Mount Sinai Researchers Discover That Topical Treatment Improves Chronic Plaque Psoriasis

Researchers at the Icahn School of Medicine report that roflumilast cream (ARQ-151), which contains a highly potent, selective phosphodiesterase-4 (PDE4) inhibitor demonstrated significant improvements in patients with psoriasis signs and symptoms in as early as two weeks. The phase 2b trial results showed that when patients with plaque psoriasis applied topical roflumilast once-daily they reported clear skin as well as improvement in itch and burden of disease. The results of the paper were published online today in The New England Journal of Medicine.

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Mount Sinai and Cross County Cardiology Partner to Expand Advanced Cardiac Services in New Jersey

Mount Sinai Health System and Cross County Cardiology announced a new cooperative partnership today that will include five cardiology practices located throughout Bergen and Hudson counties in New Jersey. Cross County Cardiology-Mount Sinai Doctors will work to enhance clinical care for patients with cardiovascular disease bringing the most advanced techniques within the field of cardiology and vascular care to the region.

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The Mount Sinai Hospital and Healthfirst partnered to develop an educational intervention and payment redesign program to improve timely postpartum visits for low-income high-risk mothers in New York City

A health care system (The Mount Sinai Hospital) and a Medicaid payer (Healthfirst) partnered to develop an educational intervention and payment redesign program to improve timely postpartum visits for low-income high-risk mothers in New York City between April 2015 and October 2016.

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Mount Sinai Researcher Receives NIH Award to Study Immune Responses of Patients With Inflammatory Skin Diseases in the Setting of COVID-19 Infection

The study will aim to understand whether systemic medications and biologics, such as dupilumab—a monoclonal antibody that binds to an inflammatory molecule, IL-4 receptor alfa, and inhibits the inflammatory response that leads to rashes and itching from atopic dermatitis/eczema—may have a positive or negative impact on COVID-19 responses in patients who have the disease.

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Mount Sinai Health System, Emergent BioSolutions, and ImmunoTek Bio Centers Form Collaboration to Develop Emergent’s COVID-19 Hyperimmune Globulin (COVID-HIG) Product Candidate with U.S. Department of Defense Funding

Mount Sinai and Emergent to conduct clinical trials to evaluate COVID-HIG for post-exposure prophylaxis of COVID-19 in front-line health care workers and to support a potential Expanded Access Program for military personnel with funding from the U.S. Department of Defense
– ImmunoTek to extend operating license and provide training to Mount Sinai to establish onsite plasma collection to support production of COVID-HIG

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Simulation-based Training Helps Providers Prepare for Prone Position Ventilation for Patients With ARDS

An interprofessional simulation-based educational program helped Mount Sinai Hospital train nearly 90% of its medical ICU staff to care for patients in prone position, as part of its 2018 implementation of a new protocol related to prone position ventilation for patients with acute respiratory distress syndrome.

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Elevated Leukemia Incidence Is Found in World Trade Center Rescue and Recovery Workers

Responders who worked at the World Trade Center site after the attacks on September 11, 2001, have an increased overall cancer incidence compared to the general population, particularly in thyroid cancer, prostate cancer, and, for the first time ever reported, leukemia, according to a Mount Sinai study published in JNCI Cancer Spectrum in January.

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Study Links Prenatal Exposure to Air Pollution to Negative Impact on Infants’ Heart Rate Response to Stress

A mother’s exposure to particulate air pollution during pregnancy is associated with reduced cardiac response to stress in six-month-old infants, according to Mount Sinai research published in Environmental Health Perspectives in October. This study is the first to find that particulate air pollution exposure in utero can affect heart rate variability, which is a known risk factor for health issues.

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Mount Sinai Awarded $25 Million to Study the Environment’s Influence on People’s Health Throughout Their Lifetimes

Three world-renowned environmental health researchers from the Institute for Exposomic Research at Mount Sinai have been awarded grants worth a total of $25 million from the National Institutes of Health (NIH) for the newly formed Human Health Environmental Assessment Resource (HHEAR). This program is dedicated to measuring all the environmental factors faced in people’s lives—a new science called “exposomics,” which is expected to yield important insights about disease processes and potential treatments.

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