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UrduA new study published today in Cancer Discovery is providing insights into why some Merkel cell carcinoma patients respond to this type of immunotherapy while others do not.
Tag: Cancer
FAU Researcher Receives Grant to Personalize Radiation Therapy for Cancer
While chemotherapy has advanced in personalization, personalized radiation therapy for cancer remains underdeveloped. A new project will use AI, in particular, deep reinforcement learning, to analyze multimodal data, and enhance cancer characterization and treatment to ultimately improve patient outcomes. Using personal health data, genetic information about the tumor, and patient treatment and follow-up data, digital twins will simulate diagnoses and treatment options to help physicians choose the most effective treatments and monitor responses over time.
MD Anderson and Summit Therapeutics announce strategic collaboration to accelerate development of ivonescimab
MD Anderson and Summit Therapeutics announced a strategic five-year collaboration to accelerate the development of ivonescimab, a novel PD-1/VEGF bispecific antibody.
Cancer survivors and doctors show their Olympic mettle
Cancer survivors and doctors show their Olympic mettle Sylvester experts examine athletics and resilience as the Paris 2024 Summer Olympic Games begin MIAMI, FLA. (July 22, 2024) – Cancer affects the world’s top athletes, forcing some Olympians to compete against disease. Athletes in…
Socioeconomic status affects survival of children with cancer
Socioeconomic factors can influence the diagnosis and treatment of children in Texas with malignant solid tumors, increasing the risk of the cancer’s spread and lowering the five-year survival rate, according to researchers at UT Southwestern Medical Center. The study, published in Journal of the American College of Surgeons, identifies vulnerable populations in an effort to improve outreach and distribution of resources for better health outcomes for pediatric patients.
Loyola Medicine Offers Free Cancer Screenings for Women at 10th Annual See, Test and Treat® Event
On Saturday, August 17, 2024, qualified women who make an appointment can receive free cervical and breast cancer screenings as part of Loyola Medicine’s 10th Annual See, Test and Treat® event. This annual event will be held at the Loyola Outpatient Center, 2160 S. First Ave., Maywood, Illinois.
New tech addresses manufacturing bottlenecks in a lifesaving blood cancer treatment
Relapsed B-cell ALL is the leading cause of cancer-related deaths in children and young adults. UniSA research has shown the potential of new microfluidic technology, to improve the CAR T-cell manufacturing process by efficiently removing contaminating cancerous cells and other large white blood cells – potentially leading to greater access and lower costs of treatment.
UTSW study identifies RNA molecule that regulates cellular aging
A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division.
The Mount Sinai Hospital Ranked Among Top in the Nation by U.S. News & World Report®; Department of Geriatrics Claims No. 1 Spot in Specialty Rankings
The Mount Sinai Hospital, the flagship hospital of Mount Sinai Health System, was listed among the nation’s top hospitals for care excellence by U.S. News & World Report®, marking the ninth straight year the hospital has been listed among the top 20 in the country on the publication’s “Honor Roll.”
Statement on Passage of Legislation Expanding Access to Breast Cancer Treatment for Missourians
Susan G. Komen®, the world’s leading breast cancer organization, today issued the following statement on the passage of legislation to expand eligibility for the MO HealthNet Breast and Cervical Cancer Treatment (BCCT) program, ensuring that all eligible individuals have access to vital treatment services, regardless of where they received their cancer screening and diagnosis.
Many breast cancer survivors do not receive genetic testing, despite being eligible
As cancer treatment and survivorship care relies more on understanding the genetic make-up of an individual’s tumor, a new study from the University of Michigan Health Rogel Cancer Center finds that many breast cancer survivors who meet criteria for genetic counseling and testing are not receiving it.
MedStar Washington Hospital Center Ranks Among Nation’s Best Hospitals and Shares the #1 Spot in the Washington Region
MedStar Washington Hospital Center is tied for the #1 hospital in the Washington metro region in the 2024-2025 edition of U.S. News & World Report’s Best Hospitals. Additionally, two of MedStar Washington’s clinical programs are nationally ranked. Cardiology, Heart & Vascular Surgery again ranked at #38 in the country.
MD Anderson ranked No. 1 in the nation for cancer care
The University of Texas MD Anderson Cancer Center today was ranked number one in the nation for cancer care in U.S. News & World Report’s 2024-25 “Best Hospitals” survey. Since the survey’s inception in 1990, MD Anderson has consistently been one of the top two hospitals in the nation for cancer care, and it has maintained the top ranking for the past 10 years.
UT Southwestern once again ranked best hospital in DFW
UT Southwestern Medical Center is the No. 1 hospital in Dallas-Fort Worth for the eighth consecutive year and ranks among the nation’s top hospitals for care in 11 specialties – the most of any hospital in Texas, according to U.S. News & World Report’s annual Best Hospitals list released today.
MD Anderson Research Highlights for July 11, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
New Study Finds 40-Percent of Cancer Cases and Almost Half of all Deaths in the U.S. Linked to Modifiable Risk Factors
A new study led by researchers at the American Cancer Society finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet, and infections.
New solutions to keep drinking water safe as pesticide use skyrockets worldwide
Water scientists from Australia and China have proposed a more effective method of removing organic pesticides from drinking water, reducing the risk of contamination and potential health problems.
Revolutionizing Cancer Treatment: Wistar and Accelerated Biosciences Collaborate to Pioneer Transformative Immune Cell Therapies
The Wistar Institute is pleased to announce a research collaboration with Accelerated Biosciences Corp. aimed at creating a platform based on human trophoblast stem cells to explore new immunotherapies that use Accelerated Bio’s proprietary technology.
Intensity Therapeutics, Inc. Announces First Patient Dosed in its Global Randomized, Phase 3 Study (INVINCIBLE-3) in Metastatic Soft Tissue Sarcoma
Intensity Therapeutics, Inc. , a late-stage clinical biotechnology company focused on the discovery and development of proprietary, novel immune-based intratumorally injected cancer therapies intended to kill tumors directly and increase immune system recognition of cancers, announces that the first U.S. patient has been dosed in the Company’s Phase 3 study to treat metastatic sarcoma (NCT06263231).
Physician-scientist awarded two grants to develop immune therapies for ovarian cancer
Dr. Sanaz Memarzadeh has received two grants totaling $4.1 million to develop advanced cell based immune therapies for high-grade serous ovarian cancers that have become resistant to conventional treatments.
Advancing cervical cancer prevention in China: new insights and future strategies
Recent findings highlight significant advancements and challenges in cervical cancer prevention in China, particularly focusing on rising incidence and mortality rates in rural areas. The study underscores the effectiveness of the HPV vaccine and emphasizes the necessity for comprehensive public health strategies.
Survivorship Standards Help Address the Distinct Needs of Adult Cancer Survivors
Survey study published in JAMA Network Open demonstrates the value of American College of Surgeons’ survivorship accreditation standards, though specialized services in fertility and sexual health are less accessible.
Radiation oncologists awarded $1.8 million grant to advance personalized cancer therapy
The funding helps further the team’s work in improving the quality of life for men diagnosed with prostate cancer by predicting and preventing significant long-term side effects from radiation treatment.
New Treatment for Uterine Cancer Receives FDA Approval
The U.S. Food & Drug Administration has approved use of a new treatment option for patients with advanced or recurring uterine cancer. The news comes after completion of the first Phase III trial to statistically evaluate an anti-PD1 immunotherapy, called…
Ultrasounds may not find this cancer in Black women
The study looked back at ultrasound data from 1,500 Black women who ended up undergoing hysterectomy at 10 health centers. The study found that having a thinner endometrium measured on transvaginal ultrasound did not mean that there was no cancer risk.
Study supports precision radiation therapy in lung cancer
Results from a new study led by researchers at The University of Texas MD Anderson Cancer Center support standard use of the more precise intensity-modulated radiotherapy (IMRT) over the alternative 3D-conformal radiotherapy (3D-CRT) for patients with unresectable, locally advanced non-small cell lung cancer (NSCLC).
Chemotherapy disrupts gut microbiome in patients with breast cancer
“For the first time ever, our Intelligut Study found that the gut microbiome has been implicated in cognitive side effects of chemotherapy in humans,” said senior author Leah Pyter, associate professor of psychiatry and neuroscience with The Ohio State University Wexner Medical Center and College of Medicine.
Tai Chi reduces risk of inflammatory disease, treats insomnia among breast cancer survivors
New research led by UCLA Health confirms that both Tai Chi and cognitive behavioral therapy can reduce insomnia in breast cancer survivors but also may provide additional health benefits by reducing inflammation and bolstering anti-viral defenses.
SOS Signal for Canine Muscle Loss
Researchers at Cummings School of Veterinary Medicine are now working with engineers at the Massachusetts Institute of Technology (MIT) to determine whether a blood test, ultrasound, or a combination of both can be developed to detect cachexia sooner, more consistently, and to grade how advanced the condition is.
UK study reveals concerning decline in cervical cancer screenings
LEXINGTON, Ky. (June 25, 2024) — New University of Kentucky research published in JAMA Network Open reveals concerning declines in cervical cancer screening rates among women in the U.S. during the COVID-19 pandemic, especially in rural areas. The study led by UK Markey Cancer Center researcher Ty Borders, Ph.D., analyzed nationally representative survey data from the National Cancer Institute to examine Pap test screening rates before and during the pandemic.
Researchers awarded $2.78M federal grant to improve rectal cancer treatment with artificial intelligence
With a new five-year, $2.78 million grant from the National Institutes of Health and National Cancer Institute, researchers at Case Western Reserve University (CWRU), Cleveland Clinic and University Hospitals (UH) will use artificial intelligence (AI) to better treat rectal cancer patients.
Roswell Park Insights on Role of Exportin 1 Protein Suggest Strategy for Improving Cancer Immunotherapy
Research by Hemn Mohammadpour, DVM, PhD, and colleagues at Roswell Park Comprehensive Cancer Center offers new insights into tumor biology and may lay the groundwork for more effective cancer immunotherapy. Their preclinical findings were published today in the journal Cellular & Molecular Immunology.
Accessibility issues in cancer care
Research identifies issues with booking new appointments at clinics for cancer treatment
Swimming microrobots deliver cancer-fighting drugs to metastatic lung tumors in mice
UC San Diego engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors.
Obesity-cancer connection discovery suggests strategies for improving immunotherapy
The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy.
New Study Finds Most Eligible U.S. Adults not Getting Screened for Lung Cancer
A new study led by American Cancer Society researchers shows less than one-in-five eligible individuals in the United States were up-to-date with recommended lung cancer screening. The screening uptake was much lower in persons without health insurance or usual source of care and in Southern states with the highest lung cancer burden.
Groundbreaking LLNL and BridgeBio Oncology Therapeutics collaboration announces start of human trials for supercomputing-discovered cancer drug
In a substantial milestone for supercomputing-aided drug design, Lawrence Livermore National Laboratory (LLNL) and BridgeBio Oncology Therapeutics (BridgeBio) today announced clinical trials have begun for a first-in-class medication that targets specific genetic mutations implicated in many types of cancer.
How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders
Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.
Molecular switch linked to lineage plasticity, therapy resistance
Two genes working in tandem play a critical role in shaping the identity and behavior of prostate cancer cells and their response to treatment, UT Southwestern Medical Center researchers report.
ASCO: Proton therapy demonstrates advantages in Phase III head and neck cancer trial
According to preliminary data from a multi-institution Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, intensity modulated proton therapy (IMPT) achieved similar clinical outcomes and offered significant patient benefits when compared to traditional intensity modulated radiation therapy (IMRT) as part of chemoradiation treatment for patients with oropharyngeal (head and neck) cancer.
Stepping Up Summer Fun: the Cancer Research – Scholarship and Training Experience in Population Sciences (C‐STEPS) Program
Over the last two decades, strides in cancer prevention, earlier detection, and novel treatments have reduced overall cancer mortality; however, cancer health disparities (CHD) persist among demographically diverse and intersecting populations.
LJI scientists develop new method to match genes to their molecular ‘switches’
LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity. Their work may help researchers connect genes to the molecular “switches” that turn them on or off. This research, published in Genome Biology, is an important step toward harnessing machine learning approaches to better understand links between gene expression and disease development.
Safety and efficacy of osimertinib plus consolidative stereotactic ablative radiation (SABR) in advanced EGFR mutant non-small cell lung cancer (NSCLC): results from a multi-center Phase II trial
BackgroundDespite high response rates to EGFR inhibitors, patients with advanced EGFR mutant NSCLC generally experience disease progression within two years (osimertinib median PFS 18.9 months, median OS 38.6 months). We sought to determine whether administration of SABR to residual sites…
Fibrolamellar hepatocellular carcinoma (FL-HCC) epidemiology, survival characteristics, and outcomes: Surveillance, epidemiology, and end results database (SEER) study
Background:Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare and distinctive form of liver cancer that primarily affects adolescents and young adults without underlying liver disease. Unlike conventional HCC, it exhibits unique clinical and histological features and poses a diagnostic and therapeutic…
Association between congenital heart disease and cancer: A meta-analysis of 30 million patients
Background: Birth defects have been associated with increased cancer risk; however, the association between congenital heart disease (CHD) and cancer risk has not been well established with limited and conflicting literature till date. Children afflicted with CHD possess multiple risk factors…
Clinically significant variant classification resulting from the addition of RNA sequencing: Experience at high-volume cancer genetics center
Background: Germline cancer genetic testing plays an important role in prevention, early detection, and targeted therapy1. The increasing use of multi-gene panel testing (MGPT) underscores the importance of accurate variant classification. We report on the significant contribution of RNA analysis…
Cancer screening in sexual and gender minority populations: A systematic review and meta-analysis
Background: The sexual and gender minority (SGM) populations experience a greater cancer burden than their heterosexual or cisgender counterparts. Screening rates for cancer within this cohort are frequently suboptimal, highlighting notable deficiencies in screening recommendations. Inadequate culturally competent care and screening…
Non-Hodgkin lymphoma mortality disparities across different sexes, races, and geographic locations
Background: Non-Hodgkin lymphoma (NHL) is one of the common hematological cancers in the United States (U.S.), accounting for 4% of new cancer cases in 2023. The mortality rate of NHL is the sixth highest among all cancers in the U.S. Our…
Evaluating the impact of socioeconomic status on patient satisfaction in radiation oncology
Background: Patient satisfaction (PS) is a critical indicator in evaluating healthcare quality. While the impact of socioeconomic status (SES), on healthcare outcomes is well-documented, its specific connection to PS in the context of radiation oncology remains unclear. This study aims to…
Trilaciclib use for prevention of hematological adverse events in chemotherapy: A meta-analysis of real-world studies and clinical trials
Background: Trilaciclib, a cyclin-dependent kinase (CDK)-4 and -6 inhibitor, is the only FDA-approved agent that preemptively protects hematopoietic stem cells from chemotherapy-induced myelosuppression (CIM) without compromising efficacy. It transiently arrests hematopoietic stem cells in the G1 phase, thus temporarily blocking progression…