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UrduThe new model, developed by researchers at the UNC School of Medicine, can produce more accurate and reliable analysis of brain structures, which is critical for early detection, medical diagnosis, and neurological research.
Tag: Pathology
Research pathologist wins national award for AI-powered immuno-oncology tool that predicts lung cancer treatment outcomes
Research pathologist wins national award for AI-powered immuno-oncology tool that predicts lung cancer treatment outcomes
Healthcare to Research: The Many Ways Genetic Counselors Help Patients and Families
Genetic counselors are experts in genetics and how it impacts our health and development. Learn more about who they are, what they do and how they may help you and your family….
Research concentrates on genes that cause tumors in the Meibomian gland
Tufts University researcher dedicated to finding treatments for cancer by researching tumors that develop in Meibomian glands, the specialized oil-secreting glands of the eyelid.
Association for Molecular Pathology publishes joint consensus report on SARS-CoV-2 genomic surveillance for hospitals and public health laboratories
The Association for Molecular Pathology published a joint consensus report with the Association of Public Health Laboratories that reviews and summarizes standard concepts and best practices for next-generation sequencing methods for SARS-CoV-2 genomic surveillance.
Onur Kanisicak, PhD, to Receive 2025 American Society for Investigative Pathology Cotran Early Career Investigator Award
The 2025 recipient of the American Society for Investigative Pathology Cotran Early Career Investigator Award is Dr. Onur Kanisicak, an Associate Professor in the Department of Emergency Medicine at the Ohio State University Wexner Medical Center.
New Barcode Technology Could Help Diagnose Cancer More Precisely
A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), was discussed in a new study that published Sept. 30 in the journal Cell. Co-corresponding author Dr. Mina Xu, a Yale Cancer Center (YCC) member, professor of pathology at Yale School of Medicine (YSM), and the YSM director of hematopathology, shared her enthusiasm for the new tool.
Pathway tied to cancer-driving genome alterations identified
Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.
UTSW’s Simmons Cancer Center awarded more than $11.5 million in CPRIT funding
Eight scientists and physicians in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern have been awarded more than $11.5 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to support the state’s fight against cancer.
Beyond Conventional Pathology, Label-free Histology Meets AI
POSTECH team develops deep-learning powered label-free photoacoustic histology for virtual staining, segmentation, and classification of human liver cancers.
Children’s Research Institute at UT Southwestern scientists discover kidney cancers rely on mitochondrial metabolism to metastasize
Contrary to how tumors operate while still in the kidney, metastatic kidney cancers rely heavily on mitochondrial metabolism, according to new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Nature.
MD Anderson recognizes outstanding faculty
The University of Texas MD Anderson Cancer Center last night recognized over 100 faculty members at its annual Celebration of Faculty Excellence awards ceremony, acknowledging their compassionate care, exceptional contributions to their fields and the distinction they have brought to the institution.
Pathologists awarded grant from American Society of Hematology
Dr. Zhen Mei, a clinical pathologist, and Dr. Vivian Chang, a pediatric hematologist-oncologist, both at UCLA Health, have been awarded $30,000 from the American Society of Hematology to revise blood cell ranges for people with Duffy-null Associated Neutrophil Count, which is also known as Duffy-negative
Indica Labs Receives FDA Clearance for HALO AP Dx Digital Pathology Platform for Use with Hamamatsu Images Acquired with the NanoZoomer® S360MD Slide Scanner
Indica Labs, an industry leader in AI-powered digital pathology solutions, and Hamamatsu Photonics K.K., a pioneer in whole slide imaging systems, announce that the U.S. Food and Drug Administration (FDA) has issued a 510(k) clearance to Indica Labs for HALO AP Dx, an enterprise digital pathology platform. HALO AP Dx is indicated for primary diagnosis of surgical pathology slides prepared from formalin-fixed paraffin embedded (FFPE) tissue scanned by the NanoZoomer® S360MD Slide scanner1.
UTSW discovers protective ‘acid wall’ formed by cancer cells
Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
New Oncology Pathology Chief Named to New Jersey’s only NCI-Designated Comprehensive Cancer Center
Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Nirag Jhala, MD, as chief of the Division of Oncologic Pathology at New Jersey’s leading cancer program and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center.
Nanoparticles developed at UTSW effectively fight tumors
A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types. Their findings, published in Science Immunology, offer a new way to potentially harness the power of the body’s immune system against cancer.
UC Irvine-led research team creates novel rabies viral vectors for neural circuit mapping
Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.
Device keeps brain alive, functioning separate from body
Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.
Internationally recognized computational researcher Spyridon Bakas, PhD, to serve as inaugural director of Division of Computational Pathology
Indiana University School of Medicine Department of Pathology is launching a new Division of Computational Pathology and a Research Center for Federated Learning in Precision Medicine.
nference and Vanderbilt University Medical Center sign agreement to advance real-world evidence generation in complex disease populations
nference, a science-first software company transforming health care by making biomedical data computable, and Vanderbilt University Medical Center, a leading academic medical center, have announced a strategic agreement aimed at advancing research through the deployment of nference’s state-of-the-art federated clinical analytics platform.
Gulf War Illness Caused by Mitochondrial Dysfunction, Not Inflammation
UC San Diego scientists contest longstanding hypothesis about mysterious illness affecting Gulf War veterans, providing first direct evidence that symptoms are driven by impaired mitochondria.
A potential new weapon in the war against superbugs
For nearly 25 years, Dr. James Kirby has worked to advance the fight against infectious diseases by finding and developing new, potent antimicrobials, and by better understanding how disease-causing bacteria make us sick. In a recent paper published in PLOS Biology, Kirby and colleagues investigated a naturally occurring antimicrobial agent discovered more than 80 years ago.
UT Southwestern researchers discover mechanism responsible for genome rearrangements
The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells. However, this process often goes awry and may be responsible for a new class of chromosomal abnormalities found in cancers and congenital disorders, UT Southwestern Medical Center scientists report in a new study. The discovery, published in Nature, sheds light on how cancer cells rapidly evolve genomic changes that fuel their proliferation.
The Acute Problem of Chronic Disease
In medicine and science, the term “pathogenesis” describes the origin and development of disease. There is not, however, a broadly accepted term to describe the other half of the equation: the process of healing and recovery.
Stephen J. Galli, MD, to Receive 2024 American Society for Investigative Pathology Gold-Headed Cane Award
The American Society for Investigative Pathology awards Stephen J. Galli, MD, the 2024 ASIP Gold-Headed Cane Award.
Asma Nusrat, MD, to Receive 2024 American Society for Investigative Pathology Rous-Whipple Award
The American Society for Investigative Pathology awards Asma Nusrat, MD, the 2024 ASIP Rous-Whipple Award.
Qing Zhang, PhD, to Receive 2024 American Society for Investigative Pathology Outstanding Investigator Award
The American Society for Investigative Pathology awards Qing Zhang, PhD, the 2024 ASIP Outstanding Investigator Award.
Simmons Cancer Center investigators receive nearly $15 million in CPRIT funding
Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.
AMP Assesses Clinical Implementation of Past Standards and Guidelines for Interpretation and Reporting of Sequence Variants in Cancer
The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, has published a report that was designed to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” The AMP manuscript, “Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines” was released online ahead of publication in The Journal of Molecular Diagnostics.
Researchers Identify a Regulator of Breast Cancer Development
UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.
UCI is key member of multi-institutional, $126 million NIH brain mapping project
Irvine, Calif., Sept. 22, 2022 – The University of California, Irvine will participate in a five-year, multi-institutional, $126 million grant from the National Institutes of Health supporting the BRAIN Initiative Cell Atlas Network. The project aims to describe the cells that make up the human brain in unprecedented molecular detail, classifying them into more precise subtypes and pinpointing their location.
Sperm are masters of Tetris packing
If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.
Mayo Clinic receives first-of-its-kind accreditation for diagnosis of primary ciliary dyskinesia
Mayo Clinic’s Department of Laboratory Medicine and Pathology, the academic testing arm for Mayo Clinic Laboratories, has been accredited as a diagnostic site by the PCD Foundation. Mayo Clinic is the first and only center of excellence to receive PCD Foundation accreditation for the diagnosis of primary ciliary dyskinesia, a rare and debilitating lung disease.
Data Deep Dive
A new tool makes high-resolution imaging data on human tissues easier to understand and use
A Target for Potential Cancer Drugs May, In Fact, Worsen Disease
Researchers reveal a previously unrealized complexity in cancer development, one that raises concerns and caution about targeting an enzyme popular in oncological treatments.
Millipede species, rarely documented in West Virginia, detected by WVU researchers as part of National Geographic project
Angie Macias, a doctoral student at West Virginia University, and Matt Kasson, an associate professor, are part of a National Geographic-funded project to study the fungal diversity associated with fungus-feeding millipedes.
First atomic-level imaging of lethal prions provide sharpened focus for potential treatments
The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals—and how they can be potentially targeted by new therapies.
CAP Foundation Announces $2M Fundraising Campaign Supporting Cancer Screening, Pathology
The College of American Pathologists (CAP) Foundation announced in July 2021 a new fundraising campaign with a minimum goal of $2 million that will secure life-saving cancer screening and pathology education and training programs for the next decade.
AMP Publishes Recommendations to Facilitate Widespread Adoption of Genetic Variant Data Sharing Practices
The Association for Molecular Pathology (AMP) today released recommendations to support and facilitate sharing of variant data through the use of public repositories.
CAP Releases Updates to Cancer Protocols, Essential for Cancer Reporting and Patient Care
The College of American Pathologists (CAP) released updates to the CAP Cancer Protocols, clinical guidance for reporting pathologic features in the treatment of cancer patients.
Study shows rapid return of respiratory viruses after COVID-19 restrictions relaxed
A new Houston Methodist study shows a rapid return of seasonal respiratory viruses after COVID-19 restrictions were relaxed in Texas, demonstrating the apparent effectiveness of masking, distancing and other precautionary measures at stopping the spread of respiratory illnesses. This rise in infections to pre-pandemic levels followed updated governmental guidelines lifting mask, distancing and occupancy requirements.
Immunomics: A Conversation on the Future of Diagnostics with Ramy Arnaout
In a recent perspective article, pathologists outline how the immunome — all of the genes collectively expressed by an individual’s immune cells — holds the potential to provide researchers and physicians with unprecedented insight into an individual’s health. Collecting that information from large numbers of patients could one day facilitate diagnostics via a near-universal blood test and pave the way to targeted therapies for a wide variety of conditions.
Microchip Models of Human Lungs Enable Better Understanding of Disease, Immune Response
In Biomicrofluidics, researchers review lung-on-chip technologies that represent the vital properties of lung tissue and are capable of recapitulating the fundamental aspects of various pathologies. The researchers reviewed various lung-on-chips and their applications in examining, diagnosing, and treating human viruses, including the coronavirus that causes COVID-19. The knowledge accumulated paves the way to use these models to study the interaction of several human respiratory viruses with the airway epithelium and alveolus in an organ-relevant setting.
Speakers Announced for Virtual Experimental Biology 2021 Meeting
Renowned scientists—including Nobel laureates, research pioneers and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. Bringing together thousands of life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.
Novel Coronavirus Circulated Undetected Months before First COVID-19 Cases in Wuhan, China
Using molecular dating tools and epidemiological simulations, researchers at UC San Diego School of Medicine estimate that the SARS-CoV-2 virus likely circulated undetected for two months before the first human cases of COVID-19 were described in Wuhan, China in late-December 2019.
Cancer discovery up for year’s biggest biomedical advance in a different kind of March Madness
The public can vote in STAT Madness, which is like the scientific version of the NCAA basketball tournament.
Press Registration Now Open for Virtual Experimental Biology 2021 Meeting
Complimentary press passes are now available for the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. EB is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
Cone Snail Venom Shows Potential for Treating Severe Malaria
Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.
Go Inside the Most Innovative Minds in Science and Medicine on “Real, Smart People,” a New Podcast
Podcast from the Icahn School of Medicine at Mount Sinai offers a glimpse into the real story of how science and medicine moves forward, one smart person at a time.