A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings, published in Cell Reports, suggest a new drug target for treating IBD and related conditions.
The September issue of AJG highlights new clinical science, including a potential therapy to improve IBS-C symptoms, reintroduction of infliximab for Crohn’s disease, and population-based data to examine incidence and mortality of certain GI and hepatology diseases.
Cells in the gut send secret messages to the immune system. Thanks to new research from La Jolla Institute for Immunology (LJI) scientists, we can finally get a look at what they’re saying.
The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.
Researchers at Cedars-Sinai found that patients with inflammatory bowel disease (IBD)─whose treatment can weaken the immune system─produced a strong antibody response to COVID-19 vaccination. The study findings have been published in the Annals of Internal Medicine.
Featured science includes increased incidence of pancreatic cancer among young women, quality of life improvements in IBD, colorectal cancer risk from weight loss surgery and medications, and more
A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.
Diet, more than body mass, may play a role in the risk for gut infection, and eating more fiber could be the key to prevention. The study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
Johns Hopkins Medicine researchers, in collaboration with national and international researchers, have identified a genetic mutation in a small number of children with a rare type of inflammatory bowel disease. The discovery of the mutation, which weakens the activity of a protein linked to how the immune system fights viruses in the gut, may help researchers pinpoint the cause of more common bowel diseases, investigators say.
Bacteria’s role in gut health has received a lot of attention in recent years. But new research publishing in Nature shows that fungi—another microorganism that lives within us—may be equally important in health and disease. Fungi thrive in the healthy gut, but when interactions with the immune system are off-balance, they cause intestinal damage that may contribute to gastrointestinal disease. Additional investigation demonstrate that vaccines could be developed as therapeutics to improve gut health.
A new study at the University of Chicago has determined that restoring a single microbial species — Bacteroides sp. CL1-UC (Bc) — to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition.
Article title: Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease Authors: Charles E. Norton, Elizabeth A. Grunz-Borgmann, Marcia L. Hart, Benjamin W. Jones, Craig L. Franklin, Erika M. Boerman From the authors: “Our study is the…
A Cleveland Clinic-led team of researchers has discovered an infection that prevents healing in Crohn’s disease. According to study results published in Science, a type of yeast commonly found in cheese and processed meat is elevated in areas of unhealed wounds in Crohn’s disease patients, a discovery that may point to much-needed new treatment or prevention approaches for the common inflammatory bowel disease. The work was led by Thaddeus Stappenbeck, M.D., PhD., chair of Cleveland Clinic Lerner Research Institute’s Department of Inflammation and Immunity.
Discussions about digestion and elimination can be embarrassing, so many people, young and old, tend to avoid them. But ignoring the topic and skipping colorectal cancer screening can lead to deadly results, experts say.
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows.
The prevalence of inflammatory bowel diseases has significantly increased both in Finland and globally.
New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities
Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn’s disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.
An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the possibility that anti-inflammatory drug therapies for IBD may aid recovery from coronavirus.
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children’s Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. The researchers went on to implicate new genes involved in IBD risk that are enriched in both derived hypothalamic neurons, from a part of the brain that has a vital role in controlling stress and depression, and organoids derived from colon cells, a region more commonly studied in the context of IBD.
Cedars-Sinai researchers might have solved a mystery surrounding Crohn’s disease: Why does fat appear to migrate into patients’ small intestines?
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract.
A new study describes how poor oral health may worsen gut inflammation.
Delta opioid receptors have a built-in mechanism for pain relief and can be precisely targeted with drug-delivering nanoparticles—making them a promising target for treating chronic inflammatory pain with fewer side effects, according to a new study from an international team of researchers. The study, published in Proceedings of the National Academy of Sciences (PNAS), was conducted using cells from humans and mice with inflammatory bowel disease, which can cause chronic pain.
For children and young adults with Crohn’s disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests.
A new $6 million, 5-year grant from the National Institutes of Health extends funding for the Silvio O. Conte Cleveland Digestive Diseases Research Core Center (DDRCC), a cross-institutional collaboration of digestive disease investigators.
Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.
New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities
Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and inflammation?
The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).
Mayo Clinic physicians will present findings at the American College of Gastroenterologists Annual Scientific Meeting, Oct. 25–30 in San Antonio.
William Sandborn, MD, chief of the Division of Gastroenterology and director of the Inflammatory Bowel Disease Center, is one of the world’s top experts in the management of ulcerative colitis and Crohns disease. His groundbreaking research has been instrumental to…