Scientists identify promising immunotherapy combination for pediatric brain cancer

Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy.

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Cancer survival disparities in minority children, adolescents greater for more treatable cancers

Racial and ethnic minority children and adolescents with cancer have a higher risk of death than non-Hispanic white children and adolescents, with evidence for larger disparities in survival for more treatable cancers, finds a new study from the Brown School at Washington University in St. Louis.“The results suggest that there are modifiable racial and ethnic disparities in childhood cancer survival,” said Kim Johnson, associate professor and senior author of “Associations Between Race/Ethnicity and US Childhood and Adolescent Cancer Survival by Treatment Amenability,” published Feb.

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Algorithm Reduces Need for Therapy in Children With Intermediate-Risk Neuroblastoma

Roswell Park’s Dr. Clare Twist led an effort to develop and validate a new treatment algorithm for infants and children with neuroblastoma. In a new study in the Journal of Clinical Oncology, the team reports that many patients can safely receive less extensive therapy.

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