UTSW discovers protective ‘acid wall’ formed by cancer cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

Gene therapy offers hope for giant axonal neuropathy patients

A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.

Device keeps brain alive, functioning separate from body

Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

Study reveals how estrogen exerts its anti-diabetic effects

The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes, UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could eventually lead to new therapies for Type 2 diabetes, a disease that affects hundreds of millions of people around the globe and continues to grow more prevalent.

Public-private consortium will fund three gene therapy clinical trials at UT Southwestern and Children’s Health

A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three different rare diseases at UT Southwestern Medical Center and Children’s Health, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.

Public-private consortium will fund three gene therapy clinical trials at UT Southwestern

A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three rare diseases at UT Southwestern Medical Center, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.