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UrduScientists studying the most common and aggressive type of brain tumour in adults have discovered a new way of analysing diseased and healthy cells from the same patient.
Tag: Cancer
Cell-free DNA identifies early signs of relapse in pediatric medulloblastoma
Findings from St. Jude Children’s Research Hospital show that cell-free DNA in cerebrospinal fluid can be used to detect measurable residual disease and identify patients at risk of relapse.
MD Anderson’s Boot Walk to End Cancer® to unite thousands virtually on Nov. 6
The University of Texas MD Anderson Cancer Center celebrates its sixth annual Boot Walk to End Cancer® on Saturday, Nov. 6. Due to ongoing COVID-19 precautions, the 1.2-mile walk will be held virtually to keep participants, their families and their communities safe. Participants are encouraged to walk a personalized route in their own neighborhoods, whether it be on a trail, track or sidewalk. Registration is open at mdanderson.org/bootwalk.
The Medical Minute: You got your mother’s blue eyes. Will you get her breast cancer, too?
Family traits can be a source of pride – and a source of worry. Fortunately, only 5% to 10% of all cancers can be linked to a genetic mutation passed on from your mom or dad. How can you gauge your genetic risk?
How high-fat diets allow cancer cells to go unnoticed
A high-fat diet increases the incidence of colorectal cancer. Cold Spring Harbor Laboratory Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that in mice, fat disrupts the relationship between intestinal cells and the immune cells that patrol them looking for emerging tumors.
Rare cancer of immune cells linked to gene mutations in bone marrow and smoking
Mutations in blood cells likely caused by smoking and aging-related changes may lead to a rare type of blood cancer that affects immune cells, shows a study published today in eLife.
Memorial Sloan Kettering Cancer Center Announces New Early-Career Physician Research Program in Cancer Science
Memorial Sloan Kettering Cancer Center (MSK) today announced a $25 million gift from Louis V. Gerstner, Jr. to create the Louis V. Gerstner, Jr. Physician Scholars Program. Designed to support the innovative research of physician-scientists who are early in their career at MSK, the Gerstner Physician Scholars Program will advance promising scientific research and further the careers of outstanding junior faculty.
Three Steps Forward
Mariah Candelaria is a three-time survivor of Hodgkin Lymphoma and received a stem cell transplant at the University of New Mexico Comprehensive Cancer Center. During and after her recovery she’s leaned on dance to make it through. Now she wants to give back to others who are going through similar challenges fighting cancer.
NCI renews prestigious ‘comprehensive’ designation for cancer center
The National Cancer Institute renewed the “comprehensive” designation of the UC Davis Comprehensive Cancer Center in recognition of its breadth and depth in cancer research, clinical care, cancer control and population sciences.
Hopkins Med News Update
Hopkins Med News Update
Peter Adams and Gerald Shadel awarded $13 million from NIH to study aging and liver cancer
Sanford Burnham Prebys professor Peter D. Adams, Ph.D., and Salk Institute professor Gerald Shadel, Ph.D., have been awarded a grant from the NIH’s National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer.
Active Living After Cancer program improves physical functioning of breast cancer survivors
Breast cancer survivors who participated in Active Living After Cancer, an evidence-based 12-week group program, markedly increased their physical activity and ability to accomplish the basic pursuits of daily life, researchers from The University of Texas
MD Anderson Cancer Center reported today in Cancer.
Therapy Using Dual Immune System Cells Effectively Controls Neuroblastoma
A newly developed immunotherapy that simultaneously uses modified immune-fighting cells to home in on and attack two antigens, or foreign substances, on cancer cells was highly effective in mice implanted with human neuroblastoma tissue.
MD Anderson Research Highlights for September 22, 2021
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a new method to measure breast cancer response, a new immunotherapy approach for multiple myeloma, characterization of the immune landscape of cholangiocarcinoma, a new contrast agent to improve molecular imaging techniques, and new treatment targets in breast, gynecologic and pancreatic cancers.
Coriell Institute for Medical Research, Van Andel Institute Awarded Estimated $12.4 Million SPORE Grant from National Cancer Institute
The Coriell Institute for Medical Research and Van Andel Institute (VAI) have been awarded a prestigious Specialized Programs of Research Excellence (or SPORE) grant from the National Cancer Institute (award P50CA254897). The five-year grant valued at an estimated $12.4 million will support nearly 20 scientists as they work to improve epigenetic therapies for cancer. The project is co-led by Coriell’s President and CEO Jean-Pierre Issa, MD, Van Andel Institute’s Chief Scientific Officer Peter A. Jones, PhD, DSc (hon), and Johns Hopkins University and VAI’s Stephen Baylin, MD.
UNM Cancer Center Renews NCI Comprehensive Designation
The University of New Mexico Comprehensive Cancer Center has once again been awarded the highest designation and rating in the United States for cancer treatment and research programs.
Cancer shortens lifespan in transplant recipients
People who have received organ transplants face an elevated risk of developing cancer, primarily due to immunosuppression from medications to prevent organ rejection, as well as underlying medical conditions.
Dr. Armando Sardi of Mercy Medical Center Recognized as an Expertscape Expert
Armando Sardi, M.D., FACS, Medical Director of The Institute for Cancer Care at Mercy and Chief of the Division of Surgical Oncology with Mercy Medical Center in Baltimore, MD, was recently recognized as an Expertscape Expert in Peritoneal Neoplasms.
Scientists Find a Pair of Proteins Control Supply Lines That Feed Cancer Cells
In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow. The protein twosome, PADI4 and HIF-1, ramp up their activity under low-oxygen conditions that are typically found in a fast-growing tumor, allowing it to build new blood vessels that feed the cancer’s growth.
Focused Ultrasound Breakthroughs from the Summer of 2021
Here are eight amazing developments in the use of Focused Ultrasound from just the last three months, including: treating cancerous tumours, triggering the targeted release of medicine in the body, immunotherapy, and pain management. See more in the Focused Ultrasound Channel
Yale Cancer Center Study Finds New Drug Combination Shows Clinical Activity for Patients with Prostate Cancer
New findings by researchers at Yale Cancer Center show the drug combination of nivolumab and rucaparib shows clinical activity for patients with chemotherapy-naïve, metastatic castration resistant prostate cancer.
Antibody-drug conjugate shows impressive activity in patients with non-small cell lung cancer with mutation in HER2 gene
More than half of patients with non-small cell lung cancer (NSCLC) bearing a mutation in the HER2 gene had their tumors stop growing or shrink for an extended time after treatment with a drug that hitches a chemotherapy agent to a highly targeted antibody, an international clinical trial led by investigators at Dana-Farber Cancer Institute has found.
Programmable Off-the-Shelf Dendritic Cells as an Immunotherapy Discovery Platform
A new therapeutic era has been ushered in with Adoptive Cell Immunotherapy, which uses patient-harvested T cells genetically engineered against tumor-specific targets.
Multiple Myeloma – the Blood Cancer that Silently Impacts Vital Organs
Every year more than 1.3 million Americans will be living with, or be in remission from, a blood cancer. John Conti, M.D. discusses common symptoms and treatment.
The Medical Minute: Real-time tumor tracking delivers high cure rates, decreased side effects for cancer patients
Think of it like radio making way for television. Image-guided radiation therapy has evolved to include the ability to track tumors in real time during treatment. It’s improving cure rates and limiting side effects for a growing number of cancer patients.
Johns Hopkins Cancer Researcher Ashani Weeraratna Appointed To National Cancer Advisory Board By President Biden
Johns Hopkins scientist Ashani Weeraratna, PhD, a leading cancer researcher who specializes in melanoma and the effects of aging on cancer, has been appointed by President Joe Biden to serve as a member of the National Cancer Advisory Board.
Classifying EGFR mutations by structure and function offers better way to match non-small cell lung cancer patients to treatments
Researchers from The University of Texas MD Anderson Cancer Center have discovered that grouping epidermal growth factor receptor (EGFR) mutations by structure and function provides an accurate framework to match patients with non-small cell lung cancer (NSCLC) to the right drugs.
Investigators Uncover Cellular Pathway Involved in Cancer Growth
A hallmark of cancer is its ability to replicate, a process commonly driven by the reactivation of the telomerase enzyme complex, which helps prevent the aging and death of healthy cells and keeps stem cells in bone marrow and the intestines from producing normal cells in those organs. When telomerase is activated in cancer cells, it helps them survive and duplicate in the body.
How a plant virus could protect and save your lungs from metastatic cancer
Using a virus that grows in black-eyed pea plants, researchers developed a new therapy that could keep metastatic cancers from spreading to the lungs, as well as treat established tumors in the lungs.
White blood cells that can help destroy malignant tumors
A new study at Tel Aviv University found that eosinophils – a type of white blood cells – are recruited to the battle against cancer metastases in the lungs.
Um novo entendimento sobre o funcionamento interno da terapia celular CAR-T
Os pesquisadores da Mayo Clinic biomanufaturaram a terapia de células T receptoras de antígenos quiméricos (terapia celular CAR-T) de uma nova maneira, a fim de rastrear a jornada de combate ao câncer das células e prever efeitos tóxicos colaterais.
Nueva perspectiva sobre el funcionamiento interno de la terapia de células T con receptor de antígeno quimérico
Los investigadores de Mayo Clinic manipularon biológicamente y de forma novedosa la terapia de células T con receptor de antígeno quimérico (CAR-T, por sus siglas en inglés) a fin de averiguar cómo es la batalla de las células cancerosas y predecir los efectos secundarios tóxicos.
Researchers identify a novel player in acute myeloid leukemia
A new study led by scientists at Sanford Burnham Prebys has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5 binds with a second cell protein called RBBP4 to control expression of genes implicated in AML. These findings, published in Nature Communications, have important implications for improving AML patient outcomes.
Sylvester Researchers Explore Cancer Risks at Surfside Condo Collapse
“We were uniquely positioned to take the evidence gleaned from our ongoing effort to address why firefighters are at increased risk of cancer incidence and mortality and rapidly translate it to a disaster that could augment this risk substantially,” said Dr. Kobetz, Sylvester’s associate director for population sciences and cancer disparity and the University of Miami’s vice provost for research and scholarship. “Our hope is that we and our firefighter colleagues learn together how to mitigate the risks that emerge in a different disaster scenario.”
LUDWIG LAUSANNE RESEARCHERS SHOW A LITTLE RADIATION GOES A LONG WAY IN HEATING UP COLD TUMORS
A Ludwig Cancer Research study conducted in both mice and a small group of patients with advanced cancers has shown that so-called “cold” tumors that are nearly devoid of immune cells—and therefore unresponsive to immunotherapy—can be turned “hot” with extremely low doses of radiation and the rational use of existing therapies.
Study links free radicals to heart damage caused by cancer
A new study in animal models shows that a cancer tumor alone can lead to cardiac damage, and suggests the culprits are free radicals interacting with cells in the heart. Adding antioxidants to food consumed by fruit flies with tumors reversed the damage to their hearts.
Right Program Could Turn Immune Cells into Cancer Killers
Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program” that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Newly developed software unveils relationships between RNA modifications and cancers
Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at NUS has developed a software called ModTect that can help reveal the relationships between RNA modifications and the development of diseases and disorders. Their work highlights the potential of using RNA modifications as biomarkers to test for diseases.
UTHealth researcher awarded CPRIT grant to test potential large-molecule cancer drugs at preclinical development core facility
A preclinical development core where researchers can test the effectiveness of large molecule drug candidates for novel cancer treatments, led by Qingyun Liu, PhD, has been awarded a nearly $4 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT).
Making the microbiome more amenable to cancer immunotherapy
The gut microbiome can impact us in a variety of different ways, from our metabolism to our mood. Now, NIBIB-funded researchers are investigating if a fiber-based gel can restore beneficial microbes in the gut to enhance the efficacy of immune checkpoint inhibitors, a type of cancer immunotherapy treatment, in mice.
Hopkins Med News Update
Hopkins Med News Update
MD Anderson Research Highlights for September 8, 2021
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts.
Chemotherapy drug puts young children with cancer at high risk of hearing loss
A chemotherapy drug known to cause hearing loss in children is more likely to do so the earlier in life children receive it, new UBC research has found.
Blood Cancers: Hidden Diseases with Many Treatments
When most people think about cancer, they tend to think of lumps and bumps, something visible they can see and touch. But with blood cancers, there are no immediate visible signs, just the effects of the cancer in the blood system. John Conti, M.D., explains more.
Older Patients Benefit from Cancer Immunotherapies
A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.
Research provides evidence for how a key transcription factor manages access to DNA
St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer.
New Insights about Melanocytes Could Lead to More Targeted Melanoma Treatments
Huntsman Cancer Institute melanoma researchers have generated the first “atlas” of human melanocytes located in the body.
Engineering CAR T Cells to Deliver Endogenous RNA Wakes Solid Tumors to Respond to Therapy
New study shows CAR T cells expressing RN7SL1 can activate the body’s natural immune cells against difficult-to-treat cancers
The Medical Minute: On the watch for pediatric cancers
No parent wants to hear the word “cancer.” Fortunately, few will, but it’s always smart to be attuned to signs that might warrant a further look. Two Penn State Health Children’s Hospital doctors discuss the warning signs.
The PANoptosome: a new frontier in innate immune responses
St. Jude Children’s Research Hospital scientists detail how inflammasomes act as integral components of mega-cell death complexes called PANoptosomes for host defense in live viral and bacterial infections.