Researchers Engineer Yeast to Transport Medicines and Lower Inflammation for Potential Treatment of Inflammatory Bowel Disease

Researchers at the UNC Eshelman School of Pharmacy and the UNC School of Medicine have engineered a probiotic yeast that enhances probiotic absorption in the gut and has the ability to suppress and even reverse inflammation in animals.

MD Anderson Research Highlights for April 24, 2024

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

AACR: Combination treatment is well-tolerated, shows antitumor effects in KRAS G12C-mutated metastatic colorectal cancer

Combining the KRAS G12C inhibitor adagrasib with the anti-EGFR antibody cetuximab demonstrated promising anti-tumor effects in patients with KRAS G12C-mutated metastatic colorectal cancer (CRC), according to pooled results from the Phase I/II KRYSTAL-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

Tip Sheet: Weight loss drugs and cancer prevention, Fred Hutch at AACR, lymphedema Q&A — and new vice president and chief nursing officer

SEATTLE — April 3, 2024 — Below are summaries of recent Fred Hutchinson Cancer Center research findings, patient stories and other news. If you’re covering the American Association for Cancer Research (AACR) Annual Meeting, please see our list of and contact to set up interviews.

Musicians Colbie Caillat, Lisa Loeb, Rufus Wainwright, Hilary Hahn, and More Support Colorectal Cancer Awareness in Free Webcast Concert

The American College of Gastroenterology Free Virtual Event on March 28, 2024, at 8:00 pm ET, “Tune It Up: A Concert To Raise Colorectal Cancer Awareness”

Blood Test Shows Promise for Early Detection of Colorectal Cancer

A recent study published in the New England Journal of Medicine reports a DNA blood-based test that identified 83% of patients with colorectal cancer. This test is showing promise as a new option for colorectal cancer screening. Samir Gupta, MD,…

Hackensack Meridian Jersey Shore University Medical Center Welcomes Dr. Lee Peng as Chief of Gastroenterology

Hackensack Meridian Jersey Shore University Medical Center welcomed Lee F. Peng, M.D., PhD, as section chief of gastroenterology, department of medicine.

New Research in March: Colorectal Cancer, Kidney Health, OR Supply Costs, and More

The March issue of the Journal of the American College of Surgeons (JACS) features new research on topics ranging from colorectal cancer and social vulnerability to operating room supply costs, the rise in school shootings since 1970, and the impact of permitless open carry laws on suicide rates, among others.

Grand Prize Winner: The Southwest Coalition for Colorectal Cancer Screening (SuCCCeS) program

According to the American Cancer Society, the number of colorectal cancers in the US for 2024 are estimated to be about 106,590 new cases of colon cancer (54,210 in men and 52,380 in women) and about 46,220 new cases of rectal cancer (27,330 in men and 18,890 in women).

NCCN Updates Treatment Recommendations for Breast, Colorectal, Lung, and other Cancer Types Based on Emerging Evidence

Recent NCCN Guidelines updates—along with the supporting evidence—will be presented during the NCCN 2024 Annual Conference held in Orlando, Florida April 5-7, and simultaneously online. Visit to learn more and register.

Baylor Scott & White doctor discusses why cancer is impacting more young people

David Winter, MD, at Baylor Scott & White Health, discusses why cancer is impacting more young people. What You Need to Know: People aged 50 and older are living longer because of better cancer detection and treatments. Cancer diagnosis in…

Five Signs of Colorectal Cancer You Shouldn’t Ignore – Even if You’re a Younger Adult

The recent Cancer Facts & Figures 2024 report from American Cancer Society (ACS) researchers revealed a stark increase in colorectal cancer (CRC) incidence among Americans under the age of 55. In just two decades, CRC has moved up from being the fourth leading cause of cancer death in both younger men and women, to first in men and second in women.

Clues to early onset colorectal cancer found in microbiome of Hispanic patients

Nina Sanford, M.D., Chief of Gastrointestinal Radiation Oncology Service, UT Southwestern Medical Center Most people have a screening colonoscropy around age 50, however recent research has uncovered a rise in early onset colorectal cancer in patients younger than 50. What can…

Case Western Reserve University researcher awarded $2 million federal grant to further explore possible new effective treatments for colorectal and other cancers

With a new $2 million federal grant, a researcher with the Case Western Reserve University School of Medicine will lead a team to further explore preliminary findings of an effective treatment for colorectal and possibly other cancers.

New Study Shows Insurance Coverage Disruptions Affect Key Cancer Screenings for U.S. Adults

A new study by researchers at the American Cancer Society shows that adults in the United States with prior insurance coverage disruptions are significantly less likely to receive guideline-concordant and past-year cancer screening, compared to people with continuous coverage.

Exercise boosts anti-cancer immunity and reduces inflammation in Lynch Syndrome patients

Regular and intense aerobic exercise may reduce the risk of colorectal cancer in patients with Lynch Syndrome (LS) by improving the immune system’s ability to detect and remove potentially harmful cells, according to researchers at
The University of Texas MD Anderson Cancer Center.

Only about a quarter of adults overdue for colorectal cancer screening report receiving a clinician recommendation for screening during wellness visit

Most adults overdue for colorectal cancer (CRC) screening report that they did not receive a screening recommendation from their clinician during a wellness visit in the past year, especially among historically marginalized populations.

Colorectal Cancer Patients in Sub-Saharan Africa Receiving Inadequate Care; Survival After Diagnosis Poor, New Study Shows

In new findings led by researchers at the American Cancer Society, Martin-Luther University in Germany, and many other institutes worldwide, fewer than one in 20 patients diagnosed with potentially curable colorectal cancer received standard of care in Sub-Saharan Africa.

NCCN Announces Research Funding for Biomarker-Directed Therapy in Metastatic Colorectal Cancer, in Collaboration with Fight CRC and Pfizer

The National Comprehensive Cancer Network (NCCN) Oncology Research Program (ORP) today announced new grants awarded to improve quality initiatives focused on optimizing biomarker-directed therapy in metastatic colorectal cancer.

Transcription Factors Contribute to Subtypes of Colorectal Cancers

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers. Methylation is a process in which certain chemical groups attach to areas of DNA that guide genes’ on/off switches.

Alcohol Use, Even at Low Levels, Increases Risk of Developing Disease

Even low levels of alcohol use can increase the likelihood of developing diseases like cancer and heart disease. A systematic review of studies of the relationship between alcohol use and risk of disease published in Alcohol: Clinical and Experimental Research found that disease risk increases as alcohol use increases and high levels of alcohol use have clear detrimental health effects. While lower-level alcohol use can be protective against certain diseases, it can have significant adverse health effects for many other diseases. The authors urge greater awareness that any level of alcohol use can increase a person’s risk of developing serious, even fatal, diseases.

Patients with refractory metastatic colorectal cancer experience survival benefits with fruquintinib

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer. Findings from the global FRESCO-2 trial, published today in The Lancet, were first presented at the European Society for Medical Oncology (ESMO) Congress 2022.

Targeted Chemotherapy Helps Cure Some Inoperable Tumors

Physicians at Cedars-Sinai Cancer are using a unique chemotherapy delivery system that offers hope to colorectal cancer patients whose disease has spread and who now have inoperable liver tumors. Cedars-Sinai is one of the few centers in the area to offer the therapy, called hepatic artery infusion (HAI) pump chemotherapy.

Start screenings at age 45 to prevent colorectal cancer, UT Southwestern experts advise

Colorectal cancer is on the rise among younger adults. According to the American Cancer Society, the proportion of cases among people under 55 increased from 11% in 1995 to 20% in 2019, and it is now the leading cause of cancer-related deaths for men younger than 50.

ASCO23: Sylvester Cancer Experts Available for Interviews on a Wide Range of Topics

In addition to presenting Sylvester Comprehensive Cancer Center research findings, Sylvester experts are available at ASCO to share perspectives on a wide variety of topics and studies ranging from breast cancer to sarcoma, prostate cancer, mesothelioma, melanoma, CNS tumors and more.

Study Reveals How Fatty Liver Promotes Colorectal Cancer Spread

Investigators at Cedars-Sinai Cancer found that fatty liver, a condition closely associated with obesity, promotes the spread of colorectal cancer to the liver. Their study, published today in the peer-reviewed journal Cell Metabolism, details the process at the cellular level and could change the way doctors manage the disease in some patients.

Financial toxicity of cancer impacts partners’ quality of life

A cancer diagnosis can cause financial strain on patients as they cope with the cost of treatment and lost work. But what about their partners? A new study from University of Michigan Rogel Cancer Center researchers surveyed the partners of colorectal cancer patients and found the financial impact of a loved one’s diagnosis also impacts the partner’s health-related quality of life.

April Issue of AJG Discusses Colorectal Cancer Risk Factors, H. pylori Infection, and Crohn’s Therapies

The April issue of The American Journal of Gastroenterology highlights new clinical science, including an examination of changes in lifestyle habits and risk of colorectal cancer

Eng invited to White House Cancer Moonshot forum

Cathy Eng, MD, the David H. Johnson Professor of Surgical and Medical Oncology, has been invited to participate in the White House Cancer Moonshot Colorectal Cancer Forum. She will be at the White House Complex on March 10 as administration officials provide updates on progress on several key Moonshot initiatives and seek input from patients, caretakers, oncologists and researchers.

AI improving digestive cancer diagnosis, but data-sharing obstacles remain

Artificial intelligence is helping to deliver earlier and better diagnoses of digestive cancers, but many challenges remain to widespread clinical application, not least limited sharing of medical imaging data between hospitals, and lack of standardization of protocols for medical imaging for AI, a group of researchers has concluded after a comprehensive survey of recent applications of the technology to these most deadly of cancers.