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UrduCancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
Tag: Pathology
New Oncology Pathology Chief Named to New Jersey’s only NCI-Designated Comprehensive Cancer Center
Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Nirag Jhala, MD, as chief of the Division of Oncologic Pathology at New Jersey’s leading cancer program and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center.
Nanoparticles developed at UTSW effectively fight tumors
A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types. Their findings, published in Science Immunology, offer a new way to potentially harness the power of the body’s immune system against cancer.
UC Irvine-led research team creates novel rabies viral vectors for neural circuit mapping
Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.
Device keeps brain alive, functioning separate from body
Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.
Internationally recognized computational researcher Spyridon Bakas, PhD, to serve as inaugural director of Division of Computational Pathology
Indiana University School of Medicine Department of Pathology is launching a new Division of Computational Pathology and a Research Center for Federated Learning in Precision Medicine.
nference and Vanderbilt University Medical Center sign agreement to advance real-world evidence generation in complex disease populations
nference, a science-first software company transforming health care by making biomedical data computable, and Vanderbilt University Medical Center, a leading academic medical center, have announced a strategic agreement aimed at advancing research through the deployment of nference’s state-of-the-art federated clinical analytics platform.
Gulf War Illness Caused by Mitochondrial Dysfunction, Not Inflammation
UC San Diego scientists contest longstanding hypothesis about mysterious illness affecting Gulf War veterans, providing first direct evidence that symptoms are driven by impaired mitochondria.
A potential new weapon in the war against superbugs
For nearly 25 years, Dr. James Kirby has worked to advance the fight against infectious diseases by finding and developing new, potent antimicrobials, and by better understanding how disease-causing bacteria make us sick. In a recent paper published in PLOS Biology, Kirby and colleagues investigated a naturally occurring antimicrobial agent discovered more than 80 years ago.
UT Southwestern researchers discover mechanism responsible for genome rearrangements
The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells. However, this process often goes awry and may be responsible for a new class of chromosomal abnormalities found in cancers and congenital disorders, UT Southwestern Medical Center scientists report in a new study. The discovery, published in Nature, sheds light on how cancer cells rapidly evolve genomic changes that fuel their proliferation.
The Acute Problem of Chronic Disease
In medicine and science, the term “pathogenesis” describes the origin and development of disease. There is not, however, a broadly accepted term to describe the other half of the equation: the process of healing and recovery.
Stephen J. Galli, MD, to Receive 2024 American Society for Investigative Pathology Gold-Headed Cane Award
The American Society for Investigative Pathology awards Stephen J. Galli, MD, the 2024 ASIP Gold-Headed Cane Award.
Asma Nusrat, MD, to Receive 2024 American Society for Investigative Pathology Rous-Whipple Award
The American Society for Investigative Pathology awards Asma Nusrat, MD, the 2024 ASIP Rous-Whipple Award.
Qing Zhang, PhD, to Receive 2024 American Society for Investigative Pathology Outstanding Investigator Award
The American Society for Investigative Pathology awards Qing Zhang, PhD, the 2024 ASIP Outstanding Investigator Award.
Simmons Cancer Center investigators receive nearly $15 million in CPRIT funding
Ten scientists in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center have been awarded nearly $15 million in grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to advance research on a wide range of cancer issues.
AMP Assesses Clinical Implementation of Past Standards and Guidelines for Interpretation and Reporting of Sequence Variants in Cancer
The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, has published a report that was designed to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” The AMP manuscript, “Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines” was released online ahead of publication in The Journal of Molecular Diagnostics.
Researchers Identify a Regulator of Breast Cancer Development
UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.
UCI is key member of multi-institutional, $126 million NIH brain mapping project
Irvine, Calif., Sept. 22, 2022 – The University of California, Irvine will participate in a five-year, multi-institutional, $126 million grant from the National Institutes of Health supporting the BRAIN Initiative Cell Atlas Network. The project aims to describe the cells that make up the human brain in unprecedented molecular detail, classifying them into more precise subtypes and pinpointing their location.
Sperm are masters of Tetris packing
If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.
Mayo Clinic receives first-of-its-kind accreditation for diagnosis of primary ciliary dyskinesia
Mayo Clinic’s Department of Laboratory Medicine and Pathology, the academic testing arm for Mayo Clinic Laboratories, has been accredited as a diagnostic site by the PCD Foundation. Mayo Clinic is the first and only center of excellence to receive PCD Foundation accreditation for the diagnosis of primary ciliary dyskinesia, a rare and debilitating lung disease.
Data Deep Dive
A new tool makes high-resolution imaging data on human tissues easier to understand and use
A Target for Potential Cancer Drugs May, In Fact, Worsen Disease
Researchers reveal a previously unrealized complexity in cancer development, one that raises concerns and caution about targeting an enzyme popular in oncological treatments.
Millipede species, rarely documented in West Virginia, detected by WVU researchers as part of National Geographic project
Angie Macias, a doctoral student at West Virginia University, and Matt Kasson, an associate professor, are part of a National Geographic-funded project to study the fungal diversity associated with fungus-feeding millipedes.
First atomic-level imaging of lethal prions provide sharpened focus for potential treatments
The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals—and how they can be potentially targeted by new therapies.
CAP Foundation Announces $2M Fundraising Campaign Supporting Cancer Screening, Pathology
The College of American Pathologists (CAP) Foundation announced in July 2021 a new fundraising campaign with a minimum goal of $2 million that will secure life-saving cancer screening and pathology education and training programs for the next decade.
AMP Publishes Recommendations to Facilitate Widespread Adoption of Genetic Variant Data Sharing Practices
The Association for Molecular Pathology (AMP) today released recommendations to support and facilitate sharing of variant data through the use of public repositories.
CAP Releases Updates to Cancer Protocols, Essential for Cancer Reporting and Patient Care
The College of American Pathologists (CAP) released updates to the CAP Cancer Protocols, clinical guidance for reporting pathologic features in the treatment of cancer patients.
Study shows rapid return of respiratory viruses after COVID-19 restrictions relaxed
A new Houston Methodist study shows a rapid return of seasonal respiratory viruses after COVID-19 restrictions were relaxed in Texas, demonstrating the apparent effectiveness of masking, distancing and other precautionary measures at stopping the spread of respiratory illnesses. This rise in infections to pre-pandemic levels followed updated governmental guidelines lifting mask, distancing and occupancy requirements.
Immunomics: A Conversation on the Future of Diagnostics with Ramy Arnaout
In a recent perspective article, pathologists outline how the immunome — all of the genes collectively expressed by an individual’s immune cells — holds the potential to provide researchers and physicians with unprecedented insight into an individual’s health. Collecting that information from large numbers of patients could one day facilitate diagnostics via a near-universal blood test and pave the way to targeted therapies for a wide variety of conditions.
Microchip Models of Human Lungs Enable Better Understanding of Disease, Immune Response
In Biomicrofluidics, researchers review lung-on-chip technologies that represent the vital properties of lung tissue and are capable of recapitulating the fundamental aspects of various pathologies. The researchers reviewed various lung-on-chips and their applications in examining, diagnosing, and treating human viruses, including the coronavirus that causes COVID-19. The knowledge accumulated paves the way to use these models to study the interaction of several human respiratory viruses with the airway epithelium and alveolus in an organ-relevant setting.
Speakers Announced for Virtual Experimental Biology 2021 Meeting
Renowned scientists—including Nobel laureates, research pioneers and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. Bringing together thousands of life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.
Novel Coronavirus Circulated Undetected Months before First COVID-19 Cases in Wuhan, China
Using molecular dating tools and epidemiological simulations, researchers at UC San Diego School of Medicine estimate that the SARS-CoV-2 virus likely circulated undetected for two months before the first human cases of COVID-19 were described in Wuhan, China in late-December 2019.
Cancer discovery up for year’s biggest biomedical advance in a different kind of March Madness
The public can vote in STAT Madness, which is like the scientific version of the NCAA basketball tournament.
Press Registration Now Open for Virtual Experimental Biology 2021 Meeting
Complimentary press passes are now available for the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30. EB is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
Cone Snail Venom Shows Potential for Treating Severe Malaria
Using venom from the Conus nux, a sea snail, a first-of-its-kind study suggests these conotoxins could potentially treat malaria. The study provides important leads toward the development of new and cost-effective anti-adhesion or blockade-therapy drugs aimed at counteracting the pathology of severe malaria. Similarly, mitigation of emerging diseases like COVID-19 also could benefit from conotoxins as potential inhibitors of protein-protein interactions as treatment. Venom peptides from cone snails has the potential to treat myriad diseases using blockage therapies.
Go Inside the Most Innovative Minds in Science and Medicine on “Real, Smart People,” a New Podcast
Podcast from the Icahn School of Medicine at Mount Sinai offers a glimpse into the real story of how science and medicine moves forward, one smart person at a time.
Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia
A team including researchers from the NYU Tandon School of Engineering and NYU Langone Health demonstrated an in vitro organotypic “leukemia-on-a-chip” model to emulate in vivo leukemia bone marrow pathology and study chemiresistance.
Study Finds 1.7 Million New Yorkers Have Been infected with SARS-Cov-2 and Virus was in NYC Earlier than Reported
The virus that causes COVID-19 was present in New York City long before the city’s first case of the disease was confirmed on March 1
Memorial Sloan Kettering Awards and Appointments
Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.
Dr. R. Bruce Williams Named Pathologist of the Year, 19 Others Recognized
The College of American Pathologists (CAP), the world’s largest organization for the doctors who diagnose and study disease, recognized several of its members for their dedication to and advancement of pathology and laboratory medicine at the organization’s CAP20 Virtual annual meeting.
Thomas J. Fuchs, DSc, Named Dean of Artificial Intelligence and Human Health and Co-Director of the Hasso Plattner Institute for Digital Health at Mount Sinai
Appointment Advances Health System’s Role as Leader in AI and Digital Health
CAP adds SARS-CoV-2 antigen testing to its suite of quality assurance programs
The College of American Pathologists (CAP), in response to continued patient needs in the global COVID-19 pandemic, released a new proficiency testing (PT) program for the detection of antigens of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Memorial Sloan Kettering Awards and Appointments
Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.
Study Finds High Levels of Toxic Pollutants in Stranded Dolphins and Whales
Researchers examined toxins in tissue concentrations and pathology data from 83 stranded dolphins and whales from 2012 to 2018. They looked at 11 different animal species to test for 17 different substances. The study is the first to report on concentrations in blubber tissues of stranded cetaceans of atrazine, DEP, NPE and triclosan. It also is the first to report concentrations of toxicants in a white-beaked dolphin and in Gervais’ beaked whales.
New Research Defines Intrauterine Placental Transmission of COVID-19 From Pregnant Women to the Fetus
Pathologists examine whether mother-to-infant (vertical) transmission of SARS-CoV-2 occurs and, if it does, whether it develops in the uterus prior to delivery, and how it happens in a new research article published in the Archives of Pathology & Laboratory Medicine.
Artificial Intelligence Identifies Prostate Cancer with Near-Perfect Accuracy
Study reports 98% sensitivity and 97% specificity in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program.
Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma
The discovery of the oncogene responsible for glioblastoma could be the brain tumor’s Achilles’ heel, one researcher says.
A Different Chia-PET Provides Insight Into Prostate Cancer
DALLAS – July 6, 2020 – UT Southwestern researchers have identified vast webs of small snippets of the genome that interact with each other and with genes to promote prostate cancer. Their findings, published June 22 in the Journal of Clinical Investigation, could lead to new ways to treat the most common type of malignancy in American men other than skin cancer.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.
Mount Sinai Health System and Renalytix Form Joint Venture, Kantaro Biosciences, To Develop and Scale Production of COVID Antibody Test Kits
– Kantaro Biosciences partners with Bio-Techne for manufacturing and global kit distribution
– Scaled kit production to enable clinical laboratories to conduct 10M tests per month is planned to begin in July