Objective Subtle Cognitive Difficulties Predict Amyloid Accumulation and Neurodegeneration

Researchers report that accumulating amyloid protein occurred faster among persons deemed to have “objectively-defined subtle cognitive difficulties” (Obj-SCD) than among persons considered to be “cognitively normal,” offering a potential new early biomarker for Alzheimer’s disease.

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What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?

The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease

New Approach Will Lead to a Better Understanding of Most Cases

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ICU Survivors Commonly Experience Job Loss after Critical Illness, Study Confirms

National attention has been drawn to the plight of patients who have experienced the unintended side effects of prolonged ICU care such as memory loss and muscle weakness. Now, a research team led by UC San Diego have evaluated the employment impacts to ICU patients, with concerning findings.

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A Rare Diagnosis Leads to a Successful Surgery and Recovery

Drew, a 65-year-old man from Connecticut, was diagnosed with a spinal dural arteriovenous fistula (SDAVF), which is a rare vascular malformation of the spinal cord that only affects 1 in every 200,000 people.

SDAVFs are underdiagnosed because symptoms can be vague and mirror many other types of medical problems. If left untreated, SDAVFs can result in permanent spinal cord injury.

Despite the uncommon diagnosis, a multidisciplinary care team from Nuvance Health, including primary care, neurology, radiology, and neurosurgery correctly and expeditiously identified and surgically treated Drew’s SDAVF.

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