UCSF Neurologist Recognized for Innovative Epilepsy Research

Jon Kleen, MD, PhD, UC San Francisco neurologist, epileptologist and neuroscientist, has been chosen by the American Academy of Neurology (AAN) to receive its 2023 Dreifuss-Penry Epilepsy Award. He is being honored for his outstanding contributions in clinical research and leadership in the treatment of epilepsy.

UT Southwestern scientists discover agent that reverses effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new study. The findings, published in Cell Metabolism, could lead to effective treatments for acute alcohol intoxication, which is responsible for about 1 million emergency room visits in the U.S. each year.

UC Davis study uncovers age-related brain differences in autistic individuals

Differences in genes involved in inflammation, immunity response and neural transmissions begin in childhood and evolve across the lifespan in brains of people with autism, a UC Davis MIND Institute has found.

UK HealthCare neurologist working to improve access to MS treatments

Together with Multiple Sclerosis (MS) experts, biostatisticians and clinicians from across the globe, a UK HealthCare neurologist has helped compile an essential list of MS medications for patients in resource-poor settings. Jagannadha “Jay” Avasarala, M.D., Ph.D., director of the Comprehensive Care Center for MS and Neuroimmunology at the Kentucky Neuroscience Institute, currently serves as a panel member of the Multiple Sclerosis International Foundation (MSIF) and previously served as chair of the American Academy of Neurology (2020-22).

Scientists Develop Novel Approach to Enhance Drug Delivery for Brain Tumors in Children

Mount Sinai Health System and Memorial Sloan Kettering Cancer Center researchers have developed a new drug delivery approach that uses nanoparticles to enable more effective and targeted delivery of anti-cancer drugs to treat brain tumors in children.

Study: People Who Regularly Use Laxatives May Have an Increased Risk of Dementia

People who regularly use laxatives, a common treatment for constipation, may have more than a 50% increased risk of developing dementia than people who do not use laxatives, according to a study published in the February 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers also found people who used only osmotic laxatives, a type of laxative that attracts water to the colon to soften stool, had an even greater risk. Other types of laxatives are bulk-forming, stool-softening, and stimulating. The study does not prove that laxatives cause dementia. It only shows an association.

Low Estrogen Levels Paired with Higher CGRP Levels May Jump Start Migraine

As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate. The study is published in the February 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

10 ways to reduce your risk of dementia

Dementia affects millions of Americans — including nearly one in 10 adults over age 65. While the causes of different dementias vary, a 2020 report from a Lancet commission identified several modifiable risk factors that together account for around 40% of dementia worldwide. Neurologists share how you can reduce your risk for dementia and maintain a healthy brain throughout your life.

Drug Linked to Lower Risk of Dementia in People with Diabetes

People with diabetes are twice as likely to develop dementia as those without the disease. In a new study, people with newly diagnosed type 2 diabetes who took the diabetes drug pioglitazone were less likely to later develop dementia than those who did not take the drug. The study is published in the February 15, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Your Neighborhood May Affect Your Survival from Stroke, Other Neurologic Conditions

People living in disadvantaged neighborhoods—areas with higher poverty levels and fewer educational and employment opportunities—had an increased risk of dying within a month of being hospitalized for stroke, epilepsy and other neurologic diseases compared to people living in neighborhoods with fewer disadvantages, according to new research published in the February 15, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

New major international study finds thrombectomy highly effective treatment for large strokes

A large international clinical study finds that patients with large strokes had a dramatically better recovery after endovascular thrombectomy plus medical management than patients receiving only standard medical management.

The study was published Feb. 10 in the New England Journal of Medicine to coincide with its presentation at the International Stroke Conference in Dallas.

Head trauma doesn’t predict memory problems in NFL retirees, UT Southwestern study shows

A study of retired professional football players by researchers at UT Southwestern Medical Center found that their cognitive abilities did not differ significantly from a control group of similarly aged men who did not play football, nor did those abilities show significant change over one to five years. The findings were published in Brain Injury.

Advancing Care and Innovation for Pediatric Brain Tumors

The Brain Tumor Center at Children’s Hospital Los Angeles takes a team approach—and offers one of the largest clinical trial programs of its kind. The Brain Tumor Center at Children’s Hospital Los Angeles is one of the largest and most comprehensive pediatric brain tumor programs in the country, integrating experts from multiple specialty areas into a coordinated treatment team.

MS Center at Jersey Shore University Medical Center Nationally Recognized as a Center for Comprehensive MS Care

Hackensack Meridian Jersey Shore University Medical Center’s Multiple Sclerosis Center, a leading provider of care for people living with multiple sclerosis (MS) in New Jersey, has been officially recognized as a Center for Comprehensive MS Care through the National Multiple Sclerosis Society’s Partners in MS Care program. It is one of only two Centers for Comprehensive MS Care in Monmouth and Ocean counties.

Cooling brain tumor cells could make headway in glioblastoma, UTSW researcher finds

Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident. The findings, published in Science Advances, could lead to new treatments for this aggressive and deadly cancer.

Black, Latino People with Epilepsy Less Likely to Be Prescribed Newer Drugs

Among people with epilepsy, Black, Latino and Native Hawaiian and Other Pacific Islander people are less likely to be prescribed newer drugs than white people, which can be a marker of the quality of care, according to a study published in the January 11, 2023, online issue of Neurology® Clinical Practice, an official journal of the American Academy of Neurology.

New technique from UTSW improves high-intensity focused ultrasound treatment for brain disorders

UT Southwestern physicians have developed an improved targeting method, four-tract tractography, to personalize MRI-guided, high-intensity focused ultrasound (HIFU) used at UTSW to treat medication refractory tremor in essential tremor and tremor-dominant Parkinson’s disease.

Stem Cell Transplants May Delay Disability Longer than Some MS Medications

In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a study published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person’s own body to replace diseased cells.

Subjective Cognitive Decline Linked to Higher Dementia Risk for Black, Latino People

Some people report a decline in their memory before any decline is large enough to show up on standard tests. This experience, called subjective cognitive decline, is associated with an increased risk of later developing dementia in white, Black and Latino people, according to a study published in the November 30, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

With High Costs and Similar Benefits, Use of New Neurology Drugs Is Low

A number of new neurologic medications for diseases like multiple sclerosis (MS), Parkinson’s disease and migraine have received U.S. Food and Drug Administration (FDA) approval over the past decade. However, with most having higher out-of-pocket costs and benefits similar to existing, less expensive drugs, only a small percentage of people with neurologic conditions are being treated with these new drugs, according to a study funded by the American Academy of Neurology and published in the November 30, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

UC San Diego Awarded $8M to Expand Stem Cell Therapy Clinical Trials

UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.

UTSW scientists identify brain circuit that triggers rare, blood sugar-dependent epilepsy

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

UCI-led study discovers pre-treatment cognitive impairment in younger cancer patients

Irvine, Calif., Nov. 16, 2022 — A team of researchers led by the University of California, Irvine has discovered that adolescent and young adult cancer patients can experience cancer-related cognitive impairment before chemotherapy or radiation treatment, highlighting the importance of evaluating and managing toxicity at the time of diagnosis to help prevent further deterioration.

Addressing Health Inequities Could Help Avert a Neurologic Health Crisis

The closing plenary session at ANA2022 spotlighted neurologic health inequities and presented new research finding that neighborhood disadvantage strongly predicted likelihood of death from neurologic conditions independent of individual wealth and demographics.