Mouse Model of COVID-19–induced Lung Injury May Aid Development of Coronavirus Treatments

Article title: The SARS-CoV-2 spike protein subunit 1 induces COVID-19–like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells Authors: Ruben Colunga Biancatelli, Pavel Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul Ellis Marik, John…

Chronic Alcohol Consumption Inhibits Intestinal Absorption of Vitamin B7, May Lead to Deficiency

Article title: Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites Authors: Kalidas Ramamoorthy, Subrata Sabui, Padmanabhan Srinivasan, Saleh Al-Juburi, Quang Pham, Brian D. Chu, Rita D. Simoes, James M.…

Rat Model of Preeclampsia Gives new Insight into Immunological Changes during Pregnancy

Article title: Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia Authors: Erin B. Taylor, Eric M. George, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser From the authors: “The current study…

Intrauterine Growth Restriction in Rats Causes Long-term Increases in Offspring’s Blood Pressure, Impairs Renal Artery Vascular Tone

Article title: Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction Authors: Jenny Voggel, Lubomir Lubomirov, Felix Lechner, Gregor Fink, Eva Nüsken, Maria Wohlfarth, Gabriele Pfitzer, Kija Shah-Hosseini, Martin Hellmich, Miguel A. Alejandre…

Lack of DUSP5 Protein Leads to Pulmonary Hypertension and Heart Enlargement in Mice

Article title: DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy Authors: Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Marcello Rubino, Emma L. Robinson, Maria A. Cavasin, Matthew S. Stratton, Andrew M. Kidger, Tianjing…

Editors’ Choice—Quantification of the Impact of Chemo-Mechanical Degradation on the Performance and Cycling Stability of NCM-Based Cathodes in Solid-State Li-Ion Batteries

The use of solid electrolytes in lithium batteries promises to increase their power and energy density, but several challenges still need to be overcome. One critical issue is capacity-fading, commonly ascribed to various degradation reactions in the composite cathode. Chemical,…

UNLV Alzheimer’s Researcher and Expert Panel Present First-Use Recommendations For Aducanumab

A group of six leading Alzheimer’s experts has convened to make the first recommendations for the appropriate use of aducanumab (Aduhelm, Biogen/Eisai), a newly approved treatment for early Alzheimer’s disease. The recommendations will help provide clinicians with greater clarity and…

Deterrence against terrorist attacks in sports-mega events: A method to identify the optimal portfolio of defensive countermeasures

Sports mega-events, such as the upcoming Olympic Games, are ideal targets for terrorist attacks, due to their visibility, size, and number of people involved. Sports mega-events differ from other well-studied counter-terrorism analysis due to the defensive measures being made public…

Automobile class society

Up to now passenger cars are classified by experts in each country into categories such as micro, small, middle, upper middle, large and luxury class. But this old fashioned method has limitations in terms of compatibility. Moreover, some crossover vehicles are difficult to categorize. Empa scientists found a method to do this sorting fairly and in an efficient way by browsing databases with machine learning methods.

Earthquake Threat! Understanding the Intention to Prepare for the Big One

How do people in high-risk regions for natural disasters, perceive risks and what influences their intentions to prepare? A new study, soon to be published in the journal Risk Analysis, investigates whether residents of higher-risk earthquake areas within the region…

Equity and Vaccine Allocation: Beyond Ethics in Prioritization to Equitable Production, Distribution, and Consumption

In a new paper in Ethics & International Affairs, Binghamton University Professor of Philosophy Nicole Hassoun first considers existing proposals for equitable vaccine allocation focusing on the COVID-19 Vaccines Global Access (COVAX) facility. She then argues that to better promote…

Protein Deficiency Impairs Muscle Clock, Mitochondrial Function in Muscular Dystrophy

Article title: Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice Authors: Justin P. Hardee, Marissa K. Caldow, Audrey S.M. Chan, Stuart K. Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S. Lynch From the authors: “These findings suggest that…

American Journal of Medical Quality supplement explores innovative solutions to health care quality and performance improvement

July 2, 2021 – For health care organizations looking to improve performance and patient experiences, implementing data-driven solutions can be effective when focusing on addressing health equity and reducing patient length of stay. These topics are explored in selected member-submitted abstracts…

Fat Tissue Protein Signaling May Lead to Treatment to Improve Heart Health in People Who Can’t Exercise

Article title: Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin Authors: Jacob T. Caldwell, Karissa M. Dieseldorff Jones, Hyerim Park, Jose R. Pinto, Payal Ghosh, Emily C. Reid-Foley, Brody Ulrich, Michael D. Delp, Brad…

Reduced Expression of Dual Oxidase 1 Enzyme May Contribute to Age-related Emphysema

Article title: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema Authors: Caspar Schiffers, Lennart K.A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M.…

Engineered Neural Networks Help ID Responses Associated with Abnormalities in Parkinson’s Disease

Article title: Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks Authors: Vibeke D. Valderhaug, Kristine Heiney, Ola Huse Ramstad, Geir Bråthen, Wei-Li Kuan, Stefano Nichele, Axel Sandvig, Ioanna Sandvig From the authors: “In this study, we investigate the…

Organizational Resilience to Disruption Risks: Developing Metrics and Testing Effectiveness of Operational Strategies

This study draws from the system resilience literature to propose three different metrics for evaluating the resilience performance of organizations against disruptions: the initial loss due to the disruption, the maximum loss, and the total loss over time. The first…

System analysis of wildfire-water supply risk in Colorado, U.S.A. with Monte Carlo wildfire and rainfall simulation

Water supply impairment from increased contaminant mobilization and transport after a wildfire is a major concern for communities that depend on surface water from fire prone watersheds. This work demonstrates the importance of considering water system characteristics when assessing wildfire…

Assessing the Risk of Robbery in Bank Branches to Reduce Impact on Personnel

Although bank robbery has been declining over the last decades, there are still offenders willing to rob bank branches, even if economic benefits are small. The impact from bank robberies goes well beyond the direct economic loss with considerable human toll and possible psychological after-effects on employees, customers or police officers. Sometimes, the consequences are fatal.