Tail regeneration in lungfish provides insight into evolution of limb regrowth

A new study published in the Proceedings of the Royal Society B from researchers at the University of Chicago and Universidade Federal do Pará explores regenerative ability in the tails of West African lungfish for the first time, and finds that the process shares many of the same traits as tail regeneration in salamanders. Their results indicate that this trait was likely found in a common ancestor – and provide a new opportunity for better understanding and harnessing the mechanisms of limb regrowth.

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How “Pioneer” Protein Turns Stem Cells into Organs

Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.

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Guarding against a devastating tropical disease

Schistosomiasis is one of the most devastating tropical diseases in the world, second only to malaria in its prevalence. The only treatment currently used is extremely limited in its effectiveness and in who it can help. The Newmark Lab wants to develop something that protects people from being infected in the first place.

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