Scientists kill cancer cells by “shutting the door” to the nucleus

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes—large channels that control the flow of materials in and out of the cell nucleus—shrank aggressive tumors in mice while leaving healthy cells unharmed. The study, published in Cancer Discovery, a journal of the American Association for Cancer Research, reveals a new Achilles heel for cancer that may lead to better treatments for deadly tumors such as melanoma, leukemia and colorectal cancer.

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KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in early trial

For patients with advanced solid cancers and KRAS G12C mutations, the targeted therapy sotorasib, a KRAS G12C inhibitor, resulted in manageable toxicities and durable clinical benefits, particularly in lung and colorectal cancer, in Phase I study

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Daily coffee consumption associated with improved survival in patients with metastatic colorectal cancer

In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers at Dana-Farber Cancer Institute and other organizations report in a new study.

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To Reduce Colorectal Cancer Disparities among African American Men, More Intervention Research Is Urgently Needed

African American men have the lowest five-year survival rate for colorectal cancer (CRC) out of any other racial group. A major factor is low adherence to recommended early detection screening. Yet published research on effective strategies to increase screening for this group specifically are minimal. These findings were published today in PLOS ONE.

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High-risk Patients for Colorectal Cancer Lack Knowledge About Colonoscopy

Many clinicians rely on self-reports from their high-risk patients about their need and proper interval for repeat surveillance colonoscopy. Researchers analyzed data over four years to explore the knowledge of these high-risk patients. Twenty-eight percent were unaware of either the need for a repeat colonoscopy or the proper surveillance interval. Of these, 16.6 percent were unaware of the proper three-year interval to obtain a follow-up surveillance colonoscopy. Also, 12 percent were not even aware that they required a follow-up surveillance colonoscopy.

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Center for Asian Health Equity awarded $4.25 million CDC grant to prevent colorectal cancer in Illinois

The University of Chicago Medicine’s Center for Asian Health Equity has received a five-year, $4.25 million federal grant to increase colorectal cancer screenings, particularly among underserved and rural Illinois communities.

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Cancer Care Can’t Wait

Further delaying your preventative cancer care may cause more harm than good. Expert from Rutgers Cancer Institute of New Jersey explains how most colorectal cancers can be prevented through regular screenings, and it is safe to get your screenings, even during these difficult times.

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