New Study Finds Most Eligible U.S. Adults not Getting Screened for Lung Cancer

A new study led by American Cancer Society researchers shows less than one-in-five eligible individuals in the United States were up-to-date with recommended lung cancer screening. The screening uptake was much lower in persons without health insurance or usual source of care and in Southern states with the highest lung cancer burden.

Groundbreaking LLNL and BridgeBio Oncology Therapeutics collaboration announces start of human trials for supercomputing-discovered cancer drug

In a substantial milestone for supercomputing-aided drug design, Lawrence Livermore National Laboratory (LLNL) and BridgeBio Oncology Therapeutics (BridgeBio) today announced clinical trials have begun for a first-in-class medication that targets specific genetic mutations implicated in many types of cancer.

How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.

ASCO: Proton therapy demonstrates advantages in Phase III head and neck cancer trial

According to preliminary data from a multi-institution Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, intensity modulated proton therapy (IMPT) achieved similar clinical outcomes and offered significant patient benefits when compared to traditional intensity modulated radiation therapy (IMRT) as part of chemoradiation treatment for patients with oropharyngeal (head and neck) cancer.

LJI scientists develop new method to match genes to their molecular ‘switches’

LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity. Their work may help researchers connect genes to the molecular “switches” that turn them on or off. This research, published in Genome Biology, is an important step toward harnessing machine learning approaches to better understand links between gene expression and disease development.

Safety and efficacy of osimertinib plus consolidative stereotactic ablative radiation (SABR) in advanced EGFR mutant non-small cell lung cancer (NSCLC): results from a multi-center Phase II trial

BackgroundDespite high response rates to EGFR inhibitors, patients with advanced EGFR mutant NSCLC generally experience disease progression within two years (osimertinib median PFS 18.9 months, median OS 38.6 months). We sought to determine whether administration of SABR to residual sites…

Fibrolamellar hepatocellular carcinoma (FL-HCC) epidemiology, survival characteristics, and outcomes: Surveillance, epidemiology, and end results database (SEER) study

Background:Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare and distinctive form of liver cancer that primarily affects adolescents and young adults without underlying liver disease. Unlike conventional HCC, it exhibits unique clinical and histological features and poses a diagnostic and therapeutic…

Clinically significant variant classification resulting from the addition of RNA sequencing: Experience at high-volume cancer genetics center

Background: Germline cancer genetic testing plays an important role in prevention, early detection, and targeted therapy1. The increasing use of multi-gene panel testing (MGPT) underscores the importance of accurate variant classification. We report on the significant contribution of RNA analysis…

Cancer screening in sexual and gender minority populations: A systematic review and meta-analysis

Background: The sexual and gender minority (SGM) populations experience a greater cancer burden than their heterosexual or cisgender counterparts. Screening rates for cancer within this cohort are frequently suboptimal, highlighting notable deficiencies in screening recommendations. Inadequate culturally competent care and screening…

Evaluating the impact of socioeconomic status on patient satisfaction in radiation oncology

Background: Patient satisfaction (PS) is a critical indicator in evaluating healthcare quality. While the impact of socioeconomic status (SES), on healthcare outcomes is well-documented, its specific connection to PS in the context of radiation oncology remains unclear. This study aims to…

Trilaciclib use for prevention of hematological adverse events in chemotherapy: A meta-analysis of real-world studies and clinical trials

Background: Trilaciclib, a cyclin-dependent kinase (CDK)-4 and -6 inhibitor, is the only FDA-approved agent that preemptively protects hematopoietic stem cells from chemotherapy-induced myelosuppression (CIM) without compromising efficacy. It transiently arrests hematopoietic stem cells in the G1 phase, thus temporarily blocking progression…

The effect of resting dendritic cells on overall survival in the hepatocellular carcinoma tumor microenvironment

Background: Hepatocellular carcinoma (HCC) continues to have a poor prognosis even in the advent of new immunotherapy regimens. An area of growing interest in HCC is its tumor immune microenvironment. Classifying the immune microenvironment based on available genomics can lead to…

Epidemiology, symptomatology, diagnosis and clinical implications of cystic tumors of atrioventricular node (CTAVN): A systematic review

Background: Primary cardiac tumors have an incidence of 0.0017% to 0.03% of all autopsies. CTAVN is a rare tumor associated with sudden cardiac death, and its incidence cannot be accurately determined as the diagnosis has been historically made on incidental or…

Socioeconomic disparities in survival outcomes of patients with SCLC with brain metastases: A nationwide analysis

Background:Despite advances in the management of cancer, socioeconomic disparities have been reported to impact survival outcomes. However, recent state of disparities in SCLC patients with brain metastases (BM) remains unknown. We explored socioeconomic disparities in survival outcomes of SCLC BM…

Trend and burden of cancer related hospitalizations in the US: Insights from a National Inpatient Sample Database analysis

Background: Cancer-related hospitalizations constitute one of the primary drivers of cancer-related healthcare expenses. Understanding the burden and characteristics of these hospitalizations is essential to appropriately direct resources, improve outcomes, and avoid unnecessary hospitalizations. Our study sought to evaluate the national…

NUS scientists discover a novel way of activating muscle cells’ natural defences against cancer using magnetic pulses

A team of researchers led by Associate Professor Alfredo Franco-Obregón from the NUS Institute for Health Innovation & Technology (iHealthtech) has unveiled a novel approach to stimulate muscle, by way of using brief and mild pulsed electromagnetic field exposure, to produce and release proteins possessing anticancer properties.

Skin-Saving Solutions: The Power of Radiotherapy for Treating Skin Cancers

Skin Brachytherapy, also called radiation seed therapy, offers a non-invasive radiation therapy solution to complement or replace surgery for certain skin cancers. Rajesh V. Iyer, MD, is a radiation oncologist at RWJBarnabas Health and chairman of radiation oncology at Community Medical Center, shares more about this treatment option for patients.

Meeting preview: Hot topics at NUTRITION 2024

Thousands of top nutrition experts will gather next month for a dynamic program of research announcements, policy discussions and award lectures at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition. Reporters and bloggers are invited to apply for a complimentary press pass to attend the meeting in Chicago from June 29–July 2.

MIRA Pharmaceuticals in Discussions with Memorial Sloan Kettering to Collaborate on Preclinical Cancer Pain Model Utilizing The Company’s Novel Oral Ketamine Analog

MIRA Pharmaceuticals, Inc. (NASDAQ: MIRA) (“MIRA” or the “Company”), a pre-clinical-stage pharmaceutical company focused on the treatment of neurologic and neuropsychiatric disorders, announced it is in advanced discussions with Memorial Sloan Kettering Cancer Center (MSK) to initiate a preclinical study evaluating MIRA’s novel oral ketamine analog, Ketamir-2, for the treatment of cancer-related pain and depression.

Breaking bad blood: how rogue neutrophils help lung cancer spread

Lung cancer remains the leading cause of cancer-related deaths worldwide, with a significant portion of these deaths attributed to the aggressive nature of the disease and its resistance to traditional treatments. The study’s findings offer a promising new avenue for therapeutic intervention by targeting the interaction between neutrophils and lung cancer cells, potentially improving patient outcomes.

Alarming Rise of Electronic Vaping Use in U.S. Adolescents

A study among 57,006 adolescents shows daily electronic vapor use has significantly increased by more than three-and-one-half times from 2015 to 2019. In 2015, daily use was significantly higher in boys (2.8%) than girls (1.1%). By 2021, it was higher in girls (5.6%) than boys (4.5%).

Study Sheds Light on Cancer Cell ‘Tug-of-War’

In APL Bioengineering, researchers used a breast cancer cell line panel and primary tumor explants from breast and cervical cancer patients to examine two different cellular contractility modes: one that generates collective tissue surface tension that keeps cell clusters compact and another, more directional, contractility that enables cells to pull themselves into the extracellular matrix.

Game-changer in cancer science: how TP53gene loss drives gastric cancer evolution

“The independent research groups, led by Prof. Scott W. Lowe and Christina Curtis,respectively, have uncovered a similar definitive pathway in the progression of gastric cancer (GC) initiated with loss of the TP53 gene, representing a milstone in understanding the early stages of this deadly disease”. Dr. Zhaocai Zhou, head of a GC laboratory from Fudan University, stated.