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UrduHighlights Microorganisms can effectively extract scandium (Sc) from ore and waste. Microbial biomass can be used for Sc concentration and separation from other elements. Sc stimulates cryptic genes and the metabolism of microbes. Sc-based microbial technologies have great potential in…
Category: Research Alert
High Social Vulnerability Predicts Worse Long-Term Outcomes After Traumatic Injury
Traumatic injuries — such as physical injuries resulting from a car accident, fall, gunshot or stabbing — are one of the most common causes of impairment and disability worldwide. A team of investigators led by Juan P. Herrera-Escobar, MD, MPH,…
Continuity of Primary Care Reduces Hospitalizations in People with Chronic Kidney Disease
People with chronic kidney disease (CKD) require three- to eight-times higher levels of acute care than the general population for comorbidities such as hypertension, diabetes and cardiovascular disease. It is unclear how regular access to primary care influences subsequent acute…
Study finds higher excess deaths during Omicron period compared to Delta period in Massachusetts
WHO: Jeremy Faust, MD, Department of Emergency Medicine, Brigham and Women’s Hospital, corresponding author of JAMA paper WHAT: The COVID-19 pandemic has led to excess deaths — a higher number of fatalities than would be expected over a given period. A new study compares…
Researchers uncover how tumors circumvent prostate cancer therapy, identify promising treatment strategy
A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…
UCI-led study explores the value of cross-sector coalitions in addressing food insecurity
Cross-sector coalitions can be a powerful driver of change in low-income, urban communities of color with high rates of chronic disease and food insecurity, according to a recent study led by a researcher at the University of California, Irvine, and…
Readability of English, German, and Russian Disease-Related Wikipedia Pages: Automated Computational Analysis
Background: Wikipedia is a popular encyclopedia for health- and disease-related information in which patients seek advice and guidance on the web. Yet, Wikipedia articles can be unsuitable as patient education materials, as investiga…
The Accuracy of Artificial Intelligence in the Endoscopic Diagnosis of Early Gastric Cancer: Pooled Analysis Study
Background: Artificial intelligence (AI) for gastric cancer diagnosis has been discussed in recent years. The role of AI in early gastric cancer is more important than in advanced gastric cancer since early gastric cancer is not easi…
Comparing SARS-CoV-2 antibody response after Moderna, Pfizer-BioNTech vaccines in immunosuppressed patients
About The Study: Researchers compared antispike antibody titers after the 2-dose Pfizer-BioNTech and Moderna COVID-19 vaccines in incrementally immunosuppressed patients. These individuals, such as people with rheumatic and musculoskeletal diseases and solid organ transplant recipients, have decreased immune responses to these…
Study Finds Wide Variations in Prostate Cancer Risk Within Hispanic Subgroups
Research underscores the need to subdivide Hispanics and other racial and ethnic groups to fully understand actual disparities. Brandon A. Mahal, M.D. In a massive study, clinical researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School…
Research on Digital Technology Use in Cardiology: Bibliometric Analysis
Background: Digital technology uses in cardiology have become a popular research focus in recent years. However, there has been no published bibliometric report that analyzed the corresponding academic literature in order to derive k…
Triage Accuracy of Symptom Checker Apps: 5-Year Follow-up Evaluation
Background: Symptom checkers are digital tools assisting laypersons in self-assessing the urgency and potential causes of their medical complaints. They are widely used but face concerns from both patients and health care professiona…
Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational
Background: Digital health interventions could help to prevent age-related diseases, but little is known about how older adults engage with such interventions, especially in the long term, or whether engagement is associated with cha…
The Effects of a Web-Based Tool for Parents of Children With Juvenile Idiopathic Arthritis: Randomized Controlled Trial
Background: Juvenile idiopathic arthritis (JIA) is a group of autoinflammatory diseases that cause pain and disability if not controlled by treatment. Parenting a child with JIA is stressful for parents, who express concerns about th…
The Influence of Perceived Social Presence on the Willingness to Communicate in Mobile Medical Consultations: Experimental Study
Background: With the rise of online health care service, there is growing discussion on the relationship between physicians and patients online, yet few researchers have paid attention to patients’ perception of social presence, es…
eHealth Tools That Assess and Track Health and Well-being in Children and Young People: Systematic Review
Background: eHealth tools that assess and track health outcomes in children or young people are an emerging type of technology that has the potential to reform health service delivery and facilitate integrated, interdisciplinary care…
Improving Research Patient Data Repositories From a Health Data Industry Viewpoint
Organizational, administrative, and educational challenges in establishing and sustaining biomedical data science infrastructures lead to the inefficient use of Research Patient Data Repositories (RPDRs). The challenges, including but not limited to …
Multimodal Chronic Pain Therapy for Adults via Smartphone: Randomized Controlled Clinical Trial
Background: Combination therapies delivered remotely via the internet or mobile devices are increasingly being used to improve and promote the self-management of chronic conditions. However, little is known regarding the long-term ef…
New tech can double spectral bandwidth in some 5G systems
Using the properties of a unique class of materials, researchers, including Aravind Nagulu at the McKelvey School of Engineering, may have found a way to dramatically increase the bandwidth available for wireless communications.
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid …
Renal fibrosis is a common pathological process of chronic kidney diseases induced
by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance
the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …
Risk prediction of CMV reactivation after allogeneic stem cell transplantation using five non-HLA immunogenetic polymorphisms
Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV)
infection, it remains as one of the most common infectious complications after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …
Treatment Efficacy Score a Better Way to Predict Long-Term Survival in Breast Cancer Trials
In a study led by Dr. Lajos Pusztai, Professor of Medicine (Medical Oncology) at Yale Cancer Center, researchers across various institutions, and on behalf of the I-SPY consortium, developed a novel continuous residual cancer based metric to compare neoadjuvant chemotherapy efficacy between randomized trial arms in preoperative breast cancer trials.
The Effect of Dissemination Pathways on Uptake and Relative Costs for a Transdiagnostic, Self-guided Internet Intervention for Reducing Depression, Anxiety, and Suicidal Ideation: Comparative Implementation Study
Background: Self-guided web-based programs are effective; however, inadequate implementation of these programs limits their potential to provide effective and low-cost treatment for common mental health problems at scale. There is a …
A Virtual Community of Practice to Support Physician Uptake of a Novel Abortion Practice: Mixed Methods Case Study
Background: Virtual communities of practice (VCoPs) have been used to support innovation and quality in clinical care. The drug mifepristone was introduced in Canada in 2017 for medical abortion. We created a VCoP to support implemen…
Health Care Professionals’ Experiences of Web-Based Symptom Checkers for Triage: Cross-sectional Survey Study
Background: Web-based symptom checkers are promising tools that provide help to patients seeking guidance on health problems. Many health organizations have started using them to enhance triage. Patients use the symptom checker to re…
Direct measurement of optical properties of glacier ice using a photon-counting diffuse LiDAR
Physicists from the University of Oregon’s Oregon Center for Optical Molecular and Quantum Science along with glaciologists from the Department of Geography as well as the Oregon Glacier Institute spent the last year developing a new measurement technique to investigate…
Disturbance of calcium homeostasis and myogenesis caused by TET2 deletion in muscle stem cells
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell
proliferation and differentiation, leading to notable changes in mouse body weight
and muscle morphology during development. We further assayed the genome-wide …
New UM Study Adds New Perspective on Latino Health in the U.S.
Dr. Olveen Carrasquillo, a principal investigator with the NIH’s All of Us research program at the University of Miami, just today published a new study that tests the Latino Epidemiological Paradox–a heavily debated finding that despite having more risk factors…
Reversal of Heart Enlargement Differs in the Sexes; Doesn’t Use Universal Signaling Pathways
Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…
Sex Differences in Rat Heart Ventricle Function Aren’t Caused Only by Hormones
Article title: Female rats are less prone to clinical heart failure than male rats in a juvenile rat model of right ventricular pressure load Authors: Guido P.L. Bossers, Quint A.J. Hagdorn, Anne Marie C. Koop, Diederik E. van der Feen,…
Researchers Explore Manipulation of Proteins as Way to Leverage Changes in Extracellular Matrix
Article title: PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2 Authors: Andrew L. Hellewell, Kate J. Heesom, Mark A. Jepson, Josephine C. Adams From the authors: “Thus, manipulation of PDIA3 or other relevant resident proteins within the…
High Blood Insulin Levels Lead to More Nervous System Activity in Muscles
Article title: Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans Authors: Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabañas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg…
Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease
Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…
Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity
Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…
Study Explores Function and Characteristics of Enteric Nervous System Cells in Context of Injury
Article title: Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury Authors: Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek,…
Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease
Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…
Light Exposure Enhances Circadian Rhythm Protein, Protects against Bacterial Lung Injury in Mice
Article title: Intense light elicited alveolar type 2 specific circadian PER2 protects from bacterial lung injury via BPIFB1 Authors: Yoshimasa Oyama, Sydney R. Shuff, Nana Burns, Christine U. Vohwinkel, Tobias Eckle From the authors: “Our studies indicate that light-elicited [alveolar…
Public Beware: Study Finds Potential for Massive Cancer Nutrition Misinformation on Pinterest
A multi-center team including researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine claims that the social media site Pinterest is rife with cancer misinformation. Their study found that about a third of posts…
Association of raising US-Mexico wall with migrant deaths, trauma center admissions, injury severity
About The Study: This retrospective trauma registry study of the University of California, San Diego level 1 trauma center, which receives patients with border wall injuries from San Diego and Imperial counties, examined deaths, injuries and hospital costs after construction of…
A Framework for Femtech: Guiding Principles for Developing Digital Reproductive Health Tools in the United States
The United States has abysmal reproductive health indices that, in part, reflect stark inequities experienced by people of color and those with preexisting medical conditions. The growth of “femtech,” or technology-based solutions to women’s he…
Wonder of Wonders, Miracle of Miracles: The Unprecedented Speed of COVID-19 Science
Article title: Wonder of Wonders, Miracle of Miracles: The Unprecedented Speed of COVID-19 Science Author: Michael Saag From the author: “Although a wide variety of scientific disciplines established the platform upon which the remarkable response to COVID-19 was based, the study…
Oncology specialists’ perspective on caring for patients with cancer during the early days of war in Kyiv, Ukraine
Recently, members of The Institute for Cancer Care at Mercy Medical Center oncology research team, working in conjunction with two oncologists in war-torn Ukraine, developed a report now appearing in THE LANCET/Oncology, describing the challenges faced in cancer care delivery under…
Hype up fitness to support kids’ health post-lockdowns
As COVID-19 reaches record levels in the UK, health experts are calling for a focus on children’s physical fitness as new research reveals concerning changes to children’s health and physical fitness following the pandemic.
Female Mice More Susceptible to Salt-induced Hypertension and Kidney Dysfunction
Rockville, Md. (April 27, 2022)—A new study finds male and female mice with a novel mutation in the protein cullin3 that causes deletion of the coding region exon-9 developed salt-induced high blood pressure and renal injury. The effect of salt…
The significance of all life can be left in traceable way: Freshwater pearl mussels
Freshwater pearl mussels are found in rivers in Japan.
Extremely rapid up-and-down motions of island arc crust during arc-continent collision
Mountain building and the rock cycle often involve large vertical crustal motions, but theirrates and timescales in unmetamorphosed rocks remain poorly understood.We utilize high-resolution magneto-biostratigraphy and backstripping analysis of marine deposits in an activearc-continent suture zone of eastern Taiwan to…
Study finds markups in prices of cancer therapies, lack of price transparency across cancer centers
U.S. spending on cancer therapies has risen sharply in recent years. Researchers from Brigham and Women’s Hospital analyzed data on drug pricing from 61 National Cancer Institute-designated cancer centers to determine how much U.S. hospitals mark up the price of…
Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
… stem cell commitment, the field’s mechanistic understanding of this phenomenon
largely derives from simplified two-dimensional (2D) culture substrates. Here, we
found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
Auxilin regulates intestinal stem cell proliferation through EGFR
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the
activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data
uncover the underlying mechanism of Aux in stem cell proliferation control and …
Moderate solar flare erupts from sun
The Sun emitted a moderate solar flare on April 20, 2022, peaking at 9:59 p.m. EST. NASA’s Solar Dynamics Observatory, which watches the Sun constantly, captured an image of the event.