Mayo Clinic co-leads a new coalition to improve patient care through community-level clinical trials

Mayo Clinic and several health organizations launched the Advancing Clinical Trials at the Point of Care Coalition to improve patient care by giving clinicians quality clinical research evidence in real time to better evaluate treatments and therapeutics, including those to treat COVID-19. The [email protected] coalition will bring together health systems, community-based care organizations, health research organizations and a more diverse group of patients and providers to support the design of adaptable clinical trials and develop digital health tools that make clinical trials simpler to conduct and more accessible to patients.

Seizure forecasting with wrist-worn devices possible for people with epilepsy, study shows

Despite medications, surgery and neurostimulation devices, many people with epilepsy continue to have seizures. The unpredictable nature of seizures is severely limiting. If seizures could be reliably forecast, people with epilepsy could alter their activities, take a fast-acting medication or turn up their neurostimulator to prevent a seizure or minimize its effects.

A new study in Scientific Reports by Mayo Clinic researchers and international collaborators found patterns could be identified in patients who wear a special wristwatch monitoring device for six to 12 months, allowing about 30 minutes of warning before a seizure occurred. This worked well most of the time for five of six patients studied.

Expert Alert: 5 ways patients who are immunocompromised can protect themselves from COVID-19

As families prepare to gather later this month for Thanksgiving, it is important for patients who are immunocompromised to take extra steps to protect themselves from becoming infected with COVID-19. People who are immunocompromised have weakened immune systems, which means they have a higher risk of becoming severely ill from COVID-19.

Mayo Clinic, NAACP join forces to create new pathways to success for Black, underrepresented students

Mayo Clinic and the Rochester Branch of NAACP today launched “RISE for Youth,” an innovative program that will provide Black and underrepresented students with new pathways to success in education and employment, while also addressing the racial disparities that stand in the way of their success. The program is part of Mayo Clinic’s $100 million commitment against racism.

Mayo Clinic researchers find new treatment for HPV-associated oral cancer

Mayo Clinic researchers have found that a new, shorter treatment for patients with HPV-associated oropharynx cancer leads to excellent disease control and fewer side effects, compared to standard treatment.

The new treatment employs minimally invasive surgery and half the standard dose of radiation therapy, compared to current treatments. The new treatment also lasts for two weeks, rather than the standard six weeks.

Concord Hospitality and Whitman Peterson to Construct New Hilton Hotel at Mayo Clinic in Florida

To offer patients and visitors a premiere hospitality experience, Concord Hospitality Enterprises and Whitman Peterson, in collaboration with Mayo Clinic, will build an eight-story Hilton hotel with 252 guest rooms at Mayo Clinic in Florida. Expected to join Hilton’s flagship brand, Hilton Hotels & Resorts, construction on the $70 million project is scheduled to begin in the summer of 2022, with completion slated for early 2024.

Patients in Phoenix area now can benefit from Mayo Clinic’s advanced care at home model of care

Mayo Clinic has expanded its innovative advanced care at home model of care, which provides comprehensive care to patients in the comfort of their own homes, to Mayo Clinic in Arizona. Beginning this week, many patients in the Phoenix and Scottsdale area who otherwise would need to be hospitalized will be able to receive in-person and virtual care through Mayo Clinic’s advanced care at home platform.

Mayo researchers link gut microbiome to rheumatoid arthritis prognosis

A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine.

The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in on the trillions of bacteria, viruses and fungi that inhabit their gastrointestinal tract, known as the gut microbiome. The findings suggest that gut microbes and a patient’s outcome of rheumatoid arthritis are connected.

Mayo Clinic Conference on Brain Health and Dementia to welcome people living with dementia, caregivers and health care providers

The inaugural Mayo Clinic Conference on Brain Health and Dementia will be held virtually on Oct. 29 from 9:15 a.m. to 2:15 p.m. CDT with an optional workshop to follow. The event is a collaboration among Mayo Clinic, AARP and the Alzheimer’s Association.

Mayo Clinic, Verily to build advanced clinical decision support to enhance care

Mayo Clinic and Verily, an Alphabet company founded at the convergence of health care, data science and technology, today announced a strategic two-year collaboration. This collaboration focuses on the development of a digital point-of-care resource of vetted knowledge to support an individualized approach to patient care. This modular, evidence-based decision support solution, will provide contextualized and validated knowledge on disease management, care guidelines and treatment to help clinician’s make decisions.

Combined effects of masking and distance on aerosol exposure potential

The Centers for Disease Control and Prevention (CDC) recommended this week that people vaccinated against COVID-19 resume wearing masks in public indoor spaces in areas of the United States where the virus is spreading. “Appropriate masking in addition to vaccination remain the best methods to help protect individuals from the Coronavirus,” says Gregory Poland, M.D., an infectious disease expert at Mayo Clinic.

20-year Mayo Clinic study suggests return to play is manageable for athletes with most genetic heart diseases

Receiving the diagnosis of a genetic heart disease such as long QT syndrome, which can cause sudden cardiac death, has long been a game-ender for young athletes. But a 20-year study at Mayo Clinic following such athletes who were allowed to return to play suggests that the risks can be managed through a shared decision-making process. The retrospective study findings will be presented at the annual meeting of the Heart Rhythm Society on Tuesday, July 27, and simultaneously published in the Journal of the American College of Cardiology.

Mayo Clinic research suggests women over 65 be offered hereditary cancer genetic testing

A new study by Fergus Couch, Ph.D., of Mayo Clinic Cancer Center, along with collaborators from the CARRIERS consortium, suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study was published Thursday, July 22, in the Journal of Clinical Oncology.

Monoclonal antibodies help COVID-19 patients avoid hospitalization

In a large observational study, Mayo Clinic researchers have shown that two monoclonal antibodies administered separately helped prevent hospitalization in high-risk patients who became infected with COVID-19. The study also showed more hospitalizations were observed among patients with more comorbidities. The findings appear in The Journal of Infectious Diseases.

Strong immune response underlies acute kidney injury related to COVID-19

Mayo Clinic researchers have found that acute kidney injury associated with COVID-19 resembles sepsis-caused kidney injury, and the immune response triggered by the infection plays a pivotal role.

The findings, published in Mayo Clinic Proceedings, also suggest that mitochondrial dysfunction — a loss of function in cellular energy production — is commonly found in kidney injury related to COVID-19.

Mayo research provides insights into high-risk younger demographics for severe COVID-19

Using data from 9,859 COVID-19 infections, Mayo Clinic researchers have new insights into risk factors for younger populations, some of which differ significantly from their older counterparts. People younger than 45 had a greater than threefold increased risk of severe infection if they had cancer or heart disease, or blood, neurologic or endocrine disorders, the research found. These associations were weaker in older age groups. The study was published in Mayo Clinic Proceedings.

Study may show why MS patients develop progressive disability but those with related diseases do not

Did you know multiple sclerosis (MS) means multiple scars? New research shows that the brain and spinal cord scars in people with MS may offer clues to why they developprogressive disability but those with related diseases where the immune system attacks the central nervous system do not.

In a study published in Neurology, Mayo Clinic researchers and colleagues assessed if inflammation leads to permanent scarring in these three diseases:

Monoclonal antibody therapy for COVID-19 safe, effective for transplant patients

Treating transplant patients with mild to moderate cases of COVID-19 with monoclonal antibodies is safe and helps prevent serious illness, according to a Mayo Clinic study recently published in Open Forum Infectious Diseases. These results are especially important because transplant patients who are infected with COVID-19 have a higher risk of severe illness and death.

Senolytics reduce COVID-19 symptoms in preclinical studies

Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, the senolytic drugs discovered at Mayo significantly reduced inflammation, illness, and mortality from COVID infection in older mice. The findings appear in the journal Science.

Remote patient monitoring may reduce need to hospitalize cancer patients

ROCHESTER, Minn. — A study by researchers at Mayo Clinic Cancer Center has found that cancer patients diagnosed with COVID-19 who received care at home via remote patient monitoring were significantly less likely to require hospitalization for their illness, compared to cancer patients with COVID-19 who did not participate in the program. Results of the study were presented Friday, June 4, at the American Society of Clinical Oncology Annual Meeting and published in the Journal of Clinical Oncology.

Mayo Clinic study provides clarity on use of anticoagulants in gastrointestinal cancers

A study by Mayo Clinic researchers provides some clarity in the use of direct oral anticoagulants (DOAC), such as apixaban and rivaroxaban, to treat acute venous thromboembolism (VTE) in patients with gastrointestinal cancers. The findings were published Wednesday, June 2, in Mayo Clinic Proceedings.

La fatiga, el deterioro cognitivo percibido y los trastornos del estado de ánimo se asocian al síndrome posterior a la COVID-19, según un estudio de Mayo Clinic

Los pacientes a los que se les diagnostica el síndrome posterior a la COVID-19, también conocido como “PCS”, “síndrome de COVID-19 de larga duración” y “secuelas posagudas del SARS COV-2”, experimentan síntomas como trastornos del estado de ánimo, fatiga y deterioro cognitivo percibido que pueden afectar de manera negativa el regreso al trabajo y la reanudación de las actividades normales.

El filtro HEPA reduce las partículas respiratorias transmitidas por el aire que se generan durante el ejercicio intenso

Los aerosoles respiratorios son un componente común de la respiración y constituyen una vía común de propagación de virus respiratorios como la COVID-19 a personas y superficies. Los investigadores que realizan pruebas de esfuerzo físico en pacientes con problemas cardíacos en Mayo Clinic hallaron que el ejercicio a niveles mayores de esfuerzo aumentaba la concentración de aerosoles en el entorno circundante. Además, descubrieron que el filtro recogedor de partículas de alta eficiencia (HEPA, por sus siglas en inglés) descartaba de manera eficaz los aerosoles y disminuía el tiempo necesario para purificar el aire entre los pacientes.

As crianças também enfrentam efeitos de longo prazo da COVID-19

Os efeitos de longo prazo da infecção por COVID-19 estão afetando a saúde de algumas crianças e adolescentes, bem como de adultos. Embora a maioria das crianças com infecção por COVID-19 tenha sintomas leves ou nenhum sintoma, qualquer pessoa que teve COVID-19, mesmo se leve ou sem sintomas, pode ter efeitos de longo prazo.

Los niños también enfrentan los efectos a largo plazo de la COVID-19

Los efectos a largo plazo de la infección por COVID-19 están repercutiendo en la salud de algunos niños y adolescentes, además de los adultos. Si bien la mayoría de los niños con infección por COVID-19 tienen síntomas leves o no tienen síntomas en absoluto, cualquier persona que haya tenido COVID-19 (incluso si la enfermedad fue leve o no tuvieron síntomas) puede tener efectos a largo plazo.

Mayo Clinic preclinical discovery triggers wound healing, skin regeneration

Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The Mayo Clinic research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration.

Ischemic wounds occur when arteries are clogged or blocked, preventing important nutrients and oxygen from reaching the skin to drive repair. This groundbreaking study titled, “TGF-β Donor Exosome Accelerates Ischemic Wound Healing,” is published in Theranostics.

Mayo Clinic’s New Research Building Growing to 11 Floors

The long tradition of biomedical innovation that makes up Mayo Clinic’s DNA will continue with the Anna-Maria and Stephen Kellen Building on the Rochester, Minnesota, campus, set to open in the fourth quarter of 2023. Research is the engine that drives advances in medical care, and the new facility will enable the team-based scientists of Mayo Clinic to continue finding care solutions for patients.

Funded in part through a gift from the Anna-Maria and Stephen Kellen Foundation as well as other generous benefactors, the energy-efficient structure will feature 11 floors and 176,000 square feet of flexible laboratory space.

Leading US hospitals team up to promote COVID-19 vaccination

A coalition of 60 top hospitals and health care institutions have joined forces in a nationwide campaign to encourage adults to get vaccinated against COVID-19. Led by Cleveland Clinic and Mayo Clinic, the campaign “Get the Vaccine to Save Lives” is designed to reassure the public that vaccines are safe, effective and necessary to achieve herd immunity and return to normal activities.

Reverse-order heart-liver transplant helps prevent rejection for highly sensitized patients

Patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a higher risk of death while waiting for suitable organs. But there is new hope for highly sensitized patients in need of a combined heart and liver transplant, thanks to an innovative surgical approach at Mayo Clinic.

A medicina de precisão e a tecnologia digital apresentam potencial como ferramentas poderosas contra a tuberculose

A luta global contra a tuberculose está ganhando algumas ferramentas poderosas. A medicina de precisão — já usada para personalizar o diagnóstico e o tratamento de doenças não transmissíveis, como o câncer — e as tecnologias de saúde, como a telemedicina, têm potencial para avançar na prevenção e no tratamento da tuberculose, afirma Zelalem Temesgen, M.D.

精准医学和数字技术有潜力作为抗击肺结核的强大工具

全球抗击肺结核的努力获得了医疗技术的强大助力。精准医学已经用于非传染性疾病(例如癌症)的诊断和治疗,它和远程医学等医疗技术有可能促进结核病的预防和治疗,妙佑医疗国际 (Mayo Clinic) 肺结核中心的传染病专家和医学主任 Zelalem Temesgen 医学博士 说。

信使RNA COVID-19疫苗大幅降低无症状COVID-19感染和传播给他人的风险

接受第二剂信使RNA或mRNA COVID-19疫苗10天后,与未接种COVID-19疫苗的患者相比,无症状COVID-19感染者检测为阳性和在不知不觉中传播COVID-19的可能性大幅降低。Pfizer-BioNTech和Moderna信使RNA COVID-19疫苗已在美国获得紧急使用授权。

As vacinas para COVID-19 de RNA mensageiro reduzem muito o risco de infecção assintomática por COVID-19 disseminada para outras pessoas

Dez dias após receber uma segunda dose de uma vacina para COVID-19 de RNA mensageiro, ou mRNA, pacientes sem sintomas de COVID-19 têm muito menos probabilidade de apresentar teste positivo e espalhar COVID-19 inadvertidamente, em comparação com pacientes que não foram vacinados para COVID-19.

لقاحات الحمض النووي الريبوزي المرسال لفيروس كورونا المستجد (كوفيد-19) تُقلل بشكل كبير من خطر انتشار فيروس كورونا المستجد (كوفيد-19) عديم الأعراض للآخرين

بعد عشرة أيام من تلقي الجرعة الثانية من لقاح الحمض النووي الريبوزي المرسال، أو ما يُسمى بـ mRNA لفيروس كورونا المستجد (كوفيد-19)، فإن المرضى الذين لا يعانون من أعراض فيروس كورونا المستجد (كوفيد-19) هم أقل عرضة بأن تكون نتائجهم إيجابية للاختبار وأقل عرضة أن يقوموا بنشر فيروس كورونا المستجد (كوفيد-19) بشكل غير مقصود، مقارنةً بالمرضى الذين لم يتم تطعيمهم ضد فيروس كورونا المستجد (كوفيد-19). وقد تم التصريح لاستخدام لقاحات الحمض النووي الريبوزي المرسال “بيونتك” الخاصة بشركة فايزر ولقاح موديرنا في حالات الطوارئ في الولايات المتحدة.

Medicina de precisión y tecnología digital como instrumentos poderosos contra la tuberculosis

La lucha mundial contra la tuberculosis ahora cuenta con algunos instrumentos poderosos. La medicina de precisión que ya se aplica para personalizar el diagnóstico y el tratamiento de enfermedades no contagiosas, como el cáncer, junto a las tecnologías para la atención de la salud, como la telemedicina, tienen la capacidad de avanzar la prevención y el tratamiento de la tuberculosis, dice el Dr. Zelalem Temesgen, experto en enfermedades infecciosas y director médico del Centro para Tuberculosis en Mayo Clinic.

Precision medicine, digital technology hold potential as powerful tools against tuberculosis

The global fight against tuberculosis is gaining some powerful tools. Precision medicine — already used to personalize diagnosis and treatment of noncommunicable diseases such as cancer — and health care technologies such as telemedicine have the potential to advance the prevention and treatment of tuberculosis, says Zelalem Temesgen, M.D., an infectious diseases expert and medical director of the Mayo Clinic Center for Tuberculosis.

Lack of diversity in genomic databases may affect therapy selection for minority groups

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.

The researchers investigated the use of genomic databases and found that tumor mutation burden was significantly inflated in Black patients compared to White patients.

As a result of the study, clinicians who are using public genomic databases need to be aware of the potential for inflated tumor mutation burden values and how that may affect therapy selection and outcomes, especially for patients from underrepresented groups.