers investigated how the smooth muscle in…
Study on implementation of a hospital based Brexanolone program released
Waltham, MA September 8th, 2022 What: An article in the September edition of The Journal of Psychiatric Practice has a new report on the program development and treatment of 26 postpartum patients in a program that administered brexanolone. The program…
Cardiovascular disease risk in adults with compromised bone health
These risk factors included male sex, older age, smoking, alcohol consumption, atrial fibrillation, use of anti-hypertensive medications, prior heart attack or stroke, established cardiovascular disease, low kidney function, high systolic blood pressure, elevated cholesterol level, and use of multiple concomitant…
NASA’s Webb Takes Its First-Ever Direct Image of Distant World
This image shows the exoplanet HIP 65426 b in different bands of infrared light, as seen from the James Webb Space Telescope: purple shows the NIRCam instrument’s view at 3.00 micrometers, blue shows the NIRCam instrument’s view at 4.44 micrometers,…
New Therapeutics Could Help Treat Excess Urine in the Kidneys
Rockville, Md. (September 1, 2022)—Physiologists at the University of Nevada, Reno have identified two ion channels necessary for urine to flow from the kidneys to the ureters. A calcium-activated chloride channel and a voltage-dependent calcium channel are required for contractions…
The Effects of Copper, Patient-Relevant Tissue Models, and Artificial Intelligence Featured in Sept. 2022 Issue of ToxSci
A new ToxPoint articles argues that “Copper Is the New Showstopper,” while a commentary calls for patient-relevant tissue models in the September 2022 issue of Toxicological Sciences (ToxSci), the official journal of the Society of Toxicology (SOT). Other featured articles…
Researchers Explore Role of Plasma Membrane Pump in Calcium Signaling
Rockville, Md. (September 1, 2022)—Research published ahead of print in the journal Function suggests the plasma membrane Ca2+ ATPase (PMCA) pump helps regulate cytosolic calcium signaling. Cytosolic calcium is found within the cells’ intracellular fluid—the cytosol is one such liquid—and…
Accessibility of Nonprofit Services: Transportation Network Companies and Client Mobility
Abstract Nonprofit organizations often partner with government agencies to deliver public services. As communities adapt to new transportation options and technologies, nonprofit organizations and the services they provide need to be kept accessible to their clients. This exploratory research note…
Visual Abstract: Standard vs Enhanced Self-Measurement of Blood Pressure Paired With Smartphone Application
Media advisory: The full study is linked to this news release. A visual abstract is below. Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2022.3355?guestAccessKey=fd9d8a9c-2d02-4b28-9e0d-0e4b4c9afdf9&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=081522 Visual Abstract…
Health care use following SARS-CoV-2 infection
About The Study: Among 127,000 patients with a positive SARS-CoV-2 test, health care use was elevated six months after the acute infection compared with patients with negative SARS-CoV-2 test results. These findings suggest that health care systems should consider long-term strategic…
Study Sheds Light on Residential Energy Use
Now that the U.S. Senate has passed the Inflation Reduction Act—expected to provide homeowners with access to thousands of dollars in cash incentives for new hot water heaters, HVAC, insulation, and other enhancements—a spotlight has been cast on the residential energy…
Triple Therapy Halved the Risk of Death Among Patients Hospitalized With Severe COVID-19
Adding baricitinib to remdesivir and dexamethasone improved outcomes among patients hospitalized with Covid-19, according to a Rutgers researcher
Researchers Identify Common Long COVID Symptoms and Potential Causes for The Condition
Chronic COVID, also called Long COVID, is becoming an increasingly concerning condition where people who have recovered from the initial infection are still facing a number of health problems that make it difficult to get through everyday life. A recent…
Study: Psychological Safety Can Enable Innovation
Psychological safety has long been recognized in the context of information sharing, risk taking and collaboration, but its effects on the process of innovation have not been tested. A study published in the International Journal of Innovation Management investigates the role of…
Diaphragm Muscle Fiber Mitochondria Adapt to Varying Levels of Activity
Article title: Mitochondrial adaptations to inactivity in diaphragm muscle fibers Authors: Alyssa D. Brown, Matthew J. Fogarty, Leah A. Davis, Debanjali Dasgupta, Carlos B. Mantilla, Gary C. Sieck From the authors: “Type I and IIa [diaphragm muscle] fibers were far…
Virtual Model Predicts Body Temperature for Hot and Cold States, May Aid Injury Prevention
Article title: A 3D virtual human model for simulating heat and cold stress Authors: Tushar Gulati, Rajeev Hatwar, Ginu Unnikrishnan, Jose E. Rubio, Jaques Reifman From the authors: “Our 3D thermoregulatory virtual human model consistently predicted the body’s thermal state…
Researchers ID Low Immune Cell Responsiveness and High Level of Proteins as Features of COVID-19 Severity
Article title: Chemokines, soluble PD-L1 and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness Authors: Eric D. Morrell, Pavan K. Bhatraju, Neha A. Sathe, Jonathan Lawson, Linzee Mabrey, Sarah E. Holton, Scott R. Presnell, Alice Wiedeman, Carolina Acosta-Vega,…
Intestinal Abnormalities in People with Posttraumatic Stress Disorder Don’t Improve Even When PTSD Symptoms Abate
Article title: Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms Authors: Robin M. Voigt, Alyson K. Zalta, Shohreh Raeisi, Lijuan Zhang, J. Mark Brown, Christopher B. Forsyth, Randy A. Boley, Philip Held, Mark…
Men Performing Heavy Resistance Exercise Have Disruptions to Gene Expression in Muscles
Article title: Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance exercise Authors: Casper Soendenbroe, Mette F. Heisterberg, Peter Schjerling, Michael Kjaer, Jesper L. Andersen, Abigail L. Mackey From the authors: “Taken together, the results demonstrate…
Heart of Aging Female Mice Produce More Collagen than Males, Develops More Scarring
Article title: Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis Authors: Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, Anilkumar K. Reddy, Anna Malovannaya, Antrix Jain, Mark L. Entman, George E. Taffet, Katarzyna A. Cieslik From the authors:…
Peptide Treatment May Improve High White Blood Cell Count Associated with Smoking
Article title: Recombinant human β-defensin 2 delivery improves smoking-associated lung neutrophilia and bacterial exacerbation Authors: Nadia Milad, Marie Pineault, Gabrielle Bouffard, Michaël Maranda-Robitaille, Ariane Lechasseur, Marie-Josée Beaulieu, Sophie Aubin, Benjamin A. H. Jensen, Mathieu C. Morissette From the authors: This…
Association of fourth Pfizer-BioNTech vaccine dose with SARS-CoV-2 infection
About The Study: Researchers found that 4-dose recipients of the Pfizer-BioNTech vaccine had a lower risk of acquiring COVID-19 than 3-dose recipients during the peak Omicron variant wave in this study of 29,000 health care workers in Israel. Authors: Allon E. Moses,…
RNA-Binding Protein Intrinsically Suppresses Lung Inflammation in Asthma
Innate lymphoid cells (ILCs) promote lung inflammation in asthma but little is known about how they are suppressed. Researchers at University of California San Diego School of Medicine found RNA-binding protein RBM3 is increased in human and mouse ILCs during…
Association of state COVID-19 vaccine mandates with staff vaccination coverage, staffing shortages in nursing homes
This study of nursing homes in 38 states found that states with a vaccine mandate experienced an increase in staff vaccination coverage compared with facilities in states with no mandate and no worsening of reported staffing shortages following the mandates.
A methodological leap in the exploration of memory
Neurons communicate with each other across synapses, areas of close contact where neurotransmitter molecules released from one neuron act on receptors embedded in the membrane of the opposite neuron.
Sylvester Leads Study on New Treatment Option for Brain Tumor that Relapses or Fails to Respond to Standard of Care
Taken twice daily, oral olutasidenib helped to stabilize relapsed or refractory gliomas in heavily pretreated patients with less toxicity than standard of care treatment, according to a study led by Sylvester Comprehensive Cancer Center at the University of Miami School…
Investigational test may detect Alzheimer’s disease at early stages
Currently, the only accurate diagnosis of Alzheimer’s disease is through postmortem analyses after a patient dies, but investigators have now developed a highly sensitive method for quantifying levels of tau protein—a hallmark of the condition—in cerebrospinal fluid surrounding the brain and spinal cord.
Marijuana Plant Might Hold Key to Treating Chronic Inflammation
Rockville, Md. (July 18, 2022)—Several minor cannabinoids contained in the cannabis plant “strongly inhibit” the activation of human immune cells that lead to chronic inflammation, according to physiologists at The Queen’s Medical Center and University of Hawaii. The study also…
Key Enzyme Identified in Protection of Beta Cells and Regulation of Insulin
Rockville, Md. (July 14, 2022)—Physiologists at the Medical College of Wisconsin have identified the enzyme thioredoxin reductase as playing a key role in protecting beta cells from oxidative stress and in the regulation of insulin secretion. Researchers also show in…
Exploring Improved Treatment for Advanced-Stage Hodgkin’s Lymphoma
Hodgkin’s lymphoma is a type of cancer that affects the lymphatic system, which is part of the body’s germ-fighting immune system. For patients with advanced-stage Hodgkin’s Lymphoma, the standard approach for treatment usually includes a four-drug chemotherapy called ABVD, which…
New structure found in cells
A research group led by Rohit Pappu in the McKelvey School of Engineering and Anthony Hyman at the Max Planck Institute have discovered a new, relevant level of structure in cells.
Sylvester Plays Pivotal Role in Practice-Changing Anal Cancer Prevention Study Published by NEJM
The New England Journal of Medicine (NEJM) has published the results of a study by Sylvester Comprehensive Cancer Center at the University of Miami Miller School and other investigators on anal cancer prevention in people living with HIV (PLHIV) that will likely establish a…
Behavioral Change Factors and Retention in Web-Based Interventions for Informal Caregivers of People Living With Dementia: Scoping Review
Background: Web-based interventions aimed at supporting informal caregivers of people living with dementia have the potential to improve caregivers’ well-being and psychological health. However, few interventions are widely impleme…
Performance-related bonuses for family healthcare workers in Brazil can improve the quality of primary health care, especially in more deprived areas
In your coverage, please use this URL to provide access to the freely available paper in PLOS Medicine: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004033 Press-only preview: https://plos.io/3bwE7XK Image Caption: PMAQ (National Programme for Improving Primary Care Access and Quality) score by municipality bonus design in the matched sample. Image Credit: Fardousi…
Chemo-Radio-Immunotherapy Treats Local Cancers, Minimizes Side Effects
In a study published July 5, 2022, researchers at University of California San Diego School of Medicine present a three-prong approach to targeting local cancers while minimizing adverse effects in other parts of the body. The precision cancer therapy combines…
‘One Health’ Approach Is Necessary to Address Rising Environmental Causes of Childhood Cancers
A multi-disciplinary, “One Health” approach to cancer research is necessary to guide society in reduction of toxic substances, as well as regulation of chemical impacts on the environment and public health, according to an editorial published recently in Issue II of Annals of Research in Oncology.
Women earn less than men overall, but the gender pay gap is smaller in occupations with a higher ratio of male employees, according to study of over 6,000 Germans
Women earn less than men overall, but the gender pay gap is smaller in occupations with a higher ratio of male employees, according to study of over 6,000 Germans Press-only preview: https://plos.io/3Of0cIM Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270343 Article Title: The gender pay gap is smaller…
Leading Causes of Death in US During Pandemic
About The Study: Heart disease, cancer, COVID-19, accidents and stroke were the most common causes of death in the United States from March 2020 to October 2021 during the pandemic, with COVID-19 accounting for 1 in 8 deaths, according to this…