Discovery of New Element in Class of Enzymes Informs Cancer Drug Design
The enzyme mTORC2 has been an enigmatic regulator of other enzymes (kinases) such as Protein Kinase C (PKC) and Akt. Now
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Editors’ Choice—Power-Generating Electrochemical CO2 Scrubbing from Air Enabling Practical AEMFC Application
Anion exchange membrane fuel cells (AEMFCs) have been widely touted as a low-cost alternative to existing proton exchange membrane fuel
Read moreStudy Identifies Similar Problems Prior to Nurse Suicide
In a new national study from UC San Diego Health, researchers found that nurses who lose a nursing position or
Read moreImpaired Potassium Channels Cause Vascular Problems in Traumatic Brain Injury
New research published ahead of print in the journal Function finds that traumatic brain injury (TBI) disrupts inward-rectifier potassium channel
Read moreEditors’ Choice—Ionomer Side Chain Length and Equivalent Weight Impact on High Current Density Transport Resistances in PEMFC Cathodes
Cell voltage at high current densities (HCD) of an operating proton-exchange membrane fuel cell (PEMFC) suffers from losses due to
Read moreNew Research First to Link Sinus Inflammation with Brain Changes
In a new study published in JAMA Otolaryngology-Head & Neck Surgery on April 8, 2021, researchers have identified certain cognitive
Read moreEditors’ Choice—A Miniaturized Enzymatic Biosensor for Detection of Sensory-Evoked D-serine Release in the Brain
D-serine has been implicated as a brain messenger with central roles in neural signaling and plasticity. Disrupted levels of D-serine
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First results from Fermilab’s Muon g-2 experiment strengthen evidence of new physics
The long-awaited first results from the Muon g-2 experiment at the U.S. Department of Energy’s Fermi National Accelerator Laboratory show
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Mount Sinai researchers discover multiple types of DNA methylation from individual bacteria and microbiome using nanopore sequencing
MEDIA ADVISORY – UNDER EMBARGO UNTIL Monday, April 5 at 11:00 AM EST Journal Name: Nature Methods Title of the
Read moreResearch examines market design to accelerate COVID-19 vaccine supply
Each month, COVID-19 kills hundreds of thousands of people, reduces global gross domestic product (GDP) by hundreds of billions of
Read moreResearchers Use Two-photon Microscopy, Optical Coherence Tomography to View Age-related Blood-brain Barrier Changes
Article title: Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by two-photon microscopy and optical coherence tomography
Read moreNot a Musician? Your Brain Can Still Tell What’s Music
Article title: Music-selective neural populations arise without musical training Authors: Dana Boebinger, Samuel Norman-Haignere, Josh H. McDermott, Nancy Kanwisher From the
Read moreSurprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury
Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan
Read moreBlood Pressure Drug Losartan Found to Improve Nicotine-induced Pulmonary Hypertension in Mice
Article title: Angiotensin-II type 1 receptor mediates pulmonary hypertension and right ventricular remodeling induced by inhaled nicotine Authors: Nicholas D.
Read moreStudy Explores Effects of Exercise on Heart, Lung and Metabolic Physiology during Dialysis
Article title: Cardiopulmonary and metabolic physiology during hemodialysis and inter-/intra-dialytic exercise Authors: Scott McGuire, Elizabeth Jane Horton, Derek Renshaw, Klaris Chan,
Read moreBetamethasome before Delivery May Preserve Right Ventricular Heart Function in Preemies
Article title: Antenatal betamethasone redistributes central blood flows and preferentially augments right ventricular output and pump function in preterm fetal
Read morePlacental Stem Cells Show Promise for Treating Preemies’ Necrotizing Enterocolitis
Article title: Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis Authors: Victoria G. Weis, Anna C. Deal, Gehad Mekky,
Read moreNewly Identified Pathway, Biomarkers May Be Tools to Prevent Kidney Injury-induced Lung Damage
Article title: Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury Authors: Mark Hepokoski, Jing Wang,
Read moreAssociation between Hypertension and Gut Microbiome Imbalance during Pregnancy May Lead to New Preeclampsia Treatments
Article title: Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension Authors: Jeanne
Read moreIL-28 Cytokine’s Epithelial Barrier Regulation May Lead to Targeted Treatment for Crohn’s Disease
Article title: Interleukin-28A induces epithelial barrier dysfunction in [Crohn’s disease] patient-derived intestinal organoids Authors: Pan Xu, Heike Becker, Montserrat Elizalde,
Read moreHow do People Judge Risk? Availability may Upstage Affect in the Construction of Risk Judgments
In a new study published in the journal Risk Analysis, author Emir Efendić explores how people judge risk. Heuristics are
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Removal of AKAP11 Protein by Autophagy as a Key to Fuel Mitochondrial Metabolism and Tumor Cell Growth Through Activating Protein Kinase A (PKA)
MEDIA ADVISORY FOR IMMEDIATE RELEASE: Proceedings of the National Academy of Sciences of the United States (PNAS) Published Online on
Read moreUCLA issues policy brief on reducing COVID vaccine hesitancy in multiethnic Los Angeles communities
The UCLA-led coalition called the COVID-19 California Alliance, or STOP COVID-19 CA has issued a policy brief to reduce COVID-19
Read moreLower Enzyme Expression Prevents Elastin Insufficiency-induced Hypertension
New research published ahead of print in the journal Function suggests that blocking the expression of the NOX1 enzyme in
Read moreParty Drug MDMA Doesn’t Mix Well With Many Other Meds
Midomafetamine (MDMA), also known as ecstasy or molly, is a psychoactive drug primarily used for recreational purposes, but it’s now
Read moreApril 2021 study in DISEASES OF THE COLON AND RECTUM introduces a modification of Sir Alan Parks classification of anal fistula
The Parks classification has been used for the classification of anal fistula for several years, but it does not allow for risk
Read moreLarge computer language models carry environmental, social risks
Computer engineers at the world’s largest companies and universities are using machines to scan through tomes of written material. The goal? Teach these machines the gift of language. Do that, some even claim, and computers will be able to mimic the human brain.
But this impressive compute capability comes with real costs, including perpetuating racism and causing significant environmental damage, according to a new paper, “On the Dangers of Stochastic Parrots: Can Language Models Be Too Big?
Read moreEvidence-Based Care of Children With Tracheostomies: Hospitalization to Home Care
This issue contains a clinical update of evidence-based care of children with tracheostomies. The article reviews both stoma care and
Read moreDevelopment and Validation of an Age-Appropriate Website for Children Requiring Clean Intermittent Catheterization
Our nursing colleagues in Brazil developed an age-appropriate website for pre-school aged children requiring clean intermittent catheterization (CIC). The website
Read moreEffects of Laughter Therapy on Life Satisfaction and Loneliness in Older Adults Living in Nursing Homes in Turkey: A Parallel Group Randomized Controlled Trial
Researchers sought to determine if laughter therapy could make a difference in the life satisfaction and loneliness of older adults
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New Mouse Line Leads to Noninvasive Study of Mitochondrial Calcium Signaling
New research published ahead of print in the journal Function explores the creation of a new transgenic mouse line that
Read moreNicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation
MEDIA ADVISORY – FOR IMMEDIATE RELEASE Published March 5, 2021 in Science Advances Mount Sinai Researchers find a new way to
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Shade-Grown Coffee Could Help Save Birds, If Only People Knew About It
The message about the bird-conservation benefits of shade-grown coffee may not be getting through to the people most likely to
Read moreResearchers ID New Mechanism to Promote Healing of Digestive System’s Mucus Barrier
Article title: Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function Authors: Bridie Jane Goggins,
Read moreExercise Improves Blood Vessel Dysfunction Caused by Lack of Sleep
Article title: Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep Authors: Kelly A. Stockelman, Anthony R. Bain,
Read moreAirway Smooth Muscle Clock May Be a Target for Treating Preemies
Article title: Cellular clocks in hyperoxia effects on [Ca2+]i regulation in developing human airway smooth muscle Authors: Colleen M. Bartman,
Read moreStudy Explores Way to Block Liver Cancer Interaction with Nervous System
Article title: AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro Authors: Katrin Böttcher,
Read moreNicotine Damages Kidney Filters in Smokers with Diabetes
Article title: Nicotine, smoking, podocytes and diabetic nephropathy Authors: Edgar A. Jaimes, Ming-Sheng Zhou, Mohammed Siddiqui, Gabriel Rezonzew, Runxia Tian, Surya
Read morePostmenopausal Estrogen Drop May Increase Taste for Fat, Drive Weight Gain
Article title: Sex differences in fat taste responsiveness are modulated by estradiol Authors: Naima S. Dahir, Ashley N. Calder, Blake
Read moreHigh Potassium May Interfere with Electrolyte Balance in Kidneys
Article title: WNKs are potassium-sensitive kinases Authors: John M. Pleinis, Logan Norrell, Radha Akella, John M. Humphreys, Haixia He, Qifei
Read moreShift Work Disrupts Kidney Rhythms, Contributes to Kidney and Heart Disease
Article title: Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of
Read moreMarijuana May Increase Risk of Heart Disease in Healthy Adults
Article title: Habitual cannabis use is associated with altered cardiac mechanics and arterial stiffness, but not endothelial function in young
Read moreBuilding gender equity in surgery: unless we are comfortable to wait until the year 2136, there is some serious work to do
Read more in the March 2021 issue of Diseases of the Colon and Rectum about a study by Dr Yu-Ting van
Read moreEffectiveness of HIIE versus MICT in Improving Cardiometabolic Risk Factors in Health and Disease
A healthy lifestyle is composed primarily of regular structured physical activity (i.e., exercise). As a result, there is vast research
Read moreDoes More Physical Activity and Less TV Viewing Reduce the Risk of Death?
Insufficient physical activity and sedentary behavior are both associated with higher risk of chronic disease and death. However, the long-term
Read moreBlood-flow Restriction Training Delay the Progression of Chronic Kidney Disease
Chronic kidney disease (CKD) is recognized as a public health problem, affecting more than 15% of the population. Although CKD
Read moreReduced Sitting Time Improves Blood Flow in Brain and Legs
During a regular day, the average person sits for eight to 10 hours. These high levels of sitting time seem
Read moreAttenuated Rapid-Onset Vasodilation to Forearm Muscle Contraction in Black Men
Kaur and colleagues reported that rapid onset vasodilation induced by a single contraction of the forearm muscles was significantly attenuated
Read moreTime-restricted Eating Reduces Body Weight in Runners without Impacting Performance
Intermittent fasting is becoming increasingly popular due to its simple advice: Don’t change what you eat; simply change when you
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Treating Parasites with Cancer Drugs
Entamoeba histolytica is a parasitic disease affecting up to 50 million people and killing more than 50,000 people each year
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