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UrduA study led by UC Davis distinguished professor Andreas Bäumler uncovered how Salmonella, a major cause of food poisoning, can invade the gut despite the presence of protective bacteria.
Tag: Inflammatory Bowel Disease
Binghamton University researcher to aid innovative Mayo Clinic project to treat inflammatory diseases
Binghamton University, State University of New York will play a key role in a federal grant of up to $42.8 million to develop an implantable device that acts as a living pharmacy to treat inflammatory diseases. Mayo Clinic is the prime site for this groundbreaking research, and researchers at Binghamton will assist with bioengineering the transplanted cells.
Cleveland Clinic Researchers Discover New Bacterium that Causes Gut Immunodeficiency
Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.
The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut’s multi-faceted protective immune barrier.
Identifying this bacterium is the first step to developing new treatments for a variety of inflammatory and infectious gut diseases.
Organoids Derived From Gut Stem Cells Reveal Two Distinct Molecular Subtypes of Crohn’s Disease
UC San Diego researchers discover two distinct molecular subtypes of Crohn’s disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.
Landmark Study Reveals How Antibiotics Contribute to Inflammatory Bowel Disease Risk
In a landmark study published today in Science Advances, Dr. Shai Bel and his research team at the Azrieli Faculty of Medicine of Bar-Ilan University have uncovered crucial insights into how antibiotic use increases the risk of inflammatory bowel disease (IBD).
Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice
Engineers at the University of California San Diego have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice.
Researchers Engineer Yeast to Transport Medicines and Lower Inflammation for Potential Treatment of Inflammatory Bowel Disease
Researchers at the UNC Eshelman School of Pharmacy and the UNC School of Medicine have engineered a probiotic yeast that enhances probiotic absorption in the gut and has the ability to suppress and even reverse inflammation in animals.
The Rising Costs of Alcohol-Associated Liver Disease and More in the February Issue of AJG
A modeling study projecting the economic and social burden of alcohol-associated liver disease by 2040 is featured in the February 2024 issue of AJG, just one month after the new ACG Clinical Guideline on Alcohol-Associated Liver Disease
Studies on Higher Infliximab Concentrations in IBD, Opioid-Related Constipation and More in the November Issue of AJG
The November issue of AJG highlights new clinical science and reviews including additional colonoscopy quality measures, higher infliximab concentrations in IBD patients with higher visceral adipose tissue (VAT), an automated tissue systems pathology test for Barrett’s esophagus, and opioid-related constipation.
Cedars-Sinai Graduate School Earns Renewed Accreditation
The Graduate School of Biomedical Sciences at Cedars-Sinai has again been accredited by the Senior College and University Commission of the Western Association of Schools and Colleges.
Digital Therapeutics and Innovations in GI Highlighted in the August Issue of AJG
The August issue of The American Journal of Gastroenterology includes several articles on digital therapeutics and innovations in GI, encouraging adoption of emerging GI technologies to advance GI care.
May Issue of AJG Features Colonoscopy Quality and Bowel Prep, CME on Social Media
The May issue of AJG features new clinical science and reviews, including bowel prep recommendations for physicians, longer withdrawal times for screening colonoscopy, the use of social media for continuing medical education, and tofacitinib de-escalation and re-escalation for ulcerative colitis.
The use of artificial sweeteners have been investigated for their potential negative consequences in a number of chronic conditions.
Dr. Abigail Basson, PhD, RD, LD, is a registered dietitian and NIH-funded Instructor in the Department of Nutrition with a secondary appointment with the Division of Gastroenterology, School of Medicine at Case Western Reserve University. Abigail’s research goal is to…
Patients with IBD at higher risk of lymphoma
The risk of developing lymphoma is slightly elevated in inflammatory bowel disease (IBD) and has increased in recent years in patients with Crohn’s disease, report researchers from Karolinska Institutet in a study published in Clinical Gastroenterology and Hepatology.
April Issue of AJG Discusses Colorectal Cancer Risk Factors, H. pylori Infection, and Crohn’s Therapies
The April issue of The American Journal of Gastroenterology highlights new clinical science, including an examination of changes in lifestyle habits and risk of colorectal cancer
UChicago Medicine trains physicians on ‘game-changing’ intestinal ultrasound
UChicago Medicine is the only hospital in the Midwest, and one of just two nationwide, to offer intestinal ultrasound to patients.
Genetic variation that protected against Black Death still helps against respiratory diseases today, but increases autoimmune disease risks
The same genetics that helped some of our ancestors fight the plague is still likely to be at work in our bodies today, potentially providing some of the population with extra protection against respiratory diseases such as COVID-19. However, there is a trade-off, where this same variation is also linked to increased autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease.
Can Butyrate Help Hispanic Children With Ulcerative Colitis?
New study is the first of its kind to focus on Hispanic children, who often have more severe disease. A novel clinical trial at Children’s Hospital Los Angeles is investigating whether butyrate—a short-chain fatty acid typically produced by gut bacteria—can be a potential therapy for children with ulcerative colitis.
UTSW researchers discover new drug target for inflammatory bowel disease
A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings, published in Cell Reports, suggest a new drug target for treating IBD and related conditions.
Transcutaneous Electrical Acustimulation for IBS-C, Infliximab Retreatment for Crohn’s Disease Featured in September Issue of AJG
The September issue of AJG highlights new clinical science, including a potential therapy to improve IBS-C symptoms, reintroduction of infliximab for Crohn’s disease, and population-based data to examine incidence and mortality of certain GI and hepatology diseases.
The gut patrol
Cells in the gut send secret messages to the immune system. Thanks to new research from La Jolla Institute for Immunology (LJI) scientists, we can finally get a look at what they’re saying.
Smartphone App to Assess Stool Form, Rural-Urban Disparities in Cirrhosis Mortality, Lung Infection Risk in Severe Alcoholic Hepatitis in July Issue of AJG
The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.
COVID-19 Vaccine Gets Strong Response in Some With Weak Immunity
Researchers at Cedars-Sinai found that patients with inflammatory bowel disease (IBD)─whose treatment can weaken the immune system─produced a strong antibody response to COVID-19 vaccination. The study findings have been published in the Annals of Internal Medicine.
New Clinical Advances in Gastroenterology Presented at the American College of Gastroenterology’s 86th Annual Scientific Meeting
Featured science includes increased incidence of pancreatic cancer among young women, quality of life improvements in IBD, colorectal cancer risk from weight loss surgery and medications, and more
Novel mechanism links genetic defect in IBD patients to gut leakiness
A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.
Low-fiber Diet May Lead to Gut Infection Even if You’re Not Overweight
Diet, more than body mass, may play a role in the risk for gut infection, and eating more fiber could be the key to prevention. The study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
Gene Mutation Weakens Virus-Fighting Protein in the Gut Causing Rare Inflammatory Bowel Disease
Johns Hopkins Medicine researchers, in collaboration with national and international researchers, have identified a genetic mutation in a small number of children with a rare type of inflammatory bowel disease. The discovery of the mutation, which weakens the activity of a protein linked to how the immune system fights viruses in the gut, may help researchers pinpoint the cause of more common bowel diseases, investigators say.
Fungi That Live in the Gut Influence Health and Disease
Bacteria’s role in gut health has received a lot of attention in recent years. But new research publishing in Nature shows that fungi—another microorganism that lives within us—may be equally important in health and disease. Fungi thrive in the healthy gut, but when interactions with the immune system are off-balance, they cause intestinal damage that may contribute to gastrointestinal disease. Additional investigation demonstrate that vaccines could be developed as therapeutics to improve gut health.
Restoring gut microbes missing in early life dysbiosis can reduce the risk of colitis in genetically prone mice
A new study at the University of Chicago has determined that restoring a single microbial species — Bacteroides sp. CL1-UC (Bc) — to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition.
Inflammatory Bowel Disease Impairs Artery Function in GI Tract
Article title: Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease Authors: Charles E. Norton, Elizabeth A. Grunz-Borgmann, Marcia L. Hart, Benjamin W. Jones, Craig L. Franklin, Erika M. Boerman From the authors: “Our study is the…
Cleveland Clinic Researchers Discover Microbial Infection That Impairs Healing in Crohn’s Disease
A Cleveland Clinic-led team of researchers has discovered an infection that prevents healing in Crohn’s disease. According to study results published in Science, a type of yeast commonly found in cheese and processed meat is elevated in areas of unhealed wounds in Crohn’s disease patients, a discovery that may point to much-needed new treatment or prevention approaches for the common inflammatory bowel disease. The work was led by Thaddeus Stappenbeck, M.D., PhD., chair of Cleveland Clinic Lerner Research Institute’s Department of Inflammation and Immunity.
March is the Month to Get to the Bottom of Colorectal Cancer
Discussions about digestion and elimination can be embarrassing, so many people, young and old, tend to avoid them. But ignoring the topic and skipping colorectal cancer screening can lead to deadly results, experts say.
Study Reveals Details of Immune Defense Guidance System
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
Surgery to Heal Inflamed Gut May Create New Target for Disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows.
Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
The prevalence of inflammatory bowel diseases has significantly increased both in Finland and globally.
Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities
Genetic Risk for Fatal Blood Clots Identified in IBD Patients
Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn’s disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.
COVID-19: Enzyme Targeted by Virus Also Influences Gut Inflammation
An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the possibility that anti-inflammatory drug therapies for IBD may aid recovery from coronavirus.
CHOP Genomic Study Reveals Role for Hypothalamus in Inflammatory Bowel Disease
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children’s Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. The researchers went on to implicate new genes involved in IBD risk that are enriched in both derived hypothalamic neurons, from a part of the brain that has a vital role in controlling stress and depression, and organoids derived from colon cells, a region more commonly studied in the context of IBD.
Medical Mystery: ‘Creeping Fat’ in Crohn’s Patients Linked to Bacteria
Cedars-Sinai researchers might have solved a mystery surrounding Crohn’s disease: Why does fat appear to migrate into patients’ small intestines?
Inflammatory Bowel Disease Linked to an Immune Cell Run Amok
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract.
Could the Cure for IBD Be Inside Your Mouth?
A new study describes how poor oral health may worsen gut inflammation.
Delta Opioid Receptor Identified as Promising Therapeutic Target for Inflammatory Pain Relief
Delta opioid receptors have a built-in mechanism for pain relief and can be precisely targeted with drug-delivering nanoparticles—making them a promising target for treating chronic inflammatory pain with fewer side effects, according to a new study from an international team of researchers. The study, published in Proceedings of the National Academy of Sciences (PNAS), was conducted using cells from humans and mice with inflammatory bowel disease, which can cause chronic pain.
Serious Complication of Crohn’s Disease May Be Preventable in Young People
For children and young adults with Crohn’s disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests.
$6M, 5-year NIH grant extends funding for collaborative Cleveland Digestive Diseases Research Core Center
A new $6 million, 5-year grant from the National Institutes of Health extends funding for the Silvio O. Conte Cleveland Digestive Diseases Research Core Center (DDRCC), a cross-institutional collaboration of digestive disease investigators.
Radiation therapy for colon cancer works better when specific protein blocked
Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.
Researchers Identify Opportunities to Advance Genomic Medicine
New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities
VERSATILE BILE ACIDS
Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and inflammation?
The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.
Case Western Reserve University researchers discover critical link to controlling inflammation in Crohn’s disease
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).
Mayo Clinic researchers to present study findings at American College of Gastroenterologists Annual Scientific Meeting
Mayo Clinic physicians will present findings at the American College of Gastroenterologists Annual Scientific Meeting, Oct. 25–30 in San Antonio.