Cancer study may accidentally help researchers create usable blood stem cells

University of Colorado Cancer Center study shows healthy form of the leukemia-causing gene MLL may push pluripotent stem cells (which have proven difficult to use in human patients) to become durable hematopoietic stem cells (which are usable in patients, but have until now been impossible to make).

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Elevated Leukemia Incidence Is Found in World Trade Center Rescue and Recovery Workers

Responders who worked at the World Trade Center site after the attacks on September 11, 2001, have an increased overall cancer incidence compared to the general population, particularly in thyroid cancer, prostate cancer, and, for the first time ever reported, leukemia, according to a Mount Sinai study published in JNCI Cancer Spectrum in January.

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ASH: Research revises classification of acute myeloid leukemia and myelodysplastic syndrome

Results from a study conducted by St. Jude Children’s Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at the American Society of Hematology annual meeting. The study integrates genomic and transcriptomic sequencing to provide the most detailed classification of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) to date.

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New Mayo Clinic studies to be presented at American Society of Hematology meeting

Mayo Clinic researchers will present findings at the American Society of Hematology Annual Meeting Dec. 7–10 in Orlando.
New Mayo Clinic studies to be presented include:
DNA analysis identifies elevated risk factor for myeloma in individuals of African ancestry
Study identifies more precise assessment measures for patients newly diagnosed with chronic lymphocytic leukemia
Researchers develop method to assess cancer-fighting cell therapy’s effectiveness

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Use of venetoclax in reduced-intensity transplant conditioning regimen in patients with high-risk myeloid cancers shows promise in early trial

For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients’ bodies, a study led by Dana-Farber Cancer Institute researchers suggests.

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‘It’s not about just surviving. It’s about seeing my patients living normally’

Dr. Eugene Chang was 25, recently engaged and halfway through a physical medicine and rehabilitation residency in Vancouver when he started feeling sick. Fatigue, dizziness and nausea took over his normally active lifestyle. Suddenly his bike to work was not so easy.

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New NCCN Guidelines Debut to Manage Complications and Improve Readiness for Stem Cell Transplant Recipients

The National Comprehensive Cancer Network (NCCN) published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Hematopoietic Cell Transplantation, (aka stem cell transplant or bone marrow transplant), with step-by-step information on best practices for this blood cancer treatment

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Antibody eradicates leukemia stem cells

Now, in experiments in mice as well as isolated human cancer cells, UCLA researchers have discovered a way to eliminate the CML stem cells. Their approach uses an antibody to block a protein that the stem cells rely on to grow. The advance, described in a study published in the Journal of Clinical Investigation, might eventually help treat not only chronic myelogenous leukemia but other cancers as well.

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