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UrduMore than four times as many businesses and clinics than were identified in 2016 are selling stem cell products not approved by the U.S. Food and Drug Administration and lack convincing evidence of safety and efficacy, according to a five-year study conducted by University of California, Irvine Program in Public Health professor of health, society and behavior Leigh Turner. The analysis appears online in the journal Cell Stem Cell.
Tag: Regenerative Medicine
AMSSM Releases Position Statement on Regenerative Medicine in Sports Medicine
The American Medical Society for Sports Medicine (AMSSM) has released a position statement on Principles for the Responsible Use of Regenerative Medicine in Sports Medicine.
UCI receives 5-year, $5 million CIRM award for training of diverse researchers
The University of California, Irvine has received a five-year, $5 million award from the California Institute for Regenerative Medicine to support a comprehensive doctoral, postdoctoral and clinical researcher training program to prepare the current and next generation of leaders in stem cell biology, gene therapy and regenerative medicine.
The Promise of Regenerative Medicine to Treat Chronic Pain
Regenerative medicine has enormous implications for treatment and prevention of chronic pain including conditions like osteoarthritis, diabetic and peripheral neuropathy, and even spinal cord injuries and degenerative disk disease. According to one expert, there is potential to “[turn] back the time clock.”
RegeneratOR Workforce Development Receives NSF Award
With the recent announcement of the RegeneratOR Test Bed to support regenerative medicine start up companies, the Wake Forest Institute for Regenerative Medicine (WFIRM) and the RegenMed Development Organization (RemDO) are embarking on the next step – to help create the future workforce.
Phase Holographic Imaging Supports New RegeneratOR Test Bed with Label Free Non-destructive Live Cell Imaging
Phase Holographic Imaging is collaborating with the RegeneratOR Test Bed, a new regenerative medicine endeavor in North Carolina, by providing its technology to help support start-up companies in the regenerative medicine space.
RegeneratOR Test Bed to Launch Start Ups, Advance Regenerative Medicine Ecosystem
The RegenMed Development Organization (ReMDO), a non-profit foundation headquartered in Winston-Salem, NC, and dedicated to advancing the regenerative medicine field nationwide, and the Wake Forest Institute for Regenerative Medicine (WFIRM), the largest regenerative medicine institute in the world, announce the launch of the RegeneratOR Test Bed.
ACSM Annual Meeting Research Highlights for June 3
ACSM’s comprehensive sports medicine and exercise science conference takes place virtually from June 1 to 5 with programming covering the science, practice, public health and policy aspects of sports medicine, exercise science and physical activity.
Research Highlights from 2021 ACSM Virtual Annual Meeting: Exercise in Regenerative Medicine
The 2021 Virtual ACSM Basic Science World Congress focuses on regenerative medicine. Chaired by Marcas M. Bamman, Ph.D., FACSM, from the University of Alabama at Birmingham, this world congress brings together researchers to discuss cutting-edge science in this rapidly developing field.
Journalists: Be our guest at the 2021 Virtual ACSM Research Conference
Gain story ideas and learn about cutting-edge science at ACSM’s comprehensive sports medicine and exercise science conference that covers the science, practice, public health and policy aspects of sports medicine, exercise science and physical activity.
Helping humans heal
In a lab on the upper floors of Engineering Hall, something is growing. It’s not a plant. And it’s not an animal. What Ronke Olabisi is growing in her lab is us. From new skin and retinal tissue to hearts and livers, she’s developing the tools to rebuild and repair the human body. A UCI assistant professor of biomedical engineering, Olabisi has been working with regenerative tissue for the better part of seven years, using a hydrogel based on polyethylene glycol diacrylate.
UCI biomedical engineers spotlight disparities in knee and jaw joint treatments
Irvine, Calif., May 5, 2021 – If you haven’t had knee surgery, you may have a friend or relative who has. But do you know anyone who has had an operation on their jaw? Although the temporomandibular joint is crucial to speaking, chewing and even breathing, treatments for TMJ disorders are far less common than those for the knee.
Mayo Clinic preclinical discovery triggers wound healing, skin regeneration
Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The Mayo Clinic research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration.
Ischemic wounds occur when arteries are clogged or blocked, preventing important nutrients and oxygen from reaching the skin to drive repair. This groundbreaking study titled, “TGF-β Donor Exosome Accelerates Ischemic Wound Healing,” is published in Theranostics.
Audacious projects develop imaging technology to aid eye tissue regeneration
As regenerative therapies for blinding diseases move closer to clinical trials, the National Eye Institute’s functional imaging consortium, a part of the NEI Audacious Goals Initiative (AGI), is pioneering noninvasive technologies to monitor the function of the retina’s light-sensing neurons and their connections to the brain.
Pericardial Injection Effective, Less Invasive Way to Get Regenerative Therapies to Heart
Injecting hydrogels containing stem cell or exosome therapeutics directly into the pericardial cavity could be a less invasive, less costly, and more effective means of treating cardiac injury.
Evan Snyder named Fellow of the American Institute for Medical and Biological Engineering
The American Institute for Medical and Biological Engineering (AIMBE) has elected to its College of Fellows Evan Y. Snyder, M.D., Ph.D., professor and founding director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute. Snyder was nominated, reviewed, and elected by his peers and members of the College of Fellows for his seminal contributions to regenerative medicine.
Leaders in stem cell science, regenerative medicine combine efforts in 2021
Leaders in stem cell science and regenerative medicine will combine two separate courses into one in June 2021.
Advances in Stem Cell Science and Regenerative Medicine Highlighted in New Regenerative Medicine Essentials Course Co-Located with 2021 World Stem Cell Summit
Leaders in stem cell science and regenerative medicine will combine two separate courses into one in June 2021.
Scientists discover how COVID-19 virus causes multiple organ failure in mice
UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs.
Scientists use bacteria as micro-3D printers
A team at Aalto University has used bacteria to produce intricately designed three-dimensional objects made of nanocellulose. With their technique, the researchers are able to guide the growth of bacterial colonies through the use of strongly water repellent – or superhydrophobic – surfaces.
Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year.
AAOS Advances Biologics Initiative with Innovative Dashboard
The American Academy of Orthopaedic Surgeons (AAOS) continues to demonstrate its commitment to advancing the quality of musculoskeletal care in a fully transparent and scientific way. Debuting today as a new member benefit, the AAOS Biologics Dashboard is a dynamic online tool designed to help orthopaedic surgeons navigate the approval status of biologic-based interventions. The development of the AAOS Biologics Dashboard is just one of several efforts within the Academy’s Biologics Initiative that offers evidence-based guidance to the musculoskeletal health community. An additional effort is the revision of two biologics-related position statements, recently approved by the AAOS Board of Directors.
Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mix of heart muscle, endothelial and smooth muscle cells — all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.
Could a tiny fish hold the key to curing blindness?
Imagine this: A patient learns that they are losing their sight because an eye disease has damaged crucial cells in their retina. Then, under the care of their doctor, they simply grow some new retinal cells, restoring their vision.
Although science hasn’t yet delivered this happy ending, researchers are working on it – with help from the humble zebrafish. When a zebrafish loses its retinal cells, it grows new ones. This observation has encouraged scientists to try hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease. That is why among the National Eye Institute’s 1,200 active research projects, nearly 80 incorporate zebrafish.
Scientists uncover a novel approach to treating Duchenne muscular dystrophy
Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. The study, published in EMBO Reports, reveals a promising new therapeutic approach for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting condition.
Alliance for Regenerative Rehabilitation and Training Receives $5 Million NIH Grant to Continue Innovative Work
The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.
WFIRM Scientists Prove Bioengineered Uteri Support Pregnancy
WFIRM scientists were able to show that bioengineered uteri in an animal model developed the native tissue-like structures needed to support normal reproductive function.
National Eye Institute establishes office of regenerative medicine
The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.
Putting “Super” in Natural Killer Cells
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.
Rejuvenated fibroblasts can recover the ability to contract
A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.
Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.
Growing back the lymph system
Study provides hope for cancer-related lymphedema
Researchers restore sight in mice by turning skin cells into light-sensing eye cells
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes.
UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.
How “Pioneer” Protein Turns Stem Cells into Organs
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.
Leveraging layers for enhanced tissue repair
Bioengineers have created a 3D-printed scaffold designed to regenerate complex tissues composed of multiple layers of cells with different biological and mechanical properties.
‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.
Superior “Bio-Ink” for 3D Printing Pioneered
Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.
Platelet Microparticles Give Antibody Drug ‘Piggyback Ride’ to Repair Damaged Heart
Platelet microparticles are an effective way to deliver therapeutic drugs directly to the heart following a heart attack.
Study Reveals New Way to Treat Stroke Using an Already FDA-Approved Drug
Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. The study is the first to report on the neuroprotective effect of GCSF in vivo and showed that it improved neurological deficits that occur in the first few days following cerebral ischemia. GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model.
Exosomes promote remarkable recovery in stroke
Scientists present brain-imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe stroke.
A Robot and Software Make it Easier to Create Advanced Materials
A Rutgers-led team of engineers has developed an automated way to produce polymers, making it much easier to create advanced materials aimed at improving human health. The innovation is a critical step in pushing the limits for researchers who want to explore large libraries of polymers, including plastics and fibers, for chemical and biological applications such as drugs and regenerative medicine through tissue engineering.
Case report: Stem cells a step toward improving motor, sensory function after spinal cord injury
Stem cells derived from a patient’s own fat offer a step toward improving — not just stabilizing — motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.
Dial In to the Cutting-edge Neuroscience at ANA2019 during the October 15 Media Roundtable
In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.