UC Irvine-led research team creates novel rabies viral vectors for neural circuit mapping

Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.

Device keeps brain alive, functioning separate from body

Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

Internationally recognized computational researcher Spyridon Bakas, PhD, to serve as inaugural director of Division of Computational Pathology

Indiana University School of Medicine Department of Pathology is launching a new Division of Computational Pathology and a Research Center for Federated Learning in Precision Medicine.

nference and Vanderbilt University Medical Center sign agreement to advance real-world evidence generation in complex disease populations

nference, a science-first software company transforming health care by making biomedical data computable, and Vanderbilt University Medical Center, a leading academic medical center, have announced a strategic agreement aimed at advancing research through the deployment of nference’s state-of-the-art federated clinical analytics platform.

A potential new weapon in the war against superbugs

For nearly 25 years, Dr. James Kirby has worked to advance the fight against infectious diseases by finding and developing new, potent antimicrobials, and by better understanding how disease-causing bacteria make us sick. In a recent paper published in PLOS Biology, Kirby and colleagues investigated a naturally occurring antimicrobial agent discovered more than 80 years ago.

UT Southwestern researchers discover mechanism responsible for genome rearrangements

The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells. However, this process often goes awry and may be responsible for a new class of chromosomal abnormalities found in cancers and congenital disorders, UT Southwestern Medical Center scientists report in a new study. The discovery, published in Nature, sheds light on how cancer cells rapidly evolve genomic changes that fuel their proliferation.

Simmons Cancer Center investigators receive nearly $15 million in CPRIT funding

Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.

AMP Assesses Clinical Implementation of Past Standards and Guidelines for Interpretation and Reporting of Sequence Variants in Cancer

The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, has published a report that was designed to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” The AMP manuscript, “Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines” was released online ahead of publication in The Journal of Molecular Diagnostics.

UCI is key member of multi-institutional, $126 million NIH brain mapping project

Irvine, Calif., Sept. 22, 2022 – The University of California, Irvine will participate in a five-year, multi-institutional, $126 million grant from the National Institutes of Health supporting the BRAIN Initiative Cell Atlas Network. The project aims to describe the cells that make up the human brain in unprecedented molecular detail, classifying them into more precise subtypes and pinpointing their location.

Mayo Clinic receives first-of-its-kind accreditation for diagnosis of primary ciliary dyskinesia

Mayo Clinic’s Department of Laboratory Medicine and Pathology, the academic testing arm for Mayo Clinic Laboratories, has been accredited as a diagnostic site by the PCD Foundation. Mayo Clinic is the first and only center of excellence to receive PCD Foundation accreditation for the diagnosis of primary ciliary dyskinesia, a rare and debilitating lung disease.

Millipede species, rarely documented in West Virginia, detected by WVU researchers as part of National Geographic project

Angie Macias, a doctoral student at West Virginia University, and Matt Kasson, an associate professor, are part of a National Geographic-funded project to study the fungal diversity associated with fungus-feeding millipedes.

Study shows rapid return of respiratory viruses after COVID-19 restrictions relaxed

A new Houston Methodist study shows a rapid return of seasonal respiratory viruses after COVID-19 restrictions were relaxed in Texas, demonstrating the apparent effectiveness of masking, distancing and other precautionary measures at stopping the spread of respiratory illnesses. This rise in infections to pre-pandemic levels followed updated governmental guidelines lifting mask, distancing and occupancy requirements.

Immunomics: A Conversation on the Future of Diagnostics with Ramy Arnaout

In a recent perspective article, pathologists outline how the immunome — all of the genes collectively expressed by an individual’s immune cells — holds the potential to provide researchers and physicians with unprecedented insight into an individual’s health. Collecting that information from large numbers of patients could one day facilitate diagnostics via a near-universal blood test and pave the way to targeted therapies for a wide variety of conditions.

Microchip Models of Human Lungs Enable Better Understanding of Disease, Immune Response

In Biomicrofluidics, researchers review lung-on-chip technologies that represent the vital properties of lung tissue and are capable of recapitulating the fundamental aspects of various pathologies. The researchers reviewed various lung-on-chips and their applications in examining, diagnosing, and treating human viruses, including the coronavirus that causes COVID-19. The knowledge accumulated paves the way to use these models to study the interaction of several human respiratory viruses with the airway epithelium and alveolus in an organ-relevant setting.

Speakers Announced for Virtual Experimental Biology 2021 Meeting

Renowned scientists—including Nobel laureates, research pioneers and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. Bringing together thousands of life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.

Novel Coronavirus Circulated Undetected Months before First COVID-19 Cases in Wuhan, China

Using molecular dating tools and epidemiological simulations, researchers at UC San Diego School of Medicine estimate that the SARS-CoV-2 virus likely circulated undetected for two months before the first human cases of COVID-19 were described in Wuhan, China in late-December 2019.

Press Registration Now Open for Virtual Experimental Biology 2021 Meeting

Complimentary press passes are now available for the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. EB is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.

Cone Snail Venom Shows Potential for Treating Severe Malaria

Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.

Go Inside the Most Innovative Minds in Science and Medicine on “Real, Smart People,” a New Podcast

Podcast from the Icahn School of Medicine at Mount Sinai offers a glimpse into the real story of how science and medicine moves forward, one smart person at a time.

Memorial Sloan Kettering Awards and Appointments

Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.

Thomas J. Fuchs, DSc, Named Dean of Artificial Intelligence and Human Health and Co-Director of the Hasso Plattner Institute for Digital Health at Mount Sinai

Appointment Advances Health System’s Role as Leader in AI and Digital Health

Memorial Sloan Kettering Awards and Appointments

Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.

Study Finds High Levels of Toxic Pollutants in Stranded Dolphins and Whales

Researchers examined toxins in tissue concentrations and pathology data from 83 stranded dolphins and whales from 2012 to 2018. They looked at 11 different animal species to test for 17 different substances. The study is the first to report on concentrations in blubber tissues of stranded cetaceans of atrazine, DEP, NPE and triclosan. It also is the first to report concentrations of toxicants in a white-beaked dolphin and in Gervais’ beaked whales.

Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma

The discovery of the oncogene responsible for glioblastoma could be the brain tumor’s Achilles’ heel, one researcher says.

A Different Chia-PET Provides Insight Into Prostate Cancer

DALLAS – July 6, 2020 – UT Southwestern researchers have identified vast webs of small snippets of the genome that interact with each other and with genes to promote prostate cancer. Their findings, published June 22 in the Journal of Clinical Investigation, could lead to new ways to treat the most common type of malignancy in American men other than skin cancer.

Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.

Mount Sinai Health System and Renalytix Form Joint Venture, Kantaro Biosciences, To Develop and Scale Production of COVID Antibody Test Kits

– Kantaro Biosciences partners with Bio-Techne for manufacturing and global kit distribution
– Scaled kit production to enable clinical laboratories to conduct 10M tests per month is planned to begin in July

Mount Sinai’s Blood Test to Detect Antibodies to COVID-19 Receives Emergency Use Authorization From U.S. Food and Drug Administration

Today, the Mount Sinai Laboratory (MSL), Center for Clinical Laboratories received emergency use authorization from the U.S. Food and Drug Administration (FDA) for an antibody test that was developed, validated, and launched at Mount Sinai by a team of internationally renowned researchers and clinicians of the Icahn School of Medicine at Mount Sinai. This test detects the presence or absence of antibodies to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19) and importantly, may also be used to identify positive specimens with an antibody titer (level) up to a dilution of 1:2880 for the identification of individuals with higher antibody titers.