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UrduCancer patients frequently experience metabolic dysfunction leading to severe weight loss correlating with a poor prognosis. Causes for this dysfunction include malnutrition and cachexia, a systemic inflammation affecting brain mechanisms regulating satiety and hunger.
Tag: Cachexia
Disruptions to Fatty Compounds Inside Muscle Cells Coincides with Model of Cancer-induced Muscle Wasting
Article title: Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia Authors: Thomas D. Cardaci, Brandon N. VanderVeen, Alexander R. Huss, Brooke M. Bullard, Kandy T. Velazquez, Norma Frizzell, James A. Carson, Robert L. Price, E.…
SOS Signal for Canine Muscle Loss
Researchers at Cummings School of Veterinary Medicine are now working with engineers at the Massachusetts Institute of Technology (MIT) to determine whether a blood test, ultrasound, or a combination of both can be developed to detect cachexia sooner, more consistently, and to grade how advanced the condition is.
Ketogenic diet and its effects on tumour growth and ‘wasting syndrome’
Professor Ashok Venkitaraman, Director of the Cancer Science Institute of Singapore at the National University of Singapore, together with Assistant Professor Tobias Janowitz, Principal Investigator at the Cold Spring Harbor Laboratory in New York, and an international group of researchers from the USA and UK, have discovered that ketogenic diets delay tumour growth but accelerate cachexia, a wasting syndrome, an unintended side effect that could cause death.
Exercise Could Help Reduce Severity of Serious Cancer Complication
A new study has identified yet another benefit of keeping up your exercise routine. In experiments performed with mice, researchers found that exercising prior to developing cancer was associated with slower tumor growth and helped reduce the effects of a cancer complication known as wasting syndrome, or cachexia.
New Model May Help Us Better Understand Cancer-Related Disability in Humans
A novel preclinical mouse model of pancreatic cancer may promote better understanding of the mechanisms that lead to disability in human cancer patients, according to the findings of a new study presented this week at the Association of Academic Physiatrists Annual Meeting.
Researchers identify therapeutic targets to prevent cancer-associated muscle loss
Researchers at the University of Nebraska Medical Center have identified a key cell signaling pathway that drives the devastating muscle loss, or cachexia, suffered by many cancer patients. The study, which will be published May 22 in the Journal of Experimental Medicine, suggests that targeting this pathway with a drug already in phase 2 clinical trials for diabetes could prevent this syndrome.
Amino Acid Supplement + Radiation for Cancer = A Dangerous Mix for Some
Research in mice suggests that supplementing the essential nutrient methionine combined with radiation therapy impairs gut function to promote a life-threatening form of radiation toxicity. The study highlights the importance of food and nutrition professionals as part of a cancer treatment team.