news, journals and articles from all over the world.
As the height of the COVID-19 outbreak in New York City and the Tri-State area begins to subside, Memorial Sloan Kettering Cancer Center oncologists are urging patients to schedule cancer screenings and treatments now – as the long-term toll of missed diagnoses and delayed treatments could be devastating for patients and their loved ones across the region and the country.
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.
Some types of gut bacteria are better than others at stimulating certain immune cells, specifically CD8+ T cells. And while these CD8+ T cells normally help protect the body against cancer, overstimulating them may promote inflammation and exhaust the T cells — which can actually increase susceptibility to cancer, according to new mouse model study published in Cell Reports.
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday, throughout the duration of the outbreak.
In the study, a group of lab mice that had consumed a diet that included the HM-10/10 peptide was found to have a significantly lower tumor load than mice that had not eaten the peptide.
Patrick A. Hyatt, M.D., is a highly skilled specialist with The Center for Heartburn and Reflux Disease in Baltimore, Maryland, which is part of The Melissa L. Posner Institute for Digestive Health & Liver Disease at Mercy. The Center is dedicated…
Jeffery Nelson, M.D., FACS, FASCRS, is an experienced colorectal surgeon who serves as Surgical Director of The Center for Inflammatory Bowel and Colorectal Diseases, The Institute for Digestive Health & Liver Disease at Mercy. Dr. Jeffery Nelson has more than 25…
A colonoscopy is the best way to screen for and prevent colorectal cancer (CRC) because it allows your doctor to find and remove precancerous growths called polyps before they have a chance to turn into cancer.
The U.S. Preventive Services Task Force (USPSTF) recommends that most people have colonoscopy screenings starting at age 50. People who are at a higher risk for CRC due to family history or other factors should begin having screenings at a younger age based on their doctor’s recommendation.
Cologuard, an at-home test, is not a preventive CRC screening tool because it detects cancer after you develop it.
Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.
The density of immune cells, called tumor infiltrating lymphocytes, when combined with analysis of tumor budding may serve as a method to more accurately predict survival in patients with stage III colon cancer. The findings, by a team of researchers led by Mayo Clinic gastroenterologist and oncologist, Frank Sinicrope, M.D., were published today in Annals of Oncology.
Like most people, John Gifford wasn’t looking forward to a colonoscopy when he arrived on the UCI Medical Center campus in Orange in 2018. The Riverside man, 65, was concerned about his family history of colorectal cancer and had dutifully scheduled an appointment with UCI Health gastroenterologist Dr. William Karnes. The exam turned out to be intriguing and enlightening – a far cry from what one expects during a colonoscopy, Gifford recalls with a laugh.
A study led by The University of Texas MD Anderson Cancer Center furthered understanding about mitochondria, the cell components known as the “powerhouse of the cell.” Knowing more about the genome is crucial given that mitochondria play important roles in tumorigenesis.
Along with a healthy lifestyle, regular screening can help with the prevention of cancer. Rutgers Cancer Institute of New Jersey experts share additional information during this Cancer Prevention Month.
University of Colorado Cancer Center study presented at the 2020 Gastrointestinal Cancers Symposium shows patients with locally advanced rectal cancer receiving lower-than-recommended doses of neoadjuvant chemotherapy in fact saw their tumors shrink more than patients receiving the full dose.
Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it can drive cell proliferation. Inhibiting this transport step could block the growth of most colorectal cancers caused by elevated βcatenin levels.
This edition of Science Snapshots highlights the discovery of an investigational cancer drug that targets tumors caused by mutations in the KRAS gene, the development of a new library of artificial proteins that could accelerate the design of new materials, and new insight into the natural toughening mechanism behind adult tooth enamel.
A Mayo Clinic study involving 5,540 patients with metastatic colorectal cancer finds that maintenance chemotherapy after initial treatment is more beneficial for patients whose disease is under control, compared with more aggressive treatment.
Taking a baby aspirin every day to prevent a heart attack or stroke should no longer be recommended to patients who haven’t already experienced one of these events.
Researchers have found that 2,4,6-trihydroxybenzoic acid, one of the compounds produced when the body metabolizes or breaks down flavonoids, can inhibit cancer cell growth under specific conditions.
Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study. The study, published in the journal Gastroenterology, describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.
Cancer-control researchers at the University of Kentucky Markey Cancer Center and The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) aim to increase colorectal cancer screening and follow-up care among underserved individuals in Appalachia through a $5.7 million grant from the National Cancer Institute.
American College of Gastroenterology announces 2019 SCOPY Award winners (Service Award for Colorectal Cancer Outreach, Prevention, and Year-Round Excellence) to recognize the achievements of ACG members in their community engagement, education and awareness efforts for colorectal cancer prevention
Findings showcasing a connection between bacteria in the microbiome and colon cancer, which may be used to screen younger populations at risk, were published in the journal Gastroenterology by researchers from the George Washington University.
The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
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