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UrduResearchers from Cleveland Clinic, Case Western Reserve University School of Medicine, and Moffitt Cancer Center have found that the genomic adjusted radiation dose (GARD) may be used to personalize radiotherapy (RT) to maximize the therapeutic effect of a given physical RT dose. This research was published Aug. 4 in The Lancet Oncology journal.
Tag: Cancer
Frequent Consumption of Peanuts by Cancer Patients May Increase Risk of Cancer Spread
A study by University of Liverpool researchers has identified new factors accompanying previous findings that frequent consumption of peanuts by cancer patients could increase risk of cancer spread.
Most Comprehensive Review Yet of Keto Diets Finds Heart Risks, Cancer Risk, Dangers to Pregnant Women and Kidney Patients
In the most comprehensive analysis yet of ketogenic (keto) diets, a review in Frontiers in Nutrition finds keto diets place pregnant women and kidney disease patients at risk of adverse health effects.
Graphic Warning Labels on Cigarette Packaging Changes Perceptions
A Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego clinical trial showed that graphic warning labels on cigarette packaging changes perceptions of smokers to recognize the negative consequences of tobacco and consider quitting.
LUDWIG CANCER RESEARCH WELCOMES MIKAËL PITTET TO LUDWIG LAUSANNE
It is with great pleasure that we announce the appointment of Mikaël Pittet as a full Member of the Lausanne Branch of the Ludwig Institute for Cancer Research.
Large catheters, small veins, increase blood clot risk for cancer patients
A world-first study led by the University of South Australia has found that cancer patients receiving chemotherapy intravenously have more than double the risk of developing a blood clot or thrombosis if the vein is too small and the catheter occupies more than 45 per cent of the vein.
Study finds cancer-related follow-up care is underutilized among young adult survivors of childhood cancer
A research team, led by Joel Milam, PhD, professor of epidemiology and biostatistics at the UCI Program in Public Health, is examining gaps and disparities in lifelong follow-up among survivors, including taking a closer look at long term follow-up care plans, specifically for underserved populations. The study shows that age and ethnic background is associated with inadequate follow-up care among young adult childhood cancer survivors.
Experimental Model of Ovarian Cancer Shows Effect of Healthy Cell Arrangement in Metastasis
A key element to slowing metastasis in ovarian cancer is understanding the mechanisms of how tumor cells invade tissues. In APL Bioengineering, biophysics researchers explain how microscopic defects in how healthy cells line up can alter how easily ovarian cancer cells invade tissue. Using an experimental model, the group found that disruptions in the normal cellular layout, called topological defects, affect the rate of tumor cell invasion.
Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice
As the third-most lethal cancer in the United States, with only a 1% five-year survival rate for people with its most aggressive form, pancreatic cancer has long been a target of researchers who search for ways to slow or stop its growth and spread. Now, a team of Johns Hopkins Medicine researchers have found that an anti-parasitic drug prevents pancreatic cancer’s initiation, progression and metastasis in genetically engineered mice.
Intracellular pH, Oxygen Consumption Rate Study Raises Questions about Limiting Metabolic Programming in Cancer Cells
Article title: Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells Authors: Sagar S. Manoli, Kyle Kisor, Bradley A. Webb, Diane L. Barber From the authors: “Our findings that a lower [intracellular pH (pHi)]…
Shih-Ting (Christine) Wang: Designing Materials for Biomedicine
Using DNA-based assembly, the Center for Functional Nanomaterials postdoc has assembled functional proteins into ordered lattices and coated nanostructures for drug delivery.
Loyola Medicine to Offer Free Cancer Screenings to Uninsured Women during See, Test and Treat® Event
On Saturday, August 14, 2021, qualified women who make an appointment can receive free cervical and breast cancer screenings as part of Loyola Medicine’s 6th annual See, Test and Treat® event. See, Test and Treat® will be held at the Loyola Outpatient Center, 2160 S. First Ave., Maywood, Illinois. Interested women are invited to call 708-216-7284 to verify eligibility and make an appointment.
Princess Margaret Cancer Centre researchers discover key stem cell dormancy mechanism which could help unlock future cancer treatments
Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.
Researchers uncover a way to harness the power of immunotherapy for advanced prostate cancer
Researchers led by the University of Michigan Rogel Cancer Center identified an inhibitor that showed promise against metastatic castration-resistant prostate cancer cells.
Jersey Shore University Medical Center Now Offers Elite Regional Expertise in Orthopedic Oncology
The care of cancer (sarcomas) of the bones and soft tissues requires the expertise of a highly specialized team. Jersey Shore University Medical Center is among two of the elite Hackensack Meridian Health locations in New Jersey to offer clinical expertise in the field of orthopedic oncology.
Study reveals source of DNA mutations in melanoma
GRAND RAPIDS, Mich. (JULY 30, 2021) — The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight — not just a DNA copying error as previously believed, reports a study by Van Andel Institute scientists published today in Science Advances.
MD Anderson announces 2021 class of Andrew Sabin Family Fellows
The University of Texas MD Anderson Cancer Center has named 10 early career faculty members to the 2021 class of Andrew Sabin Family Fellows. Established by philanthropist Andrew Sabin through a generous $30 million endowment in 2015, the Sabin Family Fellowship program encourages creativity, innovation and impactful cancer research at MD Anderson in the areas of basic science, clinical, physician-scientist and population and quantitative science.
World Trade Center Responders with the Greatest Exposure to Toxic Dust Have a Higher Likelihood of Liver Disease
Mount Sinai researchers have found evidence for the first time that World Trade Center responders had a higher likelihood of developing liver disease if they arrived at the site right after the attacks as opposed to working at Ground Zero later in the rescue and recovery efforts. Their study links the increase in liver disease risk to the quantity of toxic dust the workers were exposed to, which was greatest immediately after the September 11, 2001, attacks.
Could Powerful Ovarian Cancer Treatments Benefit More Patients?
WEHI researchers have made a discovery that could help more Australian women with ovarian cancer gain access to game-changing cancer treatments called PARP inhibitors.
Dr. Beth Karlan receives lifetime achievement award for contributions to gynecologic oncology
Internationally renowned physician-scientist Dr. Beth Karlan, director of cancer population genetics at the UCLA Jonsson Comprehensive Cancer Center, is being honored with the Lifetime Achievement Award from the International Gynecologic Cancer Society (IGCS) for her contributions to gynecologic cancer research and clinical practice.
Mayo Clinic scientists advance breast, ovarian cancer research with cryo-electron microscopy
Using advanced imaging technology, Mayo Clinic scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper, published in Nature, identifies aspects of how BRCA1-BARD1 functions, supporting future translational research, cancer prevention efforts and drug development.
MD Anderson and Blueprint Medicines announce strategic collaboration to accelerate BLU-222 development
MD Anderson and Blueprint Medicines announced a three-year strategic collaboration to accelerate the development of BLU-222, an investigational targeted therapy against CDK2.
Penn-led Consortium Identifies More Genetic Markers for Inherited Testicular Cancer
A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors.
Memorial Sloan Kettering Cancer Center Recognized as One of the Best Hospitals for Cancer Care by U.S. News & World Report for the 32nd Year in a Row; Ranked #1 Nationally for Ear, Nose, and Throat Care
Memorial Sloan Kettering Cancer Center (MSK) has been recognized as the number two hospital for cancer care in the nation by U.S. News & World Report in its annual Best Hospitals listing. Since these prestigious rankings were established more than 30 years ago, MSK has consistently ranked among the top two cancer hospitals in the country.
Genomic test could help predict aggressive disease in men newly diagnosed with prostate cancer
A new, University of Michigan-led study analyzing data from more than 850 patients across the state of Michigan found a commercially available genomic test known as Decipher Biopsy may help identify patients who are at high risk of prostate cancer progression.
UC San Diego Health Ranked #1 by U.S. News & World Report
UC San Diego Health, the region’s only academic health system, is ranked #1 in San Diego and #5 in California, placing it among the nation’s best hospitals, according to the 2021-2022 U.S. News & World Report survey. UC San Diego Health was ranked in the top 50 in 10 specialties.
Rush University Medical Center Again on U.S. News & World Report Honor Roll
Of the more than 3,000 U.S. hospitals evaluated, Rush University Medical Center ranked No. 19 in the nation by U.S. News & World Report, with nine of specialties rated among the country’s very best.
Dana-Farber Brigham Cancer Center is ranked the best in New England
Dana-Farber Brigham Cancer Center is ranked #4 as a Best Hospital for cancer care by U.S. News and World Report for 2021-22
Oncotarget: Replication-stress sensitivity in breast cancer cells
Taken together these Oncotarget findings show that the CTD and OD domains of mtp53 R273H play critical roles in mutant p53 GOF that pertain to processes associated with DNA replication.
Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas
This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas
Senator Toni Atkins Visits Hospital to Recognize Plans for New Hillcrest Campus
Senate President Pro Tempore Toni Atkins visited UC San Diego Medical Center today to recognize a $30 million allocation in the 2021-2022 California state budget that will support the redevelopment of the new Hillcrest hospital.
Comprehensive clinical sequencing opens door to the promise of precision medicine
St. Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.
Research Identifies Potential Role of ‘Junk DNA’ Sequence in Aging, Cancer
The human body is essentially made up of trillions of living cells.
Mount Sinai Researchers Develop Novel Therapy That Could Be Effective in Many Cancers
Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July.
Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma
MUSC Hollings Cancer Center part of promising clinical trial for aggressive lymphoma
Novel imaging agent identifies biomarker for iron-targeted cancer therapies
Reston, VA–A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help…
Mount Sinai researchers develop novel therapy that could be effective in many cancers
New York, NY (July 23, 2021) — Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery , a…
New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors
Team identifies crucial interaction between platelets and tumors for the first time
Oncotarget: Fgr and Numb in retinoic differentiation and G0 arrest of non-APL AML cells
In sum the Oncotarget data support a paradigm where signaling molecules bound to a Numb scaffold in a signalsome are activated by RA-induced Fgr expression
Chemotherapy can induce mutations that lead to pediatric leukemia relapse
A collaboration led by St. Jude Children’s Research Hospital, Shanghai Children’s Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
Mayo Clinic research suggests women over 65 be offered hereditary cancer genetic testing
A new study by Fergus Couch, Ph.D., of Mayo Clinic Cancer Center, along with collaborators from the CARRIERS consortium, suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study was published Thursday, July 22, in the Journal of Clinical Oncology.
Artificial intelligence models to analyze cancer images can take shortcuts that introduce bias for minority patients
New study of artificial intelligence tools that analyze tumor images shows how they can make inaccurate predictions based on the institution that submitted the image
Study of Cancer Patients and COVID-19 Highlights Health Disparities
Findings from a study led by researchers at Henry Ford Cancer Institute, in collaboration with Advocate Aurora Health, the Food and Drug Administration and Syapse®, show an elevated risk for severe COVID-19 effects or death among patients with cancer, with the highest risk being among low-income and Black patients.
Study shows cancer misinformation common on social media sites
A new study published online today in the Journal of the National Cancer Institute reports that one third of the most popular cancer treatment articles on social media contain misinformation. Further, the vast majority of that misinformation has the potential…
Antibiotics may help to treat melanoma
Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental…
Bidirectional impact of cardiovascular disease, cancer in Blacks focus of new AHA center
Cardiovascular disease and cancer, the nation’s top two killers, share common ground like obesity and chronic inflammation, as well as a disproportionate impact on Black Americans. A new American Heart Association-funded center at the Medical College of Georgia is working…
Cardio-cerebrovascular disease history complicates hematopoietic cell transplant outcomes
Researchers find pre-transplant cardiovascular diseases indirectly affect mortality and survival through increased post-transplant disease occurrence
Investigational magnetic device shrinks glioblastoma in first-in-world human test
Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy…
Study on chromosomal rearrangements in yeast reveals potential avenue for cancer therapy
Researchers from Osaka University uncover a mechanism by which chromosomal rearrangements occur, with implications for novel cancer therapies
Geneticists reveal how mutation causes childhood cancer; use drug to reverse its effects
Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its…