Mount Sinai Cardiologist Develops New Risk Score to Help Predict Possible Contrast-Associated Kidney Injury After Percutaneous Coronary Intervention

Assessment can help stratify high-risk patients for monitoring before, during, and after procedures to improve outcomes

Bioprinted 3D Cardiac Patches Could Reverse Scar Formation, Promote Myocardial Regeneration After Heart Attacks

Myocardial infarction, or heart attacks, play a large part in heart diseases and the necrosis of cardiac tissue. In APL Bioengineering, researchers take stock of stem cell-laden 3D-bioprinted cardiac patch technologies and their efficacy as a therapeutic and regenerative approach for ischemic cardiomyopathy in reversing scar formation and promoting myocardial regeneration. They explore types of candidate stem cells that possess cardiac regenerative potential and share updates on the challenging implementation of the state-of-the-art 3D-bioprinting approach.

Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury

Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…

Cutting Down But Not Out: Very-Heavy Drinkers Needn’t Quit Completely for Cardiovascular Benefit

High-risk drinkers who substantially reduce their alcohol use can lower their risk of cardiovascular disease (CVD) despite not completely abstaining, according to study findings published in Alcoholism: Clinical and Experimental Research. CVD encompasses a range of conditions involving the heart or blood vessels, and is the leading cause of death in the US. It is also one of many negative health outcomes associated with heavy drinking and alcohol use disorder (AUD). Reductions in drinking can be defined using World Health Organization (WHO) ‘risk drinking levels’, which classify drinkers into ‘very high’, ‘high’, ‘moderate’ and ‘low’ risk categories based on their average daily alcohol consumption. Previous research has shown that a reduction of two or more levels (for example, from ‘very high’ to ‘moderate’) can lower the risk of multiple health issues, but did not assess the impact on CVD specifically. The latest study has examined associations between reductions in WHO risk drinking

Study Explores Role of Extracellular Vesicles in Tissue Repair after Heart Attack

Article title: CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent pro-angiogenic phenotype Authors: Kyle I. Mentkowski, Asma Mursleen, Jonathan D. Snitzer, Lindsey M. Euscher, Jennifer K. Lang From the authors: “Our study was designed to gain mechanistic insight into the…